Association of an increase in CD8+ T cells with the presence of Trypanosoma cruzi antigens in chronic, human, chagasic myocarditis

American Journal of Tropical Medicine and Hygiene

Volumn 56, Issue 5, 1997, Pages 485-489

  Higuchi, Maria De Lourdes ^a   Reis, Marcia Martins ^a   Aiello, Vera Demarchi ^a   Benvenuti, Luiz Alberto ^a   Gutierrez, Paulo Sampaio ^a   Bellotti, Giovanni ^a   Pileggi, Fulvio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PROTOZOAL PROTEIN;

ARTICLE; AUTOPSY; CHAGAS DISEASE; CLINICAL ARTICLE; HEART FAILURE; HEART MUSCLE BIOPSY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPEROXIDASE STAINING; INFLAMMATORY INFILTRATE; SUPPRESSOR CELL; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0030906266     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1997.56.485     Document Type: Article

References (30)

1. Dias JCP, 1987. Control of Chagas' disease in Brazil. Parasitol Today 3: 336-339.
2. Koberle F, 1958. Cardiopathia chagasica. Hosp (Rio de Janeiro) 53: 311-343.
3. Harel-Bellan A, Joskowicz M, Fradelizi D, Eisen H, 1985. T lymphocyte function during experimental Chagas' disease: production of and response to interleukin-2. Eur J Immunol 15: 438-442.
4. Molina HA, Kierszenbaum F, 1987. A study of human myocardial tissue in Chagas' disease: distribution and frequency of inflammatory cell types. Int J Parasitol 17: 1297-1306.
5. Rossi MA, 1990. Myocardial damage in Trypanosoma cruzi myocarditis: a role for macrophages. Can J Cardiol 6: 293-298.
6. Cossio PM, Diez D, Szarfman A, Arana RM, 1974. Chagasic cardiopathy. Demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures. Circulation 49: 13-21.
7. Santos-Buch CA, Teixeira ARL, 1988. Immunology of experimental Chagas' disease. III. Rejection of allogeneic heart cells in vitro. J Exp Med 140: 398-402.
8. Sadigurshy M, von Kreuter BF, Ling PY, Santos-Buch CA, 1989. Isolation of elevated anti-sarcolema, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas' myocarditis. Circulation 80: 1269-1276.
9. Higuchi ML, Britto T, Reis MM, Barbosa A, Bellotti G, Pereira-Barreto AC, Pileggi F, 1993. Correlation between Trypanosoma cruzi parasitism and myocardium inflammatory infiltrate in human chronic chagasic myocarditis: light microscopy and immunohistochemical findings. Cardiovasc Pathol 2: 101-106.
10. Higuchi ML, Gutierrez PS, Aiello VD, Palomino S, Bocchi E, Bellotti G, Pileggi F, 1993. Immunohistochemical characterization of infiltrating cells in human chronic myocarditis: comparison with the myocardial rejection process. Virchows Arch Pathol Anat Histopathol 423: 157-160.
11. Jones EM, Colley DG, Tostes SJ, Lopes ER, Vnencak-Jones CL, McCurley TL, 1993. Amplification of Trypanosoma cruzi DNA sequence from human inflammatory lesions in human chagasic cardiomyopathy. Am J Trop Med Hyg 48: 348-357.
12. Felix JC, von Kreuter BF, Santos-Buch CA, 1993. Mimicry of heart surface epitope in primary anti-Trypanosoma cruzi Lyt2+ T lymphocytes. Clin Immunol Immunopathol 68: 141-146.
13. Cunha-Neto E, Duranti M, Gruber A, Zingales B, De Messias I, Stolf N, Bellotti G, Pileggi F, Kalil J, 1995. Autoimmunity in Chagas' disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proc Natl Acad Sci USA 92: 3541-3545.
14. Ben Yones-Chennoufi A, Hontebeyrie-Joskowicz M, Tricottet V, Eisen H, Reynes M, Said G, 1988. Persistence of Trypanosoma cruzi antigens in the inflammatory lesions of chronically infected mice. Trans R Soc Trop Med Hyg 82: 77-83.
15. Ben Younes-Chennoufi A, Said G, Eisen H, Durand A, Hontebeyrie-Joskowicz M, 1988. Cellular immunity to Trypanosoma cruzi is mediated by helper T cells (CD4+). Trans R Soc Trop Med Hyg 82: 84-89.
16. Ribeiro-dos-Santos R, Pirmez A, Savino W, 1991. Role of autoreactive immunological mechanisms in chagasic carditis. Res Immunol 142: 134-136.
17. Sato MN, Yamashiro-Kanashiro EH, Tanji MM, Kaneno R, Higuchi ML, Duarte AJS, 1992. CD8+ cells and natural cytotoxic activity among spleen, blood and heart lymphocytes during the acute phase of Trypanosoma cruzi infection in rats. Infect Immun 60: 1024-1030.
18. Sun J, Tarleton RL, 1993. Predominance of CD8+ T lymphocytes in the inflammatory lesions of mice with acute Trypanosoma cruzi infection. Am J Trop Med Hyg 48: 161-169.
19. Rottenberg ME, Cardoni RL, Anderson RL, Segura EL, Om A, 1988. Role of T helper/inducer cells as well as natural killer cells in resistance to T. cruzi infection. Scand J Immunol 28: 573-582.
20. Araujo FG, 1989. Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes. Infect Immun 57: 2246-2248.
21. Tarleton RL, 1990. Deletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi. J Immunol 144: 717-724.
22. + lymphocytes. Am J Trop Med Hyg 48: 637-644.
23. Sher A, Coffman RJ, 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol 10: 385-409.
24. Stein MB, Cuna WR, Kierzebaum F, 1990. Trypanosoma cruzi inhibits the expression of CD3, CD4, CD8 and IL-2R by mitogen-activated helper and cytotoxic human lymphocytes. J Immunol 144: 3558-3562.
25. Viana G, 1911. Contribuicao para o estudo da anatomia patologica da "Molestia de Carlos Chagas". Mem Inst Oswaldo Cruz 3: 276-293.
26. Chagas C, 1916. Processes patogenicos da tripanosomiase americana. Mem Inst Oswaldo Cruz 8: 5-59.
27. Nickel SP, Stryker GA, Arevalo C. 1993. Isolation from Trypanosoma cruzi-infected mice of CD8+, MHC-restricted cytotoxic T cells that lyse parasite-infected target cells. J Immunol 150: 1446-1457.
28. Tarleton RL, Koller BH, Latour A, Postan M, 1992. Susceptibility of β2 microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 356: 338-340.
29. Nickel SP, Gebremichael A, Holf R, Boyer MH, 1987. Isolation and functional characterization of T cell lines and clones specific for the protozoan parasite Trypanosoma cruzi. J Immunol 138: 914-921.
30. Reis MM, Higuchi ML, Benvenuti LA, Aiello VD, Gutierrez PS, Bellotti G, Pileggi F, 1997. An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic, human, chagasic myocarditis: correlation with the presence of myocardial T. cruzi antigens. Clin Immunol Immunopathol: (in press).