Defective regulation of leukemic hematopoiesis in chronic myeloid leukemia

Leukemia Research

Volumn 22, Issue 12, 1998, Pages 1085-1096

  Eaves, C ^a   Cashman, J ^a   Eaves, A ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA CELL; LEUKEMOGENESIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW;

EID: 0032436505     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(98)00113-1     Document Type: Article

References (86)

1. Eaves CJ, Eaves AC. In: Goldman JH, guest editor. Chronic Myleoid Leukemia. Bailliere Tindall. London: Saunders, 1987:931.
2. Eaves CJ, Eaves AC. In: Goldman JM, guest editor. Chronic Myeloid Leukemia. Bailliere's Clinical Haematology, London: Saunders, 1997:233.
3. Cortes J, Kantarjian HM, Giralt S, Talpaz M. In: Goldman MJ, guest editor. Chronic Myeloid Leukemia. Bailliere Tindall. London: Saunders, 1997: 277.
4. Nowell P.C., Hungerford D.A. A minute chromosome in human chronic granulocytic leukemia. Science. 132:1960;1497.
5. Groffen J, Heisterkamp N. In: Goldman JM, guest editor. Chronic Myeloid Leukemia. Bailliere Tindall. London: Saunders, 1987:983.
6. Carella A.M., Frassoni F., Melo J., Sawyers C., Eaves C., Eaves A., Apperley J., Tura S., Hehlmann R., Lerma E., Reiffers J., Goldman J. New insights in biology and current therapeutic options for patients with chronic myeloid leukemia. Haematologica. 82:1997;478.
7. Sutherland HJ, Eaves AC, Eaves CJ. In: Gee AP, editor. Bone Marrow Processing and Purging: A Practical Guide. Boca Raton, FL: CRC Press, 1991:155.
8. Szilvassy S.J., Humphries R.K., Lansdorp P.M., Eaves A.C., Eaves C.J. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci USA. 87:1990;8736.
9. Miller C.L., Eaves C.J. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci USA. 94:1997;13648.
10. Conneally E., Cashman J., Petzer A., Eaves C. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci USA. 94:1997;9836.
11. Krause D.S., Fackler M.J., Civin C.I., May W.S. CD34: structure, biology, and clinical utility. Blood. 87:1996;1.
12. Baum C.M., Weissman I.L., Tsukamoto A.S., Buckle A.M., Peault B. Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA. 89:1992;2804.
13. - subpopulation from mobilized peripheral blood. Blood. 85:1995;368.
14. Nosten-Bertrand M., Errington M.L., Murphy K.P.S.J., Tokugawa Y., Barboni E., Kozlova E., Michalovich D., Morris R.G.M., Silver J., Stewart C.L., Bliss T.V.P., Morris R.J. Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature. 379:1996;826.
15. Mackarehtschian K., Hardin J.D., Moore K.A., Boast S., Goff S.P., Lemischka I.R. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 3:1995;147.
16. Bernad A., Kopf M., Kulbacki R., Weich N., Koehler G., Gutierrez-Ramos J.C. Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity. 1:1994;725.
17. Yoshida K., Taga T., Saito M., Suematsu S., Kumanogoh A., Tanaka T., Fujiwara H., Hirata M., Yamagami T., Nakahata T., Hirabayashi T., Yoneda Y., Tanaka K., Wang W.-Z., Mori C., Shiota K., Yoshida N., Kishimoto T. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci USA. 93:1996;407.
18. Sutherland H.J., Eaves C.J., Eaves A.C., Dragowska W., Lansdorp P.M. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood. 74:1989;1563.
19. Srour E.F., Brandt J.E., Leemhuis T., Ballas C.B., Hoffman R. Relationship between cytokine-dependent cell cycle progression and MHC class II antigen expression by human CD34+HLA-DR- bone marrow cells. J Immunol. 148:1992;815.
20. Raskind W.H., Fialkow P.J. The use of cell markers in the study of human hematopoietic neoplasia. Adv Cancer Res. 49:1987;127.
21. Eaves C., Udomsakdi C., Cashman J., Barnett M., Eaves A. The biology of normal and neoplastic stem cells in CML. Leuk Lymphoma. 11:1993;245.
22. Sirard C., Lapidot T., Vormoor J., Cashman J.D., Doedens M., Murdoch B., Jamal N., Messner H., Addey L., Minden M., Laraya P., Keating A., Eaves A., Lansdorp P.M., Eaves C.J., Dick J.E. Normal and leukemic SCID-repopulating cells (SRC) co-exist in the bone marrow and peripheral blood from CML patients in chronic phase while leukemic SRC are detected in blast crisis. Blood. 87:1996;1539.
23. + cells. Blood. 91:1998;630.
24. Wang J.C.Y., Lapidot T., Cashman J.D., Doedens M., Addy L., Sutherland D.R., Nayar R., Laraya P., Minden M., Keating A., Eaves A.C., Eaves C.J., Dick J.E. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood. 91:1998;2406.
25. Hook E.B. Exclusion of chromosomal mosaicism: Tables of 90%, 95% and 99% confidence limits and comments on use. Am J Hum Genet. 29:1977;94.
26. Dick J.E., Magli M.C., Huszar D., Phillips R.A., Bernstein A. Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell. 42:1985;71.
27. Capel B., Hawley R., Covarrubias L., Hawley T., Mintz B. Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. Proc Natl Acad Sci USA. 86:1989;4564.
28. Turhan A.G., Humphries R.K., Phillips G.L., Eaves A.C., Eaves C.J. Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation. New Engl J Med. 320:1989;1655.
29. Keller G., Snodgrass R. Life span of multipotential hematopoietic stem cells in vivo. J Exp Med. 171:1990;1407.
30. Jordan C.T., Lemischka I.R. Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev. 4:1990;220.
31. Eaves C.J., Shaw G., Horsman D., Barnett M.J., Eaves A.C. Longterm oligoclonal hematopoiesis after transplantation of culture-purged autologous bone marrow in chronic myeloid leukemia (CML). Blood. 80:1992;67a.
32. Petzer A.L., Eaves C.J., Lansdorp P.M., Ponchio L., Barnett M.J., Eaves A.C. Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia. Blood. 88:1996;2162.
33. Sutherland H.J., Hogge D.E., Eaves C.J. Characterization, quantitation and mobilization of early hematopoietic progenitors: Implications for transplantation. Bone Marrow Transplant. 18:1996;S1.
34. Ponchio L., Eaves C., Hogge D., Perotti C., Torretta L., Cerani P., Salvaneschi L., Ascari E., Cazzola M. Both cycling and noncycling primitive progenitors continue to be mobilized into the circulation during the leukapheresis of patients pretreated with chemotherapy and G-CSF. Br J Haematol. 99:1997;394.
35. Gordon M.Y., Dowding C.R., Riley G.P., Goldman J.M., Greaves M.F. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature. 328:1987;342.
36. Verfaillie C.M., McCarthy J.B., McGlave P.B. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. J Clin Invest. 90:1992;1232.
37. 4 integrin. Proc Natl Acad Sci USA. 90:1993;9374.
38. + cells from patients with chronic myeloid leukemia (CML). Blood. 90:1997;392a.
39. Hoyle C., Gray R., Goldman J. Autografting for patients with CML in chronic phase: An update. Br J Haematol. 86:1994;76.
40. Petzer A.L., Eaves C.J., Barnett M.J., Eaves A.C. Selective expansion of primitive normal hematopoietic cells in cytokine-supplemented cultures of purified cells from patients with chronic myeloid leukemia. Blood. 90:1997;64.
41. Barnett MJ, Klingemann H-G, Eaves CJ, Eaves AC. In: Carella AM, editor. Autologous Stem Cell Transplantations: Biological and Clinical Results in Malignancies. Reading, UK: Harwood, 1997:287-298.
42. Moore M.A.S., Williams N., Metcalf D. In vitro colony formation by normal and leukemic human hematopoietic cells: Characterization of the colony-forming cells. J Natl Cancer Inst. 50:1973;603.
43. Eaves A.C., Eaves C.J. Abnormalities in the erythroid progenitor compartments in patients with chronic myelogenous leukemia (CML). Exp Hematol. 7:1979;65.
44. 1-positive chronic myelogenous leukemia. Ann Intern Med. 83:1975;820.
45. Shenkenberg T.D., Waddell C.C., Rice L. Erythrocytosis and marked leukocytosis in overlapping myeloproliferative diseases. South Med J. 75:1982;868.
46. Ponchio L., Cashman J., Zoumbos N., Eaves C.J., Eaves A. Primitive CML cells show a deregulation of their cycling status both in vivo and in longterm cultures which is not normalized in the presence of interferon-α Blood. 86:1995;493a.
47. Daley G.Q., Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210 bcr-abl protein. Proc Natl Acad Sci USA. 85:1988;9312.
48. Hariharan I.K., Adams J.M., Cory S. BCR-ABL oncogene renders myeloid cell line factor independent: Potential autocrine mechanism in chronic myeloid leukemia. Oncogene Res. 3:1988;387.
49. Sirard C., Laneuville P., Dick J. Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism. Blood. 83:1994;1575.
50. Zandstra P.W., Conneally E., Petzer A.L., Piret J.M., Eaves C.J. Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci USA. 94:1997;4698.
51. Udomsakdi C., Eaves C.J., Swolin B., Reid D.S., Barnett M.J., Eaves A.C. Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci USA. 89:1992;6192.
52. Ogawa M., Porter P.N., Nakahata T. Renewal and commitment to differentiation of hemopoietic stem cells (an interpretive review). Blood. 61:1983;823.
53. Xiao M., Leemhuis T., Broxmeyer H.E., Lu L. Influence of combinations of cytokines on proliferation of isolated single cell-sorted human bone marrow hematopoietic progenitor cells in the absence and presence of serum. Exp Hematol. 20:1992;276.
54. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 81:1993;2844.
55. Keller J.R., Jacobsen S.E.W., Dubois C.M., Hestdal K., Ruscetti F.W. Transforming growth factor-β: A bidirectional regulator of hematopoietic cell growth. Int J Cell Cloning. 10:1992;2.
56. +++ stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum. Exp Hematol. 21:1993;1442.
57. Fauser A.A., Messner H.A. Proliferative state of human pluripotent hemopoietic progenitors (CFU-GEMM) in normal individuals and under regenerative conditions after bone marrow transplantation. Blood. 54:1979;1197.
58. Cashman J., Eaves A.C., Eaves C.J. Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures. Blood. 66:1985;1002.
59. Eaves A.C., Cashman J.D., Gaboury L.A., Kalousek D.K., Eaves C.J. Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells. Proc Natl Acad Sci USA. 83:1986;5306.
60. Eaves C.J., Cashman J.D., Kay R.J., Dougherty G.J., Otsuka T., Gaboury L.A., Hogge D.E., Lansdorp P.M., Eaves A.C., Humphries R.K. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer. Blood. 78:1991;110.
61. Eaves C.J., Cashman J.D., Wolpe S.D., Eaves A.C. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1α, an inhibitor of primitive normal hematopoietic cells. Proc Natl Acad Sci USA. 90:1993;12015.
62. Cashman JD, Sarris H, Eaves AC, Eaves CJ. MCP-1, not MIP-1α is the endogenous chemokine that cooperates with TGF-β to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in longterm human marrow cultures. Blood, in press.
63. Sing G.K., Keller J.R., Ellingsworth L.R., Ruscetti F.W. Transforming growth factor β selectively inhibits normal and leukemic human bone marrow cell growth in vitro. Blood. 72:1988;1504.
64. Cashman J.D., Eaves A.C., Eaves C.J. Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-β on normal and leukemic human hematopoietic progenitor cells. Leukemia. 6:1992;886.
65. Otsuka T., Eaves C.J., Humphries R.K., Hogge D.E., Eaves A.C. Lack of evidence for abnormal autocrine or paracrine mechanisms underlying the uncontrolled proliferation of primitive chronic myeloid leukemia progenitor cells. Leukemia. 5:1991;861.
66. Broxmeyer H.E., Sherry B., Cooper S., Lu L., Maze R., Beckmann M.P., Cerami A., Ralph P. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. J Immunol. 150:1993;3448.
67. Broxmeyer H.E., Sherry B., Lu L., Cooper S., Oh K.O., Tekamp-Olson P., Kwon B.S., Cerami A. Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Blood. 76:1990;1110.
68. Hurley R.W., McCarthy J.B., Verfaillie C.M. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. J Clin Invest. 96:1995;511.
69. Verfaillie C.M., Catanzaro P. Direct contact with stroma inhibits proliferation of human long-term culture initiating cells. Leukemia. 10:1996;498.
70. Wayner E.A., Garcia-Pardo A., Humphries M.J., McDonald J.A., Carter W.G. Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J Cell Biol. 109:1989;1321.
71. Guan J.L., Hynes R.O. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1. Cell. 60:1990;53.
72. Lesley J., Hyman R., Kincade P.W. CD44 and its interaction with extracellular matrix. Adv Immunol. 54:1993;271.
73. Ghaffari S., Dougherty G.J., Eaves A.C., Eaves C.J. Diverse effects of anti-CD44 antibodies on the stromal cell-mediated support of normal but not leukaemic (CML) haemopoiesis in vitro. Br J Haematol. 97:1997;22.
74. Tanaka Y., Adams D.H., Hubscher S., Hirano H., Siebenlist U., Shaw S. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β Nature. 361:1993;79.
75. - bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin. Blood. 90:1997;2282.
76. Maguer-Satta V., Burl S., Liu L., Damen J., Chahine H., Krystal G., Eaves A., Eaves C. BCR-ABL accelerates C2-ceramide-induced apoptosis. Oncogene. 16:1998;237.
77. Sutherland H.J., Hogge D.E., Cook D., Eaves C.J. Alternative mechanisms with and without Steel factor support primitive human hematopoiesis. Blood. 81:1993;1465.
78. + cells from patients with chronic myeloid leukemia. Blood. 88:1996;1796.
79. Wetzler M., Talpaz M., Van Etten R.A., Hirsch-Ginsberg C., Beran M., Kurzrock R. Subcellular localization of BCR, ABL and BCR-ABL proteins in normal and leukemic cells and correlation of expression with myeloid differentiation. J Clin Invest. 92:1993;1925.
80. Bedi A., Zehnbauer B.A., Collector M.I., Barber J.P., Zicha M.S., Sharkis S.J., Jones R.J. BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia. Blood. 81:1993;2898.
81. Ichimaru M, Ishimaru T, Mikami M, Yamada Y, Ohkita T. Incidence of leukemia in a fixed cohort of atomic bomb survivors and controls, Hiroshima and Nagasaki October 1950-December 1978: Technical Report RERF TR 13-81. Hiroshima: Radiation Effects Research Foundation, 1981.
82. Biernaux C., Loos M., Sels A., Huez G., Stryckmans P. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood. 86:1995;3118.
83. Hogge D.E., Lansdorp P.M., Reid D., Gerhard B., Eaves C.J. Enhanced detection, maintenance and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human Steel factor, interleukin-3 and granulocyte colony-stimulating factor. Blood. 88:1996;3765.
84. Dube I.D., Gupta C.M., Kalousek D.K., Eaves C.J., Eaves A.C. Cytogenetic studies of early myeloid progenitor compartments in Ph1-positive chronic myeloid leukaemia (CML). I. Persistence of Ph1-negative committed progenitors that are suppressed from differentiating in vivo. Br J Haematol. 56:1984;633.
85. Kalousek D.K., Eaves C.J., Eaves A.C. In-vitro cytogenetic studies of haemopoietic malignancies. Cancer Surv. 3:1984;439.
86. Eaves C. In: Henderson ES, Lister TA, Greaves MF, editors. Leukemia. Philadelphia, PA: Saunders, 1996:46.