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Volumn 115, Issue 16, 2010, Pages 3185-3195

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

(17)  Schemionek, Mirle a   Elling, Christian a   Steidl, Ulrich b   Bäumer, Nicole a   Hamilton, Ashley c   Spieker, Tilmann a   Göthert, Joachim R d   Stehling, Martin e   Wagers, Amy f   Huettner, Claudia S g   Tenen, Daniel G h,i   Tickenbrock, Lara j   Berdel, Wolfgang E a   Serve, Hubert k   Holyoake, Tessa L c   Müller Tidow, Carsten a   Koschmieder, Steffen a  


Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; IMATINIB;

EID: 77951446379     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-04-215376     Document Type: Article
Times cited : (75)

References (44)
  • 1
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow PJ, Jacobson RJ, Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med. 1977;63(1):125-130. (Pubitemid 8146659)
    • (1977) American Journal of Medicine , vol.63 , Issue.1 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 2
    • 0032535764 scopus 로고    scopus 로고
    • Lineage involvement of stem cells bearing the philadelphia chromosome in chronic myeloid leukemia in the chronic phase as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization
    • Takahashi N, Miura I, Saitoh K, Miura AB. Lineage involvement of stem cells bearing the Philadelphia chromosome in chronic myeloid leukemia in the chronic phase as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization. Blood. 1998;92(12):4758-4763. (Pubitemid 29005878)
    • (1998) Blood , vol.92 , Issue.12 , pp. 4758-4763
    • Takahashi, N.1    Miura, I.2    Saitoh, K.3    Miura, A.B.4
  • 3
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210(bcr/abl) gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science. 1990;247(4944):824-830. (Pubitemid 20078558)
    • (1990) Science , vol.247 , Issue.4944 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 5
    • 0033519238 scopus 로고    scopus 로고
    • The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
    • DOI 10.1084/jem.189.9.1399
    • Li S, Ilaria RL Jr, Million RP, Daley GQ, Van Etten RA. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med. 1999;189(9):1399-1412. (Pubitemid 29227526)
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.9 , pp. 1399-1412
    • Li, S.1    Ilaria Jr., R.L.2    Million, R.P.3    Daley, G.Q.4    Van Etten, R.A.5
  • 6
    • 19944426030 scopus 로고    scopus 로고
    • Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis
    • Koschmieder S, Gottgens B, Zhang P, et al. Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood. 2005;105(1):324-334.
    • (2005) Blood , vol.105 , Issue.1 , pp. 324-334
    • Koschmieder, S.1    Gottgens, B.2    Zhang, P.3
  • 7
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • DOI 10.1038/nrc1567
    • Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005;5(3):172-183. (Pubitemid 40314949)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.3 , pp. 172-183
    • Ren, R.1
  • 8
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355(23):2408-2417.
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 9
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosomepositive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosomepositive leukemias. N Engl J Med. 2006;354(24):2531-2541.
    • (2006) N Engl J Med , vol.354 , Issue.24 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 11
    • 34548825795 scopus 로고    scopus 로고
    • Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
    • DOI 10.1182/blood-2007-03-066936
    • O'Hare T, Eide CA, Deininger MW. Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood. 2007;110(7):2242-2249. (Pubitemid 47523141)
    • (2007) Blood , vol.110 , Issue.7 , pp. 2242-2249
    • O'Hare, T.1    Eide, C.A.2    Deininger, M.W.N.3
  • 12
    • 41949088658 scopus 로고    scopus 로고
    • BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors
    • Copland M, Pellicano F, Richmond L, et al. BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood. 2008;111(5):2843-2853.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2843-2853
    • Copland, M.1    Pellicano, F.2    Richmond, L.3
  • 13
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland M, Hamilton A, Elrick LJ, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood. 2006;107(11):4532-4539.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3
  • 14
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R, Holtz M, Niu N, et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood. 2003;101(12):4701-4707.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3
  • 15
    • 19944385935 scopus 로고    scopus 로고
    • MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
    • Huntly BJ, Shigematsu H, Deguchi K, et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell. 2004;6(6):587-596.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 587-596
    • Huntly, B.J.1    Shigematsu, H.2    Deguchi, K.3
  • 16
    • 33750937577 scopus 로고    scopus 로고
    • Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
    • Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY, Li S. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A. 2006;103(45):16870-16875.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.45 , pp. 16870-16875
    • Hu, Y.1    Swerdlow, S.2    Duffy, T.M.3    Weinmann, R.4    Lee, F.Y.5    Li, S.6
  • 17
    • 0032529306 scopus 로고    scopus 로고
    • The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor's disease: An in vivo model of chronic myelogenous leukemia biology
    • Dazzi F, Capelli D, Hasserjian R, et al. The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor's disease: an in vivo model of chronic myelogenous leukemia biology. Blood. 1998;92(4):1390-1396.
    • (1998) Blood , vol.92 , Issue.4 , pp. 1390-1396
    • Dazzi, F.1    Capelli, D.2    Hasserjian, R.3
  • 18
    • 0034585920 scopus 로고    scopus 로고
    • Normal and chronic phase CML hematopoietic cells repopulate NOD/SCID bone marrow with different kinetics and cell lineage representation
    • Dazzi F, Hasserjian R, Gordon MY, et al. Normal and chronic phase CML hematopoietic cells repopulate NOD/SCID bone marrow with different kinetics and cell lineage representation. Hematol J. 2000;1(5):307-315.
    • (2000) Hematol J , vol.1 , Issue.5 , pp. 307-315
    • Dazzi, F.1    Hasserjian, R.2    Gordon, M.Y.3
  • 19
    • 20144374544 scopus 로고    scopus 로고
    • Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease
    • Eisterer W, Jiang X, Christ O, et al. Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease. Leukemia. 2005;19(3):435-441.
    • (2005) Leukemia , vol.19 , Issue.3 , pp. 435-441
    • Eisterer, W.1    Jiang, X.2    Christ, O.3
  • 20
    • 0030922086 scopus 로고    scopus 로고
    • Selective expansion of primitive normal hematopoietic cells in cytokine- Supplemented cultures of purified cells from patients with chronic myeloid leukemia
    • Petzer AL, Eaves CJ, Barnett MJ, Eaves AC. Selective expansion of primitive normal hematopoietic cells in cytokine-supplemented cultures of purified cells from patients with chronic myeloid leukemia. Blood. 1997;90(1):64-69. (Pubitemid 27276548)
    • (1997) Blood , vol.90 , Issue.1 , pp. 64-69
    • Petzer, A.L.1    Eaves, C.J.2    Barnett, M.J.3    Eaves, A.C.4
  • 22
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004;351(7):657-667.
    • (2004) N Engl J Med , vol.351 , Issue.7 , pp. 657-667
    • Jamieson, C.H.1    Ailles, L.E.2    Dylla, S.J.3
  • 23
    • 76249123883 scopus 로고    scopus 로고
    • Identification of a myeloid committed progenitor as the cancer initiating cell in acute promyelocytic leukemia
    • Guibal FC, Alberich-Jorda M, Hirai H, et al. Identification of a myeloid committed progenitor as the cancer initiating cell in acute promyelocytic leukemia. Blood. 2009;114(27):5415-5425.
    • (2009) Blood , vol.114 , Issue.27 , pp. 5415-5425
    • Guibal, F.C.1    Alberich-Jorda, M.2    Hirai, H.3
  • 25
    • 34247555482 scopus 로고    scopus 로고
    • Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
    • DOI 10.1038/sj.leu.2404609, PII 2404609
    • Jiang X, Zhao Y, Smith C, et al. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia. 2007;21(5):926-935. (Pubitemid 46672068)
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 926-935
    • Jiang, X.1    Zhao, Y.2    Smith, C.3    Gasparetto, M.4    Turhan, A.5    Eaves, A.6    Eaves, C.7
  • 26
    • 34948839961 scopus 로고    scopus 로고
    • Leukemia stem cells in a genetically defined murine model of blast-crisis CML
    • Neering SJ, Bushnell T, Sozer S, et al. Leukemia stem cells in a genetically defined murine model of blast-crisis CML. Blood. 2007;110(7):2578-2585.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2578-2585
    • Neering, S.J.1    Bushnell, T.2    Sozer, S.3
  • 27
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • DOI 10.1126/science.1142596
    • Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A. Tumor growth need not be driven by rare cancer stem cells. Science. 2007;317(5836):337. (Pubitemid 47106366)
    • (2007) Science , vol.317 , Issue.5836 , pp. 337
    • Kelly, P.N.1    Dakic, A.2    Adams, J.M.3    Nutt, S.L.4    Strasser, A.5
  • 28
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • DOI 10.1016/j.ccr.2006.08.020, PII S1535610806002765
    • Somervaille TC, Cleary ML. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 2006;10(4):257-268. (Pubitemid 44512188)
    • (2006) Cancer Cell , vol.10 , Issue.4 , pp. 257-268
    • Somervaille, T.C.P.1    Cleary, M.L.2
  • 29
    • 18444374439 scopus 로고    scopus 로고
    • In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions
    • DOI 10.1634/stemcells.2004-0183
    • Ishii G, Sangai T, Sugiyama K, et al. In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions. Stem Cells. 2005;23(5):699-706. (Pubitemid 40647266)
    • (2005) Stem Cells , vol.23 , Issue.5 , pp. 699-706
    • Ishii, G.1    Sangai, T.2    Sugiyama, K.3    Ito, T.4    Hasebe, T.5    Endoh, Y.6    Magae, J.7    Ochiai, A.8
  • 30
    • 42049086836 scopus 로고    scopus 로고
    • BCR/ABL, DNA damage and DNA repair: Implications for new treatment concepts
    • DOI 10.1080/03093640701859089, PII 791069242
    • Skorski T. BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk Lymphoma. 2008;49(4):610-614. (Pubitemid 351517197)
    • (2008) Leukemia and Lymphoma , vol.49 , Issue.4 , pp. 610-614
    • Skorski, T.1
  • 32
    • 35848948403 scopus 로고    scopus 로고
    • Imaging hematopoietic precursor division in real time
    • Wu M, Kwon HY, Rattis F, et al. Imaging hematopoietic precursor division in real time. Cell Stem Cell. 2007;1(5):541-554.
    • (2007) Cell Stem Cell , vol.1 , Issue.5 , pp. 541-554
    • Wu, M.1    Kwon, H.Y.2    Rattis, F.3
  • 33
    • 0037385037 scopus 로고    scopus 로고
    • The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment
    • DOI 10.1016/S0301-472X(03)00024-9
    • Punzel M, Liu D, Zhang T, Eckstein V, Miesala K, Ho AD. The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment. Exp Hematol. 2003;31(4):339-347. (Pubitemid 36407611)
    • (2003) Experimental Hematology , vol.31 , Issue.4 , pp. 339-347
    • Punzel, M.1    Liu, D.2    Zhang, T.3    Eckstein, V.4    Miesala, K.5    Ho, A.D.6
  • 34
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • Neviani P, Santhanam R, Trotta R, et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell. 2005;8(5):355-368.
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3
  • 35
    • 33847230958 scopus 로고    scopus 로고
    • Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase
    • Diaz-Blanco E, Bruns I, Neumann F, et al. Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase. Leukemia. 2007;21(3):494-504.
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 494-504
    • Diaz-Blanco, E.1    Bruns, I.2    Neumann, F.3
  • 36
    • 36749033284 scopus 로고    scopus 로고
    • Characterization of cancer stem cells in chronic myeloid leukaemia
    • DOI 10.1042/BST0351347
    • Jorgensen HG, Holyoake TL. Characterization of cancer stem cells in chronic myeloid leukaemia. Biochem Soc Trans. 2007;35(5):1347-1351. (Pubitemid 350206497)
    • (2007) Biochemical Society Transactions , vol.35 , Issue.5 , pp. 1347-1351
    • Jorgensen, H.G.1    Holyoake, T.L.2
  • 37
    • 26044443571 scopus 로고    scopus 로고
    • A mathematical model of hematopoiesis - I. Periodic chronic myelogenous leukemia
    • DOI 10.1016/j.jtbi.2005.03.033, PII S0022519305001542
    • Colijn C, Mackey MC. A mathematical model of hematopoiesis: I. Periodic chronic myelogenous leukemia. J Theor Biol. 2005;237(2):117-132. (Pubitemid 41406400)
    • (2005) Journal of Theoretical Biology , vol.237 , Issue.2 , pp. 117-132
    • Colijn, C.1    Mackey, M.C.2
  • 38
    • 9444264703 scopus 로고    scopus 로고
    • BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks
    • Nowicki MO, Falinski R, Koptyra M, et al. BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood. 2004;104(12):3746-3753.
    • (2004) Blood , vol.104 , Issue.12 , pp. 3746-3753
    • Nowicki, M.O.1    Falinski, R.2    Koptyra, M.3
  • 39
    • 30344461008 scopus 로고    scopus 로고
    • BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells
    • DOI 10.1016/j.dnarep.2005.10.005, PII S1568786405002703
    • Slupianek A, Nowicki MO, Koptyra M, Skorski T. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair (Amst). 2006;5(2):243-250. (Pubitemid 43069524)
    • (2006) DNA Repair , vol.5 , Issue.2 , pp. 243-250
    • Slupianek, A.1    Nowicki, M.O.2    Koptyra, M.3    Skorski, T.4
  • 40
    • 54049088959 scopus 로고    scopus 로고
    • BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress
    • Koptyra M, Cramer K, Slupianek A, Richardson C, Skorski T. BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress. Leukemia. 2008;22(10):1969-1972.
    • (2008) Leukemia , vol.22 , Issue.10 , pp. 1969-1972
    • Koptyra, M.1    Cramer, K.2    Slupianek, A.3    Richardson, C.4    Skorski, T.5
  • 41
    • 22544459376 scopus 로고    scopus 로고
    • Outcome of four patients with chronic myeloid leukemia after imatinib mesylate discontinuation
    • Merante S, Orlandi E, Bernasconi P, Calatroni S, Boni M, Lazzarino M. Outcome of four patients with chronic myeloid leukemia after imatinib mesylate discontinuation. Haematologica. 2005;90(7):979-981. (Pubitemid 41020302)
    • (2005) Haematologica , vol.90 , Issue.7 , pp. 979-981
    • Merante, S.1    Orlandi, E.2    Bernasconi, P.3    Calatroni, S.4    Boni, M.5    Lazzarino, M.6
  • 42
    • 20544435207 scopus 로고    scopus 로고
    • Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML): Outcome of discontinuation of imatinib therapy after achieving a molecular remission
    • Ali R, Ozkalemkas F, Ozcelik T, et al. Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML): outcome of discontinuation of imatinib therapy after achieving a molecular remission. Leuk Res. 2005;29(8):971-973.
    • (2005) Leuk Res , vol.29 , Issue.8 , pp. 971-973
    • Ali, R.1    Ozkalemkas, F.2    Ozcelik, T.3
  • 43
    • 33749987744 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achievement of complete molecular response in a Ph(+) CML patient treated while in long lasting complete cytogenetic remission (CCR) induced by interferon
    • Breccia M, Diverio D, Pane F, et al. Discontinuation of imatinib therapy after achievement of complete molecular response in a Ph(+) CML patient treated while in long lasting complete cytogenetic remission (CCR) induced by interferon. Leuk Res. 2006;30(12):1577-1579.
    • (2006) Leuk Res , vol.30 , Issue.12 , pp. 1577-1579
    • Breccia, M.1    Diverio, D.2    Pane, F.3
  • 44
    • 66149115277 scopus 로고    scopus 로고
    • IFNalpha activates dormant haematopoietic stem cells in vivo
    • Essers MA, Offner S, BlancoBose WE, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature. 2009;458(7240):904-908.
    • (2009) Nature , vol.458 , Issue.7240 , pp. 904-908
    • Essers, M.A.1    Offner, S.2    Blancobose, W.E.3


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