Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

European Journal of Immunology

Volumn 33, Issue 1, 2003, Pages 70-78

  Müller, Uwe ^a,b   Sobek, Vera ^b   Balkow, Sandra ^b   Hölscher, Christoph ^c   Müllbacher, Arno ^d   Museteanu, Crisan ^b   Mossman, Horst ^b   Simon, Markus M ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

^d Australian National University   (Australia)

Author keywords

Chagas disease; Cytotoxic T cells; Granzymes; Immunopathology; Protection

Indexed keywords

FAS ANTIGEN; FAS LIGAND; GRANZYME A; GRANZYME B; PERFORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DEATH; EXOCYTOSIS; FEMALE; GENE DISRUPTION; GROWTH INHIBITION; HOST; INFECTION CONTROL; INFECTION RESISTANCE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTOZOON; REVIEW; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; WILD TYPE;

ANIMALS; ANTIGENS, CD95; FAS LIGAND PROTEIN; FLOW CYTOMETRY; LIVER; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MYOCARDIUM; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; SPLEEN; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037261142     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/immu.200390009     Document Type: Review

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