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Volumn 14, Issue 6 B, 2010, Pages 1373-1384

Chagas' disease: An update on immune mechanisms and therapeutic strategies

Author keywords

Chagas' disease; Chemotherapy; Immunity; Immunoparasitology; Trypanosoma cruzi

Indexed keywords

CHAGAS DISEASE; HUMAN; IMMUNOLOGY; PARASITOLOGY; REVIEW; TRYPANOSOMA CRUZI;

EID: 77955123701     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2010.01007.x     Document Type: Review
Times cited : (45)

References (126)
  • 1
    • 34248583084 scopus 로고    scopus 로고
    • Trypanosoma cruzi: adhesion to the host cell and intracellular survival
    • Alves MJ, Colli W. Trypanosoma cruzi: adhesion to the host cell and intracellular survival. IUBMB Life. 2007, 59:274-9.
    • (2007) IUBMB Life. , vol.59 , pp. 274-279
    • Alves, M.J.1    Colli, W.2
  • 3
    • 34250635871 scopus 로고    scopus 로고
    • An update on Chagas disease (human American trypanosomiasis)
    • Moncayo A, Ortiz Yanine MI. An update on Chagas disease (human American trypanosomiasis). Ann Trop Med Parasitol. 2006, 100:663-77.
    • (2006) Ann Trop Med Parasitol. , vol.100 , pp. 663-677
    • Moncayo, A.1    Ortiz Yanine, M.I.2
  • 5
    • 15744385080 scopus 로고    scopus 로고
    • Parasitic central nervous system infections in immunocompromised hosts
    • Walker M, Zunt JR. Parasitic central nervous system infections in immunocompromised hosts. Clin Infect Dis. 2005, 40:1005-15.
    • (2005) Clin Infect Dis. , vol.40 , pp. 1005-1015
    • Walker, M.1    Zunt, J.R.2
  • 6
    • 34248375271 scopus 로고    scopus 로고
    • An insight on targets and patented drugs for chemotherapy of Chagas disease
    • Duschak VG, Couto AS. An insight on targets and patented drugs for chemotherapy of Chagas disease. Recent Pat Antiinfect Drug Discov. 2007, 2:19-51.
    • (2007) Recent Pat Antiinfect Drug Discov. , vol.2 , pp. 19-51
    • Duschak, V.G.1    Couto, A.S.2
  • 7
    • 33847377170 scopus 로고    scopus 로고
    • Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host
    • Maya JD, Cassels BK, Iturriaga-Vasquez P. Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host. Comp Biochem Physiol. 2007, 146:601-20.
    • (2007) Comp Biochem Physiol. , vol.146 , pp. 601-620
    • Maya, J.D.1    Cassels, B.K.2    Iturriaga-Vasquez, P.3    et al4
  • 8
    • 0036835142 scopus 로고    scopus 로고
    • Proteinases of Trypanosoma cruzi: patential targets for the chemotherapy of Changas desease
    • Cazzulo JJ. Proteinases of Trypanosoma cruzi: patential targets for the chemotherapy of Changas desease. Curr Top Med Chem. 2002, 2:1261-71.
    • (2002) Curr Top Med Chem. , vol.2 , pp. 1261-1271
    • Cazzulo, J.J.1
  • 9
    • 28844509592 scopus 로고    scopus 로고
    • A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi
    • Barr SC, Warner KL, Kornreic BG. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005, 49:5160-1.
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 5160-5161
    • Barr, S.C.1    Warner, K.L.2    Kornreic, B.G.3    et al4
  • 10
    • 0032541311 scopus 로고    scopus 로고
    • Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection
    • Engel JC, Doyle PS, Hsieh I. Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection. J Exp Med. 1998, 188:725-34.
    • (1998) J Exp Med. , vol.188 , pp. 725-734
    • Engel, J.C.1    Doyle, P.S.2    Hsieh, I.3    et al4
  • 11
    • 0033003357 scopus 로고    scopus 로고
    • Chemotherapy of Chagas' disease: the how and the why
    • Urbina JA. Chemotherapy of Chagas' disease: the how and the why. J Mol Med. 1999, 77:332-8.
    • (1999) J Mol Med. , vol.77 , pp. 332-338
    • Urbina, J.A.1
  • 12
    • 69049116505 scopus 로고    scopus 로고
    • Ergosterol biosynthesis and drug development for Chagas disease
    • Urbina JA. Ergosterol biosynthesis and drug development for Chagas disease. Mem Inst Oswaldo Cruz. 2009, 104:311-8.
    • (2009) Mem Inst Oswaldo Cruz. , vol.104 , pp. 311-318
    • Urbina, J.A.1
  • 13
    • 0035342334 scopus 로고    scopus 로고
    • Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites
    • Docampo R, Moreno SN. Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites. Curr Drug Targets Infect Disord. 2001, 1:51-61.
    • (2001) Curr Drug Targets Infect Disord. , vol.1 , pp. 51-61
    • Docampo, R.1    Moreno, S.N.2
  • 14
    • 28544439924 scopus 로고    scopus 로고
    • Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi
    • Esteva MI, Kettler K, Maidana C. Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi. J Med Chem. 2005, 48:7186-91.
    • (2005) J Med Chem. , vol.48 , pp. 7186-7191
    • Esteva, M.I.1    Kettler, K.2    Maidana, C.3    et al4
  • 15
    • 0036302735 scopus 로고    scopus 로고
    • Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution
    • Rivarola HW, Paglini-Oliva PA. Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution. Curr Drug Targets Cardiovasc Haematol Disord. 2002, 2:43-52.
    • (2002) Curr Drug Targets Cardiovasc Haematol Disord. , vol.2 , pp. 43-52
    • Rivarola, H.W.1    Paglini-Oliva, P.A.2
  • 16
    • 0346731297 scopus 로고    scopus 로고
    • Anti-Trypanosoma cruzi activity of green tea (Camellia sinensis) catechins
    • Paveto C, Guida MC, Esteva MI. Anti-Trypanosoma cruzi activity of green tea (Camellia sinensis) catechins. Antimicrob Agents Chemother. 2004, 48:69-74.
    • (2004) Antimicrob Agents Chemother. , vol.48 , pp. 69-74
    • Paveto, C.1    Guida, M.C.2    Esteva, M.I.3    et al4
  • 17
    • 26244446913 scopus 로고    scopus 로고
    • Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity
    • Chamond N, Goytia M, Coatnoan N. Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity. Mol Microbiol. 2005, 58:46-60.
    • (2005) Mol Microbiol. , vol.58 , pp. 46-60
    • Chamond, N.1    Goytia, M.2    Coatnoan, N.3    et al4
  • 18
    • 84887212363 scopus 로고    scopus 로고
    • Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruzi
    • Magdaleno A, Ahn IY, Paes LS. Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruzi. PLoS ONE. 2009, 4:e4534.
    • (2009) PLoS ONE. , vol.4
    • Magdaleno, A.1    Ahn, I.Y.2    Paes, L.S.3    et al4
  • 19
    • 0029957967 scopus 로고    scopus 로고
    • Chagas' disease reactivation after heart transplantation: efficacy of allopurinol treatment
    • Almeida DR, Carvalho AC, Branco JN. Chagas' disease reactivation after heart transplantation: efficacy of allopurinol treatment. J Heart Lung Transplant. 1996, 15:988-92.
    • (1996) J Heart Lung Transplant. , vol.15 , pp. 988-992
    • Almeida, D.R.1    Carvalho, A.C.2    Branco, J.N.3    et al4
  • 20
    • 0029008048 scopus 로고
    • Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania
    • Bodley AL, Shapiro TA. Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania. Proc Natl Acad Sci USA. 1995, 92:3726-30.
    • (1995) Proc Natl Acad Sci USA. , vol.92 , pp. 3726-3730
    • Bodley, A.L.1    Shapiro, T.A.2
  • 21
  • 22
    • 0345283305 scopus 로고    scopus 로고
    • Inhibition of in vitro intracellular growth of Trypanosoma cruzi by dicationic compounds
    • Rowland EC, Moore-Lai D, Seed JR. Inhibition of in vitro intracellular growth of Trypanosoma cruzi by dicationic compounds. J Parasitol. 2003, 89:1078-80.
    • (2003) J Parasitol. , vol.89 , pp. 1078-1080
    • Rowland, E.C.1    Moore-Lai, D.2    Seed, J.R.3    et al4
  • 23
    • 0037763899 scopus 로고    scopus 로고
    • The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani
    • Stephens CE, Brun R, Salem MM. The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani. Bioorg Med Chem Lett. 2003, 13:2065-9.
    • (2003) Bioorg Med Chem Lett. , vol.13 , pp. 2065-2069
    • Stephens, C.E.1    Brun, R.2    Salem, M.M.3    et al4
  • 24
    • 62149098024 scopus 로고    scopus 로고
    • Effect of 3,4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines
    • Stolić I, Miškovic K, Magdaleno A. Effect of 3,4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines. Bioorg Med Chem. 2009, 17:2544-54.
    • (2009) Bioorg Med Chem. , vol.17 , pp. 2544-2554
    • Stolić, I.1    Miškovic, K.2    Magdaleno, A.3    et al4
  • 25
    • 0030298134 scopus 로고    scopus 로고
    • Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection
    • Abrahamsohn IA, Coffman RL. Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection. Exp Parasitol. 1996, 84:231-44.
    • (1996) Exp Parasitol. , vol.84 , pp. 231-244
    • Abrahamsohn, I.A.1    Coffman, R.L.2
  • 26
    • 0027496343 scopus 로고
    • Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei
    • Rottenberg ME, Bakhiet M, Olsson T. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect Immun. 1993, 61:5129-33.
    • (1993) Infect Immun. , vol.61 , pp. 5129-5133
    • Rottenberg, M.E.1    Bakhiet, M.2    Olsson, T.3    et al4
  • 27
    • 0026536194 scopus 로고
    • Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection
    • Tarleton RL, Koller BH, Latour A. Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature. 1992, 356:338-40.
    • (1992) Nature. , vol.356 , pp. 338-340
    • Tarleton, R.L.1    Koller, B.H.2    Latour, A.3    et al4
  • 28
    • 4143132253 scopus 로고    scopus 로고
    • Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors
    • Campos MA, Gazzinelli RT. Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors. Mediators Inflamm. 2004, 13:139-43.
    • (2004) Mediators Inflamm. , vol.13 , pp. 139-143
    • Campos, M.A.1    Gazzinelli, R.T.2
  • 30
    • 1642525756 scopus 로고    scopus 로고
    • Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88
    • Campos MA, Closel M, Valente EP. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol. 2004, 172:1711-8.
    • (2004) J Immunol. , vol.172 , pp. 1711-1718
    • Campos, M.A.1    Closel, M.2    Valente, E.P.3    et al4
  • 31
    • 33750833949 scopus 로고    scopus 로고
    • TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi
    • Koga R, Hamano S, Kuwata H. TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi. J Immunol. 2006, 177:7059-66.
    • (2006) J Immunol. , vol.177 , pp. 7059-7066
    • Koga, R.1    Hamano, S.2    Kuwata, H.3    et al4
  • 32
    • 0035082873 scopus 로고    scopus 로고
    • DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide
    • Shoda LK, Kegerreis KA, Suarez CE. DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infect Immun. 2001, 69:2162-71.
    • (2001) Infect Immun. , vol.69 , pp. 2162-2171
    • Shoda, L.K.1    Kegerreis, K.A.2    Suarez, C.E.3    et al4
  • 33
    • 33748477504 scopus 로고    scopus 로고
    • Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    • Bafica A, Santiago HC, Goldszmid R. Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. J Immunol. 2006, 177:3515-9.
    • (2006) J Immunol. , vol.177 , pp. 3515-3519
    • Bafica, A.1    Santiago, H.C.2    Goldszmid, R.3    et al4
  • 34
    • 0026704806 scopus 로고
    • Control of Trypanosoma cruzi infection in mice deprived of T-cell help
    • Rottenberg ME, Rodriguez DA, Orn A. Control of Trypanosoma cruzi infection in mice deprived of T-cell help. Scand J Immunol. 1992, 36:261-8.
    • (1992) Scand J Immunol. , vol.36 , pp. 261-268
    • Rottenberg, M.E.1    Rodriguez, D.A.2    Orn, A.3
  • 35
    • 0031859154 scopus 로고    scopus 로고
    • The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi
    • Kumar S, Tarleton RL. The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi. Parasite Immunol. 1998, 20:207-16.
    • (1998) Parasite Immunol. , vol.20 , pp. 207-216
    • Kumar, S.1    Tarleton, R.L.2
  • 36
    • 33645513235 scopus 로고    scopus 로고
    • Distinct kinetics of effector CD8+ cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice
    • Tzelepis F, de Alencar BC, Penido ML. Distinct kinetics of effector CD8+ cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice. Infect Immun. 2006, 74:2477-81.
    • (2006) Infect Immun. , vol.74 , pp. 2477-2481
    • Tzelepis, F.1    de Alencar, B.C.2    Penido, M.L.3    et al4
  • 37
    • 0034254417 scopus 로고    scopus 로고
    • Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
    • Tarleton RL, Grusby MJ, Zhang L. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol. 2000, 165:1520-5.
    • (2000) J Immunol. , vol.165 , pp. 1520-1525
    • Tarleton, R.L.1    Grusby, M.J.2    Zhang, L.3
  • 38
    • 0242352547 scopus 로고    scopus 로고
    • Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes
    • Frank FM, Petray PB, Cazorla SI. Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes. Vaccine. 2003, 22:77-86.
    • (2003) Vaccine. , vol.22 , pp. 77-86
    • Frank, F.M.1    Petray, P.B.2    Cazorla, S.I.3    et al4
  • 39
    • 38749145898 scopus 로고    scopus 로고
    • Elicitation of specific, Th1-biased immune response precludes skeletal muscle damage in cruzipain-vaccinated mice
    • Frank FM, Cazorla SI, Sartori MJ. Elicitation of specific, Th1-biased immune response precludes skeletal muscle damage in cruzipain-vaccinated mice. Exp Mol Pathol. 2008, 84:64-70.
    • (2008) Exp Mol Pathol. , vol.84 , pp. 64-70
    • Frank, F.M.1    Cazorla, S.I.2    Sartori, M.J.3    et al4
  • 40
    • 0037261142 scopus 로고    scopus 로고
    • Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway
    • Muller U, Sobek V, Balkow S. Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway. Eur J Immunol. 2003, 33:70-8.
    • (2003) Eur J Immunol. , vol.33 , pp. 70-78
    • Muller, U.1    Sobek, V.2    Balkow, S.3    et al4
  • 41
    • 33748057802 scopus 로고    scopus 로고
    • CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
    • Martin DL, Weatherly DB, Laucella SA. CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS Pathog. 2006, 2:e77.
    • (2006) PLoS Pathog. , vol.2
    • Martin, D.L.1    Weatherly, D.B.2    Laucella, S.A.3    et al4
  • 42
    • 40749084499 scopus 로고    scopus 로고
    • Infection with Trypanosoma cruzi restricts the repertoire of parasite-specific CD8+ T cells leading to immunodominance
    • Tzelepis F, de Alencar BC, Penido ML. Infection with Trypanosoma cruzi restricts the repertoire of parasite-specific CD8+ T cells leading to immunodominance. J Immunol. 2008, 180:1737-48.
    • (2008) J Immunol. , vol.180 , pp. 1737-1748
    • Tzelepis, F.1    de Alencar, B.C.2    Penido, M.L.3    et al4
  • 43
    • 53149087102 scopus 로고    scopus 로고
    • Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection
    • Bixby LM, Tarleton RL. Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. J Immunol. 2008, 181:2644-50.
    • (2008) J Immunol. , vol.181 , pp. 2644-2650
    • Bixby, L.M.1    Tarleton, R.L.2
  • 44
    • 23944437463 scopus 로고    scopus 로고
    • CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2
    • Araujo AF, de Alencar BC, Vasconcelos JR. CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2. Infect Immun. 2005, 73:6017-25.
    • (2005) Infect Immun. , vol.73 , pp. 6017-6025
    • Araujo, A.F.1    de Alencar, B.C.2    Vasconcelos, J.R.3    et al4
  • 45
    • 0037408506 scopus 로고    scopus 로고
    • Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infection
    • Boscardin SB, Kinoshita SS, Fujimura AE. Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infection. Infect Immun. 2003, 71:2744-57.
    • (2003) Infect Immun. , vol.71 , pp. 2744-2757
    • Boscardin, S.B.1    Kinoshita, S.S.2    Fujimura, A.E.3    et al4
  • 46
    • 4544287236 scopus 로고    scopus 로고
    • Protective immunity against Trypanosoma cruzi infection in a highly susceptible mouse strain after vaccination with genes encoding the amastigote surface protein-2 and trans-sialidase
    • Vasconcelos JR, Hiyane MI, Marinho CR. Protective immunity against Trypanosoma cruzi infection in a highly susceptible mouse strain after vaccination with genes encoding the amastigote surface protein-2 and trans-sialidase. Hum Gene Ther. 2004, 15:878-86.
    • (2004) Hum Gene Ther. , vol.15 , pp. 878-886
    • Vasconcelos, J.R.1    Hiyane, M.I.2    Marinho, C.R.3    et al4
  • 47
    • 0036785658 scopus 로고    scopus 로고
    • Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection
    • Garg N, Tarleton RL. Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infect Immun. 2002, 70:5547-55.
    • (2002) Infect Immun. , vol.70 , pp. 5547-5555
    • Garg, N.1    Tarleton, R.L.2
  • 48
    • 0030049984 scopus 로고    scopus 로고
    • Chagas' disease is attenuated in mice lacking gamma delta T cells
    • Santos Lima EC, Minoprio P. Chagas' disease is attenuated in mice lacking gamma delta T cells. Infect Immun. 1996, 64:215-21.
    • (1996) Infect Immun. , vol.64 , pp. 215-221
    • Santos Lima, E.C.1    Minoprio, P.2
  • 49
    • 33646031829 scopus 로고    scopus 로고
    • V gamma 1 gammadelta T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice
    • Nomizo A, Cardillo F, Postol E. V gamma 1 gammadelta T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice. Microbes Infect. 2006, 8:880-8.
    • (2006) Microbes Infect. , vol.8 , pp. 880-888
    • Nomizo, A.1    Cardillo, F.2    Postol, E.3    et al4
  • 50
    • 9244257331 scopus 로고    scopus 로고
    • NK cells contribute to the control of Trypanosoma cruzi infection by killing free parasites by perforin-independent mechanisms
    • Lieke T, Graefe SE, Klauenberg U. NK cells contribute to the control of Trypanosoma cruzi infection by killing free parasites by perforin-independent mechanisms. Infect Immun. 2004, 72:6817-25.
    • (2004) Infect Immun. , vol.72 , pp. 6817-6825
    • Lieke, T.1    Graefe, S.E.2    Klauenberg, U.3    et al4
  • 51
    • 0024253490 scopus 로고
    • Role of T helper/inducer cells as well as natural killer cells in resistance to Trypanosoma cruzi infection
    • Rottenberg M, Cardoni RL, Andersson R. Role of T helper/inducer cells as well as natural killer cells in resistance to Trypanosoma cruzi infection. Scand J Immunol. 1988, 28:573-82.
    • (1988) Scand J Immunol. , vol.28 , pp. 573-582
    • Rottenberg, M.1    Cardoni, R.L.2    Andersson, R.3    et al4
  • 52
    • 0036138267 scopus 로고    scopus 로고
    • During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein
    • Duthie MS, Wleklinski-Lee M, Smith S. During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect Immun. 2002, 70:36-48.
    • (2002) Infect Immun. , vol.70 , pp. 36-48
    • Duthie, M.S.1    Wleklinski-Lee, M.2    Smith, S.3    et al4
  • 53
    • 33846838637 scopus 로고    scopus 로고
    • Endogenous CD4+ CD25+ regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice
    • Kotner J, Tarleton R. Endogenous CD4+ CD25+ regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice. Infect Immun. 2007, 75:861-9.
    • (2007) Infect Immun. , vol.75 , pp. 861-869
    • Kotner, J.1    Tarleton, R.2
  • 54
    • 44449154684 scopus 로고    scopus 로고
    • The regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with Trypanosoma cruzi
    • Sales PA, Golgher D, Oliveira RV. The regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with Trypanosoma cruzi. Microbes Infect. 2008, 10:680-8.
    • (2008) Microbes Infect. , vol.10 , pp. 680-688
    • Sales, P.A.1    Golgher, D.2    Oliveira, R.V.3    et al4
  • 55
    • 0031913243 scopus 로고    scopus 로고
    • Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
    • Holscher C, Kohler G, Muller U. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun. 1998, 66:1208-15.
    • (1998) Infect Immun. , vol.66 , pp. 1208-1215
    • Holscher, C.1    Kohler, G.2    Muller, U.3    et al4
  • 56
    • 34447336725 scopus 로고    scopus 로고
    • IFN-gamma, but not nitric oxide or specific IgG, is essential for the in vivo control of low-virulence Sylvio X10/4 Trypanosoma cruzi parasites
    • Marinho CR, Nunez-Apaza LN, Martins-Santos R. IFN-gamma, but not nitric oxide or specific IgG, is essential for the in vivo control of low-virulence Sylvio X10/4 Trypanosoma cruzi parasites. Scand J Immunol. 2007, 66:297-308.
    • (2007) Scand J Immunol. , vol.66 , pp. 297-308
    • Marinho, C.R.1    Nunez-Apaza, L.N.2    Martins-Santos, R.3    et al4
  • 57
    • 0035149345 scopus 로고    scopus 로고
    • Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection
    • Michailowsky V, Silva NM, Rocha CD. Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection. Am J Pathol. 2001, 159:1723-33.
    • (2001) Am J Pathol. , vol.159 , pp. 1723-1733
    • Michailowsky, V.1    Silva, N.M.2    Rocha, C.D.3    et al4
  • 58
    • 0034600746 scopus 로고    scopus 로고
    • CD4 Th1 but not Th2 clones efficiently activate macrophages to eliminate Trypanosoma cruzi through a nitric oxide dependent mechanism
    • Rodrigues MM, Ribeirao M, Boscardin SB. CD4 Th1 but not Th2 clones efficiently activate macrophages to eliminate Trypanosoma cruzi through a nitric oxide dependent mechanism. Immunol Lett. 2000, 73:43-50.
    • (2000) Immunol Lett. , vol.73 , pp. 43-50
    • Rodrigues, M.M.1    Ribeirao, M.2    Boscardin, S.B.3
  • 59
    • 56949089972 scopus 로고    scopus 로고
    • Nitric oxide synthase-2 modulates chemokine production by Trypanosoma cruzi-infected cardiac myocytes
    • Machado FS, Souto JT, Rossi MA. Nitric oxide synthase-2 modulates chemokine production by Trypanosoma cruzi-infected cardiac myocytes. Microbes Infect. 2008, 10:1558-66.
    • (2008) Microbes Infect. , vol.10 , pp. 1558-1566
    • Machado, F.S.1    Souto, J.T.2    Rossi, M.A.3    et al4
  • 60
    • 0033943272 scopus 로고    scopus 로고
    • Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi
    • Talvani A, Ribeiro CS, Aliberti JC. Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi. Microbes Infect. 2000, 2:851-66.
    • (2000) Microbes Infect. , vol.2 , pp. 851-866
    • Talvani, A.1    Ribeiro, C.S.2    Aliberti, J.C.3    et al4
  • 61
    • 29644433351 scopus 로고    scopus 로고
    • The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi
    • Hardison JL, Wrightsman RA, Carpenter PM. The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006, 74:125-34.
    • (2006) Infect Immun. , vol.74 , pp. 125-134
    • Hardison, J.L.1    Wrightsman, R.A.2    Carpenter, P.M.3    et al4
  • 62
    • 13444283754 scopus 로고    scopus 로고
    • CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi
    • Machado FS, Koyama NS, Carregaro V. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J Infect Dis. 2005, 191:627-36.
    • (2005) J Infect Dis. , vol.191 , pp. 627-636
    • Machado, F.S.1    Koyama, N.S.2    Carregaro, V.3    et al4
  • 63
    • 33646932651 scopus 로고    scopus 로고
    • Chemokine CC receptor 2 is important for acute control of cardiac parasitism but does not contribute to cardiac inflammation after infection with Trypanosoma cruzi
    • Hardison JL, Kuziel WA, Manning JE. Chemokine CC receptor 2 is important for acute control of cardiac parasitism but does not contribute to cardiac inflammation after infection with Trypanosoma cruzi. J Infect Dis. 2006, 193:1584-8.
    • (2006) J Infect Dis. , vol.193 , pp. 1584-1588
    • Hardison, J.L.1    Kuziel, W.A.2    Manning, J.E.3    et al4
  • 64
    • 0037328698 scopus 로고    scopus 로고
    • Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response
    • Galvao Da Silva AP, Jacysyn JF, De Almeida Abrahamsohn I. Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response. Immunology. 2003, 108:230-7.
    • (2003) Immunology. , vol.108 , pp. 230-237
    • Galvao Da Silva, A.P.1    Jacysyn, J.F.2    De Almeida Abrahamsohn, I.3
  • 65
    • 2642647088 scopus 로고    scopus 로고
    • Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient mice
    • Castanos-Velez E, Maerlan S, Osorio LM. Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient mice. Infect Immun. 1998, 66:2960-8.
    • (1998) Infect Immun. , vol.66 , pp. 2960-2968
    • Castanos-Velez, E.1    Maerlan, S.2    Osorio, L.M.3    et al4
  • 66
    • 47749105277 scopus 로고    scopus 로고
    • TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-alpha blockade
    • Kroll-Palhares K, Silverio JC, Silva AA. TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-alpha blockade. Mem Inst Oswaldo Cruz. 2008, 103:375-85.
    • (2008) Mem Inst Oswaldo Cruz. , vol.103 , pp. 375-385
    • Kroll-Palhares, K.1    Silverio, J.C.2    Silva, A.A.3    et al4
  • 67
    • 0031112271 scopus 로고    scopus 로고
    • IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
    • Hunter CA, Ellis-Neyes LA, Slifer T. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol. 1997, 158:3311-6.
    • (1997) J Immunol. , vol.158 , pp. 3311-3316
    • Hunter, C.A.1    Ellis-Neyes, L.A.2    Slifer, T.3    et al4
  • 68
    • 0034097448 scopus 로고    scopus 로고
    • Effects of interleukin-4 deprivation and treatment on resistance to Trypanosoma cruzi
    • Abrahamsohn IA, da Silva AP, Coffman RL. Effects of interleukin-4 deprivation and treatment on resistance to Trypanosoma cruzi. Infect Immun. 2000, 68:1975-9.
    • (2000) Infect Immun. , vol.68 , pp. 1975-1979
    • Abrahamsohn, I.A.1    da Silva, A.P.2    Coffman, R.L.3
  • 69
    • 0019050269 scopus 로고
    • Protection of congenitally athymic mice against Trypanosoma cruzi infection by passive antibody transfer
    • Kierszenbaum F. Protection of congenitally athymic mice against Trypanosoma cruzi infection by passive antibody transfer. J Parasitol. 1980, 66:673-5.
    • (1980) J Parasitol. , vol.66 , pp. 673-675
    • Kierszenbaum, F.1
  • 70
    • 0017225232 scopus 로고
    • Protective effects of specific antibodies in Trypanosoma cruzi infections
    • Krettli AU, Brener Z. Protective effects of specific antibodies in Trypanosoma cruzi infections. J Immunol. 1976, 116:755-60.
    • (1976) J Immunol. , vol.116 , pp. 755-760
    • Krettli, A.U.1    Brener, Z.2
  • 71
    • 0018407794 scopus 로고
    • Membrane-bound antibodies to bloodstream Trypanosoma cruzi in mice: strain differences in susceptibility to complement-mediated lysis
    • Krettli AU, Weisz-Carrington P, Nussenzweig RS. Membrane-bound antibodies to bloodstream Trypanosoma cruzi in mice: strain differences in susceptibility to complement-mediated lysis. Clin Exp Immunol. 1979, 37:416-23.
    • (1979) Clin Exp Immunol. , vol.37 , pp. 416-423
    • Krettli, A.U.1    Weisz-Carrington, P.2    Nussenzweig, R.S.3
  • 72
    • 0023113309 scopus 로고
    • Effect of protective and non-protective antibodies in the phagocytosis rate of Trypanosoma cruzi blood forms by mouse peritoneal macrophages
    • Lages-Silva E, Ramirez LE, Krettli AU. Effect of protective and non-protective antibodies in the phagocytosis rate of Trypanosoma cruzi blood forms by mouse peritoneal macrophages. Parasite Immunol. 1987, 9:21-30.
    • (1987) Parasite Immunol. , vol.9 , pp. 21-30
    • Lages-Silva, E.1    Ramirez, L.E.2    Krettli, A.U.3    et al4
  • 73
    • 0022377484 scopus 로고
    • Antibody-dependent cell cytotoxicity against Trypanosoma cruzi is only mediated by protective antibodies
    • Lima-Martins MV, Sanchez GA, Krettli AU. Antibody-dependent cell cytotoxicity against Trypanosoma cruzi is only mediated by protective antibodies. Parasite Immunol. 1985, 7:367-76.
    • (1985) Parasite Immunol. , vol.7 , pp. 367-376
    • Lima-Martins, M.V.1    Sanchez, G.A.2    Krettli, A.U.3    et al4
  • 74
    • 0018829136 scopus 로고
    • Cell-mediated cytotoxicity to Trypanosoma cruzi. I. Antibody-dependent cell mediated cytotoxicity to trypomastigote bloodstream forms
    • Okabe K, Kipnis TL, Calich VL. Cell-mediated cytotoxicity to Trypanosoma cruzi. I. Antibody-dependent cell mediated cytotoxicity to trypomastigote bloodstream forms. Clin Immunol Immunopathol. 1980, 16:344-53.
    • (1980) Clin Immunol Immunopathol. , vol.16 , pp. 344-353
    • Okabe, K.1    Kipnis, T.L.2    Calich, V.L.3    et al4
  • 75
    • 35948936887 scopus 로고    scopus 로고
    • B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
    • Cardillo F, Postol E, Nihei J. B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection. Immunology. 2007, 122:584-95.
    • (2007) Immunology. , vol.122 , pp. 584-595
    • Cardillo, F.1    Postol, E.2    Nihei, J.3    et al4
  • 76
    • 38449108012 scopus 로고    scopus 로고
    • Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic Trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming
    • Hoft DF, Eickhoff CS, Giddings OK. Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic Trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming. J Immunol. 2007, 179:6889-900.
    • (2007) J Immunol. , vol.179 , pp. 6889-6900
    • Hoft, D.F.1    Eickhoff, C.S.2    Giddings, O.K.3    et al4
  • 77
    • 33644698263 scopus 로고    scopus 로고
    • Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients
    • Albareda MC, Laucella SA, Alvarez MG. Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients. Int Immunol. 2006, 18:465-71.
    • (2006) Int Immunol. , vol.18 , pp. 465-471
    • Albareda, M.C.1    Laucella, S.A.2    Alvarez, M.G.3    et al4
  • 78
    • 0030026329 scopus 로고    scopus 로고
    • Chagasic patients lack CD28 expression on many of their circulating T lymphocytes
    • Dutra WO, Martins-Filho OA, Cancado JR. Chagasic patients lack CD28 expression on many of their circulating T lymphocytes. Scand J Immunol. 1996, 43:88-93.
    • (1996) Scand J Immunol. , vol.43 , pp. 88-93
    • Dutra, W.O.1    Martins-Filho, O.A.2    Cancado, J.R.3    et al4
  • 79
    • 0023579774 scopus 로고
    • Heart transplantation in patients with Chagas' disease cardiomyopathy
    • Stolf NA, Higushi L, Bocchi E. Heart transplantation in patients with Chagas' disease cardiomyopathy. J Heart Transplant. 1987, 6:307-12.
    • (1987) J Heart Transplant. , vol.6 , pp. 307-312
    • Stolf, N.A.1    Higushi, L.2    Bocchi, E.3    et al4
  • 81
    • 33947359936 scopus 로고    scopus 로고
    • Reinfections and Trypanosoma cruzi strains can determine the prognosis of the chronic chagasic cardiopathy in mice
    • Bustamante JM, Novarese M, Rivarola HW. Reinfections and Trypanosoma cruzi strains can determine the prognosis of the chronic chagasic cardiopathy in mice. Parasitol Res. 2007, 100:1407-10.
    • (2007) Parasitol Res. , vol.100 , pp. 1407-1410
    • Bustamante, J.M.1    Novarese, M.2    Rivarola, H.W.3    et al4
  • 82
    • 34447259133 scopus 로고    scopus 로고
    • Modulation of autoimmunity by treatment of an infectious disease
    • Hyland KV, Leon JS, Daniels MD. Modulation of autoimmunity by treatment of an infectious disease. Infect Immun. 2007, 75:3641-50.
    • (2007) Infect Immun. , vol.75 , pp. 3641-3650
    • Hyland, K.V.1    Leon, J.S.2    Daniels, M.D.3    et al4
  • 83
    • 34548011533 scopus 로고    scopus 로고
    • Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load
    • Tzelepis F, Persechini PM, Rodrigues MM. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE. 2007, 2:e393.
    • (2007) PLoS ONE. , vol.2
    • Tzelepis, F.1    Persechini, P.M.2    Rodrigues, M.M.3
  • 84
    • 17944366492 scopus 로고    scopus 로고
    • Acute Chagas' disease: immunohistochemical characteristics of T cell infiltrate and its relationship with T. cruzi parasitic antigens
    • Fuenmayor C, Higuchi ML, Carrasco H. Acute Chagas' disease: immunohistochemical characteristics of T cell infiltrate and its relationship with T. cruzi parasitic antigens. Acta Cardiol. 2005, 60:33-7.
    • (2005) Acta Cardiol. , vol.60 , pp. 33-37
    • Fuenmayor, C.1    Higuchi, M.L.2    Carrasco, H.3    et al4
  • 85
    • 0030906266 scopus 로고    scopus 로고
    • Association of an increase in CD8+ T cells with the presence of Trypanosoma cruzi antigens in chronic, human, chagasic myocarditis
    • Higuchi MD, Ries MM, Aiello VD. Association of an increase in CD8+ T cells with the presence of Trypanosoma cruzi antigens in chronic, human, chagasic myocarditis. Am J Trop Med Hyg. 1997, 56:485-9.
    • (1997) Am J Trop Med Hyg. , vol.56 , pp. 485-489
    • Higuchi, M.D.1    Ries, M.M.2    Aiello, V.D.3    et al4
  • 86
    • 0027269642 scopus 로고
    • Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-alpha+ cells and dominance of granzyme A+, CD8+ lymphocytes
    • Reis DD, Jones EM, Tostes S. Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-alpha+ cells and dominance of granzyme A+, CD8+ lymphocytes. Am J Trop Med Hyg. 1993, 48:637-44.
    • (1993) Am J Trop Med Hyg. , vol.48 , pp. 637-644
    • Reis, D.D.1    Jones, E.M.2    Tostes, S.3    et al4
  • 87
    • 17844385300 scopus 로고    scopus 로고
    • Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection
    • Abel LC, Rizzo LV, Ianni B. Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection. J Autoimmun. 2001, 17:99-107.
    • (2001) J Autoimmun. , vol.17 , pp. 99-107
    • Abel, L.C.1    Rizzo, L.V.2    Ianni, B.3    et al4
  • 88
    • 0033965944 scopus 로고    scopus 로고
    • Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase
    • Ribeirao M, Pereira-Chioccola VL, Renia L. Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase. Parasite Immunol. 2000, 22:49-53.
    • (2000) Parasite Immunol. , vol.22 , pp. 49-53
    • Ribeirao, M.1    Pereira-Chioccola, V.L.2    Renia, L.3    et al4
  • 89
    • 0037372978 scopus 로고    scopus 로고
    • Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response
    • Gomes JA, Bahia-Oliveira LM, Rocha MO. Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response. Infect Immun. 2003, 71:1185-93.
    • (2003) Infect Immun. , vol.71 , pp. 1185-1193
    • Gomes, J.A.1    Bahia-Oliveira, L.M.2    Rocha, M.O.3    et al4
  • 90
    • 4544243823 scopus 로고    scopus 로고
    • Monocytes from patients with indeterminate and cardiac forms of Chagas' disease display distinct phenotypic and functional characteristics associated with morbidity
    • Souza PE, Rocha MO, Rocha-Vieira E. Monocytes from patients with indeterminate and cardiac forms of Chagas' disease display distinct phenotypic and functional characteristics associated with morbidity. Infect Immun. 2004, 72:5283-91.
    • (2004) Infect Immun. , vol.72 , pp. 5283-5291
    • Souza, P.E.1    Rocha, M.O.2    Rocha-Vieira, E.3    et al4
  • 91
    • 12144291648 scopus 로고    scopus 로고
    • Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease
    • Laucella SA, Postan M, Martin D. Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease. J Infect Dis. 2004, 189:909-18.
    • (2004) J Infect Dis. , vol.189 , pp. 909-918
    • Laucella, S.A.1    Postan, M.2    Martin, D.3    et al4
  • 92
    • 34447319440 scopus 로고    scopus 로고
    • Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy
    • Fonseca SG, Reis MM, Coelho V. Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy. Scand J Immunol. 2007, 66:362-71.
    • (2007) Scand J Immunol. , vol.66 , pp. 362-371
    • Fonseca, S.G.1    Reis, M.M.2    Coelho, V.3    et al4
  • 93
    • 25144458663 scopus 로고    scopus 로고
    • Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy
    • Cunha-Neto E, Dzau VJ, Allen PD. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Am J Pathol. 2005, 167:305-13.
    • (2005) Am J Pathol. , vol.167 , pp. 305-313
    • Cunha-Neto, E.1    Dzau, V.J.2    Allen, P.D.3    et al4
  • 94
    • 0031032002 scopus 로고    scopus 로고
    • Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection
    • Dutra WO, Gollob KJ, Pinto-Dias JC. Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection. Scand J Immunol. 1997, 45:74-80.
    • (1997) Scand J Immunol. , vol.45 , pp. 74-80
    • Dutra, W.O.1    Gollob, K.J.2    Pinto-Dias, J.C.3    et al4
  • 95
    • 1842613609 scopus 로고    scopus 로고
    • Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy
    • Talvani A, Rocha MO, Barcelos LS. Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy. Clin Infect Dis. 2004, 38:943-50.
    • (2004) Clin Infect Dis. , vol.38 , pp. 943-950
    • Talvani, A.1    Rocha, M.O.2    Barcelos, L.S.3    et al4
  • 96
    • 56149089459 scopus 로고    scopus 로고
    • HLA Class I-T Cell Epitopes from trans-Sialidase Proteins Reveal Functionally Distinct Subsets of CD8 T Cells in Chronic Chagas Disease
    • Alvarez MG, Postan M, Weatherly DB. HLA Class I-T Cell Epitopes from trans-Sialidase Proteins Reveal Functionally Distinct Subsets of CD8 T Cells in Chronic Chagas Disease. PLoS Negl Trop Dis. 2008, 2:e288.
    • (2008) PLoS Negl Trop Dis. , vol.2
    • Alvarez, M.G.1    Postan, M.2    Weatherly, D.B.3    et al4
  • 97
    • 33645035782 scopus 로고    scopus 로고
    • Evaluation of IFN-gamma production by CD8 T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma cruzi
    • Diez H, Lopez MC, Del Carmen Thomas M. Evaluation of IFN-gamma production by CD8 T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma cruzi. Parasite Immunol. 2006, 28:101-5.
    • (2006) Parasite Immunol. , vol.28 , pp. 101-105
    • Diez, H.1    Lopez, M.C.2    Del Carmen Thomas, M.3    et al4
  • 98
    • 21144435504 scopus 로고    scopus 로고
    • Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients
    • Fonseca SG, Moins-Teisserenc H, Clave E. Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients. Microbes Infect. 2005, 7:688-97.
    • (2005) Microbes Infect. , vol.7 , pp. 688-697
    • Fonseca, S.G.1    Moins-Teisserenc, H.2    Clave, E.3    et al4
  • 100
    • 53149148909 scopus 로고    scopus 로고
    • Chagas heart disease pathogenesis: one mechanism or many
    • Bonney KM, Engman DM. Chagas heart disease pathogenesis: one mechanism or many. Curr Mol Med. 2008, 8:510-8.
    • (2008) Curr Mol Med. , vol.8 , pp. 510-518
    • Bonney, K.M.1    Engman, D.M.2
  • 101
    • 51649086111 scopus 로고    scopus 로고
    • Chronic American trypanosomiasis: parasite persistence in endomyocardial biopsies is associated with high-grade myocarditis
    • Benvenuti LA, Roggerio A, Freitas HF. Chronic American trypanosomiasis: parasite persistence in endomyocardial biopsies is associated with high-grade myocarditis. Ann Trop Med Parasitol. 2008, 102:481-7.
    • (2008) Ann Trop Med Parasitol. , vol.102 , pp. 481-487
    • Benvenuti, L.A.1    Roggerio, A.2    Freitas, H.F.3    et al4
  • 102
    • 48749121390 scopus 로고    scopus 로고
    • Distinct outcomes of Trypanosoma cruzi infection in hamsters are related to myocardial parasitism, cytokine/chemokine gene expression, and protein expression profile
    • Bilate AM, Teixeira PC, Ribeiro SP. Distinct outcomes of Trypanosoma cruzi infection in hamsters are related to myocardial parasitism, cytokine/chemokine gene expression, and protein expression profile. J Infect Dis. 2008, 198:614-23.
    • (2008) J Infect Dis. , vol.198 , pp. 614-623
    • Bilate, A.M.1    Teixeira, P.C.2    Ribeiro, S.P.3    et al4
  • 103
    • 33749541953 scopus 로고    scopus 로고
    • Benznidazole treatment during early-indeterminate Chagas' disease shifted the cytokine expression by innate and adaptive immunity cells toward a type 1-modulated immune profile
    • Sathler-Avelar R, Vitelli-Avelar DM, Massara RL. Benznidazole treatment during early-indeterminate Chagas' disease shifted the cytokine expression by innate and adaptive immunity cells toward a type 1-modulated immune profile. Scand J Immunol. 2006, 64:554-63.
    • (2006) Scand J Immunol. , vol.64 , pp. 554-563
    • Sathler-Avelar, R.1    Vitelli-Avelar, D.M.2    Massara, R.L.3    et al4
  • 105
    • 0025501098 scopus 로고
    • Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages
    • Lages-Silva E, Filardi LS, Brener Z. Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages. Mem Inst Oswaldo Cruz. 1990, 85:401-5.
    • (1990) Mem Inst Oswaldo Cruz. , vol.85 , pp. 401-405
    • Lages-Silva, E.1    Filardi, L.S.2    Brener, Z.3
  • 106
    • 0032867161 scopus 로고    scopus 로고
    • In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypansoma cruzi population
    • Murta SM, Ropert C, Alves RO. In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypansoma cruzi population. Parasite Immunol. 1999, 21:535-44.
    • (1999) Parasite Immunol. , vol.21 , pp. 535-544
    • Murta, S.M.1    Ropert, C.2    Alves, R.O.3    et al4
  • 107
    • 0037105691 scopus 로고    scopus 로고
    • Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure
    • Romanha AJ, Alves RO, Murta SM. Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure. J Infect Dis. 2002, 186:823-8.
    • (2002) J Infect Dis. , vol.186 , pp. 823-828
    • Romanha, A.J.1    Alves, R.O.2    Murta, S.M.3    et al4
  • 108
    • 43249116465 scopus 로고    scopus 로고
    • Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease
    • Bustamante JM, Bixby LM, Tarleton RL. Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat Med. 2008, 14:542-50.
    • (2008) Nat Med. , vol.14 , pp. 542-550
    • Bustamante, J.M.1    Bixby, L.M.2    Tarleton, R.L.3
  • 109
    • 0036896423 scopus 로고    scopus 로고
    • Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
    • Olivieri BP, Cotta-De-Almeida V, Araujo-Jorge T. Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection. Antimicrob Agents Chemother. 2002, 46:3790-6.
    • (2002) Antimicrob Agents Chemother. , vol.46 , pp. 3790-3796
    • Olivieri, B.P.1    Cotta-De-Almeida, V.2    Araujo-Jorge, T.3
  • 110
    • 44349169957 scopus 로고    scopus 로고
    • Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions
    • Caldas IS, Talvani A, Caldas S. Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions. Parasitol Res. 2008, 103:413-21.
    • (2008) Parasitol Res. , vol.103 , pp. 413-421
    • Caldas, I.S.1    Talvani, A.2    Caldas, S.3    et al4
  • 111
    • 0033836587 scopus 로고    scopus 로고
    • Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago
    • Bahia-Oliveira LM, Gomes JA, Cancado JR. Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago. J Infect Dis. 2000, 182:634-8.
    • (2000) J Infect Dis. , vol.182 , pp. 634-638
    • Bahia-Oliveira, L.M.1    Gomes, J.A.2    Cancado, J.R.3    et al4
  • 112
    • 0031714971 scopus 로고    scopus 로고
    • Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi
    • Michailowsky V, Murta SM, Carvalho-Oliveira L. Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi. Antimicrob Agents Chemother. 1998, 42:2549-56.
    • (1998) Antimicrob Agents Chemother. , vol.42 , pp. 2549-2556
    • Michailowsky, V.1    Murta, S.M.2    Carvalho-Oliveira, L.3    et al4
  • 113
    • 53549128946 scopus 로고    scopus 로고
    • Strategy to assess the overall cytokine profile of circulating leukocytes and its association with distinct clinical forms of human Chagas disease
    • Vitelli-Avelar DM, Sathler-Avelar R, Teixeira-Carvalho A. Strategy to assess the overall cytokine profile of circulating leukocytes and its association with distinct clinical forms of human Chagas disease. Scand J Immunol. 2008, 68:516-25.
    • (2008) Scand J Immunol. , vol.68 , pp. 516-525
    • Vitelli-Avelar, D.M.1    Sathler-Avelar, R.2    Teixeira-Carvalho, A.3    et al4
  • 114
    • 39749202944 scopus 로고    scopus 로고
    • Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern
    • Sathler-Avelar R, Vitelli-Avelar DM, Massara RL. Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern. Microbes Infect. 2008, 10:103-13.
    • (2008) Microbes Infect. , vol.10 , pp. 103-113
    • Sathler-Avelar, R.1    Vitelli-Avelar, D.M.2    Massara, R.L.3    et al4
  • 115
    • 0032749274 scopus 로고    scopus 로고
    • Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages
    • Revelli S, Le Page C, Piaggio E. Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages. Clin Exp Immunol. 1999, 118:271-7.
    • (1999) Clin Exp Immunol. , vol.118 , pp. 271-277
    • Revelli, S.1    Le Page, C.2    Piaggio, E.3    et al4
  • 116
    • 0035884994 scopus 로고    scopus 로고
    • Trypanocidal drug benznidazole impairs lipopolysaccharide induction of macrophage nitric oxide synthase gene transcription through inhibition of NF-kb activation
    • Piaggio E, Sanceau J, Revelli S. Trypanocidal drug benznidazole impairs lipopolysaccharide induction of macrophage nitric oxide synthase gene transcription through inhibition of NF-kb activation. J Immunol. 2001, 167:3422-6.
    • (2001) J Immunol. , vol.167 , pp. 3422-3426
    • Piaggio, E.1    Sanceau, J.2    Revelli, S.3    et al4
  • 117
    • 0034954121 scopus 로고    scopus 로고
    • Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats
    • Piaggio E, Roggero E, Pitashny M. Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats. Parasitol Res. 2001, 87:539-47.
    • (2001) Parasitol Res. , vol.87 , pp. 539-547
    • Piaggio, E.1    Roggero, E.2    Pitashny, M.3    et al4
  • 118
    • 9644258953 scopus 로고    scopus 로고
    • Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice
    • Pascutti MF, Pitashny M, Nocito AL. Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice. Life Sci. 2004, 76:685-97.
    • (2004) Life Sci. , vol.76 , pp. 685-697
    • Pascutti, M.F.1    Pitashny, M.2    Nocito, A.L.3    et al4
  • 119
    • 55849118825 scopus 로고    scopus 로고
    • Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture
    • Manarin R, Bottasso E, Bottasso O. Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture. Am J Trop Med Hyg. 2008, 79:793-6.
    • (2008) Am J Trop Med Hyg. , vol.79 , pp. 793-796
    • Manarin, R.1    Bottasso, E.2    Bottasso, O.3    et al4
  • 120
    • 0023931625 scopus 로고
    • Differences in resistance to reinfection with low and high inocula of Trypanosoma cruzi in chagasic mice treated with nifurtimox and relation to immune response
    • Cabeza Meckert P, Chambo JG, Laguens RP. Differences in resistance to reinfection with low and high inocula of Trypanosoma cruzi in chagasic mice treated with nifurtimox and relation to immune response. Antimicrob Agents Chemother. 1988, 32:241-5.
    • (1988) Antimicrob Agents Chemother. , vol.32 , pp. 241-245
    • Cabeza Meckert, P.1    Chambo, J.G.2    Laguens, R.P.3
  • 121
    • 0017610220 scopus 로고
    • Nifurtimox-induced alterations in the cell-mediated immune response to PPD tin guinea-pigs
    • Lelchuk R, Cardoni RL, Levis S. Nifurtimox-induced alterations in the cell-mediated immune response to PPD tin guinea-pigs. Clin Exp Immunol. 1977, 30:469-73.
    • (1977) Clin Exp Immunol. , vol.30 , pp. 469-473
    • Lelchuk, R.1    Cardoni, R.L.2    Levis, S.3
  • 122
    • 0017611259 scopus 로고
    • Cell-mediated immunity in Chagas' disease: alterations induced by treatment with a trypanocidal drug (nifurtimox)
    • Lelchuk R, Cardoni RL, Fuks AS. Cell-mediated immunity in Chagas' disease: alterations induced by treatment with a trypanocidal drug (nifurtimox). Clin Exp Immunol. 1977, 30:434-8.
    • (1977) Clin Exp Immunol. , vol.30 , pp. 434-438
    • Lelchuk, R.1    Cardoni, R.L.2    Fuks, A.S.3
  • 124
    • 1142291085 scopus 로고    scopus 로고
    • Chagas disease: a role for autoimmunity?
    • Tarleton RL. Chagas disease: a role for autoimmunity? Trends Parasitol. 2003, 19:447-51.
    • (2003) Trends Parasitol. , vol.19 , pp. 447-451
    • Tarleton, R.L.1
  • 126
    • 34249827881 scopus 로고    scopus 로고
    • Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy
    • Soares MB, Garcia S, Campos de Carvalho AC. Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. Regen Med. 2007, 2:257-64.
    • (2007) Regen Med. , vol.2 , pp. 257-264
    • Soares, M.B.1    Garcia, S.2    Campos de Carvalho, A.C.3    et al4


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