Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions

Parasitology Research

Volumn 103, Issue 2, 2008, Pages 413-421

  Caldas, Ivo Santana ^a   Talvani, André ^a   Caldas, Sérgio ^a   Carneiro, Cláudia Martins ^a   De Lana, Marta ^a   Da Matta Guedes, Paulo Marcos ^a   Bahia, Maria Terezinha ^a  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BENZNIDAZOLE; RODANIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSIS; HEART INJURY; HISTOPATHOLOGY; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; INOCULATION; MOUSE; NONHUMAN; PARASITEMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

ACUTE DISEASE; ANIMALS; CHAGAS DISEASE; CHRONIC DISEASE; DRUG RESISTANCE; HEART; HUMANS; MICE; MYOCARDIUM; NITROIMIDAZOLES; PARASITEMIA; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

ANIMALIA; MUS; TRYPANOSOMA CRUZI;

EID: 44349169957     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-008-0992-6     Document Type: Article

References (36)

1. Andrade SG, Andrade ZA, Figueira RM (1977) Experimental study on the resistance of a strain of Trypanosoma cruzi to Bay 2502. Rev Inst Med Trop São Paulo 19:124-129
2. Andrade SG, Magalhães JB, Pontes AL (1985) Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bull World Health Organ 63:721-726
3. Andrade SG, Magalhães JB, Pontes AL (1989) Therapy of the chronic phase of the experimental infection by Trypanosoma cruzi with benznidazole and nifurtimox. Rev Soc Bras Med Trop São Paulo 22:113-118
4. Andrade SG, Rassi A, Magalhães JB, Ferriolli FF, Luquetti AO (1992) Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains. Trans R Soc Trop Med Hyg 86:624-626
5. Ávila H, Gonçalves AM, Nehme NS, Morel CM, Simpson L (1990) Schizodeme analysis of Trypanosoma cruzi stocks from South and Central America by analysis of PCR-amplified minicircle variable region sequences. Mol Biochem Parasitol 42:175-187
6. Bahia-Oliveira LM, Gomes JA, Cançado JR, Ferrari TC, Lemos EM, Luz ZM, Moreira MC, Gazzinelli G, Correa-Oliveira R (2000) Immunological and clinical evaluation of Chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago. J Infect Dis 182:634-638
7. Braga MS, Lauria-Pires L, Arganaraz ER, Nascimento RJ, Teixeira AR (2000) Persistent infections in chronic Chagas' disease patients treated with anti-Trypanosoma cruzi nitroderivatives. Rev Inst Med Trop São Paulo 42:157-161
8. Brener Z (1962) Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi. Rev Inst Med Trop São Paulo 4:389-396
9. Bustamante JM, Presti MS, Rivarola HW, Fernández AR, Enders JE, Fretes RE, Paglini-Oliva P (2007) Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy. Int J Antimicrob Agents 29:733-737
10. Caldas S, Santos FM, Lana MD, Diniz LF, Machado-Coelho GL, Veloso VM, Bahia MT (2008) Trypanosoma cruzi: acute and long-term infection in the vertebrate host can modify the response to benznidazole. Exp Parasitol 118(3):315-323
11. Campos RF, Guerreiro ML, Sobral KS, Lima RC, Andrade SG (2005) Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II). Rev Soc Bras Med Trop 38:142-146
12. Cançado JR (2002) Long term evaluation of etiological treatment of Chagas disease with benznidazole. Rev Inst Med Trop São Paulo 44:29-37
13. Engman DM, Leon JS (2002) Pathogenesis of Chagas heart disease: role of autoimmunity. Acta Trop 2:123-32
14. Ferreira HO (1990) Treatment of the undetermined form of Chagas disease with nifurtimox and benznidazole. Rev Soc Bras Med Trop 23:209-211
15. Filardi LS, Brener Z (1987) Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans R Soc Trop Med Hyg 81:755-759
16. Galvão LM, Chiari E, Macedo AM, Luquetti AO, Silva SA, Andrade AL (2003) PCR assay for monitoring Trypanosoma cruzi parasitemia in childhood after specific chemotherapy. J Clin Microbiol 41:5066-5070
17. Garcia S, Ramos CO, Senra JF, Vilas-Boas F, Rodrigues MM, Campos-de-Carvalho AC, Ribeiro-Dos-Santos R, Soares MB (2005) Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations. Antimicrob Agents Chemother 49:1521-1528
18. Girones N, Fresno M (2003) Etiology of Chagas disease myocarditis: autoimmunity, parasite persistence, or both? Trends Parasitol 19:19-22
19. Gomes ML, Galvão LM, Macedo AM, Pena SD, Chiari E (1999) Chagas' disease diagnosis: comparative analysis of parasitologic, molecular, and serologic methods. Am J Trop Med Hyg 60:205-210
20. Guedes PM, Veloso VM, Tafuri WL, Galvão LM, Carneiro CM, Lana M, Chiari E, Ataíde Soares K, Bahia MT (2002) The dog as model for chemotherapy of the Chagas' disease. Acta Trop 84:9-17
21. Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, Machado-Coelho GL, Chiari E, Bahia MT (2004) Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts. Antimicrob Agents Chemother 48:4286-4292
22. Hyland KV, Leon JS, Daniels MD, Giafis N, Woods LM, Bahk TJ, Wang K, Engman DM (2007) Modulation of autoimmunity by treatment of an infectious disease. Infect Immun 75:3641-3650
23. Lauria-Pires L, Braga MS, Vexenat AC, Nitz N, Simões-Barbosa A, Tinoco DL, Teixeira AR (2000) Progressive chronic Chagas heart disease ten years after treatment with anti-Trypanosoma cruzi nitroderivatives. Am J Trop Med Hyg 63:111-118
24. Maltos KL, Menezes GB, Caliari MV, Rocha OA, Santos JM, Alves DL, Duarte ID, Francischi JN (2004) Vascular and cellular responses to pro-inflammatory stimuli in rat dental pulp. Arch Oral Biol 49:443-450
25. Miyamoto CT, Gomes ML, Marangon AV, Araújo SM, Bahia MT, Lana M, Toledo MJ (2006) Trypanosoma cruzi: sensitivity of the polymerase chain reaction for detecting the parasite in the blood of mice infected with different clonal genotypes. Exp Parasitol 112:198-201
26. Palomino SA, Aiello VD, Higuchi ML (2000) Systematic mapping of hearts from chronic Chagasic patients: the association between the occurrence of histopathological lesions and Trypanosoma cruzi antigens. Ann Trop Med Parasitol 94:571-579
27. Santos FR, Pena SD, Epplen JT (1993) Genetic and population study of a Y-linked tetranucleotide repeat DNA polymorphism with a simple non-isotopic technique. Hum Genet 90:655-656
28. Segura MA, Molina de RE, Basombrio MA (1994) Reversibility of muscle and heart lesions in chronic, Trypanosoma cruzi infected mice after late trypanocidal treatment. Mem Inst Oswaldo Cruz 89:213-216
29. Shikanai-Yasuda MA, Lopes MH, Tolezano JE, Umezawa E, Amato Neto V, Barreto AC, Higaki Y, Moreira AA, Funayama G, Barone AA (1990) Acute Chagas' disease: transmission routes, clinical aspects and response to specific therapy in diagnosed cases in an urban center. Rev Inst Med Trop São Paulo 32:16-27
30. Suasnábar DF, Arias E, Streiger M (2000) Evolutive behavior towards cardiomyopathy of treated (nifurtimox or benznidazole) and untreated chronic Chagasic patients. Rev Inst Med Trop São Paulo 42:99-110
31. Toledo MJ, Guilherme AL, da Silva JC, de Gasperi MV, Mendes AP, Gomes ML, de Araújo SM (1997) Trypanosoma cruzi: chemotherapy with benznidazole in mice inoculated with strains from Paraná state and from different endemic areas of Brazil. Rev Inst Med Trop São Paulo 63:721-726
32. Toledo MJ, Bahia MT, Carneiro CM, Martins-Filho OA, Tibayrenc M, Barnabé C, Tafuri WL, de Lana M (2003) Chemotherapy with benznidazole and itraconazole for mice infected with different Trypanosoma cruzi clonal genotypes. Antimicrob Agents Chemother 47:223-230
33. Toledo MJ, Bahia MT, Veloso VM, Carneiro CM, Machado-Coelho GL, Alves CF, Martins HR, Cruz RE, Tafuri WL, Lana M (2004) Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes. J Antimicrob Chemother 53:1045-1053
34. Veloso VM, Carneiro CM, Toledo MJ, Lana M, Chiari E, Tafuri WL, Bahia MT (2001) Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains. Mem Inst Oswaldo Cruz 96:1005-1011
35. Viotti R, Vigliano C, Armenti H, Segura E (1994) Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up. Am Heart J 127:151-162
36. Voller A, Bidwell DE, Bartlett A (1976) Enzyme immunoassays in diagnostic medicine. Theory and practice. Bull World Health Organ 53:55-65