Antibody expression kinetics in glycoengineered Pichia Pastoris

Biotechnology and Bioengineering

Volumn 106, Issue 6, 2010, Pages 918-927

  Potgieter, Thomas I ^a   Kersey, Sean D ^b   Mallem, Muralidhar R ^b   Nylen, Adam C ^b   D'Anjou, Marc ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b GlycoFi Incorporated   (United States)

Author keywords

Antibody; Expression kinetics; Fed batch cultivation; Glycoengineering; Glycosylation; Pichia pastoris

Indexed keywords

ANTIBODY EXPRESSION; ANTIBODY FRAGMENT; EXPRESSION KINETICS; EXPRESSION SYSTEM; FED-BATCH CULTIVATION; GLYCOENGINEERING; HETEROLOGOUS PROTEINS; IN-PROCESS; INTRINSIC NATURE; MASS BALANCE; METHANOL FEED; NONLINEAR FUNCTIONS; OXYGEN TRANSFER; OXYGEN UPTAKE RATES; P. PASTORIS; PICHIA PASTORIS; SPECIFIC GROWTH RATE; SPECIFIC PRODUCTIVITY; WILD TYPES;

ANTIBODIES; ESTERIFICATION; FUNCTIONS; GLYCOSYLATION; METHANOL; OXYGEN; PRODUCTIVITY; YEAST;

GROWTH KINETICS;

CARBON; METHANOL; MONOCLONAL ANTIBODY; OXYGEN; RECOMBINANT ANTIBODY; ANTIBODY; RECOMBINANT PROTEIN;

ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; BIOENGINEERING; BIOMASS PRODUCTION; CELL ACTIVATION; CELL DENSITY; COMPARATIVE STUDY; CORRELATION ANALYSIS; FED BATCH CULTURE; FUNGUS GROWTH; GLYCOENGINEERING; GROWTH RATE; HETEROLOGOUS EXPRESSION; NONHUMAN; NONLINEAR SYSTEM; OXYGEN CONSUMPTION; PHARMACEUTICAL ENGINEERING; PICHIA PASTORIS; PREDICTION; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; TRANSGENIC ORGANISM; WILD TYPE; YEAST; BIOMASS; FERMENTATION; GENE EXPRESSION; GENETICS; GLYCOSYLATION; METABOLISM; PICHIA; PROTEIN PROCESSING;

ANTIBODIES; BIOMASS; FERMENTATION; GENE EXPRESSION; GLYCOSYLATION; METHANOL; OXYGEN; PICHIA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

PICHIA PASTORIS;

EID: 77955673667     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22756     Document Type: Article

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