Analyses of a novel SCN5A mutation (C1850S): Conduction vs. repolarization disorder hypotheses in the Brugada syndrome

Cardiovascular Research

Volumn 78, Issue 3, 2008, Pages 494-504

  Petitprez, Séverine ^a   Jespersen, Thomas ^a   Pruvot, Etienne ^b   Keller, Dagmar I ^c   Corbaz, Cora ^b   Schläpfer, Jürg ^b   Abriel, Hugues ^a,b   Kucera, Jan P ^d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Brugada syndrome; Computational analysis; Electrophysiology; Genetics; Sodium channel

Indexed keywords

PROTEIN SCN5A; VOLTAGE GATED SODIUM CHANNEL;

ADULT; ARTICLE; BRUGADA SYNDROME; CARBOXY TERMINAL SEQUENCE; CASE REPORT; COMPARATIVE STUDY; CONTROLLED STUDY; DENSITY; EMBRYO; GENE; GENE MUTATION; GENETIC HETEROGENEITY; GENOTYPE; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CONDUCTION DISTURBANCE; HEART REPOLARIZATION; HUMAN; HUMAN CELL; HYPOTHESIS; MALE; MODEL; MUTATIONAL ANALYSIS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SCN5A GENE; SIMULATION; SODIUM CURRENT; STEADY STATE; WHOLE CELL; WILD TYPE;

ACTION POTENTIALS; BRUGADA SYNDROME; CELL LINE; COMPUTER SIMULATION; DEFIBRILLATORS, IMPLANTABLE; ELECTROCARDIOGRAPHY; GENETIC PREDISPOSITION TO DISEASE; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; KINETICS; MALE; MIDDLE AGED; MODELS, CARDIOVASCULAR; MUSCLE PROTEINS; MUTATION; PATCH-CLAMP TECHNIQUES; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; SODIUM; SODIUM CHANNELS; TRANSFECTION;

EID: 44449161964     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn023     Document Type: Article

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