Suppression of hyperglycemia in NOD mice after inoculation with recombinant vaccinia viruses

Molecular Biotechnology

Volumn 34, Issue 3, 2006, Pages 317-327

  Dénes, Béla ^a,b   Yu, Jie ^a   Fodor, Nadja ^a   Takátsy, Zsuzsanna ^a   Fodor, István ^a   Langridge, William H R ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRAL VETERINARY INSTITUTE   (Hungary)

Author keywords

Autoimmunity; Cholera toxin B subunit; GAD; IDDM; Insulin; Type 1 diabetes; Vaccinia virus

Indexed keywords

AUTOIMMUNITY; DIABETES; GLUTAMIC ACID DECARBOXYLASE (GAD); VACCINIA VIRUS;

AMINO ACIDS; GENES; INSULIN; MEDICAL PROBLEMS; PROTEINS; VIRUSES;

LIVING SYSTEMS STUDIES;

CHOLERA TOXIN B SUBUNIT; GLUTAMATE DECARBOXYLASE; IGG2C ANTIBODY; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 10; PARVOVIRUS VECTOR; PROINSULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; GENE FUSION; HUMORAL IMMUNITY; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SINGLE DRUG DOSE; VACCINIA VIRUS; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL LINE; CERCOPITHECUS AETHIOPS; CHOLERA TOXIN; DIABETES MELLITUS, TYPE 1; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEASIBILITY STUDIES; FEMALE; FIBROBLASTS; GENE THERAPY; GENES, SYNTHETIC; GENETIC VECTORS; GLUTAMATE DECARBOXYLASE; HYPERGLYCEMIA; IMMUNIZATION; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; INTERLEUKIN-10; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; PROINSULIN; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TH2 CELLS; VACCINIA VIRUS;

ANIMALIA; MUS; VACCINIA VIRUS;

EID: 33846867234     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:34:3:317     Document Type: Article

References (33)

1. Eisenbarth, G. (1986) Type I diabetes mellitus: a chronic autoimmune disease. N. Eng. J. Med. 314, 1360-1368.
2. Tisch, R. and McDevitt, H. (1996) Insulin-dependent diabetes mellitus. Cell 85, 291-297.
3. Czerkinsky, C., Anjuere, F., McGhee, J. R., et al. (1999) Mucosal immunity and tolerance: relevance to vaccine development. Immunol. Rev. 170, 197-222.
4. Bregenholt, S., Wang, M., Wolfe, T., et al. (2003) The cholera toxin B subunit is a mucosal adjuvant for oral tolerance induction in type 1 diabetes. Scand. J. Immunol. 57, 432-438.
5. Holmgren, J., Lycke, N., and Czerkinsky, C. (1993) Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine 11, 1179-1184.
6. Sadeghi, H., Bregenholt, S., Wegmannn, D., et al. (2002) Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo. Immunology 106, 237-245.
7. Sun, J. B., Holmgren, J., and Czerkinsky, C. (1994) Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc. Natl. Acad. Sci. USA 91, 10,795-10,799.
8. Nagamatsu, S., Nakamichi, Y., Ohara-Imaizumi, M., et al. (2001) Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y) mice. FEBS Lett. 509, 106-110.
9. Jun, H. S., Khil, L. Y., and Yoon, J. W. (2002) Role of glutamic acid decarboxylase in the pathogenesis of type 1 diabetes. Cell. Mol. Life Sci. 59, 1892-1901.
10. Hang, G., Li, Y., Wang, J., et al. (2005) Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD(500-585). J. Immunol. 174, 4516-4524.
11. Goudy, K., Song, S., Wasserfall, C., et al. (2001) Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice. Proc. Natl. Acad. Sci. USA 98, 13,913-13,918.
12. Yang, Z., Chen, M., Fialkow, L. B., et al. (200) Suppression of autoimmune diabetes by viral IL-10 gene transfer. J. Immunol. 168, 6479-6485.
13. Zhang, Y. C., Pileggi, A., Agarwal, A., et al. (2003) Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes 52, 708-716.
14. Oehen, S., Ohashi, P. S., Aichele, P., et al. (1992) Vaccination or tolerance to prevent diabetes. Eur. J. Immunol. 22, 3149-3153.
15. Ohashi, P. S., Oehen, S., Aichele, P., et al. (1993) Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha. J. Immunol. 150, 5185-5194.
16. Jun, H. S., Chung, Y. H., Han, J., et al. (2002) Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase. Diabetologia 45, 668-676.
17. Denes, B., Krausova, V., Yu, J., et al. (2005) Recombinant vaccinia viruses containing cholera toxin-islet autoantigen fusion genes protect NOD mice against autoimmune diabetes. J. Immunother. 28, 438-448.
18. Timiryasova, T. M., Chen, B., Haghighat, P., et al. (1999) Vaccinia virus-mediated expression of wild-type p53 suppresses glioma cell growth and induces apoptosis. Oncol. Res. 11, 133-144.
19. Chakrabarti, S., Sisler, J. R., and Moss, B. (1997) Compact, synthetic, vaccinia virus early/late promoter for protein expression. BioTechniques 23, 1094-1097.
20. Timiryasova, T. M., Chen, B., and Fodor, I. (2001) Replication-deficient vaccinia virus gene therapy vector: evaluation of exogenous gene expression mediated by PUV-inactivated virus in glioma cells. J. Gene Med. 3, 468-477.
21. Zhang, J., Davidson, L., Eisenbarth, G., et al. (1991) Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88, 10,252-10,256.
22. Arakawa, T., Chong, D. K., Merritt, J. L, et al. (1997) Expression of cholera toxin B subunit oligomers in transgenic potato plants. Transgenic Res. 6, 403-413.
23. Carter, J. D., Ellett, J. D., Chen, M., et al. (2005) Viral IL-10-mediated immune regulation in pancreatic islet transplantation. Mol. Ther. 12, 360-368.
24. Nakayama, M., Abiru, N., Moriyama, H., et al. (2005) Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435, 220-223.
25. Kent, S. C., Chen, Y., Bregoli, L., et al. 2005 Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435, 224-228.
26. Yang, Z., Chen, M., Wu, R., et al. (2002) Suppression of autoimmune diabetes by viral IL-10 gene transfer. J. Immunol. 168, 6479-6485.
27. Moss, B. (1991) Vaccinia virus: a tool for research and development. Science 252, 1660-1667.
28. Moss, B. (1996) Genetically engineered poxvirus for recombinant gene expression, vaccination and safety. Proc. Natl. Acad. Sci. USA 93, 11,341-11,348.
29. Taylor, G., Stott, E. J., Wertz, G., et al. (1991) Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice. J. Gen. Virol. 72, 125-130.
30. Verardi, P. H., Jones, L. A., Aziz, F. H., et al. (2001) Vaccinia virus vectors with an inactivated gamma interferon receptor homolog gene (B8R) are attenuated in vivo without a concomitant reduction in immunogenicity. J. Virol. 75, 11-18.
31. Bender, B. S., Rowe, C. A., Taylor, S. F., et al. (1996) Oral immunization with a replication-deficient recombinant vaccinia virus protects mice against influenza. J. Virol. 70, 6418-6424.
32. Etchart, N., Wild, F., and Kaiserlian, D. (1996) Mucosal and systemic immune responses to measles virus haemagglutinin in mice immunized with a recombinant vaccinia virus. J. Gen. Virol. 10, 2471-2478.
33. Arakawa, T., Chong, D. K. X., Yu, J., et al. (1998) A plant-based cholera toxin B subunit-insulin fusion protein protects against development of autoimmune daiabetes, Nat. Biotechnol. 16, 934-938.