Antiarrhythmic drugs and cardiac ion channels: Mechanisms of action

Progress in Biophysics and Molecular Biology

Volumn 70, Issue 1, 1998, Pages 1-72

  Carmeliet, Edward ^a   Mubagwa, Kanigula ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMBASILIDE; AMIODARONE; AMLODIPINE; ANTIARRHYTHMIC AGENT; ANTIHISTAMINIC AGENT; APRINDINE; AZIMILIDE; BUPIVACAINE; CIBENZOLINE; CLOFILIUM; DILTIAZEM; DISOPYRAMIDE; FLECAINIDE ACETATE; GLIBENCLAMIDE; INDAPAMIDE; LIDOCAINE; MEXILETINE; MORACIZINE; N [1 [4 (4 FLUOROPHENOXY)BUTYL] 4 PIPERIDINYL] N METHYL 2 BENZOTHIAZOLAMINE; NICARDIPINE; NIFEKALANT; NISOLDIPINE; PENTICAINIDE; PHENETURIDE; PROPAFENONE; QUINIDINE; TEDISAMIL; TOCAINIDE; TOLBUTAMIDE; UNINDEXED DRUG; VERAPAMIL;

ANIMAL; ANTIARRHYTHMIC ACTIVITY; CALCIUM CHANNEL; CALCIUM CURRENT; CHANNEL GATING; DRUG EFFECT; DRUG PROTEIN BINDING; ELECTROPHYSIOLOGY; HEART; HEART ARRHYTHMIA; HEART MUSCLE POTENTIAL; HUMAN; ION CHANNEL; NONHUMAN; PHYSIOLOGY; POTASSIUM CHANNEL; POTASSIUM CURRENT; REVIEW; SODIUM CHANNEL; SODIUM CURRENT;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNELS; ELECTROPHYSIOLOGY; HEART; HUMANS; ION CHANNELS; POTASSIUM CHANNELS; SODIUM CHANNELS;

ANIMALIA;

EID: 0031697564     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0079-6107(98)00002-9     Document Type: Review

References (438)

1. Aguilar Bryan, L., Nichols, C. G., Wechsler, S. W., Clement, J. P. T., Boyd, A. E. R., Gonzalez, G., Herrera Sosa, H., Nguy, K., Bryan, J., Nelson, D. A., 1995. Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion (see comments). Science 268, 423-426.
2. Alpert, L. A., Fozzard, H. A., Hanck, D. A., Makielski, J. C., 1989. Is there a second external lidocaine binding site on mammalian cardiac cells? Am. J. Physiol. 257, H79-H84.
3. Alvarez, J. L., Vassort, G., 1992. Properties of the low threshold Ca current in single frog atrial cardiomyocytes. A comparison with the high threshold Ca current. J. Gen. Physiol. 100, 519-545.
4. + channels. Circ. Res. 79, 103-108.
5. Anno, T., Hondeghem, L. M., 1990. Interactions of flecainide with guinea pig cardiac sodium channels. Importance of activation unblocking to the voltage dependence of recovery. Circ. Res. 66, 789-803.
6. Anyukhovsky, E. P., Rosen, M. R., 1991. Abnormal automatic rhythms in ischemic Purkinje fibers are modulated by a specific alpha 1-adrenergic receptor subtype. Circulation 83, 2076-2082.
7. Arena, J. P., Kass, R. S., 1988. Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked. Mol. Pharmacol. 34, 60-66.
8. Armstrong, C. M., 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58, 413-437.
9. 2+ exchanger by phenylephrine, angiotensin II and endothelin 1. J. Mol. Cell. Cardiol 28, 11-17.
10. Balser, J. R., Bennett, P. B., Hondeghem, L. M., Roden, D. M., 1991. Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodarone. Circ. Res. 69, 519-529.
11. Balser, J. R., Nuss, H. B., Romashko, D. N., Marban, E., Tomaselli, G. F., 1996. Functional consequences of lidocaine binding to slow-inactivated sodium channels. J. Gen. Physiol. 107, 643-658.
12. Barber, M. J., Wendt, D. J., Starmer, C. F., Grant, A. O., 1992. Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs. J. Clin. Invest. 90, 368-381.
13. Bean, B. P., 1984. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc. Natn. Acad. Sci. U.S.A. 81, 6388-6392.
14. Bean, B. P., 1985. Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. J. Gen. Physiol. 86, 1-30.
15. Bean, B. P., Cohen, C. J., Tsien, R. W., 1983. Lidocaine block of cardiac sodium channels. J. Gen. Physiol. 81, 613-642.
16. + current in rabbits. J. Cardiovasc. Pharmacol 28, 618-630.
17. Bechem, M. & Schramm, M. (1988) Electrophysiology of dihydropyridine calcium agonists. In M. Morad, W. Nayler, S. Kazda & M. Schramm (Eds), The Calcium Channel: Structure, Function and Implications (pp. 63-70). Berlin: Springer-Verlag.
18. Belardinelli, L., Lu, J., Dennis, D., Martens, J., Shryock, J. C., 1994. The cardiac effects of a novel Al-adenosine receptor agonist in guinea pig isolated heart. J. Pharmacol. Exp. Ther 271, 1371-1382.
19. Belardinelli, L., Shryock, J. C., Song, Y., Wang, D., Srinivas, M., 1995. Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. FASEB J. 9, 359-365.
20. Benndorf, K., Friedrich, M., Hirche, H., 1991. Reoxygenation-induced arrhythmogenic transient inward currents in isolated cells of the guinea-pig heart. Pflugers Arch 418, 248-260.
21. + channels. Modification of block by alterations in the alpha-subunit III-IV interdomain. Circ. Res. 77, 584-592.
22. + channels to antiarrhythmic drugs: the role of inactivation. J. Membr. Biol. 122, 267-278.
23. + channels to antiarrhythmic drugs: no flicker blockade by lidocaine. J. Membr. Biol 126, 257-263.
24. + channels and their sensitivity to antiarrhythmics: is there a hidden drug receptor? J. Membr. Biol 139, 191-201.
25. Billman, G. E., 1994. Effect of alpha 1-adrenergic receptor antagonists on susceptibility to malignant arrhythmias: protection from ventricular fibrillation. J. Cardiovasc. Pharmacol. 24, 394-402.
26. Bois, P., Bescond, J., Renaudon, B., Lenfant, J., 1996. Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br. J. Pharmacol. 118, 1051-1057.
27. BoSmith, R. E., Briggs, I., Sturgess, N. C., 1993. Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. Br. J. Pharmacol. 110, 343-349.
28. Bouchard, R., Fedida, D., 1995. Closed- and open-state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J. Pharmacol. Exp. Ther 275, 864-876.
29. Boutjdir, M., Restivo, M., Wei, Y., el Sherif, N., 1992. Alpha 1- and beta-adrenergic interactions on L-type calcium current in cardiac myocytes. Pflugers Arch 421, 397-399.
30. Bril, A., Forest, M. C., Cheval, B., Landais, L., Gout, B., 1994. Effect of zatebradine, a specific bradycardic agent, on ischemia-induced arrhythmias in anesthetized rabbits. Pharmacology 48, 308-319.
31. Bril, A., Gout, B., Bonhomme, M., Landais, L., Faivre, J. F., Linee, P., Poyser, R. H., Ruffolo, R. R., Jr, 1996. Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: experimental profile of BRL-32872. J. Pharmacol. Exp. Ther 276, 637-646.
32. Broughton, A., Grant, A. O., Starmer, C. F., Klinger, J. K., Stambler, B. S., Strauss, H. C., 1984. Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium. Circ. Res. 55, 513-523.
33. Brown, A. M., Kunze, D. L., Yatani, A., 1986. Dual effects of dihydropyridines on whole cell and unitary calcium currents in single ventricular cells of guinea-pig. J. Physiol. Lond. 379, 495-514.
34. 2+ channels. Ann. N.Y. Acad. Sci. 560, 373-386.
35. Busch, A. E., Malloy, K., Groh, W. J., Varnum, M. D., Adelman, J. P., Maylie, J., 1994. The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochem. Biophys. Res. Commun. 202, 265-270.
36. sK channels by the chromanol 293B. Pflügers Arch, Eur. J. Physiol. 432, 1094-1096.
37. Buxton, I. L., Brunton, L. L., 1985. Action of the cardiac alpha 1-adrenergic receptor. Activation of cyclic AMP degradation. J. Biol. Chem. 260, 6733-6737.
38. Cahalan, M. D., Almers, W., 1979. Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin. Biophys. J. 27, 39-55.
39. Campbell, D. L., Qu, Y., Rasmusson, R. L., Strauss, H. C., 1993. The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine. J. Gen. Physiol. 101, 603-626.
40. Campbell, T. J., 1983a. Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification. Cardiovasc. Res. 17, 344-352.
41. Campbell, T. J., 1983b. Resting and rate-dependent depression of maximum rate of depolarisation (Vmax) in guinea pig ventricular action potentials by mexiletine, disopyramide, and encainide. J. Cardiovasc. Pharmacol. 5, 291-296.
42. Carlsson, L., Abrahamsson, C., Andersson, B., Duker, G., Schiller Linhardt, G., 1993. Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations (see comments). Cardiovasc. Res. 27, 2186-2193.
43. Carlsson, L., Abrahamsson, C., Drews, L., Duker, G., 1992. Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization (see comments). Circulation 85, 1491-1500.
44. Carmeliet, E., 1980. Electrophysiological effects of encainide on isolated cardiac muscle and Purkinje fibers and on the Langendorffperfused guinea-pig heart. European Journal of Pharmacology 61, 247-262.
45. Carmeliet, E., 1985a. Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers. J. Pharmacol. Exp. Ther 232, 817-825.
46. Carmeliet, E. (1985b) Slow decay of sodium current and effect of quinidine in rabbit cardiac Purkinje fibers. In D. P. Zipes & J. Jalife (eds), Cardiac Electrophysiology and Arrhythmias (pp. 207-215). New York: Greene and Strattton.
47. Carmeliet, E., 1987. Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibers. Biophys. J. 51, 109-114.
48. + channel of rabbit cardiac Purkinje fibers. Circ. Res. 63, 50-60.
49. Carmeliet, E., 1988b. Slowly developing activation block of cardiac sodium channels by a lidocaine analog, transcainide. J. Cardiovasc. Pharmacol. 12, 110-115.
50. + current in cardiac myocytes by dofetilide. J. Pharmacol. Exp. Ther 262, 809-817.
51. + current by almokalant in rabbit ventricular myocytes. Circ. Res. 73, 857-868.
52. + current in rabbit ventricular myocytes. Cardiovasc. Drugs Ther. 3, 599-604.
53. Carmeliet, E. (1996) Block of delayed rectifier K+ current in cardiac cells: requirements for efficient antiarrhythmic activity. In J. Toyama, M. Hiraoka & I. Kodama (eds), Recent Progress in Electropharmacology of the Heart (pp. 133-138). Boca Raton: CRC Press.
54. Carmeliet, E. & Gruber, R. (1989) Local anesthetic and cardiac sodium channels: Modalities of block. In J. Toyama & L. M. Hondeghem (eds), Current Topics in Antiarrhythmic Agents. Mode of Action and Clinical Usage (pp. 65-72). Tokyo: Excerpta Medica.
55. + channels in guinea-pig ventricular myocytes by the local anaesthetic penticainide. J. Physiol. Lond. 409, 241-262.
56. Carmeliet, E., Saikawa, T., 1982. Shortening of the action potential and reduction of pacemaker activity by lidocaine, quinidine, and procainamide in sheep cardiac purkinje fibers. An effect on Na or K currents? Circ. Res. 50, 257-272.
57. + channel in cardiac cells. Eur. J. Pharmacol. 196, 53-60.
58. + current in adult rat ventricular myocytes (corrected and republished with original paging, article originally printed in J. Pharmacol. Exp. Ther. 1993 Mar, 264(3), 1450-1459). J. Pharmacol. Exp. Ther 265, 1450-1459.
59. 2+ channel antagonists. Trends Pharmacol. Sci. 13, 256-262.
60. + channel. Circ. Res. 72, 707-714.
61. Charnet, P., Ouadid, H., Richard, S., Nargeot, J., 1987. Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers. Fundam. Clin. Pharmacol. 1, 413-431.
62. Chen, C. C., Morishige, N., Masuda, M., Lin, W., Wieland, W., Thone, F., Mubagwa, K., Borgers, M., Flameng, W., 1993. R56865, a Na(+)- and Ca(2+)-overload inhibitor, reduces myocardial ischemia-reperfusion injury in blood-perfused rabbit hearts. J. Mol. Cell. Cardiol. 25, 1445-1459.
63. 2+ currents in cardiac ventricular myocytes. Circ. Res. 79, 184-193.
64. + current in rabbit ventricular myocytes. Cardiovasc. Res. 31, 963-974.
65. Chernoff, D. M., Strichartz, G. R., 1990. Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys. J. 58, 69-81.
66. Chester, D. W., Herbette, L. G., Mason, R. P., Joslyn, A. F., Triggle, D. J., Koppel, D. E., 1987. Diffusion of dihydropyridine calcium channel antagonists in cardiac sarcolemmal lipid multibilayers. Biophysical Journal 52, 1021-1030.
67. Clague, J. R., Langer, G. A., 1994. The pathogenesis of free radical-induced calcium leak in cultured rat cardiomyocytes. J. Mol. Cell. Cardiol. 26, 11-21.
68. + current in rat ventricle. Br. J. Pharmacol. 115, 335-343.
69. Cohen, C. J., Spires, S., Van Skiver, D., 1992. Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J. Gen. Physiol. 100, 703-728.
70. Collier, M. L., Hume, J. R., 1995. Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes. Circ. Res. 76, 317-324.
71. Coraboeuf, E., Deroubaix, E., Coulombe, A., 1979. Effect of tetrodotoxin on action potentials of the conducting system in the dog heart. Am. J. Physiol. 236, H561-H567.
72. Cordeiro, J. M., Howlett, S. E., Ferrier, G. R., 1994. Simulated ischaemia and reperfusion in isolated guinea pig ventricular myocytes. Cardiovasc. Res. 28, 1794-1802.
73. Coulombe, A., Lefevre, I. A., Baro, I., Coraboeuf, E., 1989. Barium- and calcium-permeable channels open at negative membrane potentials in rat ventricular myocytes. J. Membr. Biol 111, 57-67.
74. Covino, B. G., 1986. Recent advances in local anaesthesia. Can. Anaesth. Soc. J. 33, S5-S8.
75. Crumb, W. J., Jr, Wible, B., Arnold, D. J., Payne, J. P., Brown, A. M., 1995. Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity. Mol. Pharmacol. 47, 181-190.
76. Cui, G., Sen, L., Sager, P., Uppal, P., Singh, B. N., 1994. Effects of amiodarone, sematilide, and sotalol on QT dispersion. Am. J. Cardiol. 74, 896-900.
77. Daleau, P., Lessard, E., Groleau, M. F., Turgeon, J., 1995. Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes. Circulation 91, 3010-3016.
78. Davies, M. P., Freeman, L. C., Kass, R. S., 1996. Dual actions of the novel class III antiarrhythmic drug NE-10064 on delayed potassium channel currents in guinea pig ventricular and sinoatrial node cells. J. Pharmacol. Exp. Ther 276, 1149-1154.
79. Delgado, C., Tamargo, J., Henzel, D., Lorente, P., 1993. Effects of propafenone on calcium current in guinea-pig ventricular myocytes. Br. J. Pharmacol. 108, 721-727.
80. Dennis, D. M., Raatikainen, M. J., Martens, J. R., Belardinelli, L., 1996. Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart. Circulation 94, 2551-2559.
81. DiFrancesco, D., 1993. Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol 55, 455-472.
82. DiFrancesco, D., 1994. Some properties of the UL-FS 49 block of the hyperpolarization-activated current (i(f)) in sino-atrial node myocytes. Pflugers Arch 427, 64-70.
83. DiFrancesco, D., Tortora, P., 1991. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 351, 145-147.
84. DiMarco, J. P., 1987. Adenosine and supraventricular tachycardia. Prog. Clin. Biol. Res. 230, 271-281.
85. Doerr, T., Trautwein, W., 1990. On the mechanism of the "specific bradycardic action" of the verapamil derivative. UL Naunyn Schmiedebergs Arch Pharmacol 341, 331-340.
86. Duan, D., Fermini, B., Nattel, S., 1993. Potassium channel blocking properties of propafenone in rabbit atrial myocytes. J. Pharmacol. Exp. Ther 264, 1113-1123.
87. - currents in rabbit atrial myocytes. Characterization of a novel ionic regulatory mechanism. Circ. Res. 77, 379-393.
88. 3H]Dofetilide binding to cardiac myocytes: modulation by extracellular potassium. J. Mol. Cell. Cardiol. 29, 189-191.
89. + currents in mammalian cardiac and glial cells. J. Pharmacol. Exp. Ther 254, 560-569.
90. Ehrlich, B. E., Kaftan, E., Bezprozvannaya, S., Bezprozvanny, I., 1994. The pharmacology of intracellular Ca(2+)-release channels. Trends Pharmacol. Sci. 15, 145-149.
91. Escande, D., Coraboeuf, E., Planche, C., 1987. Abnormal pacemaking is modulated by sarcoplasmic reticulum in partially-depolarized myocardium from dilated right atria in humans. J. Mol. Cell. Cardiol. 19, 231-241.
92. + current acting as pure class III antiarrhythmic agents. J. Cardiovasc. Pharmacol. 20, S106-S113.
93. + channels in guinea-pig cardiac myocytes. Pflugers Arch 414, 669-675.
94. Falk, R. H., 1996. Pharmacologic control of heart rate in atrial fibrillation. Cardiol. Clin. 14, 521-536.
95. Fan, Z., Nakayama, K., Hiraoka, M., 1990. Multiple actions of pinacidil on adenosine triphosphate-sensitive potassium channels in guinea-pig ventricular myocytes. J. Physiol. Lond. 430, 273-295.
96. Fedida, D., 1997. Gating charge and ionic currents associated with quinidine block of human Kv1.5 delayed rectifier channels. Journal of Physiology 499, 661-675.
97. + current in rabbit ventricular myocytes. J. Physiol. Lond. 441, 673-684.
98. Fedida, D., Braun, A. P., Giles, W. R., 1993a. Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiol. Rev. 73, 469-487.
99. + channel current. Circ. Res. 73, 210-216.
100. Fei, L., Gill, J. S., McKenna, W. J., Camm, A. J., 1993. Effects of propafenone on calcium currents in single ventricular myocytes of guinea-pig. Br. J. Pharmacol. 109, 178-182.
101. Feng, J., Wang, Z., Li, G. R., Nattel, S., 1997. Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes. J. Pharmacol. Exp. Ther 281, 384-392.
102. Fermini, B., Wang, Z., Duan, D., Nattel, S., 1992. Differences in rate dependence of transient outward current in rabbit and human atrium. Am. J. Physiol. 263, H1747-H1754.
103. Ferrier, G. R., Moffat, M. P., Lukas, A., 1985. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion. Studies on isolated canine ventricular tissues. Circ. Res. 56, 184-194.
104. Ferrier, G. R., Saunders, J. H., Mendez, C., 1973. A cellular mechanism for the generation of ventricular arrhythmias by acetylstrophanthidin. Circ. Res. 32, 600-609.
105. + channels in cardiac muscle. J. Pharmacol. Exp. Ther 262, 71-79.
106. Findlay, I., 1993a. Effects of glibenclamide upon ATP-sensitive K channels during metabolic inhibition of isolated rat cardiac myocytes. Cardiovasc. Drugs Ther. 3, 495-497.
107. + channels during metabolic stress in cardiac muscle. J. Pharmacol. Exp. Ther 266, 456-467.
108. Firek, L., Giles, W. R., 1995. Outward currents underlying repolarization in human atrial myocytes. Cardiovasc. Res. 30, 31-38.
109. Fish, F. A., Prakash, C., Roden, D. M., 1990. Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators. Circulation 82, 1362-1369.
110. Follmer, C. H., Aomine, M., Yeh, J. Z., Singer, D. H., 1987. Amiodarone-induced block of sodium current in isolated cardiac cells. J. Pharmacol. Exp. Ther 243, 187-194.
111. Follmer, C. H., Colatsky, T. J., 1990. Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes. Circulation 82, 289-293.
112. Follmer, C. H., Cullinan, C. A., Colatsky, T. J., 1992. Differential block of cardiac delayed rectifier current by class Ic antiarrhythmic drugs: evidence for open channel block and unblock. Cardiovasc. Res. 26, 1121-1130.
113. Franckowiak, G., Bechem, M., Schramm, M., Thomas, G., 1985. The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur. J. Pharmacol. 114, 223-226.
114. + current by quinidine in rabbit sinoatrial and atrioventricular nodes. J. Pharmacol. Exp. Ther 251, 756-763.
115. + channel to the actin cytoskeleton. Pflugers Arch 431, 504-512.
116. Furukawa, Y., Xue, Y. X., Chiba, S., Hashimoto, K., 1996b. Effects of zatebradine on ouabain-, two-stage coronary ligation- and epinephrine-induced ventricular tachyarrhythmias. European Journal of Pharmacology 300, 203-210.
117. + pump current-voltage relationship in guinea-pig ventricular myocytes. Journal of Physiology 494, 697-708.
118. + channels by a quaternary ammonium ion: catalysis by a transition-intermediate state? J. Physiol. Lond. 471, 319-341.
119. Gintant, G. A., Hoffman, B. F., 1984. Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine. Pflugers Arch 400, 121-129.
120. Goethal̈s, M., Raes, A., van Bogaert, P. P., 1993. Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 88, 2389-2401.
121. 2+ antagonists and agonists in rabbit cardiac myocytes. Am. J. Physiol. 260, H1737-H1742.
122. Grant, A. O. (1991) Blockade of ion channels by antiarrhytmic drugs. J Cardiovasc Electrophysiol 2 (Supplement), S153-S168.
123. Grant, A. O., Dietz, M. A., Gilliam, F. R. D., Starmer, C. F., 1989. Blockade of cardiac sodium channels by lidocaine. Single-channel analysis. Circ. Res. 65, 1247-1262.
124. Grant, A. O., John, J. E., Nesterenko, V. V., Starmer, C. F., Moorman, J. R., 1996. The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels. Mol. Pharmacol 50, 1643-1650.
125. Grant, A. O., Strauss, L. J., Wallace, A. G., Strauss, H. C., 1980. The influence of pH on th electrophysiological effects of lidocaine in guinea pig ventricular myocardium. Circ. Res. 47, 542-550.
126. Grant, A. O., Trantham, J. L., Brown, K. K., Strauss, H. C., 1982. PH-Dependent effects of quinidine on the kinetics of dV/dtmax in guinea pig ventricular myocardium. Circ. Res. 50, 210-217.
127. Grant, A. O., Wendt, D. J., Zilberter, Y., Starmer, C. F., 1993. Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. J. Membr. Biol 136, 199-214.
128. Gross, G. J., Burke, R. P., Castle, N. A., 1995. Characterisation of transient outward current in young human atrial myocytes. Cardiovasc. Res. 29, 112-117.
129. Gruber, R., Carmeliet, E., 1989. The activation gate of the sodium channel controls blockade and deblockade by disopyramide in rabbit Purkinje fibres. Br. J. Pharmacol. 97, 41-50.
130. + current of guinea-pig ventricular myocytes. J. Physiol. Lond. 435, 65-81.
131. + channel activities of cultured rat cardiomyocytes. J. Mol. Cell. Cardiol. 29, 559-569.
132. Guo, J., Ono, J. K., Noma, A., 1995. A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells. J. Physiol. Lond. 483, 1-13.
133. Gurney, A. M., Nerbonne, J. M., Lester, H. A., 1985. Photoinduced removal of nifedipine reveals mechanisms of calcium antagonist action on single heart cells. J. Gen. Physiol. 86, 353-379.
134. Hadley, R. W., Lederer, W. J., 1995. Nifedipine inhibits movement of cardiac calcium channels through late, but not early, gating transitions. Am. J. Physiol. 269, H1784-H1790.
135. Hagiwara, N., Irisawa, H., Kameyama, M., 1988. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J. Physiol. Lond. 395, 233-253.
136. Hanck, D. A., Makielski, J. C., Sheets, M. F., 1994. Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J. Gen. Physiol. 103, 19-43.
137. ks in guinea-pig isolated ventricular myocytes. Exp. Physiol. 81, 587-603.
138. Henry, P., Escande, D., 1994. Do potassium channel openers compete with ATP to activate ATP sensitive potassium channels? Cardiovasc. Res. 28, 754-759.
139. Hescheler, J., Pelzer, D., Trube, G., Trautwein, W., 1982. Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane? Pflugers Arch 393, 287-291.
140. Hess, P., Lansman, J. B., Tsien, R. W., 1984. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 311, 538-544.
141. Hille, B., 1977. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69, 497-515.
142. Hille, B. (1992) Ionic Channels of Excitable Membranes, Sinauer Associates Inc., Sunderland, Massachussets.
143. + current by nicorandil (2-nicotinamidoethyl nitrate) in isolated ventricular myocytes. J. Pharmacol. Exp. Ther 250, 278-285.
144. Hondeghem, L. M., 1991. Ideal antiarrhythmic agents: chemical defribrillators. J Cardiovasc Electrophysiol 2, S169-S177.
145. Hondeghem, L. M., Katzung, B. G., 1977. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta 472, 373-398.
146. Hondeghem, L. M., Katzung, B. G., 1984. Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs. Annu. Rev. Pharmacol. Toxicol. 24, 387-423.
147. Hondeghem, L. M., Matsubara, T., 1988. Quinidine blocks cardiac sodium channels during opening and slow inactivation in guineaopig papillarumuscle. Br. J. Pharmacol. 93, 311-318.
148. Hondeghem, L. M., Snyders, D. J., 1990. Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. Circulation 81, 686-690.
149. Honjo, H., Kodama, I., Kamiya, K., Toyama, J., 1991. Block of cardiac sodium channels by amiodarone studied by using Vmax of action potential in single ventricular myocytes. Br. J. Pharmacol. 102, 651-656.
150. Honjo, H., Watanabe, T., Kamiya, K., Kodama, I., Toyama, J., 1989. Effects of propafenone on electrical and mechanical activities of single ventricular myocytes isolated from guinea-pig hearts. Br. J. Pharmacol. 97, 731-738.
151. Horie, M., Hayashi, S., Yuzuki, Y., Sasayama, S., 1992. Comparative studies of ATP sensitive potassium channels in heart and pancreatic beta cells using Vaughan-Williams class Ia antiarrhythmics. Cardiovasc. Res. 26, 1087-1094.
152. + channels. J. Pharmacol. Exp. Ther 234, 134-140.
153. Hume, J. R., Harvey, R. D., 1991. Chloride conductance pathways in heart. Am. J. Physiol 261, C399-412.
154. Iijima, T., Yanagisawa, T., Taira, N., 1984. Increase in the slow inward current by intracellularly applied nifedipine and nicardipine in single ventricular cells of the guinea-pig heart. J. Mol. Cell. Cardiol. 16, 1173-1177.
155. Imaizumi, Y., Giles, W. R., 1987. Quinidine-induced inhibition of transient outward current in cardiac muscle. Am. J. Physiol. 253, H704-H708.
156. Imanishi, S., Arita, M., Aomine, M., Kiyosue, T., 1984. Antiarrhythmic effects of nicorandil on canine cardiac Purkinje fibers. J. Cardiovasc. Pharmacol. 6, 772-779.
157. + channels. Neuron 16, 1011-1017.
158. Inagaki, N., Gonoi, T., Clement, J. P. T., Namba, N., Inazawa, J., Gonzalez, G., Aguilar Bryan, L., Seino, S., Bryan, J., 1995. Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor (see comments). Science 270, 1166-1170.
159. Innes, G. D., Vertesi, L., Dillon, E. C., Matcalfe, C., 1997. Effectiveness of verapamil-quinidine versus digoxin-quinidine in the emergency department treatment of paroxysmal atrial fibrillation. Ann. Emerg. Med. 29, 126-134.
160. Inomata, N., Ishihara, T., Akaike, N., 1989. Different time courses of the blockade of sodium current by lignocaine and SUN 1165 in single myocytes isolated from guinea-pig atrium. Br. J. Pharmacol. 98, 149-154.
161. Isenberg, G. (1985) Contractility of isolated bovine ventricular myocytes is enhanced by intracellular injection of cardiac glycosides. Evidence for an intracellular mode of action. In E. Erdmann (ed.) Cardiac Glycoside Receptors and Positive Inotropy (pp. 56-71). Darmstadt: Steinkopf.
162. + current in guinea pig atrial myocytes. Jpn. J. Pharmacol. 71, 361-365.
163. + channel in ferret ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 351, 610-617.
164. + channels in rabbit sino-atrial node cells. J. Physiol. Lond. 476, 55-68.
165. + channel in guinea-pig ventricular cell membrane. J. Physiol. Lond. 478, 101-107.
166. 2+ exchanger via protein kinase C. J. Biol. Chem. 271, 13609-13615.
167. Jahangir, A., Terzic, A., Kurachi, Y., 1994. Intracellular acidification and ADP enhance nicorandil induction of ATP sensitive potassium channel current in cardiomyocytes. Cardiovasc. Res. 28, 831-835.
168. Jahnel, U., Klemm, P., Nawrath, H., 1994. Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 349, 87-94.
169. Janse, M. J., 1992. Putting the Sicilian Gambit to the test. Eur. Heart J. 13, 30-37.
170. Janse, M. J., Wit, A. L., 1989. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol. Rev. 69, 1049-1169.
171. Johns, J. A., Anno, T., Bennett, P. B., Snyders, D. J., Hondeghem, L. M.,
172. Josephson, I. R., Cui, Y., 1994. Voltage- and concentration-dependent effects of lidocaine on cardiac Na channel gating charge movements. Pflugers Arch 428, 485-491.
173. Ju, Y. K., Saint, D. A., Gage, P. W., 1992. Effects of lignocaine and quinidine on the persistent sodium current in rat ventricular myocytes. Br. J. Pharmacol. 107, 311-316.
174. + current by dofetilide. Circ. Res. 72, 75-83.
175. + current. IKr. Circulation 94, 2938-2946.
176. Kaftan, E., Marks, A. R., Ehrlich, B. E., 1996. Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle. Circ. Res. 78, 990-997.
177. Kamiya, K., Cheng, J., Kodama, I. & Toyama, J. (1996) Acute and chronic effects of amiodarone on action potential and ionic currents in single ventricular myocytes. In J. Toyama, M. Hiraoka & I. Kodama (eds), Recent Progress in Electropharmacology of the Heart (pp. 139-149). Boca Raton: CRC Press.
178. Kamiya, K., Toyama, J., Honjo, H., Kodama, I., 1992. A model analysis for competitive binding of mexiletine and aprindine to the cardiac sodium channel. Pharmacology 44, 260-268.
179. Kamp, T. J., Sanguinetti, M. C., Miller, R. J., 1989. Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791. Circ. Res. 64, 338-351.
180. Kanaya, S., Katzung, B. G., 1984. Effects of diltiazem on transmembrane potential and current of right ventricular papillary muscle of ferrets. J. Pharmacol. Exp. Ther 228, 245-251.
181. Kanda, A., Watanabe, I., Williams, M. L., Engle, C. L., Li, S., Koch, G. G., Gettes, L. S., 1997. Unanticipated lessening of the rise in extracellular potassium during ischemia by pinacidil. Circulation 95, 1937-1944.
182. Kass, R. S., 1987. Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K 8644: implications for channel gating. Circ. Res. 61, I1-I5.
183. Kass, R. S., Arena, J. P., 1989. Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor. J. Gen. Physiol. 93, 1109-1127.
184. Kass, R. S., Arena, J. P., Chin, S., 1991. Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium. J. Gen. Physiol. 98, 63-75.
185. Kass, R. S., Krafte, D. S., 1987. Negative surface charge density near heart calcium channels. Relevance to block by dihydropyridines. J. Gen. Physiol. 89, 629-644.
186. Kawano, S., Nakamura, F., Tanaka, T., Hiraoka, M., 1992. Cardiac sarcoplasmic reticulum chloride channels regulated by protein kinase A. Circ. Res. 71, 585-589.
187. Kawashima, Y., Ochi, R., 1988. Voltage-dependent decrease in the availability of single calcium channels by nitrendipine in guinea-pig ventricular cells. J. Physiol. Lond. 402, 219-235.
188. Kerr, M. J., Wilson, R., Shanks, R. G., 1985. Suppression of ventricular arrhythmias after coronary artery ligation by pinacidil, a vasodilator drug. J. Cardiovasc. Pharmacol. 7, 875-883.
189. Kiehn, J., Lacerda, A. E., Wible, B., Brown, A. M., 1996a. Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide. Circulation 94, 2572-2579.
190. Kiehn, J., Wible, B., Lacerda, A. E., Brown, A. M., 1996b. Mapping the block of a cloned human inward rectifier potassium channel by dofetilide. Mol. Pharmacol. 50, 380-387.
191. Kim, D., Clapham, D. E., 1989. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science 244, 1174-1176.
192. Kimura, S., Bassett, A. L., Xi, H., Myerburg, R. J., 1992. Verapamil diminishes action potential changes during metabolic inhibition by blocking ATP-regulated potassium currents. Circ. Res. 71, 87-95.
193. Kimura, T., Imanishi, S., Arita, M., Hadama, T., Shirabe, J., 1988. Two differential mechanisms of automaticity in diseased human atrial fibers. Jpn. J. Physiol. 38, 851-867.
194. Kodama, I., Honjo, H., Kamiya, K., Toyama, J., 1990. Two types of sodium channel block by class-I antiarrhythmic drugs studied by using Vmax of action potential in single ventricular myocytes. J. Mol. Cell. Cardiol. 22, 1-12.
195. Kodama, I., Kamiya, K. & Toyama, J. (1997) Cellular electropharmacology of amiodarone. Cardiovascular Research (in press).
196. Kodama, I., Toyama, J., Yamada, K., 1986. Open and inactivated sodium channel block by class-I antiarrhythmic drugs. Jpn Heart J. 1, 83-89.
197. + channels by antiarrhythmic drugs: the effect of amiodarone, propafenone and diprafenone. J. Membr. Biol 102, 105-119.
198. + channels. Circ. Res. 64, 867-881.
199. Kohlhardt, M., Seifert, C., 1980. Inhibition of Vmax of the action potential by propafenone and its voltage-, time- and pH-dependence in mammalian ventricular myocardium. Naunyn Schmiedebergs Arch Pharmacol. 315, 55-62.
200. Koidl, B., Flaschberger, P., Schaffer, P., Pelzmann, B., Bernhart, E., Machler, H., Rigler, B., 1996. Effects of the class III antiarrhythmic drug ambasilide on outward currents in human atrial myocytes. Naunyn Schmiedebergs Arch Pharmacol. 353, 226-232.
201. Kokubun, S., Prod'hom, B., Becker, C., Porzig, H., Reuter, H., 1986. Studies on Ca channels in intact cardiac cells: voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers. Mol. Pharmacol. 30, 571-584.
202. Kokubun, S., Reuter, H., 1984. Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells. Proc. Natn. Acad. Sci. U.S.A. 81, 4824-4827.
203. Kollias Baker, C., Ruble, J., Dennis, D., Bruns, R. F., Linden, J., Belardinelli, L., 1994. Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. Circ. Res. 75, 961-971.
204. Konzen, G., Reichardt, B., Hauswirth, O., 1990. Fast and slow blockade of sodium channels by flecainide in rabbit cardiac Purkinje fibres. Nauny Schmiedeberg's Archives of Pharmacology 341, 565-576.
205. Koumi, S., Sato, R., Hayakawa, H., Okumura, H., 1991. Quinidine blocks cardiac sodium current after removal of the fast inactivation process with chloramine-T. J. Mol. Cell. Cardiol. 23, 427-438.
206. Koumi, S., Sato, R., Hisatome, I., Hayakawa, H., Okumura, H., Katori, R., 1992a. Disopyramide block of cardiac sodium current after removal of the fast inactivation process in guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther. 261, 1167-1174.
207. Koumi, S., Sato, R., Katori, R., Hisatome, I., Nagasawa, K., Hayakawa, H., 1992b. Sodium channel states control binding and unbinding behaviour of antiarrhythmic drugs in cardiac myocytes from the guinea pig. Cardiovasc. Res. 26, 1199-1205.
208. + channels in mammalian ventricular myocytes. Am. J. Physiol. 266, H1812-H1821.
209. Koumi, S., Wasserstrom, J. A., Ten Eick, R. E., 1995. Beta-adrenergic and cholinergic modulation of inward recrifier K+ channel function and phosphorylation in guinea-pig ventricle. J. Physiol. Lond. 486, 661-678.
210. Krafte, D. S., Volberg, W. A., 1994. Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents. J. Cardiovasc. Pharmacol 23, 37-41.
211. Krause, E., Englert, H., Gogelein, H., 1995. Adenosine triphosphate-dependent K currents activated by metabolic inhibition in rat ventricular myocytes differ from those elicited by the channel opener rilmakalim. Pflugers Arch 429, 625-635.
212. + channel is mediated by arachidonic acid metabolites. Pflugers Arch 414, 102-104.
213. Kurz, T., Yamada, K. A., DaTorre, S. D., Corr, P. B., 1991. Alpha 1-adrenergic system and arrhythmias in ischaemic heart disease. Eur. Heart J. 12, 88-98.
214. Lappi, M. D., Billman, G. E., 1993. Effect of ryanodine on ventricular fibrillation induced by myocardial ischaemia. Cardiovasc. Res. 27, 2152-2159.
215. Lathrop, D. A., Nanasi, P. P., Varro, A., 1990. In vitro cardiac models of dog Purkinje fibre triggered and spontaneous electrical activity: effects of nicorandil. Br. J. Pharmacol. 99, 119-123.
216. Lee, K., Groh, W. J., Blair, A., Maylie, J. G., Adelman, J. P., 1995. Imidazoline compounds inhibit KATP channels in guinea pig ventricular myocytes. European Journal of Pharmacology 285, 309-312.
217. + current in guinea pig ventricular cells. The Journal of Pharmacology and Experimental Therapeutics 262, 99-108.
218. Lee, K. S., Tsien, R. W., 1983. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature 302, 790-794.
219. Lefevre, I. A., Coulombe, A., Coraboeuf, E., 1991. The calcium antagonist D600 inhibits calcium-independent transient outward current in isolated rat ventricular myocytes. J. Physiol. Lond. 432, 65-80.
220. Lefevre, T., Coraboeuf, E., Ghazi, A., Coulombe, A., 1995. Divalent cation channels activated by phenothiazines in membrane of rat ventricular myocytes. J. Membr. Biol. 147, 147-158.
221. Leyssens, A., Carmeliet, E., 1991. Block of the transient inward current by R56865 in guinea-pig ventricular myocytes. Eur. J. Pharmacol. 196, 43-51.
222. + current in human atrial myocytes. Circ. Res. 78, 903-915.
223. Li, Q., Himmel, H. M., Ravens, U., 1996b. Selectivity of class-III antiarrhythmic action of clofilium in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol 27, 401-410.
224. Light, P. E., Allen, B. G., Walsh, M. P., French, R. J., 1995. Regulation of adenosine triphosphate-sensitive potassium channels from rabbit ventricular myocytes by protein kinase C and type 2A protein phosphatase. J. Biochemistry 34, 7252-7257.
225. + channels: A possible mechanistic link to ischemic preconditioning. Circ. Res. 79, 399-406.
226. Lindsay, A. R., Tinker, A., Williams, A. J., 1994. How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel? J. Gen. Physiol. 104, 425-447.
227. Litovsky, S. H., Antzelevitch, C., 1988. Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ. Res. 62, 116-126.
228. Liu, Q. Y., Vassalle, M., 1991. On the mechanism by which doxorubicin abolishes the oscillatory events induced by Ca overload in single cardiac myocytes. J. Cardiovasc. Pharmacol 18, 711-720.
229. Liu, S., Rasmusson, R. L., Campbell, D. L., Wang, S., Strauss, H. C., 1996a. Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes. Biophysical Journal 70, 2704-2711.
230. Liu, W., Clarkson, C. W., Yamasaki, S., Chang, C., Stolfi, A., Pickoff, A. S., 1992. Characterization of the rate-dependent effects of ethmozine on conduction, in vivo, and on the sodium current, in vitro, in the newborn heart. J. Pharmacol. Exp. Ther 263, 608-616.
231. + currents by protein kinase C and adenosine. Implications for ischemic preconditioning. Circ. Res. 78, 443-454.
232. + channel in cardiac cells: physiological and pharmacological characterization, pp. 136, Leuven University Press.
233. + channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents. J. Cardiovasc. Pharmacol 25, 336-340.
234. Makielski, J. C., Alpert, L. A., Hanck, D. A., 1991. Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells. J. Mol. Cell. Cardiol. 1, 95-102.
235. Makielski, J. C., Nesterenko, V. V., Nelson, W. L., Undrovinas, A. I., Starmer, C. F., Rosenshtraukh, L. V., 1990. State dependence of ethacizin and ethmozin block of sodium current in voltage clamped and internally perfused cardiac Purkinje cells. J. Pharmacol. Exp. Ther 253, 1110-1117.
236. Marban, E., Robinson, S. W., Wier, W. G., 1986. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J. Clin. Invest. 78, 1185-1192.
237. Markwardt, F., Nilius, B., 1988. Modulation of calcium channel currents in guinea-pig single ventricular heart cells by the dihydropyridine Bay K 8644. J. Physiol. Lond. 399, 559-575.
238. Martin, D. K., Nakaya, Y., Wyse, K. R., Bursill, J. A., West, P. D., Campbell, T. J., 1995. Inhibition of ATP-sensitive potassium channels in cardiac myocytes by the novel class III antiarrhythmic agent MS-551. Pharmacol. Toxicol. 77, 65-70.
239. Martynyuk, A. E., Kane, K. A., Cobbe, S. M., Rankin, A. C., 1996. Nitric oxide mediates the anti-adrenergic effect of adenosine on calcium current in isolated rabbit atrioventricular nodal cells. Pflugers Arch 431, 452-457.
240. Martynyuk, A. E., Kane, K. A., Cobbe, S. M., Rankin, A. C., 1997. Role of nitric oxide, cyclic GMP and superoxide in inhibition by adenosine of calcium current in rabbit atrioventricular nodal cells. Cardiovasc. Res. 34, 360-367.
241. Mason, J. W., Hondeghem, L. M., Katzung, B. G., 1984. Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone. Circ. Res. 55, 278-285.
242. McDonald, T., Pelzer, D., Trautwein, W., 1989a. Dual action (stimulation, inhibition) of D600 on contractility and calcium channels in guinea-pig and cat heart cells. J. Physiol. Lond. 414, 569-586.
243. McDonald, T. F., Pelzer, D., Trautwein, W., 1984. Cat ventricular muscle treated with D600: characteristics of calcium channel block and unblock. J. Physiol. Lond. 352, 217-241.
244. McDonald, T. F., Pelzer, S. & Pelzer, D. J. (1996) Interactions of calcium antagonists and agonists with calcium channels in muscle cells. In M. Morad, S. Ebashi, W. Trautwein & Y. Kurachi (eds), Molecular Physiology and Pharmacology of Cardiac Ion channels and Transporters (pp. 291-304). Dordrecht: Kluwer Academic Publishers.
245. McDonald, T. F., Pelzer, S., Trautwein, W., Pelzer, D. J., 1994. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol. Rev. 74, 365-507.
246. McDonald, T. V., Courtney, K. R., Clusin, W. T., 1989b. Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes. Biophys. J. 55, 1261-1266.
247. McGarry, S. J., Scheufler, E., Williams, A. J., 1995. Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel. Br. J. Pharmacol. 114, 231-237.
248. McGarry, S. J., Williams, A. J., 1993. Digoxin activates sarcoplasmic reticulum Ca(2+)-release channels: a possible role in cardiac inotropy. Br. J. Pharmacol. 108, 1043-1050.
249. McLarnon, J. G., Xu, R., 1995. Actions of the benzopyran compound terikalant on macroscopic currents in rat ventricular myocytes. J. Pharmacol. Exp. Ther 275, 389-396.
250. 2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation. J. Biol. Chem. 268, 26286-26295.
251. + channels in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol. 26, 761-769.
252. 2+ channels by Ro 40-5967. Circ. Res. 75, 144-148.
253. Molina Viamonte, V., Anyukhovsky, E. P., Rosen, M. R., 1991. An alpha-1-adrenergic receptor subtype is responsible for delayed afterdepolarizations and triggered activity during simulated ischemia and reperfusion of isolated canine Purkinje fibers. Circulation 84, 1732-1740.
254. Mori, K., Hara, Y., Saito, T., Masuda, Y., Nakaya, H., 1995. Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Different molecular mechanisms. Circulation 91, 2834-2843.
255. Mubagwa, K., Mullane, K., Flameng, W., 1996. Role of adenosine in the heart and circulation. Cardiovasc. Res. 32, 797-813.
256. Nakaya, H., Tohse, N., Takeda, Y., Kanno, M., 1993. Effects of MS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes. Br. J. Pharmacol. 109, 157-163.
257. + current in guinea pig ventricular myocytes. Circ. Res. 67, 1124-1133.
258. + channel in guinea-pig ventricular myocytes. Br. J. Pharmacol. 103, 1641-1648.
259. Nakayama, T., Palfrey, C., Fozzard, H. A., 1989. Modulation of the cardiac transient outward current by catecholamines. J. Mol. Cell. Cardiol. 1, 109-118.
260. Nattel, S., Bourne, G., Talajic, M., 1997. Insights into mechanisms of antiarrhythmic drug action from experimental models of atrial fibrillation. J. Cardiovasc. Electrophysiol. 8, 469-480.
261. Nichols, C. G., Lopatin, A. N., 1993. Trypsin and alpha-chymotrypsin treatment abolishes glibenclamide sensitivity of KATP channels in rat ventricular myocytes. Pflugers Arch 422, 617-619.
262. Nilius, B., Benndorf, K., Markwardt, F., 1987. Effects of lidocaine on single cardiac sodium channels. J. Mol. Cell. Cardiol. 19, 865-874.
263. Nilius, B., Hess, P., Lansman, J. B., Tsien, R. W., 1985. A novel type of cardiac calcium channel in ventricular cells. Nature 316, 443-446.
264. Nilius, B., Vereecke, J., Carmeliet, E., 1989. Properties of the bursting Na channel in the presence of DPI 201-106 in guinea-pig ventricular myocytes. Pflugers Arch 413, 234-241.
265. Nitta, J., Sunami, A., Marumo, F., Hiraoka, M., 1992. States and sites of actions of flecainide on guinea-pig cardiac sodium channels. Eur. J. Pharmacol. 214, 191-197.
266. + channel by 5-hydroxydecanoate in guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther 260, 702-708.
267. Ohler, A., Amos, G. J., Wettwer, E., Ravens, U., 1994. Frequency-dependent effects of E-4031, almokalant, dofetilide and tedisamil on action potential duration: no evidence for "reverse use dependent" block. Naunyn Schmiedebergs Arch Pharmacol. 349, 602-610.
268. - current in guinea pig ventricular myocytes. Circ. Res. 78, 1090-1099.
269. Ono, K., Fozzard, H. A., Hanck, D. A., 1993. Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Circ. Res. 72, 807-815.
270. + channel in guinea-pig ventricular myocytes. Pflugers Arch 431, 101-109.
271. Ono, M., Sunami, A., Sawanobori, T., Hiraoka, M., 1994. External pH modifies sodium channel block by mexiletine in guinea pig ventricular myocytes. Cardiovasc. Res. 28, 973-979.
272. Papp, J. G., Németh, M., Krassoi, I., Mester, L., Hala, O., Varro, A., 1996. Differential electrophysiological effects of chronically administered amiodarone on canine Purkinje fibers versus ventricular muscle. J. Cardiovasc. Pharmacol. Therapeut. 1, 287-296.
273. Pappano, A. J., Carmeliet, E. E., 1979. Epinephrine and the pacemaking mechanism at plateau potentials in sheep cardiac Purkinje fibers. Pflugers Arch 382, 17-26.
274. Pozzan, T., Rizzuto, R., Volpe, P., Meldolesi, J., 1994. Molecular and cellular physiology of intracellular calcium stores. Physiol. Rev. 74, 595-636.
275. Priori, S. G., Corr, P. B., 1990. Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. Am. J. Physiol. 258, H1796-H1805.
276. + channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome. Circ. Res. 78, 1009-1015.
277. Proks, P., Ashcroft, F. M., 1997. Phentolamine block of KATP channels is mediated by Kir6.2. Proc. Natn. Acad. Sci. U.S.A. 94, 11716-11720.
278. Puceat, M., Clement Chomienne, O., Terzic, A., Vassort, G., 1993. Alpha 1-adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cardiac cells. Am. J. Physiol. 264, H310-319.
279. + channels by local anesthetics. Science 265, 1724-1728.
280. + currents in human atrium and in cells expressing a Kvl.5-type cloned channel. J. Pharmacol. Exp. Ther. 274, 444-449.
281. + channel cloned from human heart. Mol. Pharmacol. 44, 1240-1245.
282. Ranger, S., Sheldon, R., Fermini, B., Nattel, S., 1993. Modulation of flecainide's cardiac sodium channel blocking actions by extracellular sodium: a possible cellular mechanism for the action of sodium salts in flecainide toxicity. J. Pharmacol. Exp. Ther. 264, 1160-1167.
283. + (Kv1.4) channel. Adv. Exp. Med. Biol. 382, 11-22.
284. + channel (Kv1.4) cloned from ferret ventricle and expressed in Xenopus oocytes. J. Physiol. Lond. 485, 59-71.
285. 2+ channels. TINS 14, 396-400.
286. Reuter, H., Porzig, H., Kokubun, S., Prod'hom, B., 1988. Calcium channels in the heart. Properties and modulation by dihydropyridine enantiomers. Ann. N.Y. Acad. Sci. 522, 16-24.
287. Ripoll, C., Lederer, W. J., Nichols, C. G., 1993. On the mechanism of inhibition of KATP channels by glibenclamide in rat ventricular myocytes. J. Cardiovasc. Electrophysiol. 4, 38-47.
288. Roden, D. M., Bennett, P. B., Snyders, D. J., Balser, J. R., Hondeghem, L. M., 1988. Quinidine delays IK activation in guinea pig ventricular myocytes. Circ. Res. 62, 1055-1058.
289. 2+ currents in atrial myocytes. Pflugers Arch 420, 410-412.
290. Rosenberg, R. L., Hess, P., Tsien, R. W., 1988. Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials. J. Gen. Physiol. 92, 27-54.
291. Rousseau, E., 1989. Single chloride-selective channel from cardiac sarcoplasmic reticulum studied in planar lipid bilayers. J. Membr. Biol. 110, 39-47.
292. 2+-release channel: activation by caffeine. Am. J. Physiol. 256, H328-H333.
293. 2+ release channel. Am. J. Physiol. 253, C364-C368.
294. Saez, J. C., Spray, D. C., Nairn, A. C., Hertzberg, E., Greengard, P., Bennett, M. V., 1986. cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proc. Natl. Acad. Sci. U.S.A. 83, 2473-24737.
295. Sakai, R., Inoue, D., Ishibashi, K., Inoue, M., Shirayama, T., Yamahara, Y., Asayama, J., Nakagawa, M., 1995. Kinetics of frequency-dependent conduction delay by class I antiarrhythmic drugs in human atrium. J. Cardiovasc. Pharmacol. 25, 953-960.
296. + channels in Xenopus oocytes. Br. J. Pharmacol. 107, 1061-1067.
297. + currents in Xenopus oocytes. Br. J. Pharmacol. 109, 866-872.
298. + current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96, 195-215.
299. Sanguinetti, M. C., Kass, R. S., 1984. Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ. Res. 55, 336-348.
300. Sanguinetti, M. C., Krafte, D. S., Kass, R. S., 1986. Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644. J. Gen. Physiol. 88, 369-392.
301. Sato, R., Hisatome, I., Tanaka, Y., Sasaki, N., Kotake, H., Mashiba, H., Katori, R., 1991. Aprindine blocks the sodium current in guinea-pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 344, 331-336.
302. Sato, R., Koumi, S., Hisatome, I., Takai, H., Aida, Y., Oyaizu, M., Karasaki, S., Mashiba, H., Katori, R., 1995. A new class III antiarrhythmic drug, MS-551, blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther. 274, 469-474.
303. + channels in guinea-pig ventricular cells. Br. J. Pharmacol. 108, 549-556.
304. Satoh, H., Hashimoto, K., 1986. Electrophysiological study of alinidine in voltage clamped rabbit sino-atrial node cells. Eur. J. Pharmacol. 121, 211-219.
305. Sawanobori, T., Adaniya, H., Namiki, T., Hiraoka, M., 1994. Rate-dependent effects of sematilide on action potential duration in isolated guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther. 271, 302-310.
306. + current in rat cardiac ventricular cells. Journal of Physiology 491, 81-97.
307. Schackow, T. E., Ten Eick, R. E., 1994. Enhancement of ATP-sensitive potassium current in cat ventricular myocytes by beta-adrenoreceptor stimulation. J. Physiol. Lond. 474, 131-145.
308. Schomig, A., Richardt, G., Kurz, T., 1995. Sympatho-adrenergic activation of the ischemic myocardium and its arrhythmogenic impact. Herz 20, 169-186.
309. Schreibmayer, W., Lindner, W., 1992. Stereoselective interactions of (R)- and (S)-propafenone with the cardiac sodium channel. J. Cardiovasc. Pharmacol. 20, 324-331.
310. Schubert, B., Bodewei, R., Hering, S., Wollenberger, A., 1986a. A patch clamp study of the action of ethacyzine on the rapid inward sodium current in single rat heart muscle cells. Eur. J. Pharmacol. 126, 309-312.
311. Schubert, B., Hering, S., Bodewei, R., Rosenshtraukh, L. V., Wollenberger, A., 1986b. Use- and voltage-dependent depression by ethmozine (moricizine) of the rapid inward sodium current in single rat ventricular muscle cells. J. Cardiovasc. Pharmacol. 8, 358-366.
312. + channel blockade and to increases in heart rate. Implications for gene-specific therapy (see comments). Circulation 92, 3381-3386.
313. Schwarz, K. R. (1991) The Principles of Receptor Binding Studies. In H. Fozzard, E. Haber, R. B. Jennings & A. M. Katz (eds), The Heart and Cardiovascular System (pp. 483-504). New York: Raven Press.
314. Schwarz, W., Palade, P. T., Hille, B., 1977. Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle. Biophys. J. 20, 343-368.
315. Scott, R. H., Dolphin, A. C., 1988. The agonist effect of Bay K 8644 on neuronal calcium channel currents is promoted by G-protein activation. Neurosci. Lett. 89, 170-175.
316. Shah, A., Cohen, I. S., Rosen, M. R., 1988. Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway. Biophys. J. 54, 219-225.
317. Shen, W. K., Kurachi, Y., 1995. Mechanisms of adenosine-mediated actions on cellular and clinical cardiac electrophysiology. Mayo. Clin. Proc. 70, 274-291.
318. + channel by ER-001533, a newly synthesized vasorelaxant. Circ. Res. 70, 1054-1061.
319. + channel. A comparison with pinacidil and lemakalim. Circ. Res. 69, 1152-1158.
320. Shyng, S.-L., Ferrigni, T., Nichols, C. G., 1997. Regulation of KATP channel activity bt diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. Journal General Physiology 110, 643-654.
321. Simurda, J., Simurdova, M., Christe, G., 1989. Use-dependent effects of 4-aminopyridine on transient outward current in dog ventricular muscle. Pflugers Arch 415, 244-246.
322. Simurda, J., Simurdova, M., Cupera, P., 1988. 4-Aminopyridine sensitive transient outward current in dog ventricular fibres. Pflugers Arch 411, 442-449.
323. Singh, B. N. (1995) Beta-Blockers and Calcium Channel Blockers as Antiarrhythmic Drugs. In D. P. Zipes & J. J. Jalife (eds), Cardiac Electrophysiology. From Cell to Bedside (pp. 1317-1330). Philadelphia: Saunders Company.
324. Singh, B. N., Vaughan Williams, E. M., 1970. The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br. J. Pharmacol. 39, 657-667.
325. + channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. J. Pharmacol. Exp. Ther 269, 66-74.
326. Snyders, D. J., Bennett, P. B. & Hondeghem, L. M. (1992a) Mechanisms of drug-channel interaction. In H. A. E. A. Fozzard (ed.), The Heart and Cardiovascular System, Vol. 2 (pp. 2165-2193). New York: Raven Press.
327. Snyders, D. J., Chaudhary, A., 1996. High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol. Pharmacol. 49, 949-955.
328. Snyders, D. J., Hondeghem, L. M., 1990. Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics. Circ. Res. 66, 565-579.
329. Snyders, D. J., Tamkun, M. M., Bennett, P. B., 1993. A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression. J. Gen. Physiol. 101, 513-543.
330. Snyders, D. J., Van Bogaert, P. P., 1987. Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Arch 410, 83-91.
331. Snyders, D. J., Yeola, S. W., 1995. Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKvl.5 channel. Circ. Res. 77, 575-583.
332. Snyders, J., Knoth, K. M., Roberds, S. L., Tamkun, M. M., 1992b. Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel. Mol. Pharmacol. 41, 322-330.
333. Song, Y., Belardinelli, L., 1996. Electrophysiological and functional effects of adenosine on ventricular myocytes of various mammalian species. Am. J. Physiol. 271, C1233-C1243.
334. + channel. Open-channel block by methanesulfonanilides. Circ. Res. 78, 499-503.
335. + current activated by pinacidil. Circ. Res. 68, 1127-1137.
336. Starmer, C. F., Grant, A. O., Strauss, H. C., 1984. Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. Biophys. J. 46, 15-27.
337. Starmer, C. F., Lastra, A. A., Nesterenko, V. V., Grant, A. O., 1991. Proarrhythmic response to sodium channel blockade. Theoretical model and
338. 2+ exchange in rat ventricular myocytes. Cardiovascular Research, in press.
339. Strichartz, G., Rando, T., Wang, G. K., 1987. An integrated view of the molecular toxinology of sodium channel gating in excitable cells. Annu. Rev. Neurosci. 10, 237-267.
340. + current by disopyramide and lidocaine in guinea pig ventricular myocytes. Circ. Res. 68, 653-661.
341. + currents by mexiletine at the single channel level in guinea-pig ventricular myocytes. Br. J. Pharmacol. 110, 183-192.
342. + in canine and guinea pig Purkinje fibers. J. Cardiovasc. Electrophysiol. 6, 796-812.
343. Tada, M., Kitchberger, M. A., Repke, D. I., Katz, A. M., 1974. The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3′:5′-monophosphate-dependent protein kinase. J. Biol. Chem. 249, 6174-6180.
344. Takahashi, N., Ito, M., Saikawa, T., Arita, M., 1991. Nicorandil suppresses early afterdepolarisation and ventricular arrhythmias induced by caesium chloride in rabbits in vivo. Cardiovasc. Res. 25, 445-452.
345. Takanaka, C., Sarma, J. S., Singh, B. N., 1992. Electrophysiologic effects of ambasilide (LU 47110), a novel class III antiarrhythmic agent, on the properties of isolated rabbit and canine cardiac muscle. J. Cardiovasc. Pharmacol. 19, 290-298.
346. Takasago, T., Imagawa, T., Furukawa, K., Ogurusu, T., Shigekawa, M., 1991. Regulation of the cardiac ryanodine receptor by protein kinase-dependent phosphorylation. J. Biochem. Tokyo 109, 163-170.
347. + channel openers. J. Cardiovasc. Pharmacol. 28, 799-808.
348. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology (1991) The Sicilian gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Circulation 84, 1831-1851.
349. + channels. J. Pharmacol. Exp. Ther. 268, 818-825.
350. + channel-opening drugs. Am. J. Physiol. 269, C525-C545.
351. Terzic, A., Puceat, M., Vassort, G., Vogel, S. M., 1993. Cardiac alpha 1-adrenoceptors: an overview. Pharmacol. Rev. 45, 147-175.
352. + current in human atrial myocytes. British Journal of Pharmacology 122, 291-301.
353. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators (1989) Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N. Engl. J. Med. 321, 406-412.
354. The CASCADE Investigators, (1993) Randomized antiarrhythmic drug therapy in survivors of cardiac arrest (the CASCADE Study). Am. J. Cordiol. 72, 280-287.
355. Tiaho, F., Richard, S., Lory, P., Nerbonne, J. M., Nargeot, J., 1990. Cyclic-AMP-dependent phosphorylation modulates the stereo-specific activation of cardiac Ca channels by Bay K 8644. Pflugers Arch 417, 58-66.
356. Tinker, A., Williams, A. J., 1993. Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel. Biophys. J. 65, 852-864.
357. + current of guinea pig ventricular cells through the activation of protein kinase. C. Circ. Res. 71, 1441-1446.
358. - conductance. Circ. Res. 77, 417-423.
359. Toyama, J., Kamiya, K., Kodama, I., Yamada, K., 1987. Frequency- and voltage-dependent effects of aprindine on the upstroke velocity of action potential in guinea pig ventricular muscles. J. Cardiovasc. Pharmacol 9, 165-172.
360. Trautwein, W., Hescheler, J., 1990. Regulation of cardiac L-type calcium current by phosphorylation and G proteins. Annu Rev Physiol 52, 257-274.
361. Triggle, D. J. (1996) Pharmacology of the calcium channel antagonists. In M. Morad, S. Ebashi, W. Trautwein & Y. Kurachi (eds), Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters (pp. 275-289). Dordrecht: Kluwer Academic Publishers.
362. Tseng, G.-N., Jiang, M., Yao, J.-A., 1996. Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. The Journal of Pharmacology and Experimental Therapeutics 279, 865-876.
363. Tseng, G. N., Hoffman, B. F., 1990. Actions of pinacidil on membrane currents in canine ventricular myocytes and their modulation by intracellular ATP and cAMP. Pflugers Arch 415, 414-424.
364. Tsien, R. W., Bean, B. P., Hess, P., Lansman, J. B., Nilius, B., Nowycky, M. C., 1986. Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J. Mol. Cell. Cardiol. 18, 691-710.
365. Tsushima, R. G., Kelly, J. E., Wasserstrom, J. A., 1996. Characteristics of cocaine block of purified cardiac sarcoplasmic reticulum calcium release channels. Biophys. J. 70, 1263-1274.
366. + channels in the absence of the sulphonylurea receptor. Nature 387, 179-183.
367. Tung, L., Morad, M., 1983. Voltage- and frequency-dependent block of diltiazem on the slow inward current and generation of tension in frog ventricular muscle. Pflugers Arch 398, 189-198.
368. + current, by the diuretic agent indapamide in guinea pig myocytes. Circ. Res. 75, 879-886.
369. Tytgat, J., Vereecke, J., Carmeliet, E., 1988. Differential effects of verapamil and flunarizine on cardiac L-type and T-type Ca channels. Naunyn Schmiedebergs Arch Pharmacol. 337, 690-692.
370. Tytgat, J., Vereecke, J., Carmeliet, E., 1990. Mechanism of cardiac T-type Ca channel blockade by amiloride. J Pharmacol Exp Ther 254, 546-551.
371. Uehara, A., Hume, J. R., 1985. Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J. Gen. Physiol. 85, 621-647.
372. Uemura, H., Hara, Y., Endou, M., Mori, K., Nakaya, H., 1995. Interaction of class III antiarrhythmic drugs with muscarinic M2 and M3 receptors: radioligand binding and functional studies. Naunyn Schmiedebergs Arch Pharmacol. 353, 73-79.
373. Undrovinas, A. I., Burnashev, N., Eroshenko, D., Fleidervish, I., Starmer, C. F., Makielski, J. C., Rosenshtraukh, L. V., 1990. Quinidine blocks adenosine 5′-triphosphate-sensitive potassium channels in heart. Am. J. Physiol. 259, H1609-H1612.
374. Undrovinas, A. I., Makielski, J. C., 1996. Blockade of lysophosphatidylcholine-modified cardiac Na channels by a lidocaine derivative QX-222. Am. J. Physiol. 271, H790-H797.
375. Valenzuela, C., Delpon, E., Franqueza, L., Gay, P., Perez, O., Tamargo, J., Snyders, D. J., 1996. Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage- dependent block of hKv1.5 channels. Circulation 94, 562-570.
376. Valenzuela, C., Delpon, E., Tamkun, M. M., Tamargo, J., Snyders, D. J., 1995a. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophys. J. 69, 418-427.
377. Valenzuela, C., Snyders, D. J., Bennett, P. B., Tamargo, J., Hondeghem, L. M., 1995b. Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Circulation 92, 3014-3024.
378. Van Bogaert, P. P., Goethals, M., 1987. Pharmacological influence of specific bradycardic agents on the pacemaker current of sheep cardiac Purkinje fibres. A comparison between three different molecules. Eur. Heart J. 8, 35-42.
379. Van Bogaert, P. P., Goethals, M., 1992. Blockade of the pacemaker current by intracellular application of UL-FS 49 and UL-. Eur. J. Pharmacol. 229, 55-62.
380. Van Bogaert, P. P., Goethals, M., Simoens, C., 1990. Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres. Eur. J. Pharmacol. 187, 241-256.
381. Vanhoutte, F., Vereecke, J., Verbeke, N., Carmeliet, E., 1991. Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle. Br. J. Pharmacol. 103, 1275-1281.
382. Vanhouttte, F., Vereecke, J., Verbeke, N., Carmeliet, E., 1991. Enantioselective actions of tocainide on the electrophysiological properties of the guinea pig papillary muscle. J. Cardiovasc. Electrophysiol. 2, 288-298.
383. Varro, A., Virag, L., Papp, J. G., 1996. Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes. Br. J. Pharmacol. 117, 1181-1186.
384. Vassort, G., Alvarez, J., 1994. Cardiac T-type calcium current: pharmacology and roles in cardiac tissues. J. Cardiovasc. Electrophysiol. 5, 376-393.
385. Vaughan Williams, E. M., 1984. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J. Clin. Pharmacol. 24, 129-147.
386. Veldkamp, M. W., van Ginneken, A. C., Bouman, L. N., 1993. Single delayed rectifier channels in the membrane of rabbit ventricular myocytes. Circ. Res. 72, 865-878.
387. + loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle. Circ. Res. 69, 623-637.
388. + current by R56865 in single cardiac Purkinje cells. Eur. J. Pharmacol. 203, 371-378.
389. Verduyn, S. C., Vos, M. A., Gorgels, A. P., van der Zande, J., Leunissen, J. D., Wellens, H. J., 1995. The effect of flunarizine and ryanodine on acquired torsades de pointes arrhythmias in the intact canine heart. J. Cardiovasc. Electrophysiol. 6, 189-200.
390. Virag, L., Furukawa, T., Hiraoka, M., 1993. Modulation of the effect of glibenclamide on KATP channels by ATP and ADP. Mol. Cell. Biochem. 119, 209-215.
391. Vollmer, B., Meuter, C., Janssen, P. A., 1987. R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle. Eur. J. Pharmacol. 142, 137-140.
392. Vos, M. A., van Deursen, R. T., Gorgels, A. P., Leunissen, J. D., Wellens, H. J., 1993. R56865, an antiarrhythmic drug with class III effects that terminates ouabain induced ventricular tachycardia in an inverse rate dependent manner. Cardiovasc. Res. 27, 1491-1497.
393. + channel subtypes. Biophys. J. 70, 1700-1708.
394. Wang, D. W., Sato, T., Arita, M., 1995a. Voltage dependent inhibition of ATP sensitive potassium channels by flecainide in guinea pig ventricular cells. Cardiovasc. Res. 29, 520-525.
395. Wang, J., Feng, J., Nattel, S., 1994. Class III antiarrhythmic drug action in experimental atrial fibrillation. Differences in reverse use dependence and effectiveness between d-sotalol and the new antiarrhythmic drug ambasilide. Circulation 90, 2032-2040.
396. Wang, S. Y., Clague, J. R., Langer, G. A., 1995b. Increase in calcium leak channel activity by metabolic inhibition or hydrogen peroxide in rat ventricular myocytes and its inhibition by polycation. J. Mol. Cell. Cardiol. 27, 211-222.
397. + current in cat atrial myocytes. Am. J. Physiol. 268, H1322-H1334.
398. + current similar to Kv1.5 cloned channel currents. Circ. Res. 73, 1061-1076.
399. Wang, Z., Fermini, B., Nattel, S., 1995c. Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes. J. Pharmacol. Exp. Ther 272, 184-1896.
400. Watanabe, A. M., 1985. Digitalis and the autonomie nervous system. J. Am. Coll. Cardiol. 5, 35A-42A.
401. Watanabe, H., Nishio, M., Miura, M., Iijima, T., 1995. L-type Ca channel block by highly hydrophilic dihydropyridines in single ven-tricular cells of guinea-pig hearts. J. Mol. Cell. Cardiol. 27, 1271-1279.
402. Weirich, J., Antoni, H., 1990. Differential analysis of the frequency-dependent effects of class 1 antiarrhythmic drugs according to periodical ligand binding: implications for antiarrhythmic and proarrhythmic efficacy. J. Cardiovasc. Pharmacol 15, 998-1009.
403. Weirich, J., Hohnloser, S., Antoni, H., 1992. Differential analysis of frequency-dependent effects of antiarrhythmic drugs: importance of the saturation behavior of frequency-dependent sodium-channel blockade. J. Cardiovasc. Pharmacol. 20, S8-16.
404. Welling, A., Kwan, Y. W., Bosse, E., Flockerzi, V., Hofmann, F., Kass, R. S., 1993. Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity. Circ. Res. 73, 974-980.
405. Wendt, D. J., Starmer, C. F., Grant, A. O., 1993. pH dependence of kinetics and steady-state block of cardiac sodium channels by lidocaine. Am. J. Physiol. 264, H1588-H1598.
406. Wilde, A. A., Janse, M. J., 1994. Electrophysiological effects of ATP sensitive potassium channel modulation: implications for arrhythmogenesis. Cardiovasc. Res. 28, 16-24.
407. Williams, J. S., Grupp, I. L., Grupp, G., Vaghy, P. L., Dumont, L., Schwartz, A., Yatani, A., Hamilton, S., Brown, A. M., 1985. Profile of the oppositely acting enantiomers of the dihydropyridine 202-791 in cardiac preparations: receptor binding, electrophysiological, and pharmacological studies. Biochem. Biophys. Res. Commun. 131, 13-21.
408. Wit, A. L. & Janse, M. J. (1993) The Ventricular Arrhythmias of Ischemia and Infarction, pp. 648. New York: Futura Publishing Company, Inc, Mount Kisco.
409. Woodhull, A. M., 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61, 687-708.
410. Woosley, R. L., Chen, Y., Freiman, J. P., Gillis, R. A., 1993. Mechanism of the cardiotoxic actions of terfenadine. Journal American Medical Association 269, 1532-1536.
411. Xu, L., Jones, R., Meissner, G., 1993. Effects of local anesthetics on single channel behavior of skeletal muscle calcium release channel. J. Gen. Physiol. 101, 207-233.
412. Yamamoto, D., Yeh, J. Z., 1984. Kinetics of 9-aminoacridine block of single Na channels. J. Gen. Physiol. 84, 361-377.
413. Yamashita, T., Masuda, Y., Tanaka, S., 1995a. The effects of potassium channel openers and blockers on the specific binding sites for [3H]glibenclamide in rat tissues. Jpn. J. Pharmacol. 67, 35-44.
414. Yamashita, T., Nakajima, T., Hamada, E., Hazama, H., Omata, M., Kurachi, Y., 1995b. Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J. Pharmacol. Exp. Ther. 274, 315-321.
415. Yamazaki, K., Furukawa, Y., Kasama, M., Imamura, H., Chiba, S., 1996. Negative chronotropic and dromotropic effects of E-4031, an IKr blocker, on the atrioventricular node in anesthetized dog hearts. Eur. J. Pharmacol. 297, 233-239.
416. Yang, T., Prakash, C., Roden, D. M., Snyders, D. J., 1995a. Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers. Br. J. Pharmacol. 115, 267-274.
417. Yang, T., Roden, D. M., 1996. Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation 93, 407-411.
418. + current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation 91, 1799-1806.
419. Yang, T., Snyders, D. J., Roden, D. M., 1997. Inhibition of cardiac potassium currents by the vesnarinone analog OPC-18790: comparison with quinidine and dofetilide. J. Pharmacol. Exp. Ther. 280, 1170-1175.
420. + channel mRNA in cultured atrial cardiac myocytes (AT-1 cells). Circ. Res. 75, 870-878.
421. Yao, J.-A., Trybulski, E. J., Tseng, G.-N., 1996. Quinidine preferentially blocks the slow delayed rectifier potassium channel in the rested state. The Journal of Pharmacology and Experimental Therapeutics 279, 856-864.
422. Yao, J.-A., Tseng, G.-N., 1997. Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: Dependence on blockade of K, Ca and Na channels. J. Cardiovasc. Electrophysiol. 8, 184-198.
423. Yao, J. A., Tseng, G. N., 1994. Modulation of 4-AP block of a mammalian A-type K channel clone by channel gating and membrane voltage. Biophys. J. 67, 130-142.
424. Yasutake, M., Avkiran, M., 1995. Exacerbation of reperfusion arrhythmias by alpha 1 adrenergic stimulation: a potential role for receptor mediated activation of sarcolemmal sodium-hydrogen exchange. Cardiovasc. Res. 29, 222-230.
425. + channel currents by quinidine. Circ. Res. 73, 351-359.
426. Yeh, J. Z., Tanguy, J., 1985. Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons. Biophys. J. 47, 685-694.
427. + channel. Role of S6 in antiarrhythmic drug binding (see comments). Circ. Res. 78, 1105-1114.
428. + channels. Pflügers Archiv. - Eur. J. Physiol. 434, 203-205.
429. Yue, L., Feng, J., Li, G.-R., Nattel, S., 1996. Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization. Journal of Physiology 496, 647-662.
430. 2+ release channels. Biophys. J. 64, 991-1003.
431. Zamponi, G. W., Doyle, D. D., French, R. J., 1993. Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access. Biophys. J. 65, 80-90.
432. Zamponi, G. W., French, R. J., 1994. Transcainide causes two modes of open-channel block with different voltage sensitivities in batra-chotoxin-activated sodium channels (published erratum appears in Biophys. J. 1995 Mar, 68(3): 1197). Biophys. J. 67, 1028-1039.
433. + channel blockers and muscarinic receptor stimulation. J. Pharmacol. Exp. Ther 273, 1095-1104.
434. - currents in feline ventricular myocytes. J. Circ. Res. 75, 133-143.
435. Zhang, Z. H., Follmer, C. H., Sarma, J. S., Chen, F., Singh, B. N., 1992. Effect of ambasilide, a new class III agent, on plateau currents in isolated guinea pig ventricular myocytes: block of delayed outward potassium current. J. Pharmacol. Exp. Ther. 263, 40-48.
436. + current: characterization of open channel block. J. Pharmacol. Exp. Ther 274, 249-257.
437. 2+ exchange current in latent pacemaker cells isolated from cat right atrium. J. Physiol. Lond. 466, 263-285.
438. + channels expressed in Xenopus oocytes. Am. J. Physiol. 272, H1309-H1314.