Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection

Scandinavian Journal of Immunology

Volumn 45, Issue 1, 1997, Pages 74-80

  Dutra, W O ^a   Gollob, K J ^a,b   Pinto Dias, J C ^a   Gazzinelli, G ^a   Correa Oliveira, R ^a   Coffman, R L ^c   Carvalho Parra, J F ^a,d  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d NONE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 5; MESSENGER RNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

EID: 0031032002     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-362.x     Document Type: Article

References (21)

1. Mosca W, Plaja J, Gallardo E, Garcia Barrios H. Immune response in human Chagas' disease I. Lymphocyte blastogenesis in chagasic patients without evidence of cardiomyophaty. Acta Cient (Venezolana) 1979;30:401-4.
2. de Tito EH, Braun M, Lazzari JO, Segura EL. Cell mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients. Immunol Lett 1985;9:249-54.
3. Morato MJF, Brener Z, Cancado JR, Nunes RMB, Chiari E, Gazzinelli G. Cellular immune responses of chagasic patients to antigens derived from different strains and clones. Am J Trop Med Hyg 1986;35:505-11.
4. Gazzinelli RT, Gazzinelli G, Cancado JR, Cardoso JE, Brener Z, Colley DG. Two models of idiotypic stimulation of T lymphocytes from patients with Chagas' disease: correlations with clinical forms of infection. Res Immunol 1990;140:757-70.
5. Minoprio P. Chagas' disease: CD5 B cell dependent Th2 pathology? Ann Inst Pasteur/Immunol 1991;126:137-40.
6. Dutra WO, Martins-Filho OA, Cancado JR et al. Chagasic patients lack CD28 expression in many of their circulating T lymphocytes. Scand J Immunol 1996;43:88-93.
7. Dutra WO, Martins-Filho OA, Cancado JR et al. Activated T and B lymphocytes in peripheral blood of patients with Chagas' disease. Int Immunol 1994;6:499-506.
8. O'Garra A. Cytokines and their role in infectious diseases. Viruses and the cellular immune response 1992;75-89.
9. Howard MC, Myiajima A, Coffman RL. T-cell derived cytokines and their receptors. In: Paul W, ed. Fundamental Immunology. Third ed. Bethesda: Raven Press, 1993:763-800.
10. Reed SG. In vivo administration of recombinant IFNγ induces macrophage activation, and prevents acute disease, immunosuppression and death in experimental T. cruzi infection. J Immunol 1988;140:1-7.
11. Hulsebos LH, Choromanski L, Kuhn RE. The effect of IL-2 and parasitemia and myocarditis in experimental Chagas' disease. J Protozool 1989;36:1-8.
12. Starobinas N, Russo M, Minoprio P, Hontebeyrie-Joskowicz M. Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice? Res Immunol 1991;142:117-22.
13. Reed SG, Brownell CE, Russo DM, Silva JS, Grabstein KH, Morrisey PJ. IL-10 mediates susceptibility to Trypanosoma cruzi infection. J Immunol 1994;153:3135-40.
14. Tanowitz HB, Gumprecht JP, Spurr D et al. Cytokine gene expression of endothelial cells infected with Trypanosoma cruzi. J Infect Dis 1992;166:598-603.
15. Van Voorhis WC. Coculture of human peripheral blood mononuclear cells with Trypanosoma cruzi leads to proliferation of lymphocytes and cytokine production. J Immunol 1992;148: 239-48.
16. Piuvezam MR, Russo DM, Burns Jr JM, Skeiky-YAW, Grabstein KH, Reed SG. Characterization of responses of normal human cells to Trypanosoma cruzi antigens. J Immunol 1993;150:916-24.
17. Gazzinelli G, Katz N, Rocha RS, Colley DG. Immune response during human schistosomiasis mansoni. X. Production and standartization of an antigen induced mitogenic activity by peripheral blood mononuclear cells from treated, but not active cases of schistosomiasis. J Immunol 1983;130:2981-5.
18. Powrie F, Menon S, Coffman RL. Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur J Immunol 1993;23:2223-9.
19. + Th0, Th1 and Th2 T cell clones and EBV-transformed B cells. Int Immunol 1995;7:1405-16.
20. McKenzie ANQ, Culpepper JA, de Waal Malefyt R et al. Interleukin 13, a T cell derived cytokine that regulates human monocyte and B cell function. Proc Natl Acad Sci USA 1993;90:3735-9.
21. O'Garra A, Chang R, Go N, Hastings R, Haughton G, Howard M. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur J Immunol 1992;22:711-17.