Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-QT syndrome

Circulation Research

Volumn 103, Issue 7, 2008, Pages

  Sale, Harinath ^a   Wang, Jinling ^a   O'Hara, Thomas J ^b   Tester, David J ^c   Phartiyal, Pallavi ^a   He, Jia Qiang ^a   Rudy, Yoram ^b   Ackerman, Michael J ^c   Robertson, Gail A ^a,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^c MAYO CLINIC   (United States)

^d Department of Physiology Satellite Laboratories ^*  (United States)

Author keywords

Arrhythmia; Ether a go go; KCNH2; Kv11.1; Potassium channels

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL HERG 1A; POTASSIUM CHANNEL HERG 1B; UNCLASSIFIED DRUG; ANTIARRHYTHMIC AGENT; KCNH1 PROTEIN, HUMAN; PIPERIDINE DERIVATIVE; PROTEIN SUBUNIT; PYRIDINE DERIVATIVE;

ACTION POTENTIAL; ALLELE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG SENSITIVITY; HEART REPOLARIZATION; HUMAN; HUMAN CELL; IC 50; KINETICS; LONG QT SYNDROME; MISSENSE MUTATION; MUSCLE CELL; PRIORITY JOURNAL; STEADY STATE; AMINO ACID SUBSTITUTION; BIOLOGICAL MODEL; CELL LINE; CHANNEL GATING; DRUG EFFECT; GENETICS; METABOLISM;

ACTION POTENTIALS; AMINO ACID SUBSTITUTION; ANTI-ARRHYTHMIA AGENTS; CELL LINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; KINETICS; LONG QT SYNDROME; MODELS, BIOLOGICAL; MUTATION, MISSENSE; PIPERIDINES; PROTEIN SUBUNITS; PYRIDINES;

EID: 54449099778     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.185249     Document Type: Article

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