Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-β2 microglobulin-null mice

Journal of Clinical Investigation

Volumn 107, Issue 2, 2001, Pages 199-206

  Glimm, H ^a   Eisterer, W ^a   Lee, K ^a   Cashman, J ^a   Holyoake, T L ^a   Nicolini, F ^a   Shultz, L D ^b   Von Kalle, C ^c   Eaves, C J ^a,d  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD34 ANTIGEN; CD38 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; GRAFT REJECTION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROGENY; SCID MOUSE; STEM CELL;

EID: 0035140382     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11519     Document Type: Article

References (37)

1. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling
2. Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells
3. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
4. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay
5. Seeding efficiency of primitive human hematopoietic cells in nonobese diabetic/severe combined immune deficiency mice: Implications for stem cell frequency assessment
6. High marrow seeding efficiency of human lympho-myeloid repopulating cells in irradiated NOD/SCID mice
7. The biology and clinical uses of blood stem cells
8. Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system
9. Clonal and systemic analysis of long-term hematopoiesis in the mouse
10. Life span of multipotential hematopoietic stem cells in vivo
11. Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion
12. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
13. Transient nature of early haematopoietic spleen colonies
14. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
15. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
16. Anatomy and physiology of hematopoiesis
17. Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo
18. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
19. Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haematopoietic cells in NOD/SCID mice transplanted with human cord blood
20. Unique differentiation programs of human fetal liver stem cells revealed both in vitro and in vivo in NOD/SCID mice
21. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
22. A newly discovered class of human hematopoietic cells with SCID-repopulating activity
23. Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow
24. Cytokine treatment of accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice
25. - hematopoietic cells
26. + cells
27. 2-microglobulin-deficient NOD-scid mice
28. null) NOD/SCID mice are excellent recipients for studying human stem cell function
29. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos
30. 0
31. The relationship between stem cell seeding efficiency and position in cell cycle
32. Effects of cell cycle activation on the short-term engraftment properties of ex vivo expanded murine hematopoietic cells
33. The fluctuating phenotype of the lymphohematopoietic stem cell with cell cycle transit
34. Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells
35. Isolation of hemopoietic stem cell subsets from murine bone marrow. I. Radioprotective ability of purified cell suspensions differing in the proportion of day-7 and day-12 CFU-S
36. + cells in non-obese diabetic/severe combined immune-deficient mice
37. Many multipotential gene-marked progenitor or stem cell clones contribute to hematopoiesis in nonhuman primates