How antiarrhythmic drugs increase the rate of sudden cardiac death

International Journal of Bifurcation and Chaos in Applied Sciences and Engineering

Volumn 12, Issue 9, 2002, Pages 1953-1968

  Starmer, C Frank ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antiarrhythmic drugs; Cardiac model; Nonlinear dynamics; Proarrhythmic; Re entry; Use dependent; Vulnerable window

Indexed keywords

CELLS; DRUG DOSAGE; MATHEMATICAL MODELS; WAVE PROPAGATION;

ANTIARRHYTHMIC DRUGS;

CARDIOLOGY;

EID: 0036755446     PISSN: 02181274     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0218127402005625     Document Type: Article

References (29)

1. Allessie, M., Bonke, F.I.M. & Schopman, J.G. [1973] "Circus movement in rabbit atrial muscle as a mechanism of tachycardia," Circ. Res. 33, 54-62.
2. Beeler, G.W. & Renter, H. [1977] "Reconstruction of the action potential of ventricular myocardial fibers," J. Physiol. London 268, 177-210.
3. Cardiac Arrhythmia Suppression Trial Investigators [1989] "Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction," New Eng. J. Med. 321, 406-412.
4. Cardiac Arrhythmia Suppression Trial-II Investigators [1992] "Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction," N. Eng. J. Med. 327, 227-233.
5. Cheng, Y., Mowrey, A., VanWagoner, D.R., Tchou, P.J. & Efimov, I.R. [1999] "Virtual electrode-induced reexcitation: A mechanism of defibrillation," Circ. Res. 85, 1056-1066.
6. Ferris, L.P., King, B.G., Spence, P.W. & Williams, B.H. [1936] "Effect of electric shock on the heart," Elect. Engin. 55, 489-515.
7. FitzHugh, R. [1961] "Impulses and physiologic states in theoretical models of nerve membrane," Biophys. J. 1, 445-466.
8. Gilliam, F.R., Starmer, C.F. & Grant, A.O. [1989] "Blockade of rabbit atrial sodium channels by lidocaine: Characterization of continuous and frequency-dependent blocking," Circ. Res. 65, 723-739.
9. Gomez-Gesteira, M., Fernandex-Garcia, G., Munuzuri, A.P., Perez-Munuzuri, V., Krinsky, V.I, Starmer, C. F. & Perez-Villar, V. [1994] "Vulnerability in excitable Belousov-Zhabotinsky medium: From I D to 2 D," Physica D76, 359-368.
10. Heistracher, P. [1971] "Mechanism of action of antifibrillatory drugs," Naunym-Schmiederbers Arch. Pharmak. 269, 199-211.
11. Hodgkin, A.L. & Huxley, A.F. [1952] "A quantitative description of membrane current and its application to conduction and excitation in nerve," J. Physiol. Lond. 177, 500-544.
12. Johnson, E.A. & McKinnon, M.G. [1957] "The differential effect of quinidine and pyralamine on the myocardial action potential at various rates of stimulation," J. Pharmacol. Exp. Ther. 120, 460-568.
13. Krinsky, V.I. [1966] "Spread of excitation in an inhomogeneous medium (state similar to cardiac fibrillation)," Biofizika 11, 676-683.
14. Lou, C. & Rudy, Y. [1991] "A model of the ventricular action potential: Depolarization, repolarization and their interaction," Circ. Res. 68, 1501-1526.
15. Nesterenko, V.V., Lastra, A.A., Rosenstraukh, L.V. and Starmer, C.F. [1992] "A proarrhythmic response to Na channel blockade: Prolongation of the vulnerable period in guinea-pig ventricular myocardium," J. Cardiol. Pharm. 19, 810-820.
16. Sanderson, J. [1996] "The sword of Damocles," Lancet 348, 2-3.
17. Starmer, C.F. & Grant, A.O. [1985] "Phasic ion channel blockade: A kinetic model and parameter estimation procedure," Mol. Pharmacol. 28, 348-356.
18. Starmer, C.F. [1988] "Characterizing activity-dependent processes with a piecewise exponential model," Biometrics 44, 549-559.
19. Starmer, C.F., Nesterenko, V.V., Undrovinas, A.I., Grant, A.O. & Rosenshtraukh, L.V. [1991a] "Lidocaine blockade of continuously and transiently accessible sites in cardiac sodium channels," J. Mol. Cell. Cardiol. 23, 73-83.
20. Starmer, C.F., Lastra, A.A., Nesterenko, V.V. & Grant, A.O. [1991b] "Proarrhythmic response to sodium channel blockade: Theoretical model and numerical experiments," Circulation 84, 1364-1377.
21. Starmer, C.F., Lancaster, A.R., Lastra, A.A. & Grant, A.O. [1992] "Cardiac instability amplified by usedependent Na channel blockade," Amer. J. Physiol. 262, H1305-H1319.
22. Starmer, C.F., Biktashev, V.N., Romashko, D.N., Stepanov, M.R., Makarova, O.N. & Krinsky, V.I. [1994] "Vulnerability in an excitable medium: Analytical and numerical studies of initiating unidirectional propagation," Biophysical J. 65, 1775-1787.
23. Starobin, J., Zilberter, Y.I. & Starmer, C.F. [1994] "Vulnerability in one-dimensional excitable media," Physica D70, 321-341.
24. Whitcomb, D.C., Gilliam, F.R., Starmer, C.F. 85 Grant, A.O. [1989] "Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine," J. Clin. Invest. 84, 1929-1936.
25. Wiener, N. & Rosenblueth, W. [1946] "The mathematical formulation of the problem of conduction of impulses in a network of connected excitable elements, specifically in cardiac muscle," Arch. Inst. Cardiol. Mex. 16, 205-265.
26. Wiggers, C.J. & Wegria, R. [1939] "Ventricular fibrillation due to single localized induction and condenser shocks applied during the vulnerable phase of ventricular systole," Amer. J. Physiol. 128, 500-505.
27. Winfree, A.T. [1987] When Time Breaks Down (Princeton University Press, NJ).
28. Yamanouchi, Y., Cheng, Y., Tchou, P.J. & Efimov, I.R. [2001] "The mechanisms of the vulnerable window: The role of virtual electrodes and shock polarity," Can. J. Physiol. Pharmacol. 79, 25-33.
29. Zilberter, Y.I., Starmer, C.F. & Grant, A.O. [1994] "Open Na channel blockade: Multiple rest states revealed by channel interactions with disopyramide and quinidine," Amer. J. Physiol. 266, H2007-H2017.