Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Cancer Letters

Volumn 175, Issue 1, 2002, Pages 17-25

  Zuco, Valentina ^a   Supino, Rosanna ^a   Righetti, Sabina C ^a   Cleris, Loredana ^a   Marchesi, Edoardo ^a   Gambacorti Passerini, Carlo ^a   Formelli, Franca ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Antitumor activity; Betulinic acid; Cytotoxic cytostatic effects; Normal cell; Tumor cell

Indexed keywords

BETULIC ACID; DOXORUBICIN; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG SELECTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LYMPHOCYTE; MELANOMA CELL; MOUSE; NEUROECTODERM TUMOR; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; TUMOR CELL LINE; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXONS; GENES, P53; HUMANS; KINETICS; OLEANOLIC ACID; REFERENCE VALUES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037049876     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00718-2     Document Type: Article

References (23)

1. Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera
2. Investigations on the steroidal anti-inflammatory activity of Triterpenoids from Diospyros Leucomelas
3. Antiviral therapy for human immunodeficiency virus infections
4. Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells
5. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
6. Betulin acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing
7. Betulin acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
8. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
9. Betulin acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors
10. Mithocondrion as a novel target of anticancer chemotherapy
11. Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and II alpha
12. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells
13. P53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA-damaging agents
14. DNA damage, p53 and anticancer therapies
15. Biological and enzymatic features of human melanoma clones with different invasive potential
16. A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin
17. MTT assay
18. Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland
19. Characterization of a human ovarian adenocarcinoma line, IGROV-1, in tissue culture and in nude mice
20. Betulinic acid induces apoptosis in human neuroblastoma cell lines
21. A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: Hypersensitivity of p53-mutant human tumour xenografts
22. Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems
23. Modulation and cell cycle distribution of mutant p53 protein in a human small-cell lung carcinoma cell line after exposure to cytotoxic agents