Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice

Blood

Volumn 99, Issue 3, 2002, Pages 792-799

  Cashman, Johanne ^a,b   Clark Lewis, Ian ^a,b   Eaves, Allen ^a,b   Eaves, Connie ^a,b,c  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; BCR ABL PROTEIN; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOSTASIS; DISULFIDE BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROID CELL; FLOW CYTOMETRY; GENE DISRUPTION; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SCID MOUSE; STROMA CELL;

EID: 0036464597     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.3.792     Document Type: Article

References (78)

1. The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice
2. In vivo kinetic states of hematopoietic stem and progenitor cells as inferred from labelling with bromodeoxyuridine
3. Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment
4. Cell culture studies in CML
5. Quantitation of the quiescent fraction of long-term culture-initiating cells (LTC-IC) in normal human blood and marrow and the kinetics of their growth factor-stimulated entry into S-phase in vitro
6. lo human marrow cells after in vitro cytokine exposure
7. High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations
8. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells
9. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
10. Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures
11. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures, II: Analysis of positive and negative regulators produced by stromal cells within the adherent layer
12. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures, I: Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-β
13. Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures
14. The effects of interleukin 6 and interleukin 3 on early hematopoietic events in long-term cultures of human marrow
15. MCP-1, not MIP-1α, is the endogenous chemokine that cooperates with TGF-β to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures
16. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1α, an inhibitor of primitive normal hematopoietic cells
17. BCR-ABL accelerates C2-ceramide-induced apoptosis
18. Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-β on normal and leukemic human hematopoietic progenitor cells
19. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
20. Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haematopoietic cells in NOD/SCID mice transplanted with human cord blood
21. Differentiation stage-specific regulation of primitive human hematopoietic progenitor cycling by exogenous and endogenous inhibitors in an in vivo model
22. The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
23. Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors
24. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1
25. + progenitors to peripheral blood
26. + cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin
27. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
28. CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells
29. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
30. HCC-1, a novel chemokine from human plasma
31. A novel polypeptide secreted by activated human T lymphocytes
32. Solution structure and basis for functional activity of stromal cell-derived factor-1: Dissociation of CXCR4 activation from binding and inhibition of HIV-1
33. 2-terminal residues
34. Purification of hematopoietic stem cells for further biological study
35. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors
36. Expression of CD34 on human B cell precursors
37. Enhanced detection, maintenance and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human Steel factor, interleukin-3 and granulocyte colony-stimulating factor
38. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
39. Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: A possible role in homing of haemopoietic progenitor cells to bone marrow
40. Molecular cloning and structure of a pre-B-cell growth-stimulating factor
41. Host origin of marrow stromal cells following allogeneic bone marrow transplantation
42. Long-term culture of human bone marrow, I: Characterization of adherent cells in flow cytometry
43. Differential effects of microenvironmentally presented interleukin 3 versus soluble growth factor on primitive human hematopoietic cells
44. Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells
45. The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1α
46. N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities
47. Chemokines
48. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells
49. Requirement of MIP-1α for an inflammatory response to viral infection
50. Abnormalities in monocyte recuitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice
51. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
52. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen
53. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in teukocytes
54. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
55. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: Rapid internalization and recycling upon activation
56. The α-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion
57. The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression
58. Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes
59. Chemokine receptor CXCR4 expression in endothelium
60. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
61. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
62. Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
63. Signal sequence trap: A cloning strategy for secreted proteins and type I membrane proteins
64. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
65. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1 deficient mice
66. Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors
67. Activation of HIV-1 coreceptor (CXCR4) mediates myelosuppression
68. Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines
69. + cell proliferation in synergy with cytokines: Possible role in progenitor survival
70. Transforming growth factor-β: A bidirectional regulator of hematopoietic cell growth
71. Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells
72. - human hematopoietic progenitors
73. Direct contact with stroma inhibits proliferation of human long-term culture initiating cells
74. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation
75. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia
76. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia
77. Treatment of marrow stroma with interferon-α restores normal β1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors
78. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia