메뉴 건너뛰기




Volumn 7, Issue SUPPL. 2, 2007, Pages

The challenges of targeting chronic myeloid leukemia stem cells

Author keywords

bcr abl targeted therapies; Drug resistance; Imatinib

Indexed keywords

3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CYTARABINE; DASATINIB; GENISTEIN; GLYCOPROTEIN P; HEAT SHOCK PROTEIN 90 INHIBITOR; HERBIMYCIN A; IMATINIB; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN OCT1; UNCLASSIFIED DRUG; BCR ABL PROTEIN; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

EID: 34247843031     PISSN: 15579190     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLM.2007.s.005     Document Type: Article
Times cited : (19)

References (131)
  • 1
    • 0141528828 scopus 로고    scopus 로고
    • Chronic myeloid leukemia- advances in biology and new approaches to treatment
    • Goldman JM, Melo JV. Chronic myeloid leukemia- advances in biology and new approaches to treatment. N Engl J Med 2003; 349:1451-1464.
    • (2003) N Engl J Med , vol.349 , pp. 1451-1464
    • Goldman, J.M.1    Melo, J.V.2
  • 2
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of Bcr-Abl oncogene products
    • Lugo TG, Pendergast AM, Muller AJ, et al. Tyrosine kinase activity and transformation potency of Bcr-Abl oncogene products. Science 1990; 247:1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3
  • 3
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247:824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 4
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 5
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitot of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitot of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344:1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 6
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002; 346:645-652.
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 7
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. New Engl J Med 2003; 348:994-1004.
    • (2003) New Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 9
    • 0021989297 scopus 로고
    • T cells and probably B cells arise from the malignant clone in chronic myelogenous leukemia
    • Fauser AA, Kanz L, Bross KJ, et al. T cells and probably B cells arise from the malignant clone in chronic myelogenous leukemia. J Clin Invest 1985; 75:1080-1082.
    • (1985) J Clin Invest , vol.75 , pp. 1080-1082
    • Fauser, A.A.1    Kanz, L.2    Bross, K.J.3
  • 10
    • 0022229830 scopus 로고
    • Incidence of involvement of the B and T lymphocyte lineages in chronic myelogenous leukemia
    • Nitta M, Kato Y, Strife A, et al. Incidence of involvement of the B and T lymphocyte lineages in chronic myelogenous leukemia. Blood 1985; 66:1053-1061.
    • (1985) Blood , vol.66 , pp. 1053-1061
    • Nitta, M.1    Kato, Y.2    Strife, A.3
  • 11
    • 0023084367 scopus 로고
    • The use of cell markers in the study of human hematopoietic neoplasia
    • Raskind WH, Fialkow PJ. The use of cell markers in the study of human hematopoietic neoplasia. Adv Cancer Res 1987; 49:127-167.
    • (1987) Adv Cancer Res , vol.49 , pp. 127-167
    • Raskind, W.H.1    Fialkow, P.J.2
  • 12
    • 0032535764 scopus 로고    scopus 로고
    • Lineage involvement of stem cells bearing the Philadelphia chromosome in chronic myeloid leukemia in the CP as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization
    • Takahashi N, Miuta I, Saitoh K, et al. Lineage involvement of stem cells bearing the Philadelphia chromosome in chronic myeloid leukemia in the CP as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization. Blood 1998; 92:4758-4763.
    • (1998) Blood , vol.92 , pp. 4758-4763
    • Takahashi, N.1    Miuta, I.2    Saitoh, K.3
  • 13
    • 0026531019 scopus 로고
    • Clonal analysis of Bcr-Abl rearrangement in T lymphocytes from patients with chronic myelogenous leukemia
    • Jonas D, Lubbert M, Kawasaki ES, et al. Clonal analysis of Bcr-Abl rearrangement in T lymphocytes from patients with chronic myelogenous leukemia. Blood 1992; 79:1017-1023.
    • (1992) Blood , vol.79 , pp. 1017-1023
    • Jonas, D.1    Lubbert, M.2    Kawasaki, E.S.3
  • 14
    • 0021720621 scopus 로고
    • Nonclonal hemopoietic progenitor cells detected in long-term marrow cultures from a Turner syndrome mosaic with chronic myeloid leukemia
    • Dube ID, Arlin ZA, Kalousek DK, et al. Nonclonal hemopoietic progenitor cells detected in long-term marrow cultures from a Turner syndrome mosaic with chronic myeloid leukemia. Blood 1984; 64:1284-1287.
    • (1984) Blood , vol.64 , pp. 1284-1287
    • Dube, I.D.1    Arlin, Z.A.2    Kalousek, D.K.3
  • 15
    • 0023233826 scopus 로고
    • Nonclonal hemopoietic progenitors in a G6PD hetetozygote with chronic myelogenous leukemia revealed after long-term marrow culture
    • Hogge DE, Coulombel L, Kalousek DK, et al. Nonclonal hemopoietic progenitors in a G6PD hetetozygote with chronic myelogenous leukemia revealed after long-term marrow culture. Am J Hematol 1987; 24:389-394.
    • (1987) Am J Hematol , vol.24 , pp. 389-394
    • Hogge, D.E.1    Coulombel, L.2    Kalousek, D.K.3
  • 16
    • 0011633534 scopus 로고    scopus 로고
    • Progenitot cell dynamics
    • Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlmann R, eds, London: Martin Dunitz;
    • Eaves CJ, Eaves AC. Progenitot cell dynamics. In: Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlmann R, eds. Chronic Myeloid Leukemia: Biology & Treatment. London: Martin Dunitz; 2001:73-100.
    • (2001) Chronic Myeloid Leukemia: Biology & Treatment , pp. 73-100
    • Eaves, C.J.1    Eaves, A.C.2
  • 17
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 18
    • 0037459344 scopus 로고    scopus 로고
    • Mechanisms of autoinhibition and STI571/imatinib tesistance revealed by mutagenesis of BCR-ABL
    • Azam M, Latek RR, Daley GQ. Mechanisms of autoinhibition and STI571/imatinib tesistance revealed by mutagenesis of BCR-ABL. Cell 2003; 112:831-843.
    • (2003) Cell , vol.112 , pp. 831-843
    • Azam, M.1    Latek, R.R.2    Daley, G.Q.3
  • 19
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pte-exist to the onset of treatment
    • Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pte-exist to the onset of treatment. Blood 2002; 100:1014-1018.
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3
  • 20
    • 0038137081 scopus 로고    scopus 로고
    • A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia
    • Roche-Lestienne C, Lai JL, Darre S, et al. A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia. N Engl J Med 2003; 348:2265-2266.
    • (2003) N Engl J Med , vol.348 , pp. 2265-2266
    • Roche-Lestienne, C.1    Lai, J.L.2    Darre, S.3
  • 21
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105:2640-2653.
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 22
    • 24744443720 scopus 로고    scopus 로고
    • High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: Correlation with clonal cytogenetic evolution but not response to therapy
    • Willis SG, Lange T, Demehri S, et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005; 106:2128-2137.
    • (2005) Blood , vol.106 , pp. 2128-2137
    • Willis, S.G.1    Lange, T.2    Demehri, S.3
  • 23
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY, et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305:399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3
  • 24
    • 23344440655 scopus 로고    scopus 로고
    • Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
    • Carter TA, Wodicka LM, Shah NP, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A 2005; 102:11011-11016.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11011-11016
    • Carter, T.A.1    Wodicka, L.M.2    Shah, N.P.3
  • 25
    • 13844251975 scopus 로고    scopus 로고
    • Charactetization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al. Charactetization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005; 7:129-141.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 26
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 27
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354:2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 28
    • 75449141216 scopus 로고
    • The disttibution of the Philadelphia chromosome in patients with chronic myelogenous leukemia
    • Whang J, Frei E III, Tjio JH, et al. The disttibution of the Philadelphia chromosome in patients with chronic myelogenous leukemia. Blood 1963; 22:664-673.
    • (1963) Blood , vol.22 , pp. 664-673
    • Whang, J.1    Frei III, E.2    Tjio, J.H.3
  • 29
    • 0014412310 scopus 로고
    • Direct evidence for presence of Ph1 chromosome in erythroid cells
    • Rastrick JM, Fitzgerald PH, Gunz FW. Direct evidence for presence of Ph1 chromosome in erythroid cells. Br Med J 1968; 1:96-98.
    • (1968) Br Med J , vol.1 , pp. 96-98
    • Rastrick, J.M.1    Fitzgerald, P.H.2    Gunz, F.W.3
  • 30
    • 0000271086 scopus 로고
    • Cytogenetic studies on bone-marrow in chronic myeloid leukaemia
    • Tough IM, Jacobs PA, Court Brown WM, et al. Cytogenetic studies on bone-marrow in chronic myeloid leukaemia. Lancet 1963; 1:844-846.
    • (1963) Lancet , vol.1 , pp. 844-846
    • Tough, I.M.1    Jacobs, P.A.2    Court Brown, W.M.3
  • 31
    • 0019307897 scopus 로고
    • Involvement of the B-lymphoid system in chronic myelogenous leukaemia
    • Martin PJ, Najfeld V, Hansen JA, et al. Involvement of the B-lymphoid system in chronic myelogenous leukaemia. Nature 1980; 287:49-50.
    • (1980) Nature , vol.287 , pp. 49-50
    • Martin, P.J.1    Najfeld, V.2    Hansen, J.A.3
  • 32
    • 0019405825 scopus 로고
    • Philadelphia chromosome positive blood B lymphocytes in chronic myelocytic leukemia
    • Bernheim A, Berger R, Preud'Homme JL, et al. Philadelphia chromosome positive blood B lymphocytes in chronic myelocytic leukemia. Leuk Res 1981; 5:331-339.
    • (1981) Leuk Res , vol.5 , pp. 331-339
    • Bernheim, A.1    Berger, R.2    Preud'Homme, J.L.3
  • 33
    • 0037080185 scopus 로고    scopus 로고
    • The BCR/ABL transgene causes abnormal NK cell differentiation and can be found in circulating NK cells of advanced phase chronic myelogenous leukemia patients
    • Nakajima H, Zhao R, Lund TC, et al. The BCR/ABL transgene causes abnormal NK cell differentiation and can be found in circulating NK cells of advanced phase chronic myelogenous leukemia patients. J Immunol 2002; 168:643-650.
    • (2002) J Immunol , vol.168 , pp. 643-650
    • Nakajima, H.1    Zhao, R.2    Lund, T.C.3
  • 34
    • 0034643676 scopus 로고    scopus 로고
    • Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells
    • Gunsilius E, Duba H-C, Petzer AL, et al. Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells. Lancet 2000; 355:1688-1691.
    • (2000) Lancet , vol.355 , pp. 1688-1691
    • Gunsilius, E.1    Duba, H.-C.2    Petzer, A.L.3
  • 35
    • 15944364734 scopus 로고    scopus 로고
    • Identification of human chronic myelogenous leukemia progenitot cells with hemangioblastic characteristics
    • Fang B, Zheng C, Liao L, et al. Identification of human chronic myelogenous leukemia progenitot cells with hemangioblastic characteristics. Blood 2005; 105:2733-2740.
    • (2005) Blood , vol.105 , pp. 2733-2740
    • Fang, B.1    Zheng, C.2    Liao, L.3
  • 36
    • 20144374544 scopus 로고    scopus 로고
    • Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease
    • Eisterer W, Jiang X, Christ O, et al. Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease. Leukemia 2005; 19:435-441.
    • (2005) Leukemia , vol.19 , pp. 435-441
    • Eisterer, W.1    Jiang, X.2    Christ, O.3
  • 37
    • 0346100567 scopus 로고    scopus 로고
    • Similat MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A, Passegue E, Ayton PM, et al. Similat MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev 2003; 17:3029-3035.
    • (2003) Genes Dev , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3
  • 38
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson CH, Allies LE, Dylla SJ, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004; 351:657-667.
    • (2004) N Engl J Med , vol.351 , pp. 657-667
    • Jamieson, C.H.1    Allies, L.E.2    Dylla, S.J.3
  • 39
    • 20944434753 scopus 로고    scopus 로고
    • Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
    • Castor A, Nilsson L, Astrand-Grundstrom I, et al. Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med 2005; 11:630-637.
    • (2005) Nat Med , vol.11 , pp. 630-637
    • Castor, A.1    Nilsson, L.2    Astrand-Grundstrom, I.3
  • 40
    • 0033519238 scopus 로고    scopus 로고
    • The p190, p210, and p230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
    • Li S, Ilaria RL, Million RP, et al. The p190, p210, and p230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 1999; 189:1399-1412.
    • (1999) J Exp Med , vol.189 , pp. 1399-1412
    • Li, S.1    Ilaria, R.L.2    Million, R.P.3
  • 41
    • 19544387362 scopus 로고    scopus 로고
    • - leukemic cells from CML patients with CP disease and then progressively decrease as they differentiate
    • Abstract
    • - leukemic cells from CML patients with CP disease and then progressively decrease as they differentiate. Blood 2003; 102:418a (Abstract #1520).
    • (2003) Blood , vol.102 , Issue.1520
    • Jiang, X.1    Zhao, Y.2    Chan, W.Y.3
  • 42
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML, but does not eliminate the quiescent fraction
    • Copland M, Hamilton A, Elrick LJ, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML, but does not eliminate the quiescent fraction. Blood 2006; 107:4532-4539.
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3
  • 43
    • 34247555482 scopus 로고    scopus 로고
    • Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
    • Epub ahead of print
    • Jiang X, Zhao Y, Smith C, et al. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 2007; [Epub ahead of print].
    • (2007) Leukemia
    • Jiang, X.1    Zhao, Y.2    Smith, C.3
  • 44
    • 0036565871 scopus 로고    scopus 로고
    • Modulation of p210bcr-abl activity in transduced primary human hematopoietic cells controls lineage reprogramming
    • Chalandon Y, Jiang X, Hazelwood G, et al. Modulation of p210bcr-abl activity in transduced primary human hematopoietic cells controls lineage reprogramming. Blood 2002; 99:3197-3204.
    • (2002) Blood , vol.99 , pp. 3197-3204
    • Chalandon, Y.1    Jiang, X.2    Hazelwood, G.3
  • 45
    • 0033568250 scopus 로고    scopus 로고
    • Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
    • Holyoake T, Jiang X, Eaves C, et al. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 1999; 94:2056-2064.
    • (1999) Blood , vol.94 , pp. 2056-2064
    • Holyoake, T.1    Jiang, X.2    Eaves, C.3
  • 46
    • 0032055156 scopus 로고    scopus 로고
    • High level engraftment of NOD/ SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in CP
    • Wang JCY, Lapidot T, Cashman JD, et al. High level engraftment of NOD/ SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in CP. Blood 1998; 91:2406-2414.
    • (1998) Blood , vol.91 , pp. 2406-2414
    • Wang, J.C.Y.1    Lapidot, T.2    Cashman, J.D.3
  • 47
    • 85014195943 scopus 로고    scopus 로고
    • Elucidating critical mechanisms of deregulated stem cell turnover in the CP of chronic myeloid leukemia
    • Holyoake TL, Jiang X, Drummond MW, et al. Elucidating critical mechanisms of deregulated stem cell turnover in the CP of chronic myeloid leukemia. Leukemia 2002; 16:549-558.
    • (2002) Leukemia , vol.16 , pp. 549-558
    • Holyoake, T.L.1    Jiang, X.2    Drummond, M.W.3
  • 48
    • 0026496231 scopus 로고
    • Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia
    • Udomsakdi C, Eaves CJ, Lansdorp PM, et al. Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia. Blood 1992; 80:2522-2530.
    • (1992) Blood , vol.80 , pp. 2522-2530
    • Udomsakdi, C.1    Eaves, C.J.2    Lansdorp, P.M.3
  • 49
    • 0029837399 scopus 로고    scopus 로고
    • Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia
    • Petzer AL, Eaves CJ, Lansdorp PM, et al. Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia. Blood 1996; 88:2162-2171.
    • (1996) Blood , vol.88 , pp. 2162-2171
    • Petzer, A.L.1    Eaves, C.J.2    Lansdorp, P.M.3
  • 50
    • 85058905945 scopus 로고    scopus 로고
    • + aldehyde dehydrogenase-positive cells with short- and long-term repopulating activity and transient responsiveness to imatinib mesylate in vivo
    • Abstract
    • + aldehyde dehydrogenase-positive cells with short- and long-term repopulating activity and transient responsiveness to imatinib mesylate in vivo. Blood 2004; 104:809a (Abstract #2960).
    • (2004) Blood , vol.104 , Issue.2960
    • Christ, O.1    Eisterer, W.2    Jiang, X.3
  • 51
    • 0030911358 scopus 로고    scopus 로고
    • Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
    • Bhatia M, Wang JCY, Kapp U, et al. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A 1997; 94:5320-5325.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5320-5325
    • Bhatia, M.1    Wang, J.C.Y.2    Kapp, U.3
  • 52
    • 0029860155 scopus 로고    scopus 로고
    • Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo
    • Civin CI, Almeida-Porada G, Lee M-J, et al. Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo. Blood 1996; 88:4102-4109.
    • (1996) Blood , vol.88 , pp. 4102-4109
    • Civin, C.I.1    Almeida-Porada, G.2    Lee, M.-J.3
  • 53
    • 0035140382 scopus 로고    scopus 로고
    • Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-b2 microglobulin-null mice
    • Glimm H, Eisterer W, Lee K, et al. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-b2 microglobulin-null mice. J Clin Invest 2001; 107:199-206.
    • (2001) J Clin Invest , vol.107 , pp. 199-206
    • Glimm, H.1    Eisterer, W.2    Lee, K.3
  • 54
    • 0035478641 scopus 로고    scopus 로고
    • - cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion
    • - cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion. J Immunol 2001; 167:3692-3698.
    • (2001) J Immunol , vol.167 , pp. 3692-3698
    • Kerre, T.C.1    De Smet, G.2    De Smedt, M.3
  • 55
    • 0037039361 scopus 로고    scopus 로고
    • Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice
    • Hogan CJ, Shpall EJ, Keller G. Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice. Proc Natl Acad Sci U S A 2002; 99:413-418.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 413-418
    • Hogan, C.J.1    Shpall, E.J.2    Keller, G.3
  • 56
    • 0012951216 scopus 로고    scopus 로고
    • Normal and leukemic human stem cells assayed in immune-deficient mice
    • Zon LI, ed, New York, NY: Oxford University Press;
    • Wang JCY, Dorrell C, Ito CY, et al. Normal and leukemic human stem cells assayed in immune-deficient mice. In: Zon LI, ed. Hematopoiesis: a Developmental Approach. New York, NY: Oxford University Press; 2001: 99-118.
    • (2001) Hematopoiesis: A Developmental Approach , pp. 99-118
    • Wang, J.C.Y.1    Dorrell, C.2    Ito, C.Y.3
  • 57
    • 0026742369 scopus 로고
    • Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level
    • Udomsakdi C, Eaves CJ, Swolin B, et al. Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci U S A 1992; 89:6192-6196.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 6192-6196
    • Udomsakdi, C.1    Eaves, C.J.2    Swolin, B.3
  • 58
    • 0032436505 scopus 로고    scopus 로고
    • Defective regulation of leukemic hematopoiesis in chronic myeloid leukemia
    • Eaves C, Cashman J, Eaves A. Defective regulation of leukemic hematopoiesis in chronic myeloid leukemia. Leuk Res 1998; 22:1085-1096.
    • (1998) Leuk Res , vol.22 , pp. 1085-1096
    • Eaves, C.1    Cashman, J.2    Eaves, A.3
  • 59
    • 0035254540 scopus 로고    scopus 로고
    • Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3
    • Holyoake TL, Jiang X, Jorgensen HG, et al. Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3. Blood 2001; 97:720-728.
    • (2001) Blood , vol.97 , pp. 720-728
    • Holyoake, T.L.1    Jiang, X.2    Jorgensen, H.G.3
  • 60
    • 0027519484 scopus 로고
    • Bone marrow transplantation for chronic myeloid leukemia: Long-term results
    • Gratwohl A, Hermans J, Niederwieser D, et al. Bone marrow transplantation for chronic myeloid leukemia: long-term results. Bone Marrow Transplant 1993; 12:509-516.
    • (1993) Bone Marrow Transplant , vol.12 , pp. 509-516
    • Gratwohl, A.1    Hermans, J.2    Niederwieser, D.3
  • 61
    • 0032921093 scopus 로고    scopus 로고
    • Relapse of chronic myeloid leukaemia 14 years after allogeneic bone marrow transplantation
    • Yong ASM, Goldman JM. Relapse of chronic myeloid leukaemia 14 years after allogeneic bone marrow transplantation. Bone Marrow Transplant 1999; 23:827-828.
    • (1999) Bone Marrow Transplant , vol.23 , pp. 827-828
    • Yong, A.S.M.1    Goldman, J.M.2
  • 62
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002; 99:319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 63
    • 0033607274 scopus 로고    scopus 로고
    • Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia
    • Jiang X, Lopez A, Holyoake T et al. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proc Natl Acad Sci U S A 1999; 96:12804-12809.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12804-12809
    • Jiang, X.1    Lopez, A.2    Holyoake, T.3
  • 64
    • 0141958304 scopus 로고    scopus 로고
    • Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia
    • Jiang X, Stuible M, Chalandon Y, et al. Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood 2003; 102:2976-2984.
    • (2003) Blood , vol.102 , pp. 2976-2984
    • Jiang, X.1    Stuible, M.2    Chalandon, Y.3
  • 65
    • 0027146639 scopus 로고
    • Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatoty protein 1a, an inhibitor of primitive normal hematopoietic cells
    • Eaves CJ, Cashman JD, Wolpe SD, et al. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatoty protein 1a, an inhibitor of primitive normal hematopoietic cells. P Natl Acad Sci USA 1993; 90:12015-12019.
    • (1993) P Natl Acad Sci USA , vol.90 , pp. 12015-12019
    • Eaves, C.J.1    Cashman, J.D.2    Wolpe, S.D.3
  • 66
    • 0032190067 scopus 로고    scopus 로고
    • MCP-1, not MIP-1a is the endogenous chemokine that cooperates with TGF-b to inhibit the cycling of primitive normal but not leukemic (CML) progenitots in long-term human marrow cultures
    • Cashman JD, Eaves CJ, Sarris AH, et al. MCP-1, not MIP-1a is the endogenous chemokine that cooperates with TGF-b to inhibit the cycling of primitive normal but not leukemic (CML) progenitots in long-term human marrow cultures. Blood 1998; 92:2338-2344.
    • (1998) Blood , vol.92 , pp. 2338-2344
    • Cashman, J.D.1    Eaves, C.J.2    Sarris, A.H.3
  • 67
    • 0033485307 scopus 로고    scopus 로고
    • Differentiation stage-specific regulation of primitive human hematopoietic progenitot cycling by exogenous and endogenous inhibitors in an in vivo model
    • Cashman JD, Clark-Lewis I, Eaves AC, et al. Differentiation stage-specific regulation of primitive human hematopoietic progenitot cycling by exogenous and endogenous inhibitors in an in vivo model. Blood 1999; 94:3722-3729.
    • (1999) Blood , vol.94 , pp. 3722-3729
    • Cashman, J.D.1    Clark-Lewis, I.2    Eaves, A.C.3
  • 68
    • 0036464597 scopus 로고    scopus 로고
    • Stromal-derived factot 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice
    • Cashman J, Clark-Lewis I, Eaves A, et al. Stromal-derived factot 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood 2002; 99:792-799.
    • (2002) Blood , vol.99 , pp. 792-799
    • Cashman, J.1    Clark-Lewis, I.2    Eaves, A.3
  • 69
    • 0037020855 scopus 로고    scopus 로고
    • Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their ttansplantability after in vivo treatment with cell cycle inhibitors
    • Cashman J, Dykstra B, Clark-Lewis I, et al. Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their ttansplantability after in vivo treatment with cell cycle inhibitors. J Exp Med 2002; 196:1141-1149.
    • (2002) J Exp Med , vol.196 , pp. 1141-1149
    • Cashman, J.1    Dykstra, B.2    Clark-Lewis, I.3
  • 70
    • 0026669189 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-b on normal and leukemic human hematopoietic progenitor cells
    • Cashman JD, Eaves AC, Eaves CJ. Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-b on normal and leukemic human hematopoietic progenitor cells. Leukemia 1992; 6:886-892.
    • (1992) Leukemia , vol.6 , pp. 886-892
    • Cashman, J.D.1    Eaves, A.C.2    Eaves, C.J.3
  • 71
    • 0023776105 scopus 로고
    • Transforming growth factor b selectively inhibits normal and leukemic human bone marrow cell growth in vitro
    • Sing GK, Keller JR, Ellingsworth LR, et al. Transforming growth factor b selectively inhibits normal and leukemic human bone marrow cell growth in vitro. Blood 1988; 72:1504-1511.
    • (1988) Blood , vol.72 , pp. 1504-1511
    • Sing, G.K.1    Keller, J.R.2    Ellingsworth, L.R.3
  • 72
    • 0024447853 scopus 로고
    • The suppressive effects of type b transforming growth factor (TGFb) on primitive murine hemopoietic progenitors are abrogated by interleukin-6 and granulocyte colony-stimulating factor
    • Kishi K, Ellingsworth LR, Ogawa M. The suppressive effects of type b transforming growth factor (TGFb) on primitive murine hemopoietic progenitors are abrogated by interleukin-6 and granulocyte colony-stimulating factor. Leukemia 1989; 3:687-691.
    • (1989) Leukemia , vol.3 , pp. 687-691
    • Kishi, K.1    Ellingsworth, L.R.2    Ogawa, M.3
  • 73
    • 0025122280 scopus 로고
    • Interleukin 3 opposes the action of negative regulatory protein (NRP) and of transforming growth factor-b (TGF-b) in their inhibition of DNA synthesis of the erythroid stem cell BFU-E
    • Rizzo DFD, Eskinazi D, Axelrad AA. Interleukin 3 opposes the action of negative regulatory protein (NRP) and of transforming growth factor-b (TGF-b) in their inhibition of DNA synthesis of the erythroid stem cell BFU-E. Exp Hematol 1990; 18:138-142.
    • (1990) Exp Hematol , vol.18 , pp. 138-142
    • Rizzo, D.F.D.1    Eskinazi, D.2    Axelrad, A.A.3
  • 74
    • 0026036059 scopus 로고
    • Differential and synergistic effects of human granulocyte- macrophage colony-stimulating factor and human granulocyte colony- stimulating factor on hematopoiesis in human long-term marrow cultures
    • Hogge DE, Cashman JD, Humphries RK, et al. Differential and synergistic effects of human granulocyte- macrophage colony-stimulating factor and human granulocyte colony- stimulating factor on hematopoiesis in human long-term marrow cultures. Blood 1991; 77:493-499.
    • (1991) Blood , vol.77 , pp. 493-499
    • Hogge, D.E.1    Cashman, J.D.2    Humphries, R.K.3
  • 75
    • 0025771278 scopus 로고
    • Differential effects of microenvironmentally presented interleukin 3 versus soluble growth factor on primitive human hematopoietic cells
    • Otsuka T, Thacker JD, Eaves CJ, et al. Differential effects of microenvironmentally presented interleukin 3 versus soluble growth factor on primitive human hematopoietic cells. J Clin Invest 1991; 88:417-422.
    • (1991) J Clin Invest , vol.88 , pp. 417-422
    • Otsuka, T.1    Thacker, J.D.2    Eaves, C.J.3
  • 76
    • 34249819189 scopus 로고    scopus 로고
    • + human cells in sheep transplanted in utero 3 years previously with CML cells
    • Abstract
    • + human cells in sheep transplanted in utero 3 years previously with CML cells. Blood 2002; 100:367a (Abstract #1422).
    • (2002) Blood , vol.100 , Issue.1422
    • Jiang, X.1    Eisterer, W.2    Zhao, Y.3
  • 77
    • 2342576221 scopus 로고    scopus 로고
    • Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL
    • Chalandon Y, Jiang X, Loutet S, et al. Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL. Leukemia 2004; 18:1006-1012.
    • (2004) Leukemia , vol.18 , pp. 1006-1012
    • Chalandon, Y.1    Jiang, X.2    Loutet, S.3
  • 78
    • 0037111666 scopus 로고    scopus 로고
    • Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo
    • Jiang X, Ng E, Yip C, et al. Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo. Blood 2002; 100:3731-3740.
    • (2002) Blood , vol.100 , pp. 3731-3740
    • Jiang, X.1    Ng, E.2    Yip, C.3
  • 79
    • 0032533620 scopus 로고    scopus 로고
    • BCR-ABL efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: A novel model for chronic myelogenous leukemia
    • Zhang X, Ren R. BCR-ABL efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia. Blood 1998; 92:3829-3840.
    • (1998) Blood , vol.92 , pp. 3829-3840
    • Zhang, X.1    Ren, R.2
  • 80
    • 0035837242 scopus 로고    scopus 로고
    • Autocrine and paracrine effects of an ES-cell derived, BCR/ABL- transformed hematopoietic cell line that induces leukemia in mice
    • Peters DG, Klucher KM, Perlingeiro RC, et al. Autocrine and paracrine effects of an ES-cell derived, BCR/ABL- transformed hematopoietic cell line that induces leukemia in mice. Oncogene 2001; 20:2636-2646.
    • (2001) Oncogene , vol.20 , pp. 2636-2646
    • Peters, D.G.1    Klucher, K.M.2    Perlingeiro, R.C.3
  • 81
    • 0031001564 scopus 로고    scopus 로고
    • Cytokine manipulation of primitive human hematopoietic cell self-renewal
    • Zandstra PW, Conneally E, Petzer AL, et al. Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci U S A 1997; 94:4698-4703.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4698-4703
    • Zandstra, P.W.1    Conneally, E.2    Petzer, A.L.3
  • 82
    • 0347286862 scopus 로고    scopus 로고
    • Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia
    • Dvorak P, Dvorakova D, Doubek M, et al. Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Leukemia 2003; 17:2418-2425.
    • (2003) Leukemia , vol.17 , pp. 2418-2425
    • Dvorak, P.1    Dvorakova, D.2    Doubek, M.3
  • 83
    • 0036928731 scopus 로고    scopus 로고
    • Imatinib mesylate (STI-571) reduces Bcr-Abl-mediated vascular endothelial growth factor secretion in chronic myelogenous leukemia
    • Ebos JM, Tran J, Master Z, et al. Imatinib mesylate (STI-571) reduces Bcr-Abl-mediated vascular endothelial growth factor secretion in chronic myelogenous leukemia. Mol Cancer Res 2002; 1:89-95.
    • (2002) Mol Cancer Res , vol.1 , pp. 89-95
    • Ebos, J.M.1    Tran, J.2    Master, Z.3
  • 84
    • 0037111665 scopus 로고    scopus 로고
    • BCR/ABL induces expression of vascular endothelial growth factor and its ttanscriptional activator, hypoxia inducible factor-1a, through a pathway involving phosphoinositide 3-kinase and the mammalian target of tapamycin
    • Mayerhofer M, Valent P, Sperr WR, et al. BCR/ABL induces expression of vascular endothelial growth factor and its ttanscriptional activator, hypoxia inducible factor-1a, through a pathway involving phosphoinositide 3-kinase and the mammalian target of tapamycin. Blood 2002; 100:3767-3775.
    • (2002) Blood , vol.100 , pp. 3767-3775
    • Mayerhofer, M.1    Valent, P.2    Sperr, W.R.3
  • 85
    • 0034032012 scopus 로고    scopus 로고
    • BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia
    • Deininger MW, Vieira S, Mendiola R, et al. BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia. Cancer Res 2000; 60:2049-2055.
    • (2000) Cancer Res , vol.60 , pp. 2049-2055
    • Deininger, M.W.1    Vieira, S.2    Mendiola, R.3
  • 86
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in CP and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in CP and blast crisis chronic myeloid leukemia. Cancer Cell 2002; 2:117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 87
    • 0037737707 scopus 로고    scopus 로고
    • Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity
    • Bueno-da-Silva AE, Brumatti G, Russo FO, et al. Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity. Cell Death Differ 2003; 10:592-598.
    • (2003) Cell Death Differ , vol.10 , pp. 592-598
    • Bueno-da-Silva, A.E.1    Brumatti, G.2    Russo, F.O.3
  • 88
    • 21744457612 scopus 로고    scopus 로고
    • Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro
    • Jorgensen HG, Allan EK, Graham SM, et al. Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro. Leukemia 2005; 19:1184-1191.
    • (2005) Leukemia , vol.19 , pp. 1184-1191
    • Jorgensen, H.G.1    Allan, E.K.2    Graham, S.M.3
  • 89
    • 0037093082 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
    • Holtz MS, Slovak ML, Zhang F, et al. Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation. Blood 2002; 99:3792-3800.
    • (2002) Blood , vol.99 , pp. 3792-3800
    • Holtz, M.S.1    Slovak, M.L.2    Zhang, F.3
  • 90
    • 20844463226 scopus 로고    scopus 로고
    • + progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli
    • + progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia 2005; 19:1034-1041.
    • (2005) Leukemia , vol.19 , pp. 1034-1041
    • Holtz, M.S.1    Forman, S.J.2    Bhatia, R.3
  • 91
    • 34249804933 scopus 로고    scopus 로고
    • Copland M, Hamilton A, Allan EK, et al. BMS-214662 targets quiescent chronic myeloid leukemia stem cells and enhances the activity of both imatinib and dasatinib (BMS-354825). Blood 2005; 106:204a (Absttact #693).
    • Copland M, Hamilton A, Allan EK, et al. BMS-214662 targets quiescent chronic myeloid leukemia stem cells and enhances the activity of both imatinib and dasatinib (BMS-354825). Blood 2005; 106:204a (Absttact #693).
  • 92
    • 0036736514 scopus 로고    scopus 로고
    • Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors
    • Dorsey JF, Cunnick JM, Lanehart R, et al. Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors. Leukemia 2002; 16:1589-1595.
    • (2002) Leukemia , vol.16 , pp. 1589-1595
    • Dorsey, J.F.1    Cunnick, J.M.2    Lanehart, R.3
  • 94
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R, Holtz M, Niu N, et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 2003; 101:4701-4707.
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3
  • 95
    • 14944367962 scopus 로고    scopus 로고
    • Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment
    • Chu S, Xu H, Shah NP, et al. Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment. Blood 2005; 105:2093-2098.
    • (2005) Blood , vol.105 , pp. 2093-2098
    • Chu, S.1    Xu, H.2    Shah, N.P.3
  • 96
    • 21744462100 scopus 로고    scopus 로고
    • Dynamics of chronic myeloid leukaemia
    • Michor F, Hughes TP, Iwasa Y, et al. Dynamics of chronic myeloid leukaemia. Nature 2005; 435:1267-1270.
    • (2005) Nature , vol.435 , pp. 1267-1270
    • Michor, F.1    Hughes, T.P.2    Iwasa, Y.3
  • 97
    • 33749524667 scopus 로고    scopus 로고
    • Dynamic modeling of imatinib-treated chronic myeloid leukemia: Functional insights and clinical implications
    • Roeder I, Horn M, Glauche I, et al. Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nat Med 2006; 12:1181-1184.
    • (2006) Nat Med , vol.12 , pp. 1181-1184
    • Roeder, I.1    Horn, M.2    Glauche, I.3
  • 98
    • 25444488489 scopus 로고    scopus 로고
    • Bcr-Abl expression levels determine the tate of development of resistance to imatinib mesylate in chronic myeloid leukemia
    • Barnes DJ, Palaiologou D, Panousopoulou E, et al. Bcr-Abl expression levels determine the tate of development of resistance to imatinib mesylate in chronic myeloid leukemia. Cancer Res 2005; 65:8912-8919.
    • (2005) Cancer Res , vol.65 , pp. 8912-8919
    • Barnes, D.J.1    Palaiologou, D.2    Panousopoulou, E.3
  • 99
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2002; 2:48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 100
    • 18144370731 scopus 로고    scopus 로고
    • Mechanisms of resistance to anti-cancer drugs: The role of the polymorphic ABC transporters ABCB1 and ABCG2
    • Lepper ER, Nooter K, Verweij J, et al. Mechanisms of resistance to anti-cancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2. Pharmacogenomics 2005; 6:115-138.
    • (2005) Pharmacogenomics , vol.6 , pp. 115-138
    • Lepper, E.R.1    Nooter, K.2    Verweij, J.3
  • 101
    • 0344520475 scopus 로고    scopus 로고
    • Distribution of STI-571 to the brain is limited by P-glycoptotein-mediated efflux
    • Dai H, Marbach R Lemaire M, et al. Distribution of STI-571 to the brain is limited by P-glycoptotein-mediated efflux. J Pharmacol Exp Ther 2003; 304:1085-1092.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1085-1092
    • Dai, H.1    Marbach, R.2    Lemaire, M.3
  • 102
    • 0142241268 scopus 로고    scopus 로고
    • Interaction of imatinib mesylate with human P-glycopmtein
    • Hamada A, Miyano H, Watanabe H, et al. Interaction of imatinib mesylate with human P-glycopmtein. J Pharmacol Exp Ther 2003; 307:824-828.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 824-828
    • Hamada, A.1    Miyano, H.2    Watanabe, H.3
  • 103
    • 0037443754 scopus 로고    scopus 로고
    • MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
    • Mahon FX, Belloc F, Lagatde V, et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 2003; 101:2368-2373.
    • (2003) Blood , vol.101 , pp. 2368-2373
    • Mahon, F.X.1    Belloc, F.2    Lagatde, V.3
  • 104
    • 1542713480 scopus 로고    scopus 로고
    • P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
    • Illmer T, Schaich M, Platzbecker U, et al. P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 2004; 18:401-408.
    • (2004) Leukemia , vol.18 , pp. 401-408
    • Illmer, T.1    Schaich, M.2    Platzbecker, U.3
  • 105
    • 20444482337 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines
    • Rumpold H, Wolf AM, Gtuenewald K, et al. RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines. Exp Hematol 2005; 33:767-775.
    • (2005) Exp Hematol , vol.33 , pp. 767-775
    • Rumpold, H.1    Wolf, A.M.2    Gtuenewald, K.3
  • 106
    • 0043245793 scopus 로고    scopus 로고
    • Functional consequence of MDR1 expression on imatinib intracellular concenttations
    • Widmer N, Colombo S, Buclin T, et al. Functional consequence of MDR1 expression on imatinib intracellular concenttations. Blood 2003; 102:1142.
    • (2003) Blood , vol.102 , pp. 1142
    • Widmer, N.1    Colombo, S.2    Buclin, T.3
  • 107
    • 0344305459 scopus 로고    scopus 로고
    • Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro
    • Ferrao PT, Frost MJ, Siah SP, et al. Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro. Blood 2003; 102:4499-4503.
    • (2003) Blood , vol.102 , pp. 4499-4503
    • Ferrao, P.T.1    Frost, M.J.2    Siah, S.P.3
  • 108
    • 26944452899 scopus 로고    scopus 로고
    • Loss of P-glycoprotein expression in hematopoietic stem cells does not improve responses to imatinib in a murine model of chronic myelogenous leukemia
    • Zong Y, Zhou S, Sorrentino BP. Loss of P-glycoprotein expression in hematopoietic stem cells does not improve responses to imatinib in a murine model of chronic myelogenous leukemia. Leukemia 2005; 19:1590-1596.
    • (2005) Leukemia , vol.19 , pp. 1590-1596
    • Zong, Y.1    Zhou, S.2    Sorrentino, B.P.3
  • 109
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary PM, Roninson IB. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991; 66:85-94.
    • (1991) Cell , vol.66 , pp. 85-94
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 110
    • 0034795256 scopus 로고    scopus 로고
    • The ABC transporter Bcrp1/ ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    • Zhou S, Scheutz JD, Bunting KD, et al. The ABC transporter Bcrp1/ ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 2001; 7:1028-1034.
    • (2001) Nat Med , vol.7 , pp. 1028-1034
    • Zhou, S.1    Scheutz, J.D.2    Bunting, K.D.3
  • 111
    • 2942590202 scopus 로고    scopus 로고
    • ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status
    • Uchida N, Dykstra B, Lyons K, et al. ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status. Blood 2004; 103:4487-4895.
    • (2004) Blood , vol.103 , pp. 4487-4895
    • Uchida, N.1    Dykstra, B.2    Lyons, K.3
  • 112
    • 0037079708 scopus 로고    scopus 로고
    • The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    • Scharenberg CW, Harkey MA, Torok-Storb B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 2002; 99:507-512.
    • (2002) Blood , vol.99 , pp. 507-512
    • Scharenberg, C.W.1    Harkey, M.A.2    Torok-Storb, B.3
  • 113
    • 1942506722 scopus 로고    scopus 로고
    • Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro
    • Houghton PJ, Germain GS, Harwood FC, et al. Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Res 2004; 64:2333-2337.
    • (2004) Cancer Res , vol.64 , pp. 2333-2337
    • Houghton, P.J.1    Germain, G.S.2    Harwood, F.C.3
  • 114
    • 7244232706 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) is a substrate fot the breast cancer resistance protein (BCRP)/ABCG2 drug pump
    • Burger H, van Tol H, Boersma AW, et al. Imatinib mesylate (STI571) is a substrate fot the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood 2004; 104:2940-2942.
    • (2004) Blood , vol.104 , pp. 2940-2942
    • Burger, H.1    van Tol, H.2    Boersma, A.W.3
  • 115
    • 25144450089 scopus 로고    scopus 로고
    • Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps
    • Burger H, van Tol H, Brok M, et al. Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther 2005; 4:747-752.
    • (2005) Cancer Biol Ther , vol.4 , pp. 747-752
    • Burger, H.1    van Tol, H.2    Brok, M.3
  • 116
    • 33745953739 scopus 로고    scopus 로고
    • Complex interaction of BCRP/ ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression
    • Nakanishi T, Shiozawa K, Hassel BA, et al. Complex interaction of BCRP/ ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. Blood 2006; 108:678-684.
    • (2006) Blood , vol.108 , pp. 678-684
    • Nakanishi, T.1    Shiozawa, K.2    Hassel, B.A.3
  • 118
    • 33745085275 scopus 로고    scopus 로고
    • OCT-1 mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107); reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
    • White DL, Saunders VA, Dang P, et al. OCT-1 mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107); reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006; 108:697-704.
    • (2006) Blood , vol.108 , pp. 697-704
    • White, D.L.1    Saunders, V.A.2    Dang, P.3
  • 119
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Thomas J, Wang L, Clark RE, et al. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004; 104:3739-3745.
    • (2004) Blood , vol.104 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3
  • 120
    • 23044433630 scopus 로고    scopus 로고
    • hOCT 1 and resistance to imatinib
    • Crossman LC, Druker BJ, Deininger MW, et al. hOCT 1 and resistance to imatinib. Blood 2005; 106:1133-1134.
    • (2005) Blood , vol.106 , pp. 1133-1134
    • Crossman, L.C.1    Druker, B.J.2    Deininger, M.W.3
  • 121
    • 0033614396 scopus 로고    scopus 로고
    • Mutator phenotype of BCR-ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta
    • Canitrot Y, Lautier D, Laurent G, et al. Mutator phenotype of BCR-ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta. Oncogene 1999; 18:2676-2680.
    • (1999) Oncogene , vol.18 , pp. 2676-2680
    • Canitrot, Y.1    Lautier, D.2    Laurent, G.3
  • 122
    • 0036844028 scopus 로고    scopus 로고
    • The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190Bcr-Abl transgenic mice
    • Brain J, Saksena A, Laneuville P. The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190Bcr-Abl transgenic mice. Leuk Res 2002; 26:1011-1016.
    • (2002) Leuk Res , vol.26 , pp. 1011-1016
    • Brain, J.1    Saksena, A.2    Laneuville, P.3
  • 123
    • 0041438485 scopus 로고    scopus 로고
    • Measurement of genomic instability in preleukemic P190BCR/ABL transgenic mice using inter-simple sequence repeat polymerase chain reaction
    • Brain JM, Goodyer N, Laneuville P. Measurement of genomic instability in preleukemic P190BCR/ABL transgenic mice using inter-simple sequence repeat polymerase chain reaction. Cancer Res 2003; 63:4895-4898.
    • (2003) Cancer Res , vol.63 , pp. 4895-4898
    • Brain, J.M.1    Goodyer, N.2    Laneuville, P.3
  • 124
    • 0019455210 scopus 로고
    • Evidence for a multistep pathogenesis of chronic myelogenous leukemia
    • Fialkow PJ, Martin PJ, Najfeld V, et al. Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood 1981; 58:158-163.
    • (1981) Blood , vol.58 , pp. 158-163
    • Fialkow, P.J.1    Martin, P.J.2    Najfeld, V.3
  • 125
    • 33750615550 scopus 로고    scopus 로고
    • Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia
    • Kovitz C, Kantarjian H, Garcia-Manero G, et al. Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia. Blood 2006; 108:2811-2813.
    • (2006) Blood , vol.108 , pp. 2811-2813
    • Kovitz, C.1    Kantarjian, H.2    Garcia-Manero, G.3
  • 126
    • 30644462841 scopus 로고    scopus 로고
    • Targeted CML therapy: Controlling drug resistance, seeking cure
    • O'Hare T, Corbin AS, Druker BJ. Targeted CML therapy: controlling drug resistance, seeking cure. Curr Opin Genet Dev 2006; 16:92-99.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 92-99
    • O'Hare, T.1    Corbin, A.S.2    Druker, B.J.3
  • 127
    • 4544312606 scopus 로고    scopus 로고
    • Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia
    • Sorel N, Bonnet ML, Guilliet M, et al. Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia. Biochem Biophys Res Commun 2004; 323:728-730.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 728-730
    • Sorel, N.1    Bonnet, M.L.2    Guilliet, M.3
  • 128
    • 34249825618 scopus 로고    scopus 로고
    • Jiang X, Zhao Y, Smith C, et al. Chronic myeloid leukemia stem cells possess unique properties that predict intrinsic and acquired resistance in imatinib mesylate. Blood 2006; 108:226a (Absttact #752).
    • Jiang X, Zhao Y, Smith C, et al. Chronic myeloid leukemia stem cells possess unique properties that predict intrinsic and acquired resistance in imatinib mesylate. Blood 2006; 108:226a (Absttact #752).
  • 129
    • 20844448211 scopus 로고    scopus 로고
    • A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor
    • von Bubnoff N, Veach DR, van der KH, et al. A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor. Blood 2005; 105:1652-1659.
    • (2005) Blood , vol.105 , pp. 1652-1659
    • von Bubnoff, N.1    Veach, D.R.2    van der, K.H.3
  • 130
    • 21744435290 scopus 로고    scopus 로고
    • Occurrence of de novo ABL kinase domain mutations in primary bone marrow cells after BCR-ABL gene transfer and imatinib mesylate selection
    • Flamant S, Turhan AG. Occurrence of de novo ABL kinase domain mutations in primary bone marrow cells after BCR-ABL gene transfer and imatinib mesylate selection. Leukemia 2005; 19:1265-1267.
    • (2005) Leukemia , vol.19 , pp. 1265-1267
    • Flamant, S.1    Turhan, A.G.2
  • 131
    • 33745608455 scopus 로고    scopus 로고
    • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib tesistance
    • Koptyra M, Falinski R, Nowicki MO, et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib tesistance. Blood 2006; 108:319-327.
    • (2006) Blood , vol.108 , pp. 319-327
    • Koptyra, M.1    Falinski, R.2    Nowicki, M.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.