Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy

Drug Discovery Today: Disease Models

Volumn 6, Issue 3, 2009, Pages 71-84

  Moreno, Jonathan D ^a   Clancy, Colleen E ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ANTIARRHYTHMIC AGENT; LIDOCAINE; MEXILETINE; NEUROHORMONE; NS 1643; POTASSIUM CHANNEL HERG; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ARRHYTHMOGENESIS; COMPUTER MODEL; DISEASE EXACERBATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG SENSITIVITY; EXCITATION CONTRACTION COUPLING; GENE MUTATION; GENOTYPE; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; HORMONAL REGULATION; HUMAN; LOW DRUG DOSE; NONHUMAN; PHENOTYPE; PREDICTION; REVIEW; SIGNAL TRANSDUCTION; SIMULATION; SPECIES DIFFERENCE;

EID: 77956638596     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2010.03.001     Document Type: Review

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