Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration of chitosan nanoparticles containing human insulin gene

World Journal of Gastroenterology

Volumn 14, Issue 26, 2008, Pages 4209-4215

  Niu, Li ^a   Xu, Yan Cheng ^a   Dai, Zhe ^a   Tang, Hui Qin ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Chitosan nanoparticle; Diabetes mellitus; Gastrointestinal tract; Gene expression; Human insulin gene

Indexed keywords

CHITOSAN; GLUCOSE; HUMAN INSULIN; INSULIN; MESSENGER RNA; NANOPARTICLE; DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENETIC TRANSFECTION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LAVAGE; MALE; NONHUMAN; NONVIRAL GENE THERAPY; PLASMID; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BLOOD; GENE THERAPY; GENETICS; HUMAN; METHODOLOGY; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; CHITOSAN; DIABETES MELLITUS, TYPE 1; DNA; GENE THERAPY; HUMANS; INSULIN; MALE; NANOPARTICLES; RATS; RATS, WISTAR;

EID: 54049115990     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.4209     Document Type: Article

References (33)

1. Dieterle C, Brendel MD, Seissler J, Eckhard M, Bretzel RG, Landgraf R. [Therapy of diabetes mellitus. Pancreas transplantation, islet transplantation, stem cell-and gene therapy] Internist (Berl) 2006; 47: 489-496, 498-501
2. Samson SL, Chan L. Gene therapy for diabetes: reinventing the islet. Trends Endocrinol Metab 2006; 17: 92-100
3. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238
4. Lau J, Mattsson G, Carlsson C, Nyqvist D, Kohler M, Berggren PO, Jansson L, Carlsson PO. Implantation site-dependent dysfunction of transplanted pancreatic islets. Diabetes 2007; 56: 1544-1550
5. Li M, Inaba M, Guo KQ, Hisha H, Abraham NG, Ikehara S. Treatment of streptozotocin-induced diabetes mellitus in mice by intra-bone marrow bone marrow transplantation plus portal vein injection of beta cells induced from bone marrow cells. Int J Hematol 2007; 86: 438-445
6. Brenner S, Ryser MF, Whiting-Theobald NL, Gentsch M, Linton GF, Malech HL. The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic/severe combined immunodeficient mice. Stem Cells 2007; 25: 1807-1813
7. Timper K, Seboek D, Eberhardt M, Linscheid P, Christ-Crain M, Keller U, Muller B, Zulewski H. Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells. Biochem Biophys Res Commun 2006; 341: 1135-1140
8. Fukushima M, Hattori Y, Tsukada H, Koga K, Kajiwara E, Kawano K, Kobayashi T, Kamata K, Maitani Y. Adiponectin gene therapy of streptozotocin-induced diabetic mice using hydrodynamic injection. J Gene Med 2007; 9: 976-985
9. Yoo HS, Mazda O, Lee HY, Kim JC, Kwon SM, Lee JE, Kwon IC, Jeong H, Jeong YS, Jeong SY. In vivo gene therapy of type I diabetic mellitus using a cationic emulsion containing an Epstein Barr Virus (EBV) based plasmid vector. J Control Release 2006; 112: 139-144
10. Lu YC, Sternini C, Rozengurt E, Zhukova E. Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes. Endocrinology 2005; 146: 2610-2619
11. Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun 2008; 366: 129-134
12. Jafary H, Larijani B, Farrokhi A, Pirous M, Mollamohammadi S, Baharvand H. Differential effect of activin on mouse embryonic stem cell differentiation in insulin-secreting cells under nestin-positive selection and spontaneous differentiation protocols. Cell Biol Int 2008; 32: 278-286
13. Serafimidis I, Rakatzi I, Episkopou V, Gouti M, Gavalas A. Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors. Stem Cells 2008; 26: 3-16
14. D'Anneo A, Rood P, Bottino R, Balamurugan AN, He J, Giannoukakis N. Gene therapy for type 1 diabetes: is it ready for the clinic? Immunol Res 2006; 36: 83-89
15. Mao HQ, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y, August JT, Leong KW. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release 2001; 70: 399-421
16. Giannoukakis N, Trucco M. Gene therapy for type 1 diabetes. Am J Ther 2005, 12: 512-528
17. Zaia JA. The status of gene vectors for the treatment of diabetes. Cell Biochem Biophys 2007; 48: 183-190
18. Prud'homme GJ, Glinka Y, Khan AS, Draghia-Akli R. Electroporation-enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases. Curr Gene Ther 2006; 6: 243-273
19. Koping-Hoggard M, Issa MM, Kohler T, Tronde A, Varum KM, Artursson P. A miniaturized nebulization catheter for improved gene delivery to the mouse lung. J Gene Med 2005; 7:1215-1222
20. Chaszczewska-Markowska M, Stebelska K, Sikorski A, Madej J, Opolski A, Ugorski M. Liposomal formulation of 5-fluorocytosine in suicide gene therapy with cytosine deaminase - for colorectal cancer. Cancer Lett 2008; 262: 164-172
21. Bajaj A, Kondaiah P, Bhattacharya S. Gene transfection efficacies of novel cationic gemini lipids possessing aromatic backbone and oxyethylene spacers. Biomacromolecules 2008; 9: 991-999
22. Kim HS, Kim JS, Lee YK, Koo KH, Park YS. An efficient liposomal gene delivery vehicle using Sendai F/HN proteins and protamine. Cancer Gene Ther 2008; 15: 214-224
23. Turner P, Petch A, Al-Rubeal M. Encapsulation of viral vectors for gene therapy applications. Biotechnol Prog 2007; 23: 423-429
24. Ragusa A, Garcia I, Penades S. Nanoparticles as nonviral gene delivery vectors. IEEE Trans Nanobioscience 2007; 6: 319-330
25. Schmitz T, Bravo-Osupa I, Vauthier C, Ponchel G, Loretz B, Bernkop-Schnurch A. Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system. Biomaterials 2007; 28: 524-531
26. Douglas KL, Piccirillo CA, Tabrizian M. Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. J Control Release 2006; 115: 354-361
27. Okamoto R, Watanabe M. Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. J Gastroenterol 2004; 39: 1-6
28. Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, Burcelin R, Knauf C. GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol 2007; 276: 18-23
29. Cassidy RS, Irwin N, Flatt PR. Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets. Biol Chem 2008; 389: 189-193
30. Kuo P, Chaikomin R, Pilichiewicz A, O'Donovan D, Wishart JM, Meyer JH, Jones KL, Feinle-Bisset C, Horowitz M, Rayner CK. Transient, early release of glucagon-like peptide-1 during low rates of intraduodenal glucose delivery. Regul Pept 2008; 146: 1-3
31. McClean PL, Gault VA, Irwin N, McCluskey JT, Flatt PR. Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP. Diabetes Obes Metab 2008; 10: 336-342
32. Cheung AT, Dayanandan B, Lewis JT, Korbutt GS, Rajotte RV, Bryer-Ash M, Boylan MO, Wolfe MM, Kieffer J. Glucose-dependent insulin release from genetically engineered K cells. Science 2000; 290: 1959-1962
33. Palizban AA, Salehi R, Nori N, Galehdari H. In vivo transfection rat small intestine K-cell with pGIP/Ins plasmid by DOTAP liposome. J Drug Target 2007; 15: 351-357