Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: Implications for treatment of diabetes

Tissue Engineering

Volumn 13, Issue 8, 2007, Pages 2119-2131

  Lei, Pedro ^a   Ogunade, Adebimpe ^a   Kirkwood, Keith L ^b   Laychock, Suzanne G ^c   Andreadis, Stelios T ^a  

^a the State University of New York   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ENGINEERING; PATIENT TREATMENT; PROTEINS; SKIN; TISSUE ENGINEERING;

EPIDERMIS; GENE THERAPY; KERATINOCYTES; SELF-RENEWING TISSUE;

INSULIN;

FURIN; GLUCOSE; INSULIN; PROINSULIN; RETROVIRUS VECTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ARTIFICIAL SKIN; CELL STRAIN 3T3; CONTROLLED STUDY; DIABETES MELLITUS; DNA MODIFICATION; EPIDERMIS; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TISSUE ENGINEERING;

3T3-L1 CELLS; ANIMALS; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; DIABETES MELLITUS; GENE THERAPY; HUMANS; INSULIN; KERATINOCYTES; MICE; PROINSULIN; SKIN, ARTIFICIAL; TRANSDUCTION, GENETIC;

EID: 34548064995     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2006.0210     Document Type: Article

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