Optimization of human serum albumin production in methylotrophic yeast Pichia pastoris by repeated fed-batch fermentation

Biotechnology and Bioengineering

Volumn 90, Issue 7, 2005, Pages 876-887

  Ohya, Tomoshi ^a   Ohyama, Masao ^a   Kobayashi, Kaoru ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Albumin; Dynamic programming; Optimization; Pichia pastoris; Repeated fed batch

Indexed keywords

CELL CULTURE; COMPUTER SIMULATION; FERMENTATION; METHANOL; OPTIMIZATION; YEAST;

FED-BATCH FERMENTATION; INITIAL CELL MASS; OPTIMAL OPERATION POLICY; RECOMBINANT HUMAN SERUM ALBUMIN (RHSA);

PROTEINS;

SERUM ALBUMIN;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CALCULATION; COLUMN CHROMATOGRAPHY; FED BATCH FERMENTATION; FED BATCH REACTOR; NONHUMAN; PICHIA PASTORIS; PROCESS TECHNOLOGY; RECOMBINANT DNA TECHNOLOGY; STIRRED REACTOR; YEAST;

ALGORITHMS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; COMPUTER SIMULATION; FERMENTATION; HUMANS; METHANOL; MODELS, BIOLOGICAL; PICHIA; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SERUM ALBUMIN;

PICHIA PASTORIS;

EID: 19944423441     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20507     Document Type: Article

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