Effects of betulinic acid alone and in combination with irradiation in human melanoma cells

Journal of Investigative Dermatology

Volumn 114, Issue 5, 2000, Pages 935-940

  Selzer, Edgar ^a,b   Pimentel, Emilio ^a   Wacheck, Volker ^a   Schlegel, Werner ^a   Pehamberger, Hubert ^a   Jansen, Burkhard ^a   Kodym, Reinhard ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Mcl 1; p53

Indexed keywords

BETULIC ACID; LIPOCORTIN 5;

APOPTOSIS; ARTICLE; CANCER INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034026724     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00972.x     Document Type: Article

References (20)

1. Barth A, Morton DL: The role of adjuvant therapy in melanoma management. Cancer 75:726-734, 1995
2. Chelvi TP, Ralhan R: Hyperthermia potentiates antitumor effect of thermosensitive-liposome-encapsulated melphalan and radiation in murine melanoma. Tumour Biol 18:250-260, 1997
3. Evers M, Poujade C, Soler F, et al: Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action. J Med Chem 39:1056-1068, 1996
4. Fulda S, Friesen C, Los M, et al: Betulinic acid triggers CD95 (APO-1/Fas)-and p53-independent apoptosis via activation of caspases in neuroectodermal tumor. Cancer Res 57:4956-4964, 1997
5. Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME, Debatin KM: Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 273:33942-33948, 1998
6. Geara FB, Ang KK: Radiation therapy for malignant melanoma. Surg Clin North Am 76:1383-1398, 1996
7. Jansen B, Wadl H, Inoue S, et al: Phosphorthioat oligonucleotides reduce melanoma growth in a SCIDhu mouse model by a nonantisense mechanism. Antisense Res Development 5:271-277, 1995
8. Jansen B, Schlagbauer-Wadl H, Eichler HG, Wolff K, van-Elsas A, Schrier PI, Pehamberger H: Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis. Cancer Res 57:362-365, 1997
9. Jansen B, Schlagbauer-Wadl H, Brown BD, et al: Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat Med 4:232-234, 1998
10. Jenrette JM: Malignant melanoma: the role of radiation therapy revisited. Semin Oncol 23:759-762, 1996
11. Kashiwada Y, Hashimoto F, Cosentino LM, Chen CH, Garrett PE, Lee KH: Betulinic acid and dihydro-betulinic acid derivatives as potent anti-HIV agents. J Med Chem 39:1016-1017, 1996
12. Lee SM, Betticher DC, Thatcher N: Melanoma: chemotherapy. Br Med Bull 51:609-630, 1995
13. Noda Y, Kaiya T, Kohda K, Kawazoe Y: Enhanced cytotoxicity of some triterpenes toward leukemia L1210 cells cultured in low pH media: possibility of a new mode of cell killing. Chem Pharm Bull Tokyo 45:1665-1670, 1997
14. Overgaard J, Gonzalez-Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM: Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology. Int J Hyperthermia 12:3-20, 1996
15. Pisha E, Chai H, Lee IS, et al: Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1:1046-1051, 1995
16. Rieber M, Strasberg-Rieber M: Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma. DNA Cell Biol 17:399-406, 1998
17. Schmidt ML, Kuzmanoff KL, Ling-Indeck L, Pezzuto JM: Betulinic acid induces apoptosis in human neuroblastoma cell lines. Eur J Cancer 33:2007-2010, 1997
18. Selzer E, Schlagbauer-Wadl H, Okamoto I, Pehamberger H, Pötter R, Jansen B: Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and in melanoma cell lines. Melanoma Res 8:197-203, 1998
19. Soler F, Poujade C, Evers M, et al: Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry. J Med Chem 39:1069-1083, 1996
20. Wei K, Kodym R, Jin C: Radioresistant cell strain of human fibrosarcoma cells obtained after long-term exposure to x-rays. Radiat Environ Biophys 37:133-137, 1998