Rate-dependent QT shortening mechanism for the LQT3 ΔKPQ mutant

Cardiovascular Research

Volumn 54, Issue 3, 2002, Pages 624-629

  Nagatomo, Toshihisa ^a,b   January, Craig T ^a   Ye, Bin ^a   Abe, Haruhiko ^b   Nakashima, Yasuhide ^b   Makielski, Jonathan C ^a,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c University of Wisconsin Health   (United States)

Author keywords

Arrhythmia (mechanisms); Long QT syndrome; Membrane currents; Na channel; Sudden death

Indexed keywords

PROTEIN SUBUNIT; SODIUM CHANNEL; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ACTION POTENTIAL; ALPHA CHAIN; ARTICLE; ARTIFICIAL HEART PACEMAKER; CELL LINE; CONTROLLED STUDY; DELETION MUTANT; DEPOLARIZATION; GENETIC TRANSFECTION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN CELL; LONG QT SYNDROME; MAMMAL CELL; PATCH CLAMP; PRIORITY JOURNAL; QT INTERVAL; SODIUM CURRENT; WAVEFORM;

ACTION POTENTIALS; CELL LINE, TRANSFORMED; CLONE CELLS; HEART; HUMANS; LONG QT SYNDROME; MUTATION; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS; TRANSFECTION;

EID: 0036272008     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00265-1     Document Type: Article

References (28)

1. Two long QT syndrome loci map to chromosome 3 and 7 with evidence for further heterogeneity
2. + channel α-subunit gene (SCN5A) to band 3p21
3. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
4. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia
5. Molecular mechanism for an inherited cardiac arrhythmia
6. + channels
7. + channel-linked long-QT syndrome
8. + channel mutations in the congenital long QT syndrome
9. + channels expressed in mammalian cells
10. + channels
11. + channel blockade and to increase in heart rate: Implications for gene-specific therapy
12. Genotype-phenotype correlation in the long-QT syndrome: Gene-specific triggers for life-threatening arrhythmias
13. + channel inactivation gating
14. Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells
15. 2+ current
16. + channel blockade, β-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome
17. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: Effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes
18. Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia
19. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome
20. Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management parts I and II
21. + channel mutation causing both long-QT and Brugada syndromes
22. Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes
23. + channel
24. + channel activity through interactions between α- and β1-subunits
25. Effect of tetrodotoxin on membrane currents in mammalian cardiac fibres
26. Efficacy of permanent pacing in the management of high-risk patients with long QT syndrome
27. Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing
28. + current in human ventricular myocytes