Regulated insulin delivery from human epidermal cells reverses hyperglycemia

Molecular Therapy

Volumn 16, Issue 6, 2008, Pages 1146-1153

  Tian, Jun ^a   Lei, Pedro ^b   Laychock, Suzanne G ^b   Andreadis, Stelios T ^a,b  

^a the State University of New York   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FK 506 BINDING PROTEIN; HYBRID PROTEIN; INSULIN; LENTIVIRUS VECTOR; PROINSULIN; RAPAMYCIN; STREPTOZOCIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENGINEERING; CELL BASED GENE THERAPY; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; DIMERIZATION; DNA MODIFICATION; GLYCEMIC CONTROL; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN TREATMENT; KERATINOCYTE; MOUSE; MUTANT; NONHUMAN; STREPTOZOCIN DIABETES; VIRAL GENE DELIVERY SYSTEM;

ANIMALIA; MUS;

EID: 44349107167     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.79     Document Type: Article

References (48)

1. Chernajovsky, Y, Dreja, H, Daly, G, Annenkov, A, Gould, D, Adams, G et al. (2000). Immuno- and genetic therapy in autoimmune diseases. Genes Immun 1: 295-307.
2. Bonner-Weir, S and Sharma, A (2002). Pancreatic stem cells. J Pathol 197: 519-526.
3. Zalzman, M, Gupta, S, Giri, RK, Berkovich, I, Sappal, BS, Karnieli, O et al. (2003). Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA 100: 7253-7258.
4. Ferber, S, Halkin, A, Cohen, H, Ber, I, Einav, Y, Goldberg, I et al. (2000). Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6: 568-572.
5. Kojima, H, Fujimiya, M, Matsumura, K, Younan, P, Imaeda, H, Maeda, M et al. (2003). NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 9: 596-603.
6. Cheung, AT, Dayanandan, B, Lewis, JT, Korbutt, GS, Rajotte, RV, Bryer-Ash, M et al. (2000). Glucose-dependent insulin release from genetically engineered K cells. Science 290: 1959-1962.
7. Kolodka, TM, Finegold, M, Moss, L and Woo, SL (1995). Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc Natl Acad Sci USA 92: 3293-3297.
8. Falqui, L, Martinenghi, S, Severini, GM, Corbella, P, Taglietti, MV, Arcelloni, C et al. (1999). Reversal of diabetes in mice by implantation of human fibroblasts genetically engineered to release mature human insulin. Hum Gene Ther 10: 1753-1762.
9. Shaw, JA, Delday, MI, Hart, AW, Docherty, HM, Maltin, CA and Docherty, K (2002). Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. J Endocrinol 172: 653-672.
10. Lei, P, Ogunade, A, Kirkwood, KL, Laychock, SG and Andreadis, ST (2007). Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: Implications for treatment of diabetes. Tissue Eng 13: 2119-2131.
11. Wu, L, Nicholson, W, Wu, CY, Xu, M, McGaha, A, Shiota, M et al. (2003). Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor. Gene Ther 10: 1712-1720.
12. Thulé, PM, Liu, J and Phillips, LS (2000). Glucose regulated production of human insulin in rat hepatocytes. Gene Ther 7: 205-214.
13. Yang, YW and Kotin, RM (2000). Glucose-responsive gene delivery in pancreatic islet cells via recombinant adeno-associated viral vectors. Pharm Res 17: 1056-1061.
14. Chen, R, Meseck, ML and Woo, SL (2001). Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol Ther 3: 584-590.
15. Alam, T and Sollinger, HW (2002). Glucose-regulated insulin production in hepatocytes. Transplantation 74: 1781-1787.
16. Olson, DE, Paveglio, SA, Huey, PU, Porter, MH and Thulé, PM (2003). Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats. Hum Gene Ther 14: 1401-1413.
17. Cheng, SY, Constantinidis, I and Sambanis, A (2006). Use of glucose-responsive material to regulate insulin release from constitutively secreting cells. Biotechnol Bioeng 93: 1079-1088.
18. Rivera, VM, Wang, X, Wardwell, S, Courage, NL, Volchuk, A, Keenan, T et al. (2000). Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 287: 826-830.
19. Burke, GT, Hu, SQ, Ohta, N, Schwartz, GP, Zong, L and Katsoyannis, PG (1990). Superactive insulins. Biochem Biophys Res Commun 173 982-987.
20. Schwartz, GP, Burke, GT and Katsoyannis, PG (1987). A superactive insulin: [B10-aspartic acid]insulin(human). Proc Natl Acad Sci USA 84: 6408-6411.
21. Miyoshi, H, Blömer, U, Takahashi, M, Gage, FH and Verma, IM (1998). Development of a self-inactivating lentivirus vector. J Virol 72: 8150-8157.
22. Bajaj, BG, Lei, P and Andreadis, ST (2005). Efficient gene transfer to human epidermal keratinocytes on fibronectin: in vitro evidence for transduction of epidermal stem cells. Mol Ther 11: 969-979.
23. Kumar, M, Keller, B, Makalou, N and Sutton, RE (2001). Systematic determination of the packaging limit of lentiviral vectors. Hum Gene Ther 12: 1893-1905.
24. Geer, DJ, Swartz, DD and Andreadis, ST (2005). Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo. Am J Pathol 167: 1575-1586.
25. Gomperts, BN, Belperio, JA, Fishbein, MC, Keane, MP, Burdick, MD and Strieter, RM (2007). Keratinocyte growth factor improves repair in the injured tracheal epithelium. Am J Respir Cell Mol Biol 37: 48-56.
26. Ray, P (2005). Protection of epithelial cells by keratinocyte growth factor signaling. Proc Am Thorac Soc 2: 221-225.
27. Palaparthy, R, Pradhan, R, Chan, J, Wang, Q, Ji, Q, Achari, R et al. (2005). Pharmacokinetics and safety of ABT-578, a sirolimus (rapamycin) analogue, after single intravenous bolus injection in healthy male volunteers. Clin Drug Investig 25: 491-498.
28. Valera, A, Fillat, C, Costa, C, Sabater, J, Visa, J, Pujol, A et al. (1994). Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations. FASEB J 8: 440-447.
29. Docherty, K (1997). Gene therapy for diabetes mellitus. Clin Sci (Lond) 92: 321-330.
30. Bailey, CJ, Davies, EL and Docherty, K (1999). Prospects for insulin delivery by ex-vivo somatic cell gene therapy. J Mol Med 77: 244-249.
31. Oh, TK, Li, MZ and Kim, ST (2006). Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus containing insulin gene. Diabetes Res Clin Pract 71: 233-240.
32. Ren, B, O'Brien, BA, Swan, MA, Koina, ME, Nassif, N, Wei, MQ et al. (2007). Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy. Diabetologia 50: 1910-1920.
33. Davis, SN and Granner, DK (eds) (2001). Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas. McGraw-Hill: New York.
34. 2 incorporation. Cell Mol Life Sci 60: 1019-1025.
35. 18F-labeled human C-peptide: Evaluation in monkeys using positron emission tomography. Life Sci 71: 1361-1370.
36. Fiorina, P, Folli, F, Bertuzzi, F, Maffi, P, Finzi, G, Venturini, M et al. (2003). Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. Diabetes Care 26: 1129-1136.
37. Fiorina, P, Folli, F, Maffi, P, Placidi, C, Venturini, M, Finzi, G et al. (2003). Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: A comparison between kidney-pancreas and kidney-alone transplantation. Transplantation 75: 1296-1301.
38. Chen, M, Kasahara, N, Keene, DR, Chan, L, Hoeffler, WK, Finlay, D et al. (2002). Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet 32: 670-675.
39. Woodley, DT, Keene, DR, Atha, T, Huang, Y, Ram, R, Kasahara, N et al. (2004). Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. Mol Ther 10: 318-326.
40. Siprashvili, Z and Khavari, PA (2004). Lentivectors for regulated and reversible cutaneous gene delivery. Mol Ther 9: 93-100.
41. McAllister, DV, Allen, MG and Prausnitz, MR (2000). Microfabricated microneedles for gene and drug delivery. Annu Rev Biomed Eng 2 289-313.
42. Prausnitz, MR (2001). Overcoming skin's barrier: The search for effective and user-friendly drug delivery. Diabetes Technol Ther 3: 233-236.
43. Kaushik, S, Hord, AH, Denson, DD, McAllister, DV, Smitra, S, Allen, MG et al. (2001). Lack of pain associated with microfabricated microneedles. Anesth Analg 92: 502-504.
44. Yant, SR, Huang, Y, Akache, B and Kay, MA (2007). Site-directed transposon integration in human cells. Nucleic Acids Res 35: e50.
45. Moehle, EA, Rock, JM, Lee, YL, Jouvenot, Y, DeKelver, RC, Gregory, PD et al. (2007). Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc Natl Acad Sci USA 104: 3055-3060.
46. Tiscornia, G, Singer, O and Verma, IM (2006). Production and purification of lentiviral vectors. Nat Protoc 1: 241-245.
47. Rivera, VM, Ye, X, Courage, NL, Sachar, J, Cerasoli, F Jr., Wilson, JM et al. (1999). Long-term regulated expression of growth hormone in mice after intramuscular gene transfer. Proc Natl Acad Sci USA 96: 8657-8662.
48. Koria, P and Andreadis, ST (2007). KGF promotes integrin alpha5 expression through CCAAT/enhancer-binding protein-beta. Am J Physiol Cell Physiol 293: C1020-C1031.