Production of monoclonal antibodies by glycoengineered Pichia pastoris

Journal of Biotechnology

Volumn 139, Issue 4, 2009, Pages 318-325

  Potgieter, Thomas I ^a   Cukan, Michael ^a   Drummond, James E ^a   Houston Cummings, Nga Rewa ^a   Jiang, Youwei ^a   Li, Fang ^a   Lynaugh, Heather ^a   Mallem, Muralidhar ^a   McKelvey, Troy W ^a   Mitchell, Teresa ^a   Nylen, Adam ^a   Rittenhour, Alissa ^a   Stadheim, Terrance A ^a   Zha, Dongxing ^a   d'Anjou, Marc ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibody; Fed batch cultivation; Glycoengineering; Glycosylation; Pichia pastoris

Indexed keywords

ANTIGEN-BINDING AFFINITIES; COST OF PRODUCTIONS; CULTIVATION PROCESS; CULTURE CONDITIONS; DISSOLVED OXYGEN CONCENTRATIONS; EXPRESSION SYSTEMS; FED-BATCH CULTIVATION; GLYCOENGINEERING; METHANOL FEEDS; N-LINKED GLYCAN; N-LINKED GLYCANS; N-LINKED GLYCOSYLATION; PICHIA PASTORIS; PROOF OF CONCEPTS; SDS PAGES; SIZE EXCLUSIONS; THERAPEUTIC ANTIBODIES; THERAPEUTIC FUNCTIONS; VOLUMETRIC PRODUCTIVITIES;

ALLERGIES; BINDING ENERGY; CHROMATOGRAPHIC ANALYSIS; DIFFUSERS (OPTICAL); DISSOLUTION; DISSOLVED OXYGEN; ESTERIFICATION; GLYCOSYLATION; MERGERS AND ACQUISITIONS; METHANOL; MONOCLONAL ANTIBODIES; ORGANIC POLYMERS; PRODUCTIVITY; SURFACE PLASMON RESONANCE; YEAST;

CULTIVATION;

DISSOLVED OXYGEN; METHANOL; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG SYNTHESIS; FUNGAL STRAIN; NONHUMAN; PH; PICHIA PASTORIS; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; BINDING SITES, ANTIBODY; BIOREACTORS; CELLS, CULTURED; GENETIC ENGINEERING; GENOMIC INSTABILITY; GLYCOSYLATION; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; METHANOL; OXYGEN; PICHIA; TEMPERATURE;

PICHIA PASTORIS;

EID: 60849113986     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2008.12.015     Document Type: Article

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