Oxygen transfer model in recombinant Pichia pastoris and its application in biomass estimation

Biotechnology Letters

Volumn 29, Issue 1, 2007, Pages 27-35

  Liang, Jieming ^a   Yuan, Jingqi ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Biomass estimation; Modeling; Oxygen transfer and uptake; Pichia pastoris; Recombinant human serum albumin

Indexed keywords

BIOMASS; BIOMEDICAL ENGINEERING; BIOREACTORS; COMPUTER SIMULATION; MATHEMATICAL MODELS; VOLUMETRIC ANALYSIS;

BIOMASS ESTIMATION; OXYGEN TRANSFER AND UPTAKE; PICHIA PASTORIS; RECOMBINANT HUMAN SERUM ALBUMIN;

PROTEINS;

OXYGEN; RECOMBINANT PROTEIN; SERUM ALBUMIN;

ARTICLE; BIOLOGICAL MODEL; BIOREACTOR; BIOSYNTHESIS; CELL PROLIFERATION; COMPUTER SIMULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; MICROBIOLOGY; OXIDATION REDUCTION REACTION; PICHIA; PROTEIN ENGINEERING;

BIOREACTORS; CELL PROLIFERATION; COMPUTER SIMULATION; HUMANS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; OXYGEN; PICHIA; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SERUM ALBUMIN;

PICHIA PASTORIS;

EID: 33845624868     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-006-9203-7     Document Type: Article

References (15)

1. Çalik P, Yilgör P, Demir AS (2006) Influence of controlled-pH and uncontrolled-pH operations on recombinant benzaldehyde lyase production by Escherichia coli. Enzyme Microb Tech 38:617-627
2. Cereghino JL, Cregg JM (2000) Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiol Rev 24:45-66
3. Chiruvolu V, Cregg JM, Meagher MM (1997) Recombinant protein production in an alcohol oxidase-defective strain of Pichia pastoris in fedbatch fermentations. Enzyme Microb Tech 21:277-283
4. Inan M, Meagher MM (2001) The effect of ethanol and acetate on protein expression in Pichia pastoris. J Biosci Bioeng 92:337-341
5. Kumar S, Wittmann C, Heinzle E (2004) Minibioreactors. Biotechnol Lett 26:1-10
6. Macauley-Patrick S, Fazenda ML, McNeil B, Harvey LM (2005) Heterologous protein production using the Pichia pastoris expression system. Yeast 22:249-270
7. McGee WT, Jodka P (2002) Oxygen transport and tissue oxygenation. In: Steingrub J, Kacmarek R, Stoller J (eds) Cardiopulmonary critical care. Taylor and Francis Group, UK, pp 35-48
8. Michel BJ, Miller SA (1962) Power requirements of gas-liquid agitated systems. AIChE J 8:262-266
9. Moo-Young M, Blanch HW (1981) Design of biochemical reactors: mass transfer criteria for simple and complex systems. Adv Biochem Eng Biotechnol 19:1-69
10. Ren HT, Yuan JQ, Bellgardt KH (2003) Macrokinetic model for methylotrophic Pichia pastoris based on stoichiometric balance. J Biotechnol 106:53-68
11. Rossi G (2001) The design of bioreactors. Hydrometallurgy 59:217-231
12. Royce PNC, Thornhill NF (1991) Estimation of dissolved carbon dioxide concentrations in aerobic fermentations. AIChE J 37:1681-1686
13. Vilaça PR, Badino AC Jr, Facciotti MCR, Schmidell W (2000) Determination of power consumption and volumetric oxygen transfer coefficient in bioreactors. Bioprocess Eng 22:261-265
14. Yuan JQ, Vanrolleghem PA (1999) Rolling learning-prediction of product formation in bioprocesses. J Biotechnol 69:47-62
15. Zhang W, Li ZJ, Agblevor FA (2005) Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production. Process Biochem 40:2073-2078