Acute Chagas' disease: Immunohistochemical characteristics of T cell infiltrate and its relationship with T. cruzi parasitic antigens

Acta Cardiologica

Volumn 60, Issue 1, 2005, Pages 33-37

  Fuenmayor, Carmen ^a,c   Higuchi, Maria L ^b   Carrasco, Hugo ^a   Parada, Henry ^a   Gutierrez, Paulo ^b   Aiello, Vera ^b   Palomino, Sueli ^b  

^a UNIVERSIDAD DE LOS ANDES   (Venezuela)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c PB APT 01 ^*  (Venezuela)

Author keywords

Acute Chagas' disease; CD8 lymphocytes; Immunohistochemical; T. cruzi and CD4

Indexed keywords

PARASITE ANTIGEN; PEROXIDASE;

ADOLESCENT; ADULT; ARTICLE; CHAGAS DISEASE; CLINICAL ARTICLE; CYTOTOXIC T LYMPHOCYTE; FEMALE; HEART FAILURE; HEART MUSCLE BIOPSY; HELPER CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MALE; MYOCARDITIS; SCHOOL CHILD; T LYMPHOCYTE; TRYPANOSOMA CRUZI; VENEZUELA; ACUTE DISEASE; ANALYSIS OF VARIANCE; ANIMAL; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CHILD; COHORT ANALYSIS; COMPARATIVE STUDY; HOSPITALIZATION; IMMUNOLOGY; ISOLATION AND PURIFICATION; MIDDLE AGED; NEEDLE BIOPSY; PATHOLOGY; PHYSIOLOGY; PREVALENCE; PROBABILITY; PROGNOSIS; RETROSPECTIVE STUDY; TISSUE CULTURE TECHNIQUE;

ACUTE DISEASE; ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, PROTOZOAN; BIOPSY, NEEDLE; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CHAGAS CARDIOMYOPATHY; CHAGAS DISEASE; CHILD; COHORT STUDIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PREVALENCE; PROBABILITY; PROGNOSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TISSUE CULTURE TECHNIQUES; TRYPANOSOMA CRUZI; VENEZUELA;

EID: 17944366492     PISSN: 00015385     EISSN: None     Source Type: Journal    
DOI: 10.2143/AC.60.1.2005046     Document Type: Article

References (24)

1. Dias JC, Schofield CJ. The evolution of Chagas Disease (American trypanosomiasis) control after 90 years since Carlos Chagas discovery. Mem Inst Oswaldo Cruz 1999; 24: 103-21.
2. Añez N, Carrasco H, Parada H, Crisante G, Rojas A, Gonzalez N, Ramirez JL, Guevara P, Rivero CH, Borges R, Scorza J. Acute Chagas' disease in western Venezuela: a clinical, seroparasitologic, and epidemiologic study. Am J Trop Hyg 1999; 2: 215-22.
3. World Health Organization. Control of Chagas disease. World Health Organ Tech Rep Ser 1991; 811: 1-95.
4. Fernandes O, Souto R, Castro J, Pereira J, Carrara N, Junquera A. Brazilian isolates of Trypanosoma cruzi from humans and triatomines classified into two lineages using mini-exon and ribosomal RNA sequences. Am J Trop Med Hyg 1998; 58: 807-11.
5. Weekly Epidemiological Record-Relevé Epidémiologique Hebdomadaire. Chagas disease, Venezuela. Progress towards interruption of transmission. 1999; 35 (3): 290-2.
6. Kirchhoff LV. American Tripanosomiasis (Chagas' disease). A tropical disease now in the United States. N Engl J Med 1993; 329: 639-44.
7. Ferreira M, Nishioka S, Silvestre M, Borges A, Nunes F, Rocha A. Reactivation of Chagas' disease in patients with AIDS: report of three new cases and review of the literature. Clin Infect Dis 1997; 25: 1397-400.
8. Parada H, Carrasco H, Añez N, Fuenmayor C, Inglessis I. Cardiac involvement is a constant finding in acute Chagas' disease: a clinical, parasitological and histopathological study. Int J Cardiol 1997; 60: 49-54.
9. Carrasco H, Palacios E, Scorza C, Molina C, Inglessis G, Mendoza R. Clinical histochemical and ultrastructural correlation in septal endomyocardial biopsies from chronic chagasic patients: detection of early myocardial damage. Am Heart J 1987; 113: 716-24.
10. Higuchi ML, De Morais C, Sambiase N, Pereira A, Bellotti G, Pileggi F. Histopathological criteria of myocarditis. A study based on normal heart, Chagasic Heart and dilated cardiomyopathy. Japanese Circ J 1990; 54: 391-400.
11. Miller PJ. An elastin stain. Meth Lab Technol 1971; 28: 148-9.
12. Higuchi ML, Brito T, Reis MM, Barbosa A, Bellotti G, Pereira A, Pileggi F. Correlation between Trypanosoma cruzi and myocardial inflammatory infiltrate in human chagasic myocarditis: light microscopy and immunohistochemical findings. Cardiovasc Pathol 1993; 2: 101-6.
13. Higuchi MD, Ries M, Aiello V, Benvenuti L, Gutierrez P, Bellotti G, Pileggi F. Association of an increase in CD8+ T cells with the presence of Trypanosoma cruzi antigens in chronic, human, chagasic myocarditis. Am J Trop Med Hyg 1997; 56: 485-9.
14. + in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clin Immuno 1997; 83: 165-72.
15. Higuchi ML, Gutierrez P, Aiello VD, Palomino S, Bocchi E, Kalil J, Bellotti G, Pileggi F. Immunohistochemical characterization of infiltrating cells in human chronic chagasic myocarditis comparison with myocardial rejection process. Virchows Arch A Pathol Anal 1993; 423 (3): 157-60.
16. nd Edition. PWS Publishers, Massachusetts 1986; 326-32.
17. a. Edição. Atual Editora, São. Paulo 1987: 171.
18. Sas Institute INC; Sas/Stat User's Guide, version 6, Fourth Edition, Volume I, GARY NC:SAS. Institute Inc, 1989.
19. Sas Institute INC; Sas/Stat User' Guide, version 6, Fourth Edition, Volume 2, CARY, NC:SAS Institute Inc, 1989.
20. Andrade Z, Andrade S, Correa R, Sadigursky M, Ferrans V. Myocardial changes in acute trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy. Am J Pathol 1994; 144: 1403-11.
21. Ben Younés-Chennoufi A, Said G, Eisen H, Durand A, Hontebeyrie-Joskowicz M. Cellular immunity to Trypanosoma cruzi is mediated by helper T cells (CD4+). Trans R Soc Trop Med Hyg 1988; 82: 84-9.
22. Sun J, Tarleton R. Predominance of CD8+ lymphocytes in the inflammatory lesions of mice with acute Trypanosoma cruzi infection. Am J Trop Med Hyg 1993; 42: 161-9.
23. Sato MN, Yamashiro-Kanashiro EH, Tanji MN, Kaneno R, Higuchi ML, Duarte AJ. CD8+ cells and natural cytotoxic activity among spleen, blood, and heart lymphocytes during the acute phase of Trypanosoma cruzi infection in rats. Infect Immun 1992; 60: 1024-30.
24. Higuchi ML, Morais C, Pereira A, Lopes E, Stolf N, Bellotti G, Pileggi F. The role of active myocarditis in the development of heart failure in chronic Chagas' disease: a study based on endomyocardial biopsies. Clin Cardiol 1987; 10: 665-70.