Effect of 3,4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2544-2554

  Stolić, Ivana ^a   Mišković, Katarina ^b   Magdaleno, Anahi ^c   Silber, Ariel Mariano ^c   Piantanida, Ivo ^d   Bajić, Miroslav ^a   Glavaš Obrovac, Ljubica ^b  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b JOSIP JURAJ STROSSMAYER UNIVERSITY OF OSIJEK   (Croatia)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Antiparasitic activity; Antiproliferative activity; Benzimidazole amidine; DNA RNA binding

Indexed keywords

2,5 BIS[2 (5 AMIDINOBENZIMIDAZOYL)] 3,4 ETHYLENEDIOXYTHIOPHENE; 2,5 BIS[2 [5 (N ISOPROPYLAMIDINO)BENZIMIDAZOYL]] 3,4 ETHYLENEDIOXYTHIOPHENE; 2,5 BIS[5 (2 IMIDAZOLINO)BENZIMIDAZOL 2 YL] 3,4 ETHYLENEDIOXYTHIOPHENE; AMIDINE; BENZIMIDAZOLE DERIVATIVE; CITRININ; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; ETHYLENE DERIVATIVE; OLIGOMER; ROTENONE; THIOPHENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DRUG CYTOTOXICITY; DRUG SYNTHESIS; EPIMASTIGOTE; FLUORESCENCE MICROSCOPY; HELA CELL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; RNA BINDING; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; TRYPANOSOMA CRUZI;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; ETHIDIUM; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; NUCLEIC ACID DENATURATION; RNA; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; THIOPHENES; TRYPANOSOMA CRUZI;

EID: 62149098024     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.071     Document Type: Article

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