Selective inactivation of α-ketoglutarate dehydrogenase and pyruvate dehydrogenase: Reaction of lipoic acid with 4-hydroxy-2-nonenal

Biochemistry

Volumn 37, Issue 45, 1998, Pages 15835-15841

  Humphries, Kenneth M ^a   Szweda, Luke I ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE; THIOCTIC ACID;

ANIMAL TISSUE; ARTICLE; COVALENT BOND; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HEART MITOCHONDRION; LIPID PEROXIDATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

ALDEHYDES; ANIMALS; BINDING SITES, ANTIBODY; BLOTTING, WESTERN; ENZYME ACTIVATION; IMMUNE SERA; KETOGLUTARATE DEHYDROGENASE COMPLEX; MITOCHONDRIA, HEART; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL REAGENTS; THIOCTIC ACID;

ANIMALIA;

EID: 0032506040     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981512h     Document Type: Article

References (15)

1. Nohl, H., and Hegner, D. (1978) Eur. J. Biochem. 82, 563-567.
2. Nohl, H., Breuninger, V., and Hegner, D. (1978) Eur. J. Biochem. 90, 385-390.
3. Hansford, R. G. (1983) Biochim. Biophys. Acta 726, 41-80.
4. Das, D. K., George, A., Liu, X., and Rao, P. S. (1989) Biochem. Biophys. Res. Commun. 165, 1004-1009.
5. Dexter, D. T., Carter, C. J., Wells, F. R., Javoy-Agid, F., Agid, Y., Lees, A., Jenner, P., and Marsden, C. D. (1989) J. Neurochem. 52, 381-389.
6. Ambrosio, G., Flaherty, J. T., Duilio, C., Tritto, I., Santoro, G., Elia, P. P., Condorelli, M., and Chiariello, M. (1991) J. Clin. Invest. 87, 2056-20669.
7. Ambrosio, G., Zweier, J. L., Duilio, C., Kuppusamy, P., Santoro, G., Elia, P. P., Tritto, I., Cirillo, P., Condorelli, M., Chiariello, M., and Flaherty, J. T. (1993) J. Biol. Chem. 268, 18532-18541.
8. Beal, M. F. (1995) Ann. Neurol. 38, 357-366.
9. Mizuno, Y., Mon, H., and Kondo, T. (1995) Intent. Med. 34, 1045-1054.
10. Mizuno, Y., Ikebe, S.-L, Hattori, N., Nakagawa-Hattori, Y., Mochizuki, H., Tanaka, M., and Ozawa, T. (1995) Biochim. Biophys. Acta 1271, 265-274.
11. Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., and Mizuno, Y. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 2696-2701.
12. Markesbery, W. R. (1997) Free Radical Biol. Med. 23, 134-147.
13. Sayre, L. M., Zelasko, D. A., Harris, P. L., Perry, G., Salomon, R. G., and Smith, M. A. (1997) J. Neurochem. 68, 2092-2097.
14. Ando, Y., Brannstrom, T., Uchida, K., Nyhlin, N., Nasman, B., Suhr, O., Yamashita, T., Olsson, T., El Salhy, M., Uchino, M., and Ando, M. (1998) J. Neural. Sci. 156, 172-176.
15. Beckman, K. B., and Ames, B. N. (1998) Physiol. Rev. 78, 547-581.