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Volumn 1, Issue 3, 2010, Pages 165-175

Gene therapy in diabetes

Author keywords

Autoimmunity; Core peptide; Drug delivery; Gene therapy; Lentivirus; Type 1 diabetes

Indexed keywords

BETA GALACTOSIDASE; CALCIUM PHOSPHATE; CORE PEPTIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ELONGATION FACTOR 1ALPHA; EXENDIN 4; FK 506 BINDING PROTEIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLUTAMATE DECARBOXYLASE; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; INSULIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 4; LEPTIN; LIPOSOME; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NANOPARTICLE; PEPTIDE; PROINSULIN; RIBOZYME; SCATTER FACTOR; SOMATOMEDIN C; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS VECTOR; ZINC FINGER PROTEIN;

EID: 78049278409     PISSN: 19382030     EISSN: 19382049     Source Type: Journal    
DOI: 10.4161/self.1.3.12643     Document Type: Review
Times cited : (35)

References (102)
  • 1
    • 0029963059 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Klein R. Diabetic retinopathy. Annu Rev Public Health 1996; 17:137-58.
    • (1996) Annu Rev Public Health , vol.17 , pp. 137-158
    • Klein, R.1
  • 2
    • 0028824908 scopus 로고
    • Diabetes mellitus and associated hypertension, vascular disease and nephropathy. An update
    • Sowers JR, Epstein M. Diabetes mellitus and associated hypertension, vascular disease and nephropathy. An update. Hypertension 1995; 26:869-79.
    • (1995) Hypertension , vol.26 , pp. 869-879
    • Sowers, J.R.1    Epstein, M.2
  • 4
    • 78049299344 scopus 로고    scopus 로고
    • Classification of diabetes mellitus and genetic diabetic syndromes
    • Rose B, ed, Waltham, MA: UpToDate
    • McCulloch D. Classification of diabetes mellitus and genetic diabetic syndromes. In: Rose B, ed. UpToDate. Waltham, MA: UpToDate 2007.
    • (2007) UpToDate
    • McCulloch, D.1
  • 5
    • 34247482763 scopus 로고    scopus 로고
    • Type 2 diabetes: Hypoinsulinism, hyperinsulinism or both?
    • Glaser B. Type 2 diabetes: hypoinsulinism, hyperinsulinism or both? PLoS Med 2007; 4:148.
    • (2007) PLoS Med , vol.4 , pp. 148
    • Glaser, B.1
  • 6
    • 0025203329 scopus 로고
    • Molecular analysis of the pathogenesis of beta-cell destruction in insulin-dependent diabetes mellitus
    • Lernmark A, Barmeier H, Dube S, Hagopian W, Karlsen AE, Markholst H, et al. Molecular analysis of the pathogenesis of beta-cell destruction in insulin-dependent diabetes mellitus. West J Med 1990; 153:499-502.
    • (1990) West J Med , vol.153 , pp. 499-502
    • Lernmark, A.1    Barmeier, H.2    Dube, S.3    Hagopian, W.4    Karlsen, A.E.5    Markholst, H.6    Et al.7
  • 7
    • 0028104610 scopus 로고
    • Prevalence of adult-onset IDDM in the U.S. population
    • Harris MI, Robbins DC. Prevalence of adult-onset IDDM in the U.S. population. Diabetes Care 1994; 17:1337-40.
    • (1994) Diabetes Care , vol.17 , pp. 1337-1340
    • Harris, M.I.1    Robbins, D.C.2
  • 8
    • 0025109113 scopus 로고
    • Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus
    • Landin-Olsson M, Nilsson KO, Lernmark A, Sundkvist G. Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus. Diabetologia 1990; 33:561-8.
    • (1990) Diabetologia , vol.33 , pp. 561-568
    • Landin-Olsson, M.1    Nilsson, K.O.2    Lernmark, A.3    Sundkvist, G.4
  • 10
    • 34247331387 scopus 로고    scopus 로고
    • Marked increase in type 1 diabetes mellitus incidence in children aged 0-14 yr in Victoria, Australia from 1999 to 2002
    • Chong JW, Craig ME, Cameron FJ, Clarke CF, Rodda CP, Donath SM, et al. Marked increase in type 1 diabetes mellitus incidence in children aged 0-14 yr in Victoria, Australia from 1999 to 2002. Pediatr Diabetes 2007; 8:67-73.
    • (2007) Pediatr Diabetes , vol.8 , pp. 67-73
    • Chong, J.W.1    Craig, M.E.2    Cameron, F.J.3    Clarke, C.F.4    Rodda, C.P.5    Donath, S.M.6
  • 13
    • 33646201535 scopus 로고    scopus 로고
    • Characteristics at diagnosis of type 1 diabetes in children younger than 6 years
    • Quinn M, Fleischman A, Rosner B, Nigrin DJ, Wolfsdorf JI. Characteristics at diagnosis of type 1 diabetes in children younger than 6 years. J Pediatr 2006; 148:366-71.
    • (2006) J Pediatr , vol.148 , pp. 366-371
    • Quinn, M.1    Fleischman, A.2    Rosner, B.3    Nigrin, D.J.4    Wolfsdorf, J.I.5
  • 14
    • 33646510533 scopus 로고    scopus 로고
    • Prevalence of diabetes and impaired fasting glucose levels among US adolescents: National Health and Nutrition Examination Survey 1999-2002
    • Duncan G. Prevalence of diabetes and impaired fasting glucose levels among US adolescents: National Health and Nutrition Examination Survey 1999-2002. Archives of Pediatrics & Adolescent Medicine 2006; 160:523-8.
    • (2006) Archives of Pediatrics & Adolescent Medicine , vol.160 , pp. 523-528
    • Duncan, G.1
  • 15
    • 0034035943 scopus 로고    scopus 로고
    • Type 2 diabetes among North American children and adolescents: An epidemiologic review and a public health perspective
    • Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, et al. Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 2000; 136:664-72.
    • (2000) J Pediatr , vol.136 , pp. 664-672
    • Fagot-Campagna, A.1    Pettitt, D.J.2    Engelgau, M.M.3    Burrows, N.R.4    Geiss, L.S.5    Valdez, R.6
  • 16
    • 33750107067 scopus 로고    scopus 로고
    • The burden of diabetes mellitus among US youth: Prevalence estimates from the SEARCH for Diabetes in Youth Study
    • Liese AD, D'Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 2006; 118:1510-8.
    • (2006) Pediatrics , vol.118 , pp. 1510-1518
    • Liese, A.D.1    D'agostino Jr., R.B.2    Hamman, R.F.3    Kilgo, P.D.4    Lawrence, J.M.5    Liu, L.L.6
  • 17
    • 25144487278 scopus 로고    scopus 로고
    • Obesity at the onset of diabetes in an ethnically diverse population of children: What does it mean for epidemiologists and clinicians?
    • Lipton RB, Drum M, Burnet D, Rich B, Cooper A, Baumann E, et al. Obesity at the onset of diabetes in an ethnically diverse population of children: what does it mean for epidemiologists and clinicians? Pediatrics 2005; 115:553-60.
    • (2005) Pediatrics , vol.115 , pp. 553-560
    • Lipton, R.B.1    Drum, M.2    Burnet, D.3    Rich, B.4    Cooper, A.5    Baumann, E.6
  • 18
    • 0018723725 scopus 로고
    • Garcia de los Rios M. Age at diagnosis and seasonal variation in the onset of insulin-dependent diabetes in Chile (Southern hemisphere)
    • Durruty P, Ruiz F, Garcia de los Rios M. Age at diagnosis and seasonal variation in the onset of insulin-dependent diabetes in Chile (Southern hemisphere). Diabetologia 1979; 17:357-60.
    • (1979) Diabetologia , vol.17 , pp. 357-360
    • Durruty, P.1    Ruiz, F.2
  • 19
    • 0026788387 scopus 로고
    • Epidemiology of childhood type I diabetes in Sudan 1987-90
    • Elamin A, Omer MI, Zein K, Tuvemo T. Epidemiology of childhood type I diabetes in Sudan 1987-90. Diabetes Care 1992; 15:1556-9.
    • (1992) Diabetes Care , vol.15 , pp. 1556-1559
    • Elamin, A.1    Omer, M.I.2    Zein, K.3    Tuvemo, T.4
  • 20
    • 29544445501 scopus 로고    scopus 로고
    • Genetic interaction among three genomic regions creates distinct contributions to early-and late-onset type 1 diabetes mellitus
    • Felner EI, Klitz W, Ham M, Lazaro AM, Stastny P, Dupont B, et al. Genetic interaction among three genomic regions creates distinct contributions to early-and late-onset type 1 diabetes mellitus. Pediatr Diabetes 2005; 6:213-20.
    • (2005) Pediatr Diabetes , vol.6 , pp. 213-220
    • Felner, E.I.1    Klitz, W.2    Ham, M.3    Lazaro, A.M.4    Stastny, P.5    Dupont, B.6
  • 21
    • 78049270120 scopus 로고    scopus 로고
    • Diabetes Atlas
    • International Diabetes Federation
    • International Diabetes Federation. Diabetes Atlas, Third Edition 2006.
    • (2006) Third Edition
  • 22
    • 65349119874 scopus 로고    scopus 로고
    • Diabetes in non- Hispanic white youth: Prevalence, incidence and clinical characteristics: The SEARCH for Diabetes in Youth Study
    • Bell RA, Mayer-Davis EJ, Beyer JW, D'Agostino RB Jr, Lawrence JM, Linder B, et al. Diabetes in non- Hispanic white youth: prevalence, incidence and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009; 32:102-11.
    • (2009) Diabetes Care , vol.32 , pp. 102-111
    • Bell, R.A.1    Mayer-Davis, E.J.2    Beyer, J.W.3    D'agostino Jr., R.B.4    Lawrence, J.M.5    Linder, B.6
  • 23
    • 0345535842 scopus 로고    scopus 로고
    • The onset age of type 1 diabetes in Finnish children has become younger. The Finnish Childhood Diabetes Registry Group
    • Karvonen M, Pitkaniemi J, Tuomilehto J. The onset age of type 1 diabetes in Finnish children has become younger. The Finnish Childhood Diabetes Registry Group. Diabetes Care 1999; 22:1066-70.
    • (1999) Diabetes Care , vol.22 , pp. 1066-1070
    • Karvonen, M.1    Pitkaniemi, J.2    Tuomilehto, J.3
  • 24
    • 0023620933 scopus 로고
    • Epidemiologic approach to the etiology of type I diabetes mellitus and its complications
    • Krolewski AS, Warram JH, Rand LI, Kahn CR. Epidemiologic approach to the etiology of type I diabetes mellitus and its complications. N Engl J Med 1987; 317:1390-8.
    • (1987) N Engl J Med , vol.317 , pp. 1390-1398
    • Krolewski, A.S.1    Warram, J.H.2    Rand, L.I.3    Kahn, C.R.4
  • 26
    • 0030794133 scopus 로고    scopus 로고
    • Characteristics of youth-onset noninsulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis
    • Scott CR, Smith JM, Cradock MM, Pihoker C. Characteristics of youth-onset noninsulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics 1997; 100:84-91.
    • (1997) Pediatrics , vol.100 , pp. 84-91
    • Scott, C.R.1    Smith, J.M.2    Cradock, M.M.3    Pihoker, C.4
  • 27
    • 78049240794 scopus 로고    scopus 로고
    • International Diabetes Institute. AusDiab Followup Study Report 2005
    • International Diabetes Institute. AusDiab Followup Study Report 2005.
  • 28
    • 78049260767 scopus 로고    scopus 로고
    • National Center for Chronic Disease Prevention and Health Promotion [USA]. Diabetes Projects
    • National Center for Chronic Disease Prevention and Health Promotion [USA]. Diabetes Projects.
  • 29
    • 0032857507 scopus 로고    scopus 로고
    • Temporal, seasonal and geographical incidence patterns of type I diabetes mellitus in children under 5 years of age in Germany
    • Rosenbauer J, Herzig P, von Kries R, Neu A, Giani G. Temporal, seasonal and geographical incidence patterns of type I diabetes mellitus in children under 5 years of age in Germany. Diabetologia 1999; 42:1055-9.
    • (1999) Diabetologia , vol.42 , pp. 1055-1059
    • Rosenbauer, J.1    Herzig, P.2    von Kries, R.3    Neu, A.4    Giani, G.5
  • 30
    • 0036234881 scopus 로고    scopus 로고
    • Childhood diabetes: A global perspective
    • Silink M. Childhood diabetes: a global perspective. Horm Res 2002; 57:1-5.
    • (2002) Horm Res , vol.57 , pp. 1-5
    • Silink, M.1
  • 31
    • 38949143068 scopus 로고    scopus 로고
    • A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
    • Qiao Q, Osterholm AM, He B, Pitkaniemi J, Cordell HJ, Sarti C, et al. A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland. BMC Genet 2007; 8:84.
    • (2007) BMC Genet , vol.8 , pp. 84
    • Qiao, Q.1    Osterholm, A.M.2    He, B.3    Pitkaniemi, J.4    Cordell, H.J.5    Sarti, C.6
  • 32
    • 84905752896 scopus 로고    scopus 로고
    • Epidemiology, presentation and diagnosis of type 1 diabetes mellitus in children and adolescents
    • Rose B, ed, Waltham, MA: UpToDate
    • Levitsky L, Misra M. Epidemiology, presentation and diagnosis of type 1 diabetes mellitus in children and adolescents. In: Rose B, ed. UpToDate. Waltham, MA: UpToDate 2007.
    • (2007) UpToDate
    • Levitsky, L.1    Misra, M.2
  • 33
    • 0141797625 scopus 로고    scopus 로고
    • Differences between males and females in the seasonality of birth and month of clinical onset of disease in children with type 1 diabetes mellitus in Ireland
    • Roche EF, Lewy H, Hoey HM, Laron Z. Differences between males and females in the seasonality of birth and month of clinical onset of disease in children with type 1 diabetes mellitus in Ireland. J Pediatr Endocrinol Metab 2003; 16:779-82.
    • (2003) J Pediatr Endocrinol Metab , vol.16 , pp. 779-782
    • Roche, E.F.1    Lewy, H.2    Hoey, H.M.3    Laron, Z.4
  • 34
    • 0141574379 scopus 로고    scopus 로고
    • Host and environmental factors defining the epidemiology of type 1 diabetes mellitus in a group of Lebanese children and young adults
    • Zalloua PA, Terwedow H, Shbaklo H, Halaby G, Xu X, Azar ST. Host and environmental factors defining the epidemiology of type 1 diabetes mellitus in a group of Lebanese children and young adults. J Pediatr Endocrinol Metab 2003; 16:759-69.
    • (2003) J Pediatr Endocrinol Metab , vol.16 , pp. 759-769
    • Zalloua, P.A.1    Terwedow, H.2    Shbaklo, H.3    Halaby, G.4    Xu, X.5    Azar, S.T.6
  • 36
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001; 358:221-9.
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 37
    • 85056071638 scopus 로고    scopus 로고
    • Death pathways in T cell homeostasis and their role in autoimmune diabetes
    • Gronski MA, Weinem M. Death pathways in T cell homeostasis and their role in autoimmune diabetes. Rev Diabet Stud 2006; 3:88-95.
    • (2006) Rev Diabet Stud , vol.3 , pp. 88-95
    • Gronski, M.A.1    Weinem, M.2
  • 38
    • 0035197969 scopus 로고    scopus 로고
    • Autoimmune type 1 diabetes: Resolved and unresolved issues
    • Notkins AL, Lernmark A. Autoimmune type 1 diabetes: resolved and unresolved issues. J Clin Invest 2001; 108:1247-52.
    • (2001) J Clin Invest , vol.108 , pp. 1247-1252
    • Notkins, A.L.1    Lernmark, A.2
  • 39
    • 15844397409 scopus 로고    scopus 로고
    • Complement-fixing islet cell antibodies in type-1 diabetes can trigger the assembly of the terminal complement complex on human islet cells and are potentially cytotoxic
    • Radillo O, Nocera A, Leprini A, Barocci S, Mollnes TE, Pocecco M, et al. Complement-fixing islet cell antibodies in type-1 diabetes can trigger the assembly of the terminal complement complex on human islet cells and are potentially cytotoxic. Clin Immunol Immunopathol 1996; 79:217-23.
    • (1996) Clin Immunol Immunopathol , vol.79 , pp. 217-223
    • Radillo, O.1    Nocera, A.2    Leprini, A.3    Barocci, S.4    Mollnes, T.E.5    Pocecco, M.6
  • 41
    • 78049261688 scopus 로고    scopus 로고
    • Ziel F, Talavera F, Schalch D, Cooper M, Griffing G, eds
    • Hussain A, Vincent M. Diabetes Mellitus, Type 1. In: Ziel F, Talavera F, Schalch D, Cooper M, Griffing G, eds 2007.
    • (2007) Diabetes Mellitus, Type 1
    • Hussain, A.1    Vincent, M.2
  • 42
    • 33947726341 scopus 로고    scopus 로고
    • Moving towards efficient therapies in type 1 diabetes: To combine or not to combine?
    • Bresson D, von Herrath M. Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? Autoimmun Rev 2007; 6:315-22.
    • (2007) Autoimmun Rev , vol.6 , pp. 315-322
    • Bresson, D.1    von Herrath, M.2
  • 43
    • 78049275104 scopus 로고    scopus 로고
    • Prescribing physical activity for the management of cardiovascular disease and diabetes
    • American Diabetes Association
    • American Diabetes Association. Prescribing physical activity for the management of cardiovascular disease and diabetes. Diabetes and Cardiovascular Disease Review 2005; 1-12.
    • (2005) Diabetes and Cardiovascular Disease Review , pp. 1-12
  • 44
    • 33748126226 scopus 로고    scopus 로고
    • Recent approaches to intracellular delivery of drugs and DNA and organelle targeting
    • Torchilin VP. Recent approaches to intracellular delivery of drugs and DNA and organelle targeting. Annu Rev Biomed Eng 2006; 8:343-75.
    • (2006) Annu Rev Biomed Eng , vol.8 , pp. 343-375
    • Torchilin, V.P.1
  • 45
    • 0031408758 scopus 로고    scopus 로고
    • Gene therapy for diabetes: Strategies for beta-cell modification and replacement
    • Levine F. Gene therapy for diabetes: strategies for beta-cell modification and replacement. Diabetes Metab Rev 1997; 13:209-46.
    • (1997) Diabetes Metab Rev , vol.13 , pp. 209-246
    • Levine, F.1
  • 46
    • 2342431902 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus as delivery vector for gene therapy-a review
    • Lu Y. Recombinant adeno-associated virus as delivery vector for gene therapy-a review. Stem Cells Dev 2004; 13:133-45.
    • (2004) Stem Cells Dev , vol.13 , pp. 133-145
    • Lu, Y.1
  • 48
    • 0036156567 scopus 로고    scopus 로고
    • Recent advances in insulin gene therapy for type 1 diabetes
    • Yoon JW, Jun HS. Recent advances in insulin gene therapy for type 1 diabetes. Trends Mol Med 2002; 8:62-8.
    • (2002) Trends Mol Med , vol.8 , pp. 62-68
    • Yoon, J.W.1    Jun, H.S.2
  • 49
    • 34250716494 scopus 로고    scopus 로고
    • T-cell receptor gene transfer by lentiviral vectors in adoptive cell therapy
    • Bobisse S, Zanovello P, Rosato A. T-cell receptor gene transfer by lentiviral vectors in adoptive cell therapy. Expert Opin Biol Ther 2007; 7:893-906.
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 893-906
    • Bobisse, S.1    Zanovello, P.2    Rosato, A.3
  • 50
    • 0030751585 scopus 로고    scopus 로고
    • Glucose-stimulated genes and prospects of gene therapy for type I diabetes
    • Mitanchez D, Doiron B, Chen R, Kahn A. Glucose-stimulated genes and prospects of gene therapy for type I diabetes. Endocr Rev 1997; 18:520-40.
    • (1997) Endocr Rev , vol.18 , pp. 520-540
    • Mitanchez, D.1    Doiron, B.2    Chen, R.3    Kahn, A.4
  • 51
    • 0027994097 scopus 로고
    • Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
    • Becker TC, BeltrandelRio H, Noel RJ, Johnson JH, Newgard CB. Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. J Biol Chem 1994; 269:21234-8.
    • (1994) J Biol Chem , vol.269 , pp. 21234-21238
    • Becker, T.C.1    Beltrandelrio, H.2    Noel, R.J.3    Johnson, J.H.4    Newgard, C.B.5
  • 53
    • 0030714099 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer into isolated mouse adult pancreatic islets: Normal beta-cell function despite induction of an anti-adenovirus immune response
    • Sigalla J, David A, Anegon I, Fiche M, Huvelin JM, Boeffard F, et al. Adenovirus-mediated gene transfer into isolated mouse adult pancreatic islets: normal beta-cell function despite induction of an anti-adenovirus immune response. Hum Gene Ther 1997; 8:1625-34.
    • (1997) Hum Gene Ther , vol.8 , pp. 1625-1634
    • Sigalla, J.1    David, A.2    Anegon, I.3    Fiche, M.4    Huvelin, J.M.5    Boeffard, F.6
  • 54
    • 33748508808 scopus 로고    scopus 로고
    • A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans
    • Barbu AR, Bodin B, Welsh M, Jansson L, Welsh N. A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans. Diabetologia 2006; 49:2388-91.
    • (2006) Diabetologia , vol.49 , pp. 2388-2391
    • Barbu, A.R.1    Bodin, B.2    Welsh, M.3    Jansson, L.4    Welsh, N.5
  • 55
    • 4644235563 scopus 로고    scopus 로고
    • Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors
    • Fernandes JR, Duvivier-Kali VF, Keegan M, Hollister- Lock J, Omer A, Su S, et al. Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol 2004; 13:191-200.
    • (2004) Transpl Immunol , vol.13 , pp. 191-200
    • Fernandes, J.R.1    Duvivier-Kali, V.F.2    Keegan, M.3    Hollister-Lock, J.4    Omer, A.5    Su, S.6
  • 57
    • 33744720341 scopus 로고    scopus 로고
    • Long-term gene expression and metabolic control exerted by lentivirus-transduced pancreatic islets
    • He Z, Wang F, Kumagai-Braesch M, Permert J, Holgersson J. Long-term gene expression and metabolic control exerted by lentivirus-transduced pancreatic islets. Xenotransplantation 2006; 13:195-203.
    • (2006) Xenotransplantation , vol.13 , pp. 195-203
    • He, Z.1    Wang, F.2    Kumagai-Braesch, M.3    Permert, J.4    Holgersson, J.5
  • 58
    • 0031742518 scopus 로고    scopus 로고
    • Prospects for gene therapy of insulin-dependent diabetes mellitus
    • Efrat S. Prospects for gene therapy of insulin-dependent diabetes mellitus. Diabetologia 1998; 41:1401-9.
    • (1998) Diabetologia , vol.41 , pp. 1401-1409
    • Efrat, S.1
  • 59
    • 0035491791 scopus 로고    scopus 로고
    • Gene and cell-replacement therapy in the treatment of type 1 diabetes: How high must the standards be set?
    • Halban PA, Kahn SE, Lernmark A, Rhodes CJ. Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set? Diabetes 2001; 50:2181-91.
    • (2001) Diabetes , vol.50 , pp. 2181-2191
    • Halban, P.A.1    Kahn, S.E.2    Lernmark, A.3    Rhodes, C.J.4
  • 60
    • 0021024216 scopus 로고
    • Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing and secretion on stimulation
    • Moore HP, Walker MD, Lee F, Kelly RB. Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing and secretion on stimulation. Cell 1983; 35:531-8.
    • (1983) Cell , vol.35 , pp. 531-538
    • Moore, H.P.1    Walker, M.D.2    Lee, F.3    Kelly, R.B.4
  • 61
  • 62
    • 44349107167 scopus 로고    scopus 로고
    • Regulated insulin delivery from human epidermal cells reverses hyperglycemia
    • Tian J, Lei P, Laychock SG, Andreadis ST. Regulated insulin delivery from human epidermal cells reverses hyperglycemia. Mol Ther 2008; 16:1146-53.
    • (2008) Mol Ther , vol.16 , pp. 1146-1153
    • Tian, J.1    Lei, P.2    Laychock, S.G.3    Andreadis, S.T.4
  • 63
    • 34548064995 scopus 로고    scopus 로고
    • Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: Implications for treatment of diabetes
    • Lei P, Ogunade A, Kirkwood KL, Laychock SG, Andreadis ST. Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: implications for treatment of diabetes. Tissue Eng 2007; 13:2119-31.
    • (2007) Tissue Eng , vol.13 , pp. 2119-2131
    • Lei, P.1    Ogunade, A.2    Kirkwood, K.L.3    Laychock, S.G.4    Andreadis, S.T.5
  • 64
    • 39749193212 scopus 로고    scopus 로고
    • Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model
    • Zhang Y, Yao L, Shen K, Xu M, Zhou P, Yang W, et al. Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model. Acta Biochim Biophys Sin (Shanghai) 2008; 40:149-57.
    • (2008) Acta Biochim Biophys Sin (Shanghai) , vol.40 , pp. 149-157
    • Zhang, Y.1    Yao, L.2    Shen, K.3    Xu, M.4    Zhou, P.5    Yang, W.6
  • 65
    • 45749157560 scopus 로고    scopus 로고
    • Hepatic insulin gene therapy normalizes diurnal fluctuation of oxidative metabolism in diabetic BB/Wor rats
    • Olson DE, Campell AG, Porter MH, Freeman KG, Kelso E, Flatt WP, et al. Hepatic insulin gene therapy normalizes diurnal fluctuation of oxidative metabolism in diabetic BB/Wor rats. Mol Ther 2008; 16:1235-42.
    • (2008) Mol Ther , vol.16 , pp. 1235-1242
    • Olson, D.E.1    Campell, A.G.2    Porter, M.H.3    Freeman, K.G.4    Kelso, E.5    Flatt, W.P.6
  • 66
    • 34547701718 scopus 로고    scopus 로고
    • Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy
    • Ren B, O'Brien BA, Swan MA, Koina ME, Nassif N, Wei MQ, et al. Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy. Diabetologia 2007; 50:1910-20.
    • (2007) Diabetologia , vol.50 , pp. 1910-1920
    • Ren, B.1    O'Brien, B.A.2    Swan, M.A.3    Koina, M.E.4    Nassif, N.5    Wei, M.Q.6
  • 67
    • 43049129930 scopus 로고    scopus 로고
    • Glucose- and metabolically regulated hepatic insulin gene therapy for diabetes
    • Hsu PY, Kotin RM, Yang YW. Glucose- and metabolically regulated hepatic insulin gene therapy for diabetes. Pharm Res 2008; 25:1460-8.
    • (2008) Pharm Res , vol.25 , pp. 1460-1468
    • Hsu, P.Y.1    Kotin, R.M.2    Yang, Y.W.3
  • 68
    • 33845957180 scopus 로고    scopus 로고
    • Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: An ex vivo gene therapy approach
    • Fodor A, Harel C, Fodor L, Armoni M, Salmon P, Trono D, et al. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia 2007; 50:121-30.
    • (2007) Diabetologia , vol.50 , pp. 121-130
    • Fodor, A.1    Harel, C.2    Fodor, L.3    Armoni, M.4    Salmon, P.5    Trono, D.6
  • 69
    • 33746813578 scopus 로고    scopus 로고
    • Forced expression of PDX-1 induces insulin production in intestinal epithelia
    • Koizumi M, Nagai K, Kida A, Kami K, Ito D, Fujimoto K, et al. Forced expression of PDX-1 induces insulin production in intestinal epithelia. Surgery 2006; 140:273-80.
    • (2006) Surgery , vol.140 , pp. 273-280
    • Koizumi, M.1    Nagai, K.2    Kida, A.3    Kami, K.4    Ito, D.5    Fujimoto, K.6
  • 70
    • 34548046200 scopus 로고    scopus 로고
    • Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene
    • Xu J, Lu Y, Ding F, Zhan X, Zhu M, Wang Z. Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene. World J Surg 2007; 31:1872-82.
    • (2007) World J Surg , vol.31 , pp. 1872-1882
    • Xu, J.1    Lu, Y.2    Ding, F.3    Zhan, X.4    Zhu, M.5    Wang, Z.6
  • 72
    • 54049115990 scopus 로고    scopus 로고
    • Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration of chitosan nanoparticles containing human insulin gene
    • Niu L, Xu YC, Dai Z, Tang HQ. Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration of chitosan nanoparticles containing human insulin gene. World J Gastroenterol 2008; 14:4209-15.
    • (2008) World J Gastroenterol , vol.14 , pp. 4209-4215
    • Niu, L.1    Xu, Y.C.2    Dai, Z.3    Tang, H.Q.4
  • 73
    • 34249884271 scopus 로고    scopus 로고
    • In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes
    • Soltani N, Kumar M, Glinka Y, Prud'homme GJ, Wang Q. In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes. Gene Ther 2007; 14:981-8.
    • (2007) Gene Ther , vol.14 , pp. 981-988
    • Soltani, N.1    Kumar, M.2    Glinka, Y.3    Prud'homme, G.J.4    Wang, Q.5
  • 74
    • 60049083974 scopus 로고    scopus 로고
    • Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation
    • Panakanti R, Mahato RI. Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation. Pharm Res 2009; 26:587-96.
    • (2009) Pharm Res , vol.26 , pp. 587-596
    • Panakanti, R.1    Mahato, R.I.2
  • 75
    • 0031003713 scopus 로고    scopus 로고
    • Genetic modification of an islet tumor cell line inhibits its rejection
    • Georgiou HM, Brady JL, Silva A, Lew AM. Genetic modification of an islet tumor cell line inhibits its rejection. Transplant Proc 1997; 29:1032-3.
    • (1997) Transplant Proc , vol.29 , pp. 1032-1033
    • Georgiou, H.M.1    Brady, J.L.2    Silva, A.3    Lew, A.M.4
  • 76
    • 2542579529 scopus 로고    scopus 로고
    • Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families
    • Holm P, Rydlander B, Luthman H, Kockum I. Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families. Diabetes 2004; 53:1584-91.
    • (2004) Diabetes , vol.53 , pp. 1584-1591
    • Holm, P.1    Rydlander, B.2    Luthman, H.3    Kockum, I.4
  • 77
    • 23844543330 scopus 로고    scopus 로고
    • Genetic analysis of families with autoimmune diabetes and thyroiditis: Evidence for common and unique genes
    • Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y. Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. J Clin Endocrinol Metab 2005; 90:4904-11.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4904-4911
    • Golden, B.1    Levin, L.2    Ban, Y.3    Concepcion, E.4    Greenberg, D.A.5    Tomer, Y.6
  • 78
    • 0037477605 scopus 로고    scopus 로고
    • The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    • Ansari MJ, Salama AD, Chitnis T, Smith RN, Yagita H, Akiba H, et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 2003; 198:63-9.
    • (2003) J Exp Med , vol.198 , pp. 63-69
    • Ansari, M.J.1    Salama, A.D.2    Chitnis, T.3    Smith, R.N.4    Yagita, H.5    Akiba, H.6
  • 80
    • 0032521025 scopus 로고    scopus 로고
    • Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes
    • Arnush M, Scarim AL, Heitmeier MR, Kelly CB, Corbett JA. Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. J Immunol 1998; 160:2684-91.
    • (1998) J Immunol , vol.160 , pp. 2684-2691
    • Arnush, M.1    Scarim, A.L.2    Heitmeier, M.R.3    Kelly, C.B.4    Corbett, J.A.5
  • 81
    • 0028900805 scopus 로고
    • Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase
    • Corbett JA, McDaniel ML. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J Exp Med 1995; 181:559-68.
    • (1995) J Exp Med , vol.181 , pp. 559-568
    • Corbett, J.A.1    McDaniel, M.L.2
  • 82
    • 0027301777 scopus 로고
    • Nitric oxide mediates IL-1beta-induced islet dysfunction and destruction: Prevention by dexamethasone
    • Corbett JA, Wang JL, Misko TP, Zhao W, Hickey WF, McDaniel ML. Nitric oxide mediates IL-1beta-induced islet dysfunction and destruction: prevention by dexamethasone. Autoimmunity 1993; 15:145-53.
    • (1993) Autoimmunity , vol.15 , pp. 145-153
    • Corbett, J.A.1    Wang, J.L.2    Misko, T.P.3    Zhao, W.4    Hickey, W.F.5    McDaniel, M.L.6
  • 84
    • 0030731917 scopus 로고    scopus 로고
    • Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
    • Stassi G, De Maria R, Trucco G, Rudert W, Testi R, Galluzzo A, et al. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 1997; 186:1193-200.
    • (1997) J Exp Med , vol.186 , pp. 1193-1200
    • Stassi, G.1    de Maria, R.2    Trucco, G.3    Rudert, W.4    Testi, R.5    Galluzzo, A.6
  • 85
    • 41549150638 scopus 로고    scopus 로고
    • Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
    • Creusot RJ, Yaghoubi SS, Kodama K, Dang DN, Dang VH, Breckpot K, et al. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 2008; 127:176-87.
    • (2008) Clin Immunol , vol.127 , pp. 176-187
    • Creusot, R.J.1    Yaghoubi, S.S.2    Kodama, K.3    Dang, D.N.4    Dang, V.H.5    Breckpot, K.6
  • 86
    • 53749099191 scopus 로고    scopus 로고
    • Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice
    • Kodama K, Butte AJ, Creusot RJ, Su L, Sheng D, Hartnett M, et al. Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol 2008; 129:195-201.
    • (2008) Clin Immunol , vol.129 , pp. 195-201
    • Kodama, K.1    Butte, A.J.2    Creusot, R.J.3    Su, L.4    Sheng, D.5    Hartnett, M.6
  • 87
    • 0034662271 scopus 로고    scopus 로고
    • Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes
    • Cameron MJ, Arreaza GA, Grattan M, Meagher C, Sharif S, Burdick MD, et al. Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes. J Immunol 2000; 165:1102-10.
    • (2000) J Immunol , vol.165 , pp. 1102-1110
    • Cameron, M.J.1    Arreaza, G.A.2    Grattan, M.3    Meagher, C.4    Sharif, S.5    Burdick, M.D.6
  • 88
    • 33847382027 scopus 로고    scopus 로고
    • CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses
    • Meagher C, Arreaza G, Peters A, Strathdee CA, Gilbert PA, Mi QS, et al. CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses. Diabetes 2007; 56:809-17.
    • (2007) Diabetes , vol.56 , pp. 809-817
    • Meagher, C.1    Arreaza, G.2    Peters, A.3    Strathdee, C.A.4    Gilbert, P.A.5    Mi, Q.S.6
  • 89
    • 0038292006 scopus 로고    scopus 로고
    • The cholera toxin B subunit is a mucosal adjuvant for oral tolerance induction in type 1 diabetes
    • Bregenholt S, Wang M, Wolfe T, Hughes A, Baerentzen L, Dyrberg T, et al. The cholera toxin B subunit is a mucosal adjuvant for oral tolerance induction in type 1 diabetes. Scand J Immunol 2003; 57:432-8.
    • (2003) Scand J Immunol , vol.57 , pp. 432-438
    • Bregenholt, S.1    Wang, M.2    Wolfe, T.3    Hughes, A.4    Baerentzen, L.5    Dyrberg, T.6
  • 90
    • 0036278571 scopus 로고    scopus 로고
    • Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo
    • Sadeghi H, Bregenholt S, Wegmann D, Petersen JS, Holmgren J, Lebens M. Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo. Immunology 2002; 106:237-45.
    • (2002) Immunology , vol.106 , pp. 237-245
    • Sadeghi, H.1    Bregenholt, S.2    Wegmann, D.3    Petersen, J.S.4    Holmgren, J.5    Lebens, M.6
  • 91
    • 0028007467 scopus 로고
    • Cholera toxin B subunit: An efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance
    • Sun JB, Holmgren J, Czerkinsky C. Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc Natl Acad Sci USA 1994; 91:10795-9.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10795-10799
    • Sun, J.B.1    Holmgren, J.2    Czerkinsky, C.3
  • 92
    • 33846867234 scopus 로고    scopus 로고
    • Suppression of hyperglycemia in NOD mice after inoculation with recombinant vaccinia viruses
    • Denes B, Yu J, Fodor N, Takatsy Z, Fodor I, Langridge WH. Suppression of hyperglycemia in NOD mice after inoculation with recombinant vaccinia viruses. Mol Biotechnol 2006; 34:317-27.
    • (2006) Mol Biotechnol , vol.34 , pp. 317-327
    • Denes, B.1    Yu, J.2    Fodor, N.3    Takatsy, Z.4    Fodor, I.5    Langridge, W.H.6
  • 93
    • 0032745109 scopus 로고    scopus 로고
    • A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets
    • Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C. A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets. J Exp Med 1999; 190:1135-46.
    • (1999) J Exp Med , vol.190 , pp. 1135-1146
    • Grey, S.T.1    Arvelo, M.B.2    Hasenkamp, W.3    Bach, F.H.4    Ferran, C.5
  • 94
    • 0034194580 scopus 로고    scopus 로고
    • Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme
    • Klein D, Ricordi C, Pugliese A, Pastori RL. Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme. Hum Gene Ther 2000; 11:1033-45.
    • (2000) Hum Gene Ther , vol.11 , pp. 1033-1045
    • Klein, D.1    Ricordi, C.2    Pugliese, A.3    Pastori, R.L.4
  • 95
    • 0034509569 scopus 로고    scopus 로고
    • Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I
    • Giannoukakis N, Mi Z, Rudert WA, Gambotto A, Trucco M, Robbins P. Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I. Gene Ther 2000; 7:2015-22.
    • (2000) Gene Ther , vol.7 , pp. 2015-2022
    • Giannoukakis, N.1    Mi, Z.2    Rudert, W.A.3    Gambotto, A.4    Trucco, M.5    Robbins, P.6
  • 96
    • 67349144240 scopus 로고    scopus 로고
    • Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia and promote survival in insulin-deficient diabetic mice
    • Kojima S, Asakawa A, Amitani H, Sakoguchi T, Ueno N, Inui A, et al. Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia and promote survival in insulin-deficient diabetic mice. Peptides 2009; 30:962-6.
    • (2009) Peptides , vol.30 , pp. 962-966
    • Kojima, S.1    Asakawa, A.2    Amitani, H.3    Sakoguchi, T.4    Ueno, N.5    Inui, A.6
  • 97
    • 0025314322 scopus 로고
    • Transmembrane helical interactions and the assembly of the T cell receptor complex
    • Manolios N, Bonifacino JS, Klausner RD. Transmembrane helical interactions and the assembly of the T cell receptor complex. Science 1990; 249:274-7.
    • (1990) Science , vol.249 , pp. 274-277
    • Manolios, N.1    Bonifacino, J.S.2    Klausner, R.D.3
  • 98
    • 0031013825 scopus 로고    scopus 로고
    • T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease
    • Manolios N, Collier S, Taylor J, Pollard J, Harrison LC, Bender V. T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease. Nat Med 1997; 3:84-8.
    • (1997) Nat Med , vol.3 , pp. 84-88
    • Manolios, N.1    Collier, S.2    Taylor, J.3    Pollard, J.4    Harrison, L.C.5    Bender, V.6
  • 99
    • 0345700632 scopus 로고    scopus 로고
    • Transmembrane T-cell receptor peptides inhibit B-and natural killer-cell function
    • Huynh NT, Ffrench RA, Boadle RA, Manolios N. Transmembrane T-cell receptor peptides inhibit B-and natural killer-cell function. Immunology 2003; 108:458-64.
    • (2003) Immunology , vol.108 , pp. 458-464
    • Huynh, N.T.1    Ffrench, R.A.2    Boadle, R.A.3    Manolios, N.4
  • 100
    • 33747036119 scopus 로고    scopus 로고
    • Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function
    • Amon MA, Ali M, Bender V, Chan YN, Toth I, Manolios N. Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function. Biochim Biophys Acta 2006; 1763:879-88.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 879-888
    • Amon, M.A.1    Ali, M.2    Bender, V.3    Chan, Y.N.4    Toth, I.5    Manolios, N.6
  • 101
    • 58149341303 scopus 로고    scopus 로고
    • Therapeutic Applications of Transmembrane T and Natural Killer Cell Receptor Peptides
    • In: Sigalov A, ed., From Spatiotemporal Organization to Human Disease: Landes Bioscience
    • Manolios N, Ali M, Amon M, Bender V. Therapeutic Applications of Transmembrane T and Natural Killer Cell Receptor Peptides. In: Sigalov A, ed. Multichain Immune Recognition Receptor Signalling: From Spatiotemporal Organization to Human Disease: Landes Bioscience 2007; 208-19.
    • (2007) Multichain Immune Recognition Receptor Signalling , pp. 208-219
    • Manolios, N.1    Ali, M.2    Amon, M.3    Bender, V.4
  • 102
    • 0043208903 scopus 로고    scopus 로고
    • Dendritic cells, engineered to secrete a T-cell receptor mimic peptide, induce antigen-specific immunosuppression in vivo
    • Mahnke K, Qian Y, Knop J, Enk AH. Dendritic cells, engineered to secrete a T-cell receptor mimic peptide, induce antigen-specific immunosuppression in vivo. Nat Biotechnol 2003; 21:903-8.
    • (2003) Nat Biotechnol , vol.21 , pp. 903-908
    • Mahnke, K.1    Qian, Y.2    Knop, J.3    Enk, A.H.4


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