Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo

Immunology

Volumn 106, Issue 2, 2002, Pages 237-245

  Sadeghi, Hamid ^a   Bregenholt, Søren ^b   Wegmann, Dale ^c   Petersen, Jacob S ^b   Holmgren, Jan ^a   Lebens, Michael ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE; HUMAN INSULIN CHOLERA TOXIN CONJUGATE; HYBRID PROTEIN; INSULIN; INTERLEUKIN 2; MONOCLONAL ANTIBODY; OVALBUMIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; BETA CHAIN; BYSTANDER EFFECT; CARBOXY TERMINAL SEQUENCE; CELL INCLUSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ANTIGENICITY; DRUG RECEPTOR BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FUSION; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; WESTERN BLOTTING;

ANIMALS; ANTIGEN PRESENTATION; BYSTANDER EFFECT; CHOLERA TOXIN; FEMALE; HYBRIDOMAS; IMMUNE TOLERANCE; INSULIN; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTE SUBSETS;

EID: 0036278571     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2002.01413.x     Document Type: Article

References (39)

1. Cholera toxin: Genetic analysis, regulation, and role in pathogenesis
2. Receptors for cholera toxin and Escherichia coli heat-labile enterotoxin revisited
3. Development of oral vaccines against cholera and enterotoxinogenic Escherichia coli diarrhea
4. A randomized, controlled trial of the toxin-blocking effects of B subunit in family members of patients with cholera
5. Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues
6. Cholera toxin B subunit: An efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance
7. Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit
8. A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes
9. Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine
10. Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen presenting cells
11. ompT encodes the Escherichia coli outer membrane protease that cleaves T7 RNA polymerase during purification
12. Quantitative evaluation of Escherichia coli host strains for tolerance to cytosine methylation in plasmid and phage recombinants
13. The role of different protein components from the Haemophilus ducreyi cytolethal distending toxin in the generation of cell toxicity
14. Identification of Escherichia coli heat-labile enterotoxin by means of ganglioside immunosorbent assay (GM1-ELISA) procedure
15. Monoclonal antibodies to Escherichia coli heat-labile enterotoxins. Neutralizing activity and differentiation of human and porcine LTs and cholera toxin
16. Haematopoietic cell lines capable of colonizing the thymus following in vivo transfer of expressed T-cell receptor gamma-gene immature mRNA
17. A new model for analysing immune-modulation of T cell responses induced by oral administration of islet cells antigens
18. Human insulin B chain but not A chain decreases the rate of diabetes in BB rats
19. Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines
20. Antigen based therapies to prevent diabetes in NOD mice
21. Insulin in diabetes prevention
22. Expression of cholera toxin B subunit oligomers in transgenic potato plants
23. Insertion of a HIV-1-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunit
24. Fusions to the cholera toxin B subunit. Influence on pentamerization and GM1 binding
25. Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouse
26. Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children
27. + T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway
28. Bystander suppression induced by oral tolerance
29. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
30. + T cells that suppress adoptive transfer of diabetes
31. Immune responses to dietary antigens: Oral tolerance
32. Oral administration of recombinant cholera toxin subunit B inhibits IL-12-mediated murine experimental (trinitrobenzene sulfonic acid) colitis
33. Oral tolerance in disease
34. Immunization therapies in the prevention of diabetes
35. Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial
36. No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII)
37. Oral insulin and the induction of tolerance in man: Reality or fantasy?
38. Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: Its relevance for treatment in established diabetes and islet transplantation