-
1
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
Adams J.M., Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007, 26:1324-1337.
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
2
-
-
33144488485
-
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir
-
Alexandre J., Nicco C., Chereau C., Laurent A., Weill B., Goldwasser F., Batteux F. Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir. J. Natl. Cancer Inst. 2006, 98:236-244.
-
(2006)
J. Natl. Cancer Inst.
, vol.98
, pp. 236-244
-
-
Alexandre, J.1
Nicco, C.2
Chereau, C.3
Laurent, A.4
Weill, B.5
Goldwasser, F.6
Batteux, F.7
-
3
-
-
0037021417
-
Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells
-
Andre N., Carre M., Brasseur G., Pourroy B., Kovacic H., Briand C., Braguer D. Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells. FEBS Lett. 2002, 532:256-260.
-
(2002)
FEBS Lett.
, vol.532
, pp. 256-260
-
-
Andre, N.1
Carre, M.2
Brasseur, G.3
Pourroy, B.4
Kovacic, H.5
Briand, C.6
Braguer, D.7
-
4
-
-
58149168589
-
Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy
-
Azmi A.S., Mohammad R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J. Cell Physiol. 2009, 218:13-21.
-
(2009)
J. Cell Physiol.
, vol.218
, pp. 13-21
-
-
Azmi, A.S.1
Mohammad, R.M.2
-
5
-
-
0035891212
-
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437
-
Belzacq A.S., El Hamel C., Vieira H.L., Cohen I., Haouzi D., Metivier D., Marchetti P., Brenner C., Kroemer G. Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437. Oncogene 2001, 20:7579-7587.
-
(2001)
Oncogene
, vol.20
, pp. 7579-7587
-
-
Belzacq, A.S.1
El Hamel, C.2
Vieira, H.L.3
Cohen, I.4
Haouzi, D.5
Metivier, D.6
Marchetti, P.7
Brenner, C.8
Kroemer, G.9
-
6
-
-
34547481318
-
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone
-
Bey E.A., Bentle M.S., Reinicke K.E., Dong Y., Yang C.R., Girard L., Minna J.D., Bornmann W.G., Gao J., Boothman D.A. An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. Proc. Natl. Acad. Sci. USA 2007, 104:11832-11837.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 11832-11837
-
-
Bey, E.A.1
Bentle, M.S.2
Reinicke, K.E.3
Dong, Y.4
Yang, C.R.5
Girard, L.6
Minna, J.D.7
Bornmann, W.G.8
Gao, J.9
Boothman, D.A.10
-
7
-
-
53449086865
-
Development of mitochondria-targeted derivatives of resveratrol
-
Biasutto L., Mattarei A., Marotta E., Bradaschia A., Sassi N., Garbisa S., Zoratti M., Paradisi C. Development of mitochondria-targeted derivatives of resveratrol. Bioorg. Med. Chem. Lett. 2008, 18:5594-5597.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 5594-5597
-
-
Biasutto, L.1
Mattarei, A.2
Marotta, E.3
Bradaschia, A.4
Sassi, N.5
Garbisa, S.6
Zoratti, M.7
Paradisi, C.8
-
8
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S., Archer S.L., Allalunis-Turner J., Haromy A., Beaulieu C., Thompson R., Lee C.T., Lopaschuk G.D., Puttagunta L., Harry G., Hashimoto K., Porter C.J., Andrade M.A., Thebaud B., Michelakis E.D. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007, 11:37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
Lee, C.T.7
Lopaschuk, G.D.8
Puttagunta, L.9
Harry, G.10
Hashimoto, K.11
Porter, C.J.12
Andrade, M.A.13
Thebaud, B.14
Michelakis, E.D.15
-
9
-
-
39749131031
-
Measuring apoptosis at the single cell level
-
Bouchier-Hayes L., Munoz-Pinedo C., Connell S., Green D.R. Measuring apoptosis at the single cell level. Methods 2008, 44:222-228.
-
(2008)
Methods
, vol.44
, pp. 222-228
-
-
Bouchier-Hayes, L.1
Munoz-Pinedo, C.2
Connell, S.3
Green, D.R.4
-
10
-
-
33745950626
-
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
-
Chipuk J.E., Bouchier-Hayes L., Green D.R. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 2006, 13:1396-1402.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 1396-1402
-
-
Chipuk, J.E.1
Bouchier-Hayes, L.2
Green, D.R.3
-
11
-
-
33745685054
-
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
-
Cipolat S., Rudka T., Hartmann D., Costa V., Serneels L., Craessaerts K., Metzger K., Frezza C., Annaert W., D'Adamio L., Derks C., Dejaegere T., Pellegrini L., D'Hooge R., Scorrano L., De Strooper B. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 2006, 126:163-175.
-
(2006)
Cell
, vol.126
, pp. 163-175
-
-
Cipolat, S.1
Rudka, T.2
Hartmann, D.3
Costa, V.4
Serneels, L.5
Craessaerts, K.6
Metzger, K.7
Frezza, C.8
Annaert, W.9
D'Adamio, L.10
Derks, C.11
Dejaegere, T.12
Pellegrini, L.13
D'Hooge, R.14
Scorrano, L.15
De Strooper, B.16
-
12
-
-
47049121032
-
Vitamin E and cancer: an insight into the anticancer activities of vitamin E isomers and analogs
-
Constantinou C., Papas A., Constantinou A.I. Vitamin E and cancer: an insight into the anticancer activities of vitamin E isomers and analogs. Int. J. Cancer 2008, 123:739-752.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 739-752
-
-
Constantinou, C.1
Papas, A.2
Constantinou, A.I.3
-
13
-
-
0034642510
-
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis
-
Costantini P., Belzacq A.S., Vieira H.L., Larochette N., de Pablo M.A., Zamzami N., Susin S.A., Brenner C., Kroemer G. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene 2000, 19:307-314.
-
(2000)
Oncogene
, vol.19
, pp. 307-314
-
-
Costantini, P.1
Belzacq, A.S.2
Vieira, H.L.3
Larochette, N.4
de Pablo, M.A.5
Zamzami, N.6
Susin, S.A.7
Brenner, C.8
Kroemer, G.9
-
14
-
-
35648953299
-
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
-
(Discussion 1690)
-
Cragg M.S., Kuroda J., Puthalakath H., Huang D.C., Strasser A. Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med. 2007, 4:1681-1689. (Discussion 1690).
-
(2007)
PLoS Med.
, vol.4
, pp. 1681-1689
-
-
Cragg, M.S.1
Kuroda, J.2
Puthalakath, H.3
Huang, D.C.4
Strasser, A.5
-
15
-
-
55849139095
-
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
-
Cragg M.S., Jansen E.S., Cook M., Harris C., Strasser A., Scott C.L. Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic. J. Clin. Invest. 2008, 118:3651-3659.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3651-3659
-
-
Cragg, M.S.1
Jansen, E.S.2
Cook, M.3
Harris, C.4
Strasser, A.5
Scott, C.L.6
-
16
-
-
0036494315
-
Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo
-
Decaudin D., Castedo M., Nemati F., Beurdeley-Thomas A., De Pinieux G., Caron A., Pouillart P., Wijdenes J., Rouillard D., Kroemer G., Poupon M.F. Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo. Cancer Res. 2002, 62:1388-1393.
-
(2002)
Cancer Res.
, vol.62
, pp. 1388-1393
-
-
Decaudin, D.1
Castedo, M.2
Nemati, F.3
Beurdeley-Thomas, A.4
De Pinieux, G.5
Caron, A.6
Pouillart, P.7
Wijdenes, J.8
Rouillard, D.9
Kroemer, G.10
Poupon, M.F.11
-
18
-
-
0142010897
-
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells
-
Don A.S., Kisker O., Dilda P., Donoghue N., Zhao X., Decollogne S., Creighton B., Flynn E., Folkman J., Hogg P.J. A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. Cancer Cell 2003, 3:497-509.
-
(2003)
Cancer Cell
, vol.3
, pp. 497-509
-
-
Don, A.S.1
Kisker, O.2
Dilda, P.3
Donoghue, N.4
Zhao, X.5
Decollogne, S.6
Creighton, B.7
Flynn, E.8
Folkman, J.9
Hogg, P.J.10
-
19
-
-
37549019351
-
Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress
-
Dong L.F., Swettenham E., Eliasson J., Wang X.F., Gold M., Medunic Y., Stantic M., Low P., Prochazka L., Witting P.K., Turanek J., Akporiaye E.T., Ralph S.J., Neuzil J. Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress. Cancer Res. 2007, 67:11906-11913.
-
(2007)
Cancer Res.
, vol.67
, pp. 11906-11913
-
-
Dong, L.F.1
Swettenham, E.2
Eliasson, J.3
Wang, X.F.4
Gold, M.5
Medunic, Y.6
Stantic, M.7
Low, P.8
Prochazka, L.9
Witting, P.K.10
Turanek, J.11
Akporiaye, E.T.12
Ralph, S.J.13
Neuzil, J.14
-
20
-
-
47549092354
-
Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
-
Dong L.F., Low P., Dyason J.C., Wang X.F., Prochazka L., Witting P.K., Freeman R., Swettenham E., Valis K., Liu J., Zobalova R., Turanek J., Spitz D.R., Domann F.E., Scheffler I.E., Ralph S.J., Neuzil J. Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene 2008, 27:4324-4335.
-
(2008)
Oncogene
, vol.27
, pp. 4324-4335
-
-
Dong, L.F.1
Low, P.2
Dyason, J.C.3
Wang, X.F.4
Prochazka, L.5
Witting, P.K.6
Freeman, R.7
Swettenham, E.8
Valis, K.9
Liu, J.10
Zobalova, R.11
Turanek, J.12
Spitz, D.R.13
Domann, F.E.14
Scheffler, I.E.15
Ralph, S.J.16
Neuzil, J.17
-
21
-
-
33947309495
-
Phase I trial of imexon in patients with advanced malignancy
-
Dragovich T., Gordon M., Mendelson D., Wong L., Modiano M., Chow H.H., Samulitis B., O'Day S., Grenier K., Hersh E., Dorr R. Phase I trial of imexon in patients with advanced malignancy. J. Clin. Oncol. 2007, 25:1779-1784.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1779-1784
-
-
Dragovich, T.1
Gordon, M.2
Mendelson, D.3
Wong, L.4
Modiano, M.5
Chow, H.H.6
Samulitis, B.7
O'Day, S.8
Grenier, K.9
Hersh, E.10
Dorr, R.11
-
22
-
-
33745699393
-
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
-
Frezza C., Cipolat S., Martins de Brito O., Micaroni M., Beznoussenko G.V., Rudka T., Bartoli D., Polishuck R.S., Danial N.N., De Strooper B., Scorrano L. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 2006, 126:177-189.
-
(2006)
Cell
, vol.126
, pp. 177-189
-
-
Frezza, C.1
Cipolat, S.2
Martins de Brito, O.3
Micaroni, M.4
Beznoussenko, G.V.5
Rudka, T.6
Bartoli, D.7
Polishuck, R.S.8
Danial, N.N.9
De Strooper, B.10
Scorrano, L.11
-
23
-
-
58149296552
-
Tumor resistance to apoptosis
-
Fulda S. Tumor resistance to apoptosis. Int. J. Cancer 2009, 124:511-515.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 511-515
-
-
Fulda, S.1
-
24
-
-
0033646961
-
Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors
-
Fulda S., Debatin K.M. Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors. Med. Pediatr. Oncol. 2000, 35:616-618.
-
(2000)
Med. Pediatr. Oncol.
, vol.35
, pp. 616-618
-
-
Fulda, S.1
Debatin, K.M.2
-
25
-
-
33746886979
-
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
-
Fulda S., Debatin K.M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006, 25:4798-4811.
-
(2006)
Oncogene
, vol.25
, pp. 4798-4811
-
-
Fulda, S.1
Debatin, K.M.2
-
26
-
-
0030815250
-
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
-
Fulda S., Friesen C., Los M., Scaffidi C., Mier W., Benedict M., Nunez G., Krammer P.H., Peter M.E., Debatin K.M. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res. 1997, 57:4956-4964.
-
(1997)
Cancer Res.
, vol.57
, pp. 4956-4964
-
-
Fulda, S.1
Friesen, C.2
Los, M.3
Scaffidi, C.4
Mier, W.5
Benedict, M.6
Nunez, G.7
Krammer, P.H.8
Peter, M.E.9
Debatin, K.M.10
-
27
-
-
0032545386
-
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
-
Fulda S., Scaffidi C., Susin S.A., Krammer P.H., Kroemer G., Peter M.E., Debatin K.M. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J. Biol. Chem. 1998, 273:33942-33948.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33942-33948
-
-
Fulda, S.1
Scaffidi, C.2
Susin, S.A.3
Krammer, P.H.4
Kroemer, G.5
Peter, M.E.6
Debatin, K.M.7
-
28
-
-
0032189535
-
Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
-
Fulda S., Susin S.A., Kroemer G., Debatin K.M. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res. 1998, 58:4453-4460.
-
(1998)
Cancer Res.
, vol.58
, pp. 4453-4460
-
-
Fulda, S.1
Susin, S.A.2
Kroemer, G.3
Debatin, K.M.4
-
29
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 2004, 4:891-899.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
30
-
-
35348865444
-
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols
-
Gledhill J.R., Montgomery M.G., Leslie A.G., Walker J.E. Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. Proc. Natl. Acad. Sci. USA 2007, 104:13632-13637.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 13632-13637
-
-
Gledhill, J.R.1
Montgomery, M.G.2
Leslie, A.G.3
Walker, J.E.4
-
31
-
-
41149105722
-
Mitochondria in cancer cells: what is so special about them?
-
Gogvadze V., Orrenius S., Zhivotovsky B. Mitochondria in cancer cells: what is so special about them?. Trends Cell Biol. 2008, 18:165-173.
-
(2008)
Trends Cell Biol.
, vol.18
, pp. 165-173
-
-
Gogvadze, V.1
Orrenius, S.2
Zhivotovsky, B.3
-
32
-
-
47749093652
-
Methyl jasmonate binds to and detaches mitochondria-bound hexokinase
-
Goldin N., Arzoine L., Heyfets A., Israelson A., Zaslavsky Z., Bravman T., Bronner V., Notcovich A., Shoshan-Barmatz V., Flescher E. Methyl jasmonate binds to and detaches mitochondria-bound hexokinase. Oncogene 2008, 27:4636-4643.
-
(2008)
Oncogene
, vol.27
, pp. 4636-4643
-
-
Goldin, N.1
Arzoine, L.2
Heyfets, A.3
Israelson, A.4
Zaslavsky, Z.5
Bravman, T.6
Bronner, V.7
Notcovich, A.8
Shoshan-Barmatz, V.9
Flescher, E.10
-
33
-
-
35648965243
-
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
-
Gong Y., Somwar R., Politi K., Balak M., Chmielecki J., Jiang X., Pao W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 2007, 4:e294.
-
(2007)
PLoS Med
, vol.4
-
-
Gong, Y.1
Somwar, R.2
Politi, K.3
Balak, M.4
Chmielecki, J.5
Jiang, X.6
Pao, W.7
-
34
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
35
-
-
42049104916
-
Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer
-
Hann C.L., Daniel V.C., Sugar E.A., Dobromilskaya I., Murphy S.C., Cope L., Lin X., Hierman J.S., Wilburn D.L., Watkins D.N., Rudin C.M. Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer. Cancer Res. 2008, 68:2321-2328.
-
(2008)
Cancer Res.
, vol.68
, pp. 2321-2328
-
-
Hann, C.L.1
Daniel, V.C.2
Sugar, E.A.3
Dobromilskaya, I.4
Murphy, S.C.5
Cope, L.6
Lin, X.7
Hierman, J.S.8
Wilburn, D.L.9
Watkins, D.N.10
Rudin, C.M.11
-
36
-
-
26644441651
-
ATP citrate lyase inhibition can suppress tumor cell growth
-
Hatzivassiliou G., Zhao F., Bauer D.E., Andreadis C., Shaw A.N., Dhanak D., Hingorani S.R., Tuveson D.A., Thompson C.B. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005, 8:311-321.
-
(2005)
Cancer Cell
, vol.8
, pp. 311-321
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
Andreadis, C.4
Shaw, A.N.5
Dhanak, D.6
Hingorani, S.R.7
Tuveson, D.A.8
Thompson, C.B.9
-
37
-
-
42349098051
-
BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells
-
Huang S., Sinicrope F.A. BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res. 2008, 68:2944-2951.
-
(2008)
Cancer Res.
, vol.68
, pp. 2944-2951
-
-
Huang, S.1
Sinicrope, F.A.2
-
38
-
-
0034699513
-
Superoxide dismutase as a target for the selective killing of cancer cells
-
Huang P., Feng L., Oldham E.A., Keating M.J., Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000, 407:390-395.
-
(2000)
Nature
, vol.407
, pp. 390-395
-
-
Huang, P.1
Feng, L.2
Oldham, E.A.3
Keating, M.J.4
Plunkett, W.5
-
39
-
-
44449160071
-
2-mediated oxidation and inactivation of phosphatases in growth factor signaling
-
2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc. Natl. Acad. Sci. USA 2008, 105:7147-7152.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7147-7152
-
-
Juarez, J.C.1
Manuia, M.2
Burnett, M.E.3
Betancourt, O.4
Boivin, B.5
Shaw, D.E.6
Tonks, N.K.7
Mazar, A.P.8
Donate, F.9
-
40
-
-
34548814971
-
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
-
Kang M.H., Kang Y.H., Szymanska B., Wilczynska-Kalak U., Sheard M.A., Harned T.M., Lock R.B., Reynolds C.P. Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood 2007, 110:2057-2066.
-
(2007)
Blood
, vol.110
, pp. 2057-2066
-
-
Kang, M.H.1
Kang, Y.H.2
Szymanska, B.3
Wilczynska-Kalak, U.4
Sheard, M.A.5
Harned, T.M.6
Lock, R.B.7
Reynolds, C.P.8
-
41
-
-
0141569444
-
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
-
Kitada S., Leone M., Sareth S., Zhai D., Reed J.C., Pellecchia M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J. Med. Chem. 2003, 46:4259-4264.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4259-4264
-
-
Kitada, S.1
Leone, M.2
Sareth, S.3
Zhai, D.4
Reed, J.C.5
Pellecchia, M.6
-
42
-
-
42449147919
-
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)
-
Kitada S., Kress C.L., Krajewska M., Jia L., Pellecchia M., Reed J.C. Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood 2008, 111:3211-3219.
-
(2008)
Blood
, vol.111
, pp. 3211-3219
-
-
Kitada, S.1
Kress, C.L.2
Krajewska, M.3
Jia, L.4
Pellecchia, M.5
Reed, J.C.6
-
43
-
-
34447642522
-
BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts
-
Kohl T.M., Hellinger C., Ahmed F., Buske C., Hiddemann W., Bohlander S.K., Spiekermann K. BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts. Leukemia 2007, 21:1763-1772.
-
(2007)
Leukemia
, vol.21
, pp. 1763-1772
-
-
Kohl, T.M.1
Hellinger, C.2
Ahmed, F.3
Buske, C.4
Hiddemann, W.5
Bohlander, S.K.6
Spiekermann, K.7
-
44
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
Konopleva M., Contractor R., Tsao T., Samudio I., Ruvolo P.P., Kitada S., Deng X., Zhai D., Shi Y.-X., Sneed T., Verhaegen M., Soengas M., Ruvolo V.R., McQueen T., Schober W.D., Watt J.C., Jiffar T., Ling X., Marini F.C., Harris D., Dietrich M., Estrov Z., McCubrey J., May W.S., Reed J.C., Andreeff M. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006, 10:375-388.
-
(2006)
Cancer Cell
, vol.10
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
Deng, X.7
Zhai, D.8
Shi, Y.-X.9
Sneed, T.10
Verhaegen, M.11
Soengas, M.12
Ruvolo, V.R.13
McQueen, T.14
Schober, W.D.15
Watt, J.C.16
Jiffar, T.17
Ling, X.18
Marini, F.C.19
Harris, D.20
Dietrich, M.21
Estrov, Z.22
McCubrey, J.23
May, W.S.24
Reed, J.C.25
Andreeff, M.26
more..
-
45
-
-
33845977959
-
Mitochondrial membrane permeabilization in cell death
-
Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007, 87:99-163.
-
(2007)
Physiol. Rev.
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
Galluzzi, L.2
Brenner, C.3
-
46
-
-
33749510073
-
Bim and bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
-
Kuroda J., Puthalakath H., Cragg M.S., Kelly P.N., Bouillet P., Huang D.C.S., Kimura S., Ottmann O.G., Druker B.J., Villunger A., Roberts A.W., Strasser A. Bim and bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc. Natl. Acad. Sci. USA 2006, 103:14907-14912.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14907-14912
-
-
Kuroda, J.1
Puthalakath, H.2
Cragg, M.S.3
Kelly, P.N.4
Bouillet, P.5
Huang, D.C.S.6
Kimura, S.7
Ottmann, O.G.8
Druker, B.J.9
Villunger, A.10
Roberts, A.W.11
Strasser, A.12
-
47
-
-
34548039481
-
Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia
-
Kuroda J., Kimura S., Strasser A., Andreeff M., O'Reilly L.A., Ashihara E., Kamitsuji Y., Yokota A., Kawata E., Takeuchi M., Tanaka R., Tabe Y., Taniwaki M., Maekawa T. Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia. Cell Death Differ. 2007, 14:1667-1677.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 1667-1677
-
-
Kuroda, J.1
Kimura, S.2
Strasser, A.3
Andreeff, M.4
O'Reilly, L.A.5
Ashihara, E.6
Kamitsuji, Y.7
Yokota, A.8
Kawata, E.9
Takeuchi, M.10
Tanaka, R.11
Tabe, Y.12
Taniwaki, M.13
Maekawa, T.14
-
48
-
-
54249093808
-
Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737
-
Kutuk O., Letai A. Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737. Cancer Res. 2008, 68:7985-7994.
-
(2008)
Cancer Res.
, vol.68
, pp. 7985-7994
-
-
Kutuk, O.1
Letai, A.2
-
49
-
-
0036850312
-
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
-
Kuwana T., Mackey M.R., Perkins G., Ellisman M.H., Latterich M., Schneiter R., Green D.R., Newmeyer D.D. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002, 111:331-342.
-
(2002)
Cell
, vol.111
, pp. 331-342
-
-
Kuwana, T.1
Mackey, M.R.2
Perkins, G.3
Ellisman, M.H.4
Latterich, M.5
Schneiter, R.6
Green, D.R.7
Newmeyer, D.D.8
-
50
-
-
0036238837
-
Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite
-
Lehenkari P.P., Kellinsalmi M., Napankangas J.P., Ylitalo K.V., Monkkonen J., Rogers M.J., Azhayev A., Vaananen H.K., Hassinen I.E. Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol. Pharmacol. 2002, 61:1255-1262.
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 1255-1262
-
-
Lehenkari, P.P.1
Kellinsalmi, M.2
Napankangas, J.P.3
Ylitalo, K.V.4
Monkkonen, J.5
Rogers, M.J.6
Azhayev, A.7
Vaananen, H.K.8
Hassinen, I.E.9
-
51
-
-
34247526984
-
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
-
Liby K.T., Yore M.M., Sporn M.B. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat. Rev. Cancer 2007, 7:357-369.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 357-369
-
-
Liby, K.T.1
Yore, M.M.2
Sporn, M.B.3
-
52
-
-
65649130832
-
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
-
Liu G., Kelly W.K., Wilding G., Leopold L., Brill K., Somer B. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin. Cancer Res. 2009, 15:3172-3176.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 3172-3176
-
-
Liu, G.1
Kelly, W.K.2
Wilding, G.3
Leopold, L.4
Brill, K.5
Somer, B.6
-
53
-
-
34547644483
-
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
-
Lu J., Chew E.H., Holmgren A. Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc. Natl. Acad. Sci. USA 2007, 104:12288-12293.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 12288-12293
-
-
Lu, J.1
Chew, E.H.2
Holmgren, A.3
-
54
-
-
51249185922
-
Gossypol and some other terpenoids, flavonoids, and phenols that affect quality of cottonseed protein
-
Lynn A., Jones L. Gossypol and some other terpenoids, flavonoids, and phenols that affect quality of cottonseed protein. Am. Oil Chem. Soc. 1979, 56:727-730.
-
(1979)
Am. Oil Chem. Soc.
, vol.56
, pp. 727-730
-
-
Lynn, A.1
Jones, L.2
-
55
-
-
3543084996
-
Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine
-
Maeda H., Hori S., Ohizumi H., Segawa T., Kakehi Y., Ogawa O., Kakizuka A. Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine. Cell Death Differ. 2004, 11:737-746.
-
(2004)
Cell Death Differ.
, vol.11
, pp. 737-746
-
-
Maeda, H.1
Hori, S.2
Ohizumi, H.3
Segawa, T.4
Kakehi, Y.5
Ogawa, O.6
Kakizuka, A.7
-
56
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
Majewski N., Nogueira V., Bhaskar P., Coy P.E., Skeen J.E., Gottlob K., Chandel N.S., Thompson C.B., Robey R.B., Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell 2004, 16:819-830.
-
(2004)
Mol. Cell
, vol.16
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
Chandel, N.S.7
Thompson, C.B.8
Robey, R.B.9
Hay, N.10
-
57
-
-
17144448793
-
The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus
-
Marchetti P., Zamzami N., Joseph B., Schraen-Maschke S., Mereau-Richard C., Costantini P., Metivier D., Susin S.A., Kroemer G., Formstecher P. The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus. Cancer Res. 1999, 59:6257-6266.
-
(1999)
Cancer Res.
, vol.59
, pp. 6257-6266
-
-
Marchetti, P.1
Zamzami, N.2
Joseph, B.3
Schraen-Maschke, S.4
Mereau-Richard, C.5
Costantini, P.6
Metivier, D.7
Susin, S.A.8
Kroemer, G.9
Formstecher, P.10
-
58
-
-
70450265383
-
The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia
-
Mason K.D., Khaw S.L., Rayeroux K.C., Chew E., Lee E.F., Fairlie W.D., Grigg A.P., Seymour J.F., Szer J., Huang D.C., Roberts A.W. The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia. Leukemia 2009, 23:2034-2041.
-
(2009)
Leukemia
, vol.23
, pp. 2034-2041
-
-
Mason, K.D.1
Khaw, S.L.2
Rayeroux, K.C.3
Chew, E.4
Lee, E.F.5
Fairlie, W.D.6
Grigg, A.P.7
Seymour, J.F.8
Szer, J.9
Huang, D.C.10
Roberts, A.W.11
-
59
-
-
33947227522
-
Programmed a nuclear cell death delimits platelet life span
-
Mason K.D., Carpinelli M.R., Fletcher J.I., Collinge J.E., Hilton A.A., Ellis S., Kelly P.N., Ekert P.G., Metcalf D., Roberts A.W., Huang D.C.S., Kile B.T. Programmed a nuclear cell death delimits platelet life span. Cell 2007, 128:1173-1186.
-
(2007)
Cell
, vol.128
, pp. 1173-1186
-
-
Mason, K.D.1
Carpinelli, M.R.2
Fletcher, J.I.3
Collinge, J.E.4
Hilton, A.A.5
Ellis, S.6
Kelly, P.N.7
Ekert, P.G.8
Metcalf, D.9
Roberts, A.W.10
Huang, D.C.S.11
Kile, B.T.12
-
60
-
-
56649120608
-
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
-
Mason K.D., Vandenberg C.J., Scott C.L., Wei A.H., Cory S., Huang D.C., Roberts A.W. In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proc. Natl. Acad. Sci. USA 2008, 105:17961-17966.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 17961-17966
-
-
Mason, K.D.1
Vandenberg, C.J.2
Scott, C.L.3
Wei, A.H.4
Cory, S.5
Huang, D.C.6
Roberts, A.W.7
-
61
-
-
0035862189
-
P53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma
-
Meng R.D., El-Deiry W.S. P53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. Exp. Cell Res. 2001, 262:154-169.
-
(2001)
Exp. Cell Res.
, vol.262
, pp. 154-169
-
-
Meng, R.D.1
El-Deiry, W.S.2
-
62
-
-
63149186234
-
BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis
-
Miller L.A., Goldstein N.B., Johannes W.U., Walton C.H., Fujita M., Norris D.A., Shellman Y.G. BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis. J. Invest. Dermatol. 2009, 129:964-971.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 964-971
-
-
Miller, L.A.1
Goldstein, N.B.2
Johannes, W.U.3
Walton, C.H.4
Fujita, M.5
Norris, D.A.6
Shellman, Y.G.7
-
63
-
-
15844407874
-
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
-
Nakagawa T., Shimizu S., Watanabe T., Yamaguchi O., Otsu K., Yamagata H., Inohara H., Kubo T., Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005, 434:652-658.
-
(2005)
Nature
, vol.434
, pp. 652-658
-
-
Nakagawa, T.1
Shimizu, S.2
Watanabe, T.3
Yamaguchi, O.4
Otsu, K.5
Yamagata, H.6
Inohara, H.7
Kubo, T.8
Tsujimoto, Y.9
-
64
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M., Marcellus R.C., Roulston A., Watson M., Serfass L., Murthy Madiraju S.R., Goulet D., Viallet J., Belec L., Billot X., Acoca S., Purisima E., Wiegmans A., Cluse L., Johnstone R.W., Beauparlant P., Shore G.C. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc. Natl. Acad. Sci. USA 2007, 104:19512-19517.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
Watson, M.4
Serfass, L.5
Murthy Madiraju, S.R.6
Goulet, D.7
Viallet, J.8
Belec, L.9
Billot, X.10
Acoca, S.11
Purisima, E.12
Wiegmans, A.13
Cluse, L.14
Johnstone, R.W.15
Beauparlant, P.16
Shore, G.C.17
-
65
-
-
0037221034
-
All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition
-
Notario B., Zamora M., Vinas O., Mampel T. All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition. Mol. Pharmacol. 2003, 63:224-231.
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 224-231
-
-
Notario, B.1
Zamora, M.2
Vinas, O.3
Mampel, T.4
-
66
-
-
58849164097
-
Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
-
O'Brien S.M., Claxton D.F., Crump M., Faderl S., Kipps T., Keating M.J., Viallet J., Cheson B.D. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 2009, 113:299-305.
-
(2009)
Blood
, vol.113
, pp. 299-305
-
-
O'Brien, S.M.1
Claxton, D.F.2
Crump, M.3
Faderl, S.4
Kipps, T.5
Keating, M.J.6
Viallet, J.7
Cheson, B.D.8
-
67
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T., Elmore S.W., Shoemaker A.R., Armstrong R.C., Augeri D.J., Belli B.A., Bruncko M., Deckwerth T.L., Dinges J., Hajduk P.J., Joseph M.K., Kitada S., Korsmeyer S.J., Kunzer A.R., Letai A., Li C., Mitten M.J., Nettesheim D.G., Ng S., Nimmer P.M., O'Connor J.M., Oleksijew A., Petros A.M., Reed J.C., Shen W., Tahir S.K., Thompson C.B., Tomaselli K.J., Wang B., Wendt M.D., Zhang H., Fesik S.W., Rosenberg S.H. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005, 435:677-681.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
Joseph, M.K.11
Kitada, S.12
Korsmeyer, S.J.13
Kunzer, A.R.14
Letai, A.15
Li, C.16
Mitten, M.J.17
Nettesheim, D.G.18
Ng, S.19
Nimmer, P.M.20
O'Connor, J.M.21
Oleksijew, A.22
Petros, A.M.23
Reed, J.C.24
Shen, W.25
Tahir, S.K.26
Thompson, C.B.27
Tomaselli, K.J.28
Wang, B.29
Wendt, M.D.30
Zhang, H.31
Fesik, S.W.32
Rosenberg, S.H.33
more..
-
68
-
-
0038206442
-
Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme
-
Oudard S., Carpentier A., Banu E., Fauchon F., Celerier D., Poupon M.F., Dutrillaux B., Andrieu J.M., Delattre J.Y. Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. J. Neurooncol. 2003, 63:81-86.
-
(2003)
J. Neurooncol.
, vol.63
, pp. 81-86
-
-
Oudard, S.1
Carpentier, A.2
Banu, E.3
Fauchon, F.4
Celerier, D.5
Poupon, M.F.6
Dutrillaux, B.7
Andrieu, J.M.8
Delattre, J.Y.9
-
69
-
-
0030932708
-
Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones
-
Palmeira C.M., Wallace K.B. Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones. Toxicol. Appl. Pharmacol. 1997, 143:338-347.
-
(1997)
Toxicol. Appl. Pharmacol.
, vol.143
, pp. 338-347
-
-
Palmeira, C.M.1
Wallace, K.B.2
-
70
-
-
53049106757
-
The BH3-only mimetic ABT-737 synergizes the anti-neoplastic activity of proteasome inhibitors in lymphoid malignancies
-
Paoluzzi L., Gonen M., Bhagat G., Furman R.R., Gardner J.R., Scotto L., Gueorguiev V.D., Heaney M.L., Manova K., O'Connor O.A. The BH3-only mimetic ABT-737 synergizes the anti-neoplastic activity of proteasome inhibitors in lymphoid malignancies. Blood 2008, 112:2906-2916.
-
(2008)
Blood
, vol.112
, pp. 2906-2916
-
-
Paoluzzi, L.1
Gonen, M.2
Bhagat, G.3
Furman, R.R.4
Gardner, J.R.5
Scotto, L.6
Gueorguiev, V.D.7
Heaney, M.L.8
Manova, K.9
O'Connor, O.A.10
-
71
-
-
34248362003
-
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
-
Perez-Galan P., Roue G., Villamor N., Campo E., Colomer D. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood 2007, 109:4441-4449.
-
(2007)
Blood
, vol.109
, pp. 4441-4449
-
-
Perez-Galan, P.1
Roue, G.2
Villamor, N.3
Campo, E.4
Colomer, D.5
-
72
-
-
0028239794
-
The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents
-
Petronilli V., Costantini P., Scorrano L., Colonna R., Passamonti S., Bernardi P. The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents. J. Biol. Chem. 1994, 269:16638-16642.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16638-16642
-
-
Petronilli, V.1
Costantini, P.2
Scorrano, L.3
Colonna, R.4
Passamonti, S.5
Bernardi, P.6
-
73
-
-
74549165465
-
Ongoing phase I studies of ABT-263: mitigating Bcl-XL induced thrombocytopenia with lead-in and continuous dosing
-
(Meeting Abstracts)
-
Roberts A.W., Wilson W., Gandhi L., O'Connor O.A., Rudin C.M., Brown J.R., Xiong H., Chiu Y., Enschede S., Krivoshik A.P. Ongoing phase I studies of ABT-263: mitigating Bcl-XL induced thrombocytopenia with lead-in and continuous dosing. J. Clin. Oncol. 2009, 27:3505. (Meeting Abstracts).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3505
-
-
Roberts, A.W.1
Wilson, W.2
Gandhi, L.3
O'Connor, O.A.4
Rudin, C.M.5
Brown, J.R.6
Xiong, H.7
Chiu, Y.8
Enschede, S.9
Krivoshik, A.P.10
-
74
-
-
0035028281
-
Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent
-
Salti G.I., Kichina J.V., Das Gupta T.K., Uddin S., Bratescu L., Pezzuto J.M., Mehta R.G., Constantinou A.I. Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent. Melanoma Res. 2001, 11:99-104.
-
(2001)
Melanoma Res.
, vol.11
, pp. 99-104
-
-
Salti, G.I.1
Kichina, J.V.2
Das Gupta, T.K.3
Uddin, S.4
Bratescu, L.5
Pezzuto, J.M.6
Mehta, R.G.7
Constantinou, A.I.8
-
75
-
-
58149340656
-
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
-
Schimmer A.D., O'Brien S., Kantarjian H., Brandwein J., Cheson B.D., Minden M.D., Yee K., Ravandi F., Giles F., Schuh A., Gupta V., Andreeff M., Koller C., Chang H., Kamel-Reid S., Berger M., Viallet J., Borthakur G. A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin. Cancer Res. 2008, 14:8295-8301.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 8295-8301
-
-
Schimmer, A.D.1
O'Brien, S.2
Kantarjian, H.3
Brandwein, J.4
Cheson, B.D.5
Minden, M.D.6
Yee, K.7
Ravandi, F.8
Giles, F.9
Schuh, A.10
Gupta, V.11
Andreeff, M.12
Koller, C.13
Chang, H.14
Kamel-Reid, S.15
Berger, M.16
Viallet, J.17
Borthakur, G.18
-
76
-
-
0034026724
-
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells
-
Selzer E., Pimentel E., Wacheck V., Schlegel W., Pehamberger H., Jansen B., Kodym R. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells. J. Invest. Dermatol. 2000, 114:935-940.
-
(2000)
J. Invest. Dermatol.
, vol.114
, pp. 935-940
-
-
Selzer, E.1
Pimentel, E.2
Wacheck, V.3
Schlegel, W.4
Pehamberger, H.5
Jansen, B.6
Kodym, R.7
-
77
-
-
0037002993
-
Betulinic acid-induced Mcl-1 expression in human melanoma-mode of action and functional significance
-
Selzer E., Thallinger C., Hoeller C., Oberkleiner P., Wacheck V., Pehamberger H., Jansen B. Betulinic acid-induced Mcl-1 expression in human melanoma-mode of action and functional significance. Mol. Med. 2002, 8:877-884.
-
(2002)
Mol. Med.
, vol.8
, pp. 877-884
-
-
Selzer, E.1
Thallinger, C.2
Hoeller, C.3
Oberkleiner, P.4
Wacheck, V.5
Pehamberger, H.6
Jansen, B.7
-
78
-
-
34248142302
-
2-Deoxy-d-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells
-
Simons A.L., Ahmad I.M., Mattson D.M., Dornfeld K.J., Spitz D.R. 2-Deoxy-d-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res. 2007, 67:3364-3370.
-
(2007)
Cancer Res.
, vol.67
, pp. 3364-3370
-
-
Simons, A.L.1
Ahmad, I.M.2
Mattson, D.M.3
Dornfeld, K.J.4
Spitz, D.R.5
-
79
-
-
54049145970
-
ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis
-
Song J.H., Kandasamy K., Kraft A.S. ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis. J. Biol. Chem. 2008, 283:25003-25013.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 25003-25013
-
-
Song, J.H.1
Kandasamy, K.2
Kraft, A.S.3
-
80
-
-
56149097601
-
Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins
-
Tagscherer K.E., Fassl A., Campos B., Farhadi M., Kraemer A., Bock B.C., Macher-Goeppinger S., Radlwimmer B., Wiestler O.D., Herold-Mende C., Roth W. Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins. Oncogene 2008, 27:6646-6656.
-
(2008)
Oncogene
, vol.27
, pp. 6646-6656
-
-
Tagscherer, K.E.1
Fassl, A.2
Campos, B.3
Farhadi, M.4
Kraemer, A.5
Bock, B.C.6
Macher-Goeppinger, S.7
Radlwimmer, B.8
Wiestler, O.D.9
Herold-Mende, C.10
Roth, W.11
-
81
-
-
0042388133
-
Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells
-
Thurnher D., Turhani D., Pelzmann M., Wannemacher B., Knerer B., Formanek M., Wacheck V., Selzer E. Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells. Head Neck 2003, 25:732-740.
-
(2003)
Head Neck
, vol.25
, pp. 732-740
-
-
Thurnher, D.1
Turhani, D.2
Pelzmann, M.3
Wannemacher, B.4
Knerer, B.5
Formanek, M.6
Wacheck, V.7
Selzer, E.8
-
82
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
-
Trachootham D., Zhou Y., Zhang H., Demizu Y., Chen Z., Pelicano H., Chiao P.J., Achanta G., Arlinghaus R.B., Liu J., Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 2006, 10:241-252.
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
Demizu, Y.4
Chen, Z.5
Pelicano, H.6
Chiao, P.J.7
Achanta, G.8
Arlinghaus, R.B.9
Liu, J.10
Huang, P.11
-
83
-
-
34249982915
-
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
-
Trudel S., Li Z.H., Rauw J., Tiedemann R.E., Wen X.Y., Stewart A.K. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 2007, 109:5430-5438.
-
(2007)
Blood
, vol.109
, pp. 5430-5438
-
-
Trudel, S.1
Li, Z.H.2
Rauw, J.3
Tiedemann, R.E.4
Wen, X.Y.5
Stewart, A.K.6
-
84
-
-
44849112219
-
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C., Shoemaker A.R., Adickes J., Anderson M.G., Chen J., Jin S., Johnson E.F., Marsh K.C., Mitten M.J., Nimmer P., Roberts L., Tahir S.K., Xiao Y., Yang X., Zhang H., Fesik S., Rosenberg S.H., Elmore S.W. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008, 68:3421-3428.
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
Johnson, E.F.7
Marsh, K.C.8
Mitten, M.J.9
Nimmer, P.10
Roberts, L.11
Tahir, S.K.12
Xiao, Y.13
Yang, X.14
Zhang, H.15
Fesik, S.16
Rosenberg, S.H.17
Elmore, S.W.18
-
85
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
Van Delft M.F., Wei A.H., Mason K.D., Vandenberg C.J., Chen L., Czabotar P.E., Willis S.N., Scott C.L., Day C.L., Cory S., Adams J.M., Roberts A.W., Huang D.C.S. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 2006, 10:389-399.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
Van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
Vandenberg, C.J.4
Chen, L.5
Czabotar, P.E.6
Willis, S.N.7
Scott, C.L.8
Day, C.L.9
Cory, S.10
Adams, J.M.11
Roberts, A.W.12
Huang, D.C.S.13
-
87
-
-
61949111202
-
Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors
-
Whitecross K.F., Alsop A.E., Cluse L.A., Wiegmans A., Banks K.M., Coomans C., Peart M.J., Newbold A., Lindemann R.K., Johnstone R.W. Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors. Blood 2009, 113:1982-1991.
-
(2009)
Blood
, vol.113
, pp. 1982-1991
-
-
Whitecross, K.F.1
Alsop, A.E.2
Cluse, L.A.3
Wiegmans, A.4
Banks, K.M.5
Coomans, C.6
Peart, M.J.7
Newbold, A.8
Lindemann, R.K.9
Johnstone, R.W.10
-
88
-
-
0033023669
-
Betulinic acid-induced apoptosis in glioma cells: a sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing
-
Wick W., Grimmel C., Wagenknecht B., Dichgans J., Weller M. Betulinic acid-induced apoptosis in glioma cells: a sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J. Pharmacol. Exp. Ther. 1999, 289:1306-1312.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.289
, pp. 1306-1312
-
-
Wick, W.1
Grimmel, C.2
Wagenknecht, B.3
Dichgans, J.4
Weller, M.5
-
89
-
-
33750448018
-
Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
-
Xiao D., Lew K.L., Zeng Y., Xiao H., Marynowski S.W., Dhir R., Singh S.V. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis 2006, 27:2223-2234.
-
(2006)
Carcinogenesis
, vol.27
, pp. 2223-2234
-
-
Xiao, D.1
Lew, K.L.2
Zeng, Y.3
Xiao, H.4
Marynowski, S.W.5
Dhir, R.6
Singh, S.V.7
-
90
-
-
33947223337
-
Bcl-2 family proteins are essential for platelet survival
-
Zhang H., Nimmer P.M., Tahir S.K., Chen J., Fryer R.M., Hahn K.R., Iciek L.A., Morgan S.J., Nasarre M.C., Nelson R., Preusser L.C., Reinhart G.A., Smith M.L., Rosenberg S.H., Elmore S.W., Tse C. Bcl-2 family proteins are essential for platelet survival. Cell Death Differ. 2007, 14:943-951.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 943-951
-
-
Zhang, H.1
Nimmer, P.M.2
Tahir, S.K.3
Chen, J.4
Fryer, R.M.5
Hahn, K.R.6
Iciek, L.A.7
Morgan, S.J.8
Nasarre, M.C.9
Nelson, R.10
Preusser, L.C.11
Reinhart, G.A.12
Smith, M.L.13
Rosenberg, S.H.14
Elmore, S.W.15
Tse, C.16
-
91
-
-
0037049876
-
Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
-
Zuco V., Supino R., Righetti S.C., Cleris L., Marchesi E., Gambacorti-Passerini C., Formelli F. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells. Cancer Lett. 2002, 175:17-25.
-
(2002)
Cancer Lett.
, vol.175
, pp. 17-25
-
-
Zuco, V.1
Supino, R.2
Righetti, S.C.3
Cleris, L.4
Marchesi, E.5
Gambacorti-Passerini, C.6
Formelli, F.7
|