Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice

Peptides

Volumn 30, Issue 5, 2009, Pages 962-966

  Kojima, Shinya ^a   Asakawa, Akihiro ^a   Amitani, Haruka ^a   Sakoguchi, Takeo ^a   Ueno, Naohiko ^b   Inui, Akio ^a   Kalra, Satya P ^c  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b Kobe Seaside Hospital   (Japan)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Diabetes mellitus; Gene therapy; Leptin; Longevity; Type 1

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROL GROUP; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; GENE THERAPY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERPHAGIA; INSULIN DEFICIENCY; INSULIN TREATMENT; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; DEPENDOVIRUS; DIABETES MELLITUS, EXPERIMENTAL; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HYPERGLYCEMIA; HYPERPHAGIA; INJECTIONS, INTRAVENTRICULAR; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; STREPTOZOCIN;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MUS;

EID: 67349144240     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.01.007     Document Type: Article

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