Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic chagas disease cardiomyopathy

Scandinavian Journal of Immunology

Volumn 66, Issue 2-3, 2007, Pages 362-371

  Fonseca, S G ^a,b   Reis, M M ^a   Coelho, V ^a,b   Nogueira, L G ^a,b   Monteiro, S M ^a   Mairena, E C ^a   Bacal, F ^a   Bocchi, E ^a   Guilherme, L ^a,b   Zheng, X X ^c   Liew, F Y ^d   Higuchi, M L ^a   Kalil, J ^a,b   Cunha Neto, E ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Millennium Institute   (Brazil)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 7; MESSENGER RNA;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL VIABILITY; CHAGAS DISEASE; CYTOKINE PRODUCTION; GENE EXPRESSION; HEART; HEART INJURY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CHAGAS CARDIOMYOPATHY; CHRONIC DISEASE; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-15; INTERLEUKIN-2; INTERLEUKIN-7; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE COUNT; MYOCARDIUM;

EID: 34447319440     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2007.01987.x     Document Type: Article

References (42)

1. Higuchi ML, De MC, Pereira BA et al. The role of active myocarditis in the development of heart failure in chronic Chagas' disease: a study based on endomyocardial biopsies. Clin Cardiol 1987 10 : 665 70.
2. Higuchi ML, De Brito T, Reis MM et al. Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: light microscopy and immunohistochemical finding. Cardiovasc Pathol 1993 2 : 101 6.
3. Higuchi ML, Gutierrez PS, Aiello VD, Palomino S. Immunohistochemical characterisation of infiltrating cells in human chronic myocarditis: comparison with myocardial rejection process. Virchows Arch Pathol Anat 1993 4233 : 157 60.
4. Abel LC, Rizzo LV, Ianni B et al. Chronic Chagas' disease cardiomyopathy patients display an increased IFN-γ response to Trypanosoma cruzi infection. J Autoimmun 2001 17 : 99 107.
5. Reis MM, Higuchi ML, Benvenuti LA et al. An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clin Immunol Immunopathol 1997 83 : 165 72.
6. Reis DD, Jones EM, Tostes S et al. Expression of major histocompatibility complex antigens and adhesion molecules in hearts of patients with chronic Chagas' disease. Am J Trop Med Hyg 1993 49 : 192 200.
7. Cunha-Neto E, Dzau VJ, Allen PD et al. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Am J Pathol 2005 167 : 305 13.
8. Reis DD, Jones EM, Tostes S Jr. et al. Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-alpha+ cells and dominance of granzyme A+, CD8+ lymphocytes. Am J Trop Med Hyg 1993 48 : 637 44.
9. Higuchi ML, Reis MM, Aiello VD et al. Association of an increase in CD8+ T cells with the presence of Trypanosoma cruzi antigens in chronic, human, chagasic myocarditis. Am J Trop Med Hyg 1997 56 : 485 9.
10. Fonseca SG, Moins-Teisserenc H, Clave E et al. Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients. Microbes Infect 2005 7 : 688 97.
11. Grabstein KH, Eisenman J, Shanebeck K et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994 264 : 965 8.
12. Waldmann TA, Dubois S, Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 2001 14 : 105 10.
13. Waldmann TA. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 2006 6 : 595 601.
14. Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 1998 8 : 615 23.
15. Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 2000 288 : 675 8.
16. Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000 18 : 423 49.
17. Tan JT, Ernst B, Kieper WC, LeRoy E, Sprent J, Surh CD. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med 2002 195 : 1523 32.
18. Waldmann TA, Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 1999 17 : 19 49.
19. Sato N, Patel HJ, Waldmann TA, Tagaya Y. The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells. Proc Natl Acad Sci USA 2007 104 : 588 93.
20. Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 1997 276 : 2057 62.
21. Tan JT, Tutl E, Leroy E et al. IL-7 is critical for homeostatic proliferation and survival of naïve T cells. Proc Natl Acad Sci U S A 2001 98 : 8732 7.
22. Kirberg J, Berns A, von Boehmer H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med 1997 186 : 1269 75.
23. Schluns KS, Kieper WC, Jameson SC, Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 2000 1 : 426 32.
24. Kim YS, Maslinski W, Zheng XX et al. Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity. J Immunol 1998 160 : 5742 8.
25. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001 29 : e45.
26. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001 25 : 402 8.
27. Komschlies KL, Gregorio TA, Gruys ME, Back TC, Faltynek CR, Wiltrout RH. Administration of recombinant human IL-7 to mice alters the composition of B-lineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases. J Immunol 1994 152 : 5776 84.
28. Geiselhart LA, Humphries CA, Gregório TA, Mou S, Subleski J, Komschlies KL. IL-7 administration alters the CD4:CD8 ratio, increases T cell absence of activation. J Immunol 2001 166 : 3019 27.
29. Weng NP, Liu K, Catalfamo M, Li Y, Henkart PA. IL-15 is a growth factor and an activator of CD8 memory T cells. Ann N Y Acad Sci 2002 975 : 46 56.
30. Zhang X, Sun S, Hwang I, Tough DF, Sprent J. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 1998 8 : 591 9.
31. Lodolce JP, Boone Dl, Chai S et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998 9 : 669 76.
32. Kanegane H, Tosato G. Activation of naive and memory T cells by interleukin-15. Blood 1996 88 : 230 5.
33. Geginat J, Sallusto F, Lanzavecchia A. Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells. J Exp Med 2001 194 : 1711 9.
34. Liu Z, Geboes K, Colpaert S, D́Haens GR, Rutgeerts P, Ceuppens JL. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol 2000 164 : 3608 15.
35. Khan IA, Kasper LH. IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice. J Immunol 1996 157 : 2103 8.
36. McInnes IB, Al-Mughales J, Field M et al. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996 2 : 175 82.
37. Fehninger TA, Caligiuri MA. Interelukin 15: biology and relevance to human disease. Blood 2001 97 : 14 32.
38. Jullien D, Sieling PA, Uyemura K, Mar ND, Rea TH, Modlin RL. IL-15, an immunomodulator of T cell responses in intracellular infection. J Immunol 1997 158 : 800 6.
39. Agostini C, Trentin L, Facco M et al. Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J Immunol 1996 157 : 910 18.
40. Wuttge DM, Eriksson P, Sirsjö A, Hanson GK, Stemme S. Expression of interleukin-15 in mouse and human atherosclerotic lesions. Am J Pathol 2001 159 : 417 23.
41. Avice MN, Demeure CE, Delespesse G, Rubio M, Armant M, Sarfati M. IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4+ T cells in the absence of TCR ligation. J Immunol 1998 161 : 3408 15.
42. Gu XX, Yue FY, Kovacs CM, Ostrowski MA. The role of cytokines which signal through the common gamma chain cytokine receptor in the reversal of HIV specific CD4 and CD8 T cell anergy. PLoS ONE 2007 2 : e300.