Selective expansion of primitive normal hematopoietic cells in cytokine- supplemented cultures of purified cells from patients with chronic myeloid leukemia

Blood

Volumn 90, Issue 1, 1997, Pages 64-69

  Petzer, A L ^a   Eaves, C J ^a   Barnett, M J ^a   Eaves, A C ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CHRONIC MYELOID LEUKEMIA; COLONY FORMING CELL; GROWTH STIMULATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STEM CELL;

EID: 0030922086     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.1.64.64_64_69     Document Type: Article

References (47)

1. Raskind WH, Fialkow PJ: The use of cell markers in the study of human hematopoietic neoplasia. Adv Cancer Res 49:127, 1987
2. Groffen J, Heisterkamp N: The BCR/ABL hybrid gene. Baillieres Clin Haematol 1:983, 1987
3. Rowley JD: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243:290, 1973
4. Hariharan IK, Adams JM, Cory S: BCR-ABL oncogene renders myeloid cell line factor independent: Potential autocrine mechanism in chronic myeloid leukemia. Oncogene Res 3:387, 1988
5. bcr/abl gene of the Philadelphia chromosome. Science 247:824, 1990
6. Heisterkamp N, Jenster G, ten Hoeve J, Zovich D, Pattengale PK, Groffen J: Acute leukemia in bcr/abl transgenic mice. Nature 344:251, 1990
7. Elefanty AG, Hariharan IK, Cory S: bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J 9:1069, 1990
8. Kelliher MA, McLaughlin J, Witte ON, Rosenberg N: Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA 87:6649, 1990
9. Gishizky ML, Johnson-White J, Witte ON: Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice. Proc Natl Acad Sci USA 90:3755, 1993
10. Coulombel L, Kalousek DK, Eaves CJ, Gupta CM, Eaves AC: Long-term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. N Engl J Med 308:1493, 1983
11. + chronic myelogenous leukemia and effects of intensive treatment. Blood 59:793, 1982
12. Talpaz M, Kantarjian HM, McCredie K: Hematologic remission and cytogenetic improvement induced by recombinant human interferon alphaA in chronic myelogenous leukemia. N Engl J Med 314:1065, 1986
13. Eaves C, Udomsakdi C, Cashman J, Barnett M, Eaves A: The biology of normal and neoplastic stem cells in CML. Leuk Lymphoma 11:245, 1993
14. Petzer AL, Eaves CJ, Lansdorp PM, Ponchio L, Barnett MJ, Eaves AC: Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia. Blood 88:2162, 1996
15. Carella AM, Podesta M, Frassoni F, Raffo MR, Pollicardo N, Pungolino E, Vimercati R, Sessarego M, Parodi C, Rabitti C, Ferrero R, Benvenuto F, Figari O, Carlier P, Levcasic G, Valbonesi M, Vitale V, Giordano D, Pierluigi D, Nati S, Guerracio A, Rosso C, Saglio G: Collection of "normal" blood repopulating cells during early hematopoeietic recovery after intensive conventional chemotherapy in chronic myelogenous leukemia. Bone Marrow Transplant 12:267, 1993
16. Sirard C, Lapidot T, Vormoor J, Cashman JD, Doedens M, Murdoch B, Jamal N, Messner H, Addey L, Minden M, Laraya P, Keating A, Eaves A, Lansdorp PM, Eaves CJ, Dick JE: Normal and leukemic SCID-repopulating cells (SRC) co-exist in the bone marrow and peripheral blood from CML patients in chronic phase while leukemic SRC are detected in blast crisis. Blood 87:1539, 1996
17. Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ: Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci USA 87:3584, 1990
18. Kalousek DK, Eaves CJ, Eaves AC: In-vitro cytogenetic studies of haemopoietic malignancies. Cancer Surv 3:439, 1984
19. Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH: Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J Immunol 133:157, 1984
20. - progenitor cells. Blood 77:1218, 1991
21. - progenitor cells in long-term cultures and semisolid assays. Blood 81:2916, 1993
22. + subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 91:12223, 1994
23. Petzer AL, Hogge DE, Lansdorp PM, Reid DS, Eaves CJ: Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined me-dium. Proc Natl Acad Sci USA 93:1470, 1996
24. Verfaillie CM, Miller WJ, Boylan K, McGlave PB: Selection of benign primitive hematopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR antigen expression. Blood 79:1003, 1992
25. Udomsakdi C, Eaves CJ, Lansdorp PM, Eaves AC: Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia. Blood 80:2522, 1992
26. Verfaillie CM, Bhatia R, Miller W, Mortari F, Roy V, Burger S, McCullough J, Stieglbauer K, Dewald G, Heimfeld S, Miller JS, McGlave PB: BCR/ABL-negative primitive progenitors suitable for transplantation can be selected from the marrow of most early-chronic phase but not accelerated-phase chronic myelogenous leukemia patients. Blood 87:4770, 1996
27. Barnett MJ, Eaves CJ, Phillips GL, Kalousek DK, Klingemann H-G, Lansdorp PM, Reece DE, Shepherd JD, Shaw GJ, Eaves AC: Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture. Bone Marrow Transplant 4:345, 1989
28. Barnett MJ, Eaves CJ, Phillips GL, Gascoyne RD, Hogge DE, Horsman DE, Humphries RK, Klingemann H-G, Lansdorp PM, Nantel SH, Reece DE, Shepherd JD, Spinelli JJ, Sutherland HJ, Eaves AC: Autografting with cultured marrow in chronic myeloid leukemia: Results of a pilot study. Blood 84:724, 1994
29. Udomsakdi C, Eaves CJ, Swolin B, Reid DS, Barnett MJ, Eaves AC: Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci USA 89:6192, 1992
30. -) human hematopoietic cells: Novel responses to flt3-ligand and thrombopoietin. J Exp Med 183:2551, 1996
31. Hogge DE, Lansdorp PM, Reid D, Gerhard B, Eaves CJ: Enhanced detection, maintenance and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human Steel factor, interleukin-3 and granulocyte colony-stimulated factor. Blood 88:3765, 1996
32. Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM: Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74:1563, 1989
33. Prosper F, Stroncek D, Verfaillie CM: Phenotypic and functional characterization of long-term culture-initiating cells present in peripheral blood progenitor collections of normal donors treated with granulocyte colony-stimulating factor. Blood 88:2033, 1996
34. Hao QL, Thiemann FT, Petersen D, Smogorzewska EM, Crooks GM: Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progentior population. Blood 88:3306, 1996
35. Verfaillie C, Hurley R, Bhatia R, McCarthy JB: Role of bone marrow matrix in normal and abnormal hematopoiesis. Crit Rev Oncol Hematol 16:201, 1994
36. Evans CA, Owen-Lynch J, Whetton AD, Dive C: Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells. Cancer Res 53:1735, 1993
37. Bedi A, Zehnbauer BA, Barber J, Sharkis S, Jones R: Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood 83:2038, 1994
38. Cortez D, Kadlec L, Pendergast AM: Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. Mol Cell Biol 15:5531, 1995
39. Strife A, Lambek C, Wisniewski D, Wachter M, Gulati SC, Clarkson BD: Discordant maturation as the primary biological defect in chronic myelogenous leukemia. Cancer Res 48:1035, 1988
40. Fokas AS, Keller JB, Clarkson BD: Mathematical model of granulocytopoiesis and chronic myelogenous leukemia. Cancer Res 51:2084, 1991
41. Ponchio L, Conneally E, Eaves C: Quantitation of the quiescent fraction of longterm culture-initiating cells (LTC-IC) in normal human blood and marrow and the kinetics of their growth factor-stimulated entry into S-phase in vitro. Blood 86:3314, 1995
42. Ponchio L, Cashman J, Zoumbos N, Eaves CJ, Eaves A: Primitive CML cells show a deregulation of their cycling status both in vivo and in longterm cultures which is not normalized in the presence of interferon-α. Blood 86:493a, 1995 (abstr, suppl 1)
43. + cells from patients with chronic myeloid leukemia. Blood 88:1796, 1996
44. Eaves CJ, Cashman JD, Zoumbos NC, Barnett MJ, Eaves AC: Biological strategies for the selective manipulation of normal and leukemic stem cells. Stem Cells 11:109, 1993
45. Heyssel R, Brill AB, Woodbury LA, Nishimura ET, Ghose T, Hoshino T, Yamasaki M: Leukemia in Hiroshima atomic bomb survivors. Blood 15:313, 1960
46. van Rhee F, Lin F, Cross NCP, Reid CDL, Lakhani AKV, Szydlo RM, Goldman JM: Detection of residual leukaemia more than 10 years after allogeneic bone marrow transplantation for chronic myelogenous leukaemia. Bone Marrow Transplant 14:609, 1994
47. Kantarjian HM, Vellekoop L, McCredie KB, Keating MJ, Hester J, Smith T, Barlogie B, Trujillo J, Freireich EJ: Intensive combination chemotherapy (ROAP 10) and splenectomy in the management of chronic myelogenous leukemia. J Clin Oncol 3:192, 1985