Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation

Circulation

Volumn 100, Issue 15, 1999, Pages 1660-1666

  Yan, Gan Xin ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

Electrocardiography; Electrophysiology; Fibrillation; J wave; Tachycardia; Ventricles

Indexed keywords

4 AMINOPYRIDINE; ACETYLCHOLINE; DISOPYRAMIDE; FLECAINIDE; ISOPRENALINE; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT; QUINIDINE; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DOG; ELECTROCARDIOGRAPHY; ENDOCARDIUM; EPICARDIUM; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART RIGHT VENTRICLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; NONHUMAN; PRIORITY JOURNAL; REENTRY ARRHYTHMIA; ST SEGMENT ELEVATION; SUDDEN DEATH;

EID: 0032879716     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.100.15.1660     Document Type: Article

References (33)

1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report. J Am Coll Cardiol. 1992;20: 1391-1396.
2. Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S. Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol. 1996;27:1061-1070.
3. Kasanuki H, Ohnishi S, Ohtuka M, Matsuda N, Nirei T, Isogai R, Shoda M, Toyoshima Y, Hosoda S. Idiopathic ventricular fibrillation induced with vagal activity in patients without obvious heart disease. Circulation. 1997;95:2277-2285.
4. Nademanee K. Sudden unexplained death syndrome in southeast Asia. Am J Cardiol. 1997;79:10-11.
5. 3: a marker for sudden death in patients without demonstrable structural heart disease. Circulation. 1998;97:457-460.
6. Brugada J, Brugada P. Further characterization of the syndrome of right bundle branch block, ST segment elevation, and sudden cardiac death. J Cardiovasc Electrophysiol. 1997;8:325-331.
7. Antzelevitch C. The Brugada syndrome. J Cardiovasc Electrophysiol. 1998;9:513-516.
8. Gussak I, Antzelevitch C, Bjerregaard P, Towbin JA, Chaitman BR. The Brugada syndrome: clinical, electrophysiological and genetic aspects. J Am Coll Cardiol. 1999;33:5-15.
9. Antzelevitch C, Brugada P, Brugada J, Brugada R, Nademanee K, Towbin JA. The Brugada Syndrome. Armonk, NY: Futura Publishing Co: 1999:1-99.
10. Litovsky SH, Antzelevitch C. Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ Res. 1988;62: 116-126.
11. to and action potential notch are smaller in left vs. right canine ventricular epicardium. Am J Physiol. 1996;271:H548-H561.
12. Yan GX, Antzelevitch C. Cellular basis for the electrocardiographic J wave. Circulation. 1996;93:372-379.
13. Di Diego JM, Antzelevitch C. Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues: does activation of ATP-regulated potassium current promote phase 2 reentry? Circulation. 1993;88:1177-1189.
14. Krishnan SC, Antzelevitch C. Flecainide-induced arrhythmia in canine ventricular epicardium: phase 2 reentry? Circulation. 1993;87:562-572.
15. 2+]-induced electrical heterogeneity and extrasystolic activity in isolated canine ventricular epicardium: phase 2 reentry. Circulation. 1994;89:1839-1850.
16. Lukas A, Antzelevitch C. Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia: the antiarrhythmic effects of 4-aminopyridine. Cardiovasc Res. 1996;32:593-603.
17. Yan GX, Shimizu W, Antzelevitch C. Characteristics and distribution of M cells in arterially-perfused canine left ventricular wedge preparations. Circulation. 1998;98:1921-1927.
18. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome. Circulation. 1998;98:1928-1936.
19. Imaizumi Y, Giles WR. Quinidine-induced inhibition of transient outward current in cardiac muscle. Am J Physiol. 1987;253:H704-H708.
20. Virag L, Varro A, Papp C. Effect of disopyramide on potassium currents in rabbit ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 1998;357:268-275.
21. Matsuo K, Shimizu W, Kurita T, Inagaki M, Aihara N, Kamakura S. Dynamic changes of 12-lead electrocardiograms in a patient with Brugada syndrome. J Cardiovasc Electrophysiol. 1998;9:508-512.
22. Lukas A, Antzelevitch C. Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia: role of the transient outward current. Circulation. 1993;88: 2903-2915.
23. Krishnan SC, Josephson ME. ST segment elevation induced by class IC antiarrhythmic agents: underlying electrophysiologic mechanisms and insights into drug-induced proarrhythmia. J Cardiovasc Electrophysiol. 1998;9:1167-1172.
24. Nakamura F, Segawa K, Ito H, Tanaka S, Yoshimoto N. Class Ic antiarrhythmic drugs, flecainide and pilsicainide, produce ST segment elevation simulating inferior myocardial ischemia. J Cardiovasc Electrophysiol. 1998;9:855-858.
25. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potreau D, Moya A, Borggrefe M, Breithardt G, Ortiz M, Wang Z, Antzelevitch C, O'Brien RE, Schultz-Bahr E, Keating MT, Towbin JA, Wang Q. Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation. Nature. 1997;392:293-296.
26. Matsuo K, Shimizu W, Kurita T, Suyama K, Aihara N, Kamakura S, Shimomura K. Increased dispersion of repolarization time determined by monophasic action potentials in two patients with familial idiopathic ventricular fibrillation. J Cardiovasc Electrophysiol. 1998;9:74-83.
27. Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S. Autonomie and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol. 1996;27: 1061-1070.
28. Chinushi M, Aizawa Y, Ogawa Y, Shiba M, Takahashi K. Discrepant drug action of disopyramide on ECG abnormalities and induction of ventricular arrhythmias in a patient with Brugada syndrome. J Electrocardiol. 1997;30:133-136.
29. Viskin S, Belhassen B. Increased vagal activity in idiopathic VF. Circulation. 1998;97:937-940. Letter and response.
30. + channel currents by quinidine. Circ Res. 1993;73:351-359.
31. Belhassen B, Shapira I, Shoshani D, Paredes A, Miller H, Laniado S. Idiopathic ventricular fibrillation: inducibility and beneficial effects of class I antiarrhythmic agents. Circulation. 1987;75:809-816.
32. Viskin S, Lesh MD, Eldar M, Fish R, Setbon I, Laniado S, Belhassen B. Mode of onset of malignant ventricular arrhythmias in idiopathic ventricular fibrillation. J Cardiovasc Electrophysiol. 1997;8:1115-1120.
33. Lukas A. Electrophysiology of myocardial cells in the epicardial, midmyocardial and endocardial layers of the ventricle. J Cardiovasc Pharmacol Ther. 1997;2:61-72.