High level secretion of recombinant human serum albumin by fed-batch fermentation of the methylotrophic yeast, Pichia pastoris, based on optimal methanol feeding strategy

Journal of Bioscience and Bioengineering

Volumn 90, Issue 3, 2000, Pages 280-288

  Kobayashi, Kaoru ^a   Kuwae, Shinobu ^a   Ohya, Tomoshi ^a   Ohda, Toyoo ^a   Ohyama, Masao ^a   Tomomitsu, Kenji ^b  

^a Welfide Corporation   (Japan)

^b Bipha Corporation   (Japan)

Author keywords

Fed batch fermentation; Human serum albumin; Optimal strategy; Pichia pastoris; Yeast

Indexed keywords

COMPUTER PROGRAMMING; FEEDING; MATHEMATICAL MODELS; METHANOL; OPTIMIZATION; YEAST;

FED-BATCH FERMENTATION; HUMAN SERUM ALBUMIN; METHANOL FEEDING; OPTIMAL STRATEGY; PISCHIA PISTORIS;

FERMENTATION;

METHANOL; SERUM ALBUMIN;

ANALYTIC METHOD; ARTICLE; FERMENTATION; FUNGUS GROWTH; GLYCOSYLATION; HYPOALBUMINEMIA; MATHEMATICAL MODEL; METHYLOTROPHIC BACTERIUM; NONHUMAN; PICHIA PASTORIS; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN SECRETION; YEAST;

BACTERIA (MICROORGANISMS); FUNGI; PICHIA PASTORIS;

EID: 0034281883     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1389-1723(00)80082-1     Document Type: Article

References (13)

1. Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4
2. Serum albumin
3. High-level expression and efficient assembly of hepatitis B surface antigen in the methylotrophic yeast, Pichia pastoris
4. High-level secretion of glycosylated invertase in the methylotrophic yeast, Pichia pastoris
5. High-level expression of recombinant human serum albumin from the methylotrophic yeast Pichia pastoris with minimal protease production and activation
6. General characteristics of optimal feed rate profiles for various fed-batch fermentation processes
7. Computational algorithm for optimal feed rates for a class of fed-batch fermentation: Numerical results for penicillin and cell mass production
8. Maximum histidine production by fed-batch culture of Brevibacterium flavum
9. Optimal production of glutathione by controlling the specific growth rate of yeast in fed-batch culture
10. Modeling and optimization of cloned invertase expression in Saccharomyces cerevisiae
11. Semi-batch culture of methanol-assimilating bacteria with exponentially increased methanol feed
12. High cell-density fermentation