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Volumn 21, Issue 10, 1999, Pages 535-544

In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypanosoma cruzi population

Author keywords

Chaga's disease; Drug resistance; Interferon gamma; Interleukin 12; Nitric oxide; Trypanosoma cruzi; Tumour necrosis factor alpha

Indexed keywords

BENZNIDAZOLE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA;

EID: 0032867161     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1999.00251.x     Document Type: Article
Times cited : (28)

References (42)
  • 1
    • 0030010929 scopus 로고    scopus 로고
    • IL-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
    • Alibert J.C.A., Cardoso M.A.G., Martins G.A. et al. (1996) IL-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infection and Immunity, 64, 1961-1967
    • (1996) Infection and Immunity , vol.64 , pp. 1961-1967
    • Alibert, J.C.A.1    Cardoso, M.A.G.2    Martins, G.A.3
  • 2
    • 17644432619 scopus 로고
    • Interactions between immunity and chemotherapy in the treatment of the trypanosominases and leishmaniases
    • Berger B.J. & Fairlamb A.H. (1992) Interactions between immunity and chemotherapy in the treatment of the trypanosominases and leishmaniases. Parasitology, 105, 871-878
    • (1992) Parasitology , vol.105 , pp. 871-878
    • Berger, B.J.1    Fairlamb, A.H.2
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annals of Biochemistry, 72, 248-254
    • (1976) Annals of Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 73649161135 scopus 로고
    • Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi
    • Brener Z. (1962) Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de São Paulo, 4, 389-396
    • (1962) Revista do Instituto de Medicina Tropical de São Paulo , vol.4 , pp. 389-396
    • Brener, Z.1
  • 5
    • 0030870893 scopus 로고    scopus 로고
    • Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas disease
    • Brener Z. & Gazzinelli R.T. (1997) Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas disease. International Archives of Allergy and Immunology, 114, 103-110
    • (1997) International Archives of Allergy and Immunology , vol.114 , pp. 103-110
    • Brener, Z.1    Gazzinelli, R.T.2
  • 6
    • 0023235490 scopus 로고
    • The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response
    • Brindley P.J. & Sher A. (1987) The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response. Journal of Immunology, 139, 215-220
    • (1987) Journal of Immunology , vol.139 , pp. 215-220
    • Brindley, P.J.1    Sher, A.2
  • 7
    • 78651145402 scopus 로고
    • Growth and differentiation in Trypanosoma cruzi. I. Origin of metacyclic trypanosome in liquid media
    • Camargo E.P. (1964) Growth and differentiation in Trypanosoma cruzi. I. Origin of metacyclic trypanosome in liquid media. Revista do Instituto de Medicina Tropical de São Paulo, 6, 93-100
    • (1964) Revista do Instituto de Medicina Tropical de São Paulo , vol.6 , pp. 93-100
    • Camargo, E.P.1
  • 8
    • 0031570514 scopus 로고    scopus 로고
    • Glycosylpho-sphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages
    • Camargo M.M., Almeida I.C., Pereira M.E. t al. (1997) Glycosylpho-sphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages. Journal of Immunology, 158, 5890-5901
    • (1997) Journal of Immunology , vol.158 , pp. 5890-5901
    • Camargo, M.M.1    Almeida, I.C.2    Pereira, M.E.3
  • 9
    • 0030025945 scopus 로고    scopus 로고
    • Regulation of Trypanosma cruzi infection in mice by gamma interferon and interleukin-10: The role of NK cells
    • Cardillo F., Voltarelli J.C., Reed S.G. & Silva J.S. (1996) Regulation of Trypanosma cruzi infection in mice by gamma interferon and interleukin-10: the role of NK cells. Infection and Immunity, 64, 128-134
    • (1996) Infection and Immunity , vol.64 , pp. 128-134
    • Cardillo, F.1    Voltarelli, J.C.2    Reed, S.G.3    Silva, J.S.4
  • 10
    • 0025173908 scopus 로고
    • Changes in the isoenzyme and kinetoplast DNA patterns of Trypanosoma cruzi strains induced by maintenance in mice
    • Carneiro M., Chiari E., Gonçalves A.M. et al. (1990) Changes in the isoenzyme and kinetoplast DNA patterns of Trypanosoma cruzi strains induced by maintenance in mice. Acta Tropica, 47, 35-45
    • (1990) Acta Tropica , vol.47 , pp. 35-45
    • Carneiro, M.1    Chiari, E.2    Gonçalves, A.M.3
  • 11
    • 0028208833 scopus 로고
    • Cytokine treatment of central nervous system infection: Efficacy of IL-12 alone and synergy with conventional antifugal therapy in experimental cryptococcoses
    • Clemons K.V., Brummer E. & Stevens D.A. (1994) Cytokine treatment of central nervous system infection: efficacy of IL-12 alone and synergy with conventional antifugal therapy in experimental cryptococcoses. Antimicrobial Agents and Chemotherapy, 38, 460-464
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 460-464
    • Clemons, K.V.1    Brummer, E.2    Stevens, D.A.3
  • 12
    • 0021045232 scopus 로고
    • Role of antibody in the elimination of trypanosomes after DL-α-difluoromethylornithine chemotherapy
    • Degee A.L.W., McCann P. & Mansfield J.M. (1983) Role of antibody in the elimination of trypanosomes after DL-α-difluoromethylornithine chemotherapy. Journal of Parasitology, 69, 818-822
    • (1983) Journal of Parasitology , vol.69 , pp. 818-822
    • Degee, A.L.W.1    McCann, P.2    Mansfield, J.M.3
  • 13
    • 0023796162 scopus 로고
    • Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages
    • Drapier J.C., Wietzerbin J. & Hibbs J.B. Jr (1988) Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. European Journal of Immunology, 18, 1587
    • (1988) European Journal of Immunology , vol.18 , pp. 1587
    • Drapier, J.C.1    Wietzerbin, J.2    Hibbs J.B., Jr.3
  • 14
    • 0021415428 scopus 로고
    • A rapid method for testing in vivo the susceptibility of different strains of Trypanosoma cruzi to active chemotherapeutic agents
    • Filardi L.S. & Brener Z. (1984) A rapid method for testing in vivo the susceptibility of different strains of Trypanosoma cruzi to active chemotherapeutic agents. Memórias do Instituto Oswaldo Cruz, 79, 221-225
    • (1984) Memórias do Instituto Oswaldo Cruz , vol.79 , pp. 221-225
    • Filardi, L.S.1    Brener, Z.2
  • 15
    • 0023609713 scopus 로고
    • Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas' disease
    • Filardi L.S. & Brener Z. (1987) Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas' disease. Transactions of the Royal Society of Tropical Medicine and Hygiene, 81, 755-759
    • (1987) Transactions of the Royal Society of Tropical Medicine and Hygiene , vol.81 , pp. 755-759
    • Filardi, L.S.1    Brener, Z.2
  • 16
    • 0029078676 scopus 로고
    • IL-12 increases resistance of Balb/c mice to Mycobacterium tuberculosis infection
    • Flynn J.L., Goldstein M.M., Triebold K.J. et al. (1995) IL-12 increases resistance of Balb/c mice to Mycobacterium tuberculosis infection. Journal of Immunoloy, 155, 2515-2524
    • (1995) Journal of Immunoloy , vol.155 , pp. 2515-2524
    • Flynn, J.L.1    Goldstein, M.M.2    Triebold, K.J.3
  • 17
    • 0026191976 scopus 로고
    • Lectin receptors distribution in the surface membrane of Trypanosoma cruzi blood forms collected from mice submitted to specific treatment
    • Fontes G., Romanha A.J., Pereira M.E. & Brener Z. (1991) Lectin receptors distribution in the surface membrane of Trypanosoma cruzi blood forms collected from mice submitted to specific treatment. Memórias do Instituto Oswaldo Cruz, 86, 297-299
    • (1991) Memórias do Instituto Oswaldo Cruz , vol.86 , pp. 297-299
    • Fontes, G.1    Romanha, A.J.2    Pereira, M.E.3    Brener, Z.4
  • 18
    • 0027264849 scopus 로고
    • Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-gamma by an intracellular parasite and induces resistance in T-cell deficient hosts
    • Gazzinelli R.T., Hieny S., Wynn T.A., Wolf S. & Sher A. (1993) Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-gamma by an intracellular parasite and induces resistance in T-cell deficient hosts. Proceedings of the National Academy of Sciences USA, 90, 6115-6119
    • (1993) Proceedings of the National Academy of Sciences USA , vol.90 , pp. 6115-6119
    • Gazzinelli, R.T.1    Hieny, S.2    Wynn, T.A.3    Wolf, S.4    Sher, A.5
  • 19
    • 0026805989 scopus 로고
    • The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mechanism inhabitable by interleukin-10 and transforming growth factor-β
    • Gazzinelli R.T., Oswald P., Hieny S., James S.L. & Sher A. (1992) The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mechanism inhabitable by interleukin-10 and transforming growth factor-β. European Journal of Immunology, 22, 2501-2506
    • (1992) European Journal of Immunology , vol.22 , pp. 2501-2506
    • Gazzinelli, R.T.1    Oswald, P.2    Hieny, S.3    James, S.L.4    Sher, A.5
  • 20
    • 0029967256 scopus 로고    scopus 로고
    • Interleukin-12 mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon
    • Hunter C.A., Slifer T. & Araujo F. (1996) Interleukin-12 mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infection and Immunity, 64, 2381-2386
    • (1996) Infection and Immunity , vol.64 , pp. 2381-2386
    • Hunter, C.A.1    Slifer, T.2    Araujo, F.3
  • 21
    • 0029116380 scopus 로고
    • Human antiprotozoal therapy: Past, present, and future
    • Khaw M. & Panosian C.B. (1995) Human antiprotozoal therapy: past, present, and future. Clinical Microbiology Review of, 8, 427-439
    • (1995) Clinical Microbiology Review of , vol.8 , pp. 427-439
    • Khaw, M.1    Panosian, C.B.2
  • 22
    • 0025501098 scopus 로고
    • Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages
    • Lages-Silva E., Filardi L. & Brener Z. (1990) Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages. Memórias do Instituto Oswaldo Cruz, 85, 401-405
    • (1990) Memórias do Instituto Oswaldo Cruz , vol.85 , pp. 401-405
    • Lages-Silva, E.1    Filardi, L.2    Brener, Z.3
  • 23
    • 0031714971 scopus 로고    scopus 로고
    • Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi
    • Michailowsky V., Murta S.M.F., Carvalho-Oliveira L. et al. (1998) Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy, 42, 2549-2556
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 2549-2556
    • Michailowsky, V.1    Murta, S.M.F.2    Carvalho-Oliveira, L.3
  • 24
    • 0022490294 scopus 로고
    • Trypanosoma cruzi: Isolate dependence in the induction of lytic antibodies in the mouse
    • Muller L.A., Anasco N. & Gonzales Cappa S.M. (1986) Trypanosoma cruzi: isolate dependence in the induction of lytic antibodies in the mouse. Experimental Parasitology, 61, 284-293
    • (1986) Experimental Parasitology , vol.61 , pp. 284-293
    • Muller, L.A.1    Anasco, N.2    Gonzales Cappa, S.M.3
  • 25
    • 17344379918 scopus 로고    scopus 로고
    • Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox
    • Murta S.M.F., Gazzinelli R.T., Brener Z. & Romanha A.J. (1998) Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Molecular and Biochemical Parasitology, 93 (2), 203-214
    • (1998) Molecular and Biochemical Parasitology , vol.93 , Issue.2 , pp. 203-214
    • Murta, S.M.F.1    Gazzinelli, R.T.2    Brener, Z.3    Romanha, A.J.4
  • 26
    • 0031984626 scopus 로고    scopus 로고
    • In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole
    • Murta S.M.F. & Romanha A.J. (1998) In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole. Parasitology, 116, 165-171
    • (1998) Parasitology , vol.116 , pp. 165-171
    • Murta, S.M.F.1    Romanha, A.J.2
  • 27
    • 0028934155 scopus 로고
    • A switch from a Th2 to Th1 type response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam
    • Nabors G.S., Alonso L.C.C., Farrell J.P. & Scott P. (1995) A switch from a Th2 to Th1 type response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam. Proceedings of the National Academy of Sciences, USA, 92, 3142-3146
    • (1995) Proceedings of the National Academy of Sciences, USA , vol.92 , pp. 3142-3146
    • Nabors, G.S.1    Alonso, L.C.C.2    Farrell, J.P.3    Scott, P.4
  • 29
    • 0000582767 scopus 로고
    • Sobre uma cepa de Trypanosoma cruzi altamente virulenta para camundongo branco
    • Pereira da Silva L.H.P. & Nussenzweig V. (1953) Sobre uma cepa de Trypanosoma cruzi altamente virulenta para camundongo branco. Folia Clinica et Biologica, 20, 191-207
    • (1953) Folia Clinica et Biologica , vol.20 , pp. 191-207
    • Pereira da Silva, L.H.P.1    Nussenzweig, V.2
  • 30
    • 0023770735 scopus 로고
    • In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections
    • Reed S.G. (1988) In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. Journal of Immunology, 140, 4342-4347
    • (1988) Journal of Immunology , vol.140 , pp. 4342-4347
    • Reed, S.G.1
  • 31
    • 0029071261 scopus 로고
    • Growth inhibitory effect of nafthofuran and nafthofuranquinone derivatives on Trypanosoma cruzi epimastigotes
    • Ribeiro-Rodrigues R., Dos Santos W., Oliveira A.B. et al. (1995) Growth inhibitory effect of nafthofuran and nafthofuranquinone derivatives on Trypanosoma cruzi epimastigotes. Bioorganic and Medicinal Chemistry Letters, 5, 1509-1512
    • (1995) Bioorganic and Medicinal Chemistry Letters , vol.5 , pp. 1509-1512
    • Ribeiro-Rodrigues, R.1    Dos Santos, W.2    Oliveira, A.B.3
  • 32
    • 0023489870 scopus 로고
    • The efficacy of an n-substituted imidazole, RS-49676, against a Trypanosoma cruzi infection in mice
    • Scoth V.R. & Mathews T.R. (1987) The efficacy of an n-substituted imidazole, RS-49676, against a Trypanosoma cruzi infection in mice. American Journal of Tropical Medicine and Hygiene, 37, 308-313
    • (1987) American Journal of Tropical Medicine and Hygiene , vol.37 , pp. 308-313
    • Scoth, V.R.1    Mathews, T.R.2
  • 33
    • 0026527760 scopus 로고
    • Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection
    • Silva J.S., Morrissey P.J., Grabstein K.H. et al. (1992) Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. Journal of Experimental Medicine, 175, 169-174
    • (1992) Journal of Experimental Medicine , vol.175 , pp. 169-174
    • Silva, J.S.1    Morrissey, P.J.2    Grabstein, K.H.3
  • 34
    • 0028807425 scopus 로고
    • Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages
    • Silva J.S., Vespa G.N.R., Cardoso M.A.G., Alibert J.C.S. & Cunha F.Q. (1995) Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infection and Immunity, 63 (12), 4862-4867
    • (1995) Infection and Immunity , vol.63 , Issue.12 , pp. 4862-4867
    • Silva, J.S.1    Vespa, G.N.R.2    Cardoso, M.A.G.3    Alibert, J.C.S.4    Cunha, F.Q.5
  • 36
    • 0009683411 scopus 로고
    • IL-12-induced protection against blood-stage Plasmodium chabaudi requires IFNγ and TNFα and occurs via nitric oxide-dependent mechanism
    • Stevenson M.M., Tam M.F., Wolf S.F. & Sher A. (1995) IL-12-induced protection against blood-stage Plasmodium chabaudi requires IFNγ and TNFα and occurs via nitric oxide-dependent mechanism. Journal of Immunology. 156, 263-268
    • (1995) Journal of Immunology , vol.156 , pp. 263-268
    • Stevenson, M.M.1    Tam, M.F.2    Wolf, S.F.3    Sher, A.4
  • 37
    • 0021847173 scopus 로고
    • Chemotherapy and the immune response in parasitic infections
    • Target G.A.T. (1985) Chemotherapy and the immune response in parasitic infections. Parasitology, 90, 661-673
    • (1985) Parasitology , vol.90 , pp. 661-673
    • Target, G.A.T.1
  • 39
    • 0025829971 scopus 로고
    • Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice
    • Torrico F., Heremans H., Rivera M.T. et al. (1991) Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. Journal of Immunology. 146, 3626-3632
    • (1991) Journal of Immunology , vol.146 , pp. 3626-3632
    • Torrico, F.1    Heremans, H.2    Rivera, M.T.3
  • 40
    • 0028051548 scopus 로고
    • Nitric oxide is involved in the control of Trypanosoma cruzi induced parasitemia and directly kills parasite in vitro
    • Vespa G.N.R., Cunha F.Q. & Silva J.S. (1994) Nitric oxide is involved in the control of Trypanosoma cruzi induced parasitemia and directly kills parasite in vitro. Infection and Immunity, 62, 5177-5182
    • (1994) Infection and Immunity , vol.62 , pp. 5177-5182
    • Vespa, G.N.R.1    Cunha, F.Q.2    Silva, J.S.3
  • 41
    • 0004221310 scopus 로고
    • Chagas disease
    • TDR News
    • World Health Organization (1994) Chagas Disease, WHO Technical Report Series, TDR News, p. 125-134
    • (1994) WHO Technical Report Series , pp. 125-134
  • 42
    • 0031019290 scopus 로고    scopus 로고
    • Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulation
    • Zhou P., Sieve M.C., Tewari R.P. & Seder R.A. (1997) Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulation. Infection and Immunity, 65, 1-7
    • (1997) Infection and Immunity , vol.65 , pp. 1-7
    • Zhou, P.1    Sieve, M.C.2    Tewari, R.P.3    Seder, R.A.4


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