Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response

Immunology

Volumn 108, Issue 2, 2003, Pages 230-237

  Galvão Da Silva, Ana Paula ^a   Jacysyn, Jacqueline F ^b   Abrahamsohn, Ises De Almeida ^b  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HISTOPATHOLOGY; INFECTION RESISTANCE; INFECTION SENSITIVITY; KNOCKOUT MOUSE; MORTALITY; MOUSE; NONHUMAN; PARASITEMIA; PARASITISM; PRIORITY JOURNAL; SPLEEN CELL; TH2 CELL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ACUTE DISEASE; ANIMALS; ANTIBODIES, PROTOZOAN; CELLS, CULTURED; CHAGAS DISEASE; DISEASE SUSCEPTIBILITY; FEMALE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; PARASITEMIA; TH2 CELLS; TRYPANOSOMA CRUZI; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037328698     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2003.01571.x     Document Type: Article

References (36)

1. Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol 1998; 70:83-243.
2. Oliveira MA, Santiago HC, Lisboa CR, Ceravollo IP, Trinchieri G, Gazzinelli RT, Vieira LQ. Leishmania sp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-gamma synthesis. Exp Parasitol 2000; 95:96-105.
3. Galvao da Silva AP, Abrahamsohn IA. Interleukin-12 stimulation of lymphoproliferative responses in Trypanosoma cruzi infection. Immunology 2001; 104:349-54.
4. Torrico F, Heremans H, Rivera MT, Van Marck E, Billiau A, Carlier Y. Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol 1991; 146:3626-32.
5. Abrahamsohn IA, Coffman RL. Trypanosoma cruzi: IL-10, TNF, IFN-γ and IL-12 regulate innate and acquired immunity to infection. Exp Parasitol 1996; 84:231-44.
6. Aliberti JC, Cardoso MA, Martins GA, Gazzinelli RT, Vieira LQ, Silva JS. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect Immun 1996; 64:1961-7.
7. Hunter CA, Slifer T, Araujo F. Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infection Immunity 1996; 64:2381-6.
8. Michailowsky V, Silva NM, Rocha CD, Vieira LQ, Lannes-Vieira J, Gazzinelli RT. Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection. Am J Pathol 2001; 159:1723-33.
9. Muller U, Kohler G, Mossmann H, Schaub GA, Alber G, Di Santo JP, Brombacher F, Holscher C. IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18. J Immunol 2001; 167:3346-53.
10. Barbosa de Oliveira LC, de Curotto Lafaille MA, Collet de Araujo Lima GM, Abrahamsohn IA. Antigen-specific IL-4- and IL-10-secreting CD4+ lymphocytes increase in vivo susceptibility to Trypanosoma cruzi infection. Cell Immunol 1996; 170:41-53.
11. Abrahamsohn IA, Coffman RL. Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infection. J Immunol 1995; 155:3955-63.
12. Curotto-de-Lafaille MA, Barbosa-de-Oliveira LC, Lima GC, Abrahamsohn IA. Trypanosoma cruzi: maintenance of parasite-specific T cell responses in lymph nodes during the acute phase of the infection. Exp Parasitol 1990; 70:164-74.
13. Pinge-Filho P, Tadokoro CE, Abrahamsohn IA. Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection. Cell Immunol 1999; 193:90-8.
14. Muñoz-Fernandez MA, Fernandez MA, Fresno M. Synergism between tumor necrosis factor-α and interferon-γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur J Immunol 1992; 22:301-7.
15. Gazzinelli RT, Oswald P, Hieny S, James SL, Sher A. The microbicidal activity of interferon-γ treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. Eur J Immunol 1992; 22:2501-6.
16. Cunha FQ, Moncada S, Liew FY. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem Biophys Res Commun 1992; 182:1155-9.
17. Liew FY. Regulation of nitric oxide synthesis in infectious and autoimmune diseases. Immunol Lett 1994; 43:95-8.
18. de Souza EM, Rivera MT, Araujo-Jorge TC, de Castro SL. Modulation induced by estradiol in the acute phase of Trypanosoma cruzi infection in mice. Parasitol Res 2001; 87:513-20.
19. do Prado Junior JC, Leal M, Anselmo-Franci JA, de Andrade Junior H, Kloetzel JK. Influence of female gonadal hormones on the parasitemia of female Calomys callosus infected with the 'Y' strain of Trypanosoma cruzi. Parasitol Res 1998: 84:100-5.
20. Brodskyn CI, Silva AM, Takehara HÁ, Mota I. IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi. Immunol Cell Biol 1989; 67:343-8.
21. Coffman RL, Lebman DA, Rothman P. Mechanism and regulation of immunoglobulin isotype switching. Adv Immunol 1993; 54:229-70.
22. Bastos KR, Alvarez JM, Marinho CR, Rizzo LV, Lima MR. Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile. J Leukoc Biol 2002; 71:271-8.
23. Mattner F, Magram J, Ferrante J et al. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 1996; 26:1553-9.
24. Speirs K, Caamano J, Goldschmidt MH, Hunter CA, Scott P. NF-kappa B2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell Differentiation. J Immunol 2002; 168:4406-13.
25. Jankovic D, Kullberg MC, Hieny S, Caspar P, Collazo CM, Sher A. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 2002; 16:429-39.
26. Cooper AM, Magram J, Ferrante J, Orme IM. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 1997; 186:39-45.
27. Abrahamsohn IA, da Silva AP, Coffman RL. Effects of interleukin-4 deprivation and treatment on resistance to Trypanosoma cruzi. Infect Immun 2000; 68:1975-9.
28. Oppmann B, Lesley R, Blom B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13:715-25.
29. Tripp CS, Wolf SF, Unanue ER. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 1993; 90:3725-9.
30. Castanos-Velez E, Maerlan S, Osorio LM, Aberg F, Biberfeld P, Orn A, Rottenberg ME. Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient mice. Infect Immun 1998; 66:2960-8.
31. Silva JS, Vespa GNR, Cardoso MAG, Aliberti JCS, Cunha FQ. Tumor necrosis factor alpha mediates resistance to Trypanososma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect Immun 1995; 63:4862-7.
32. Vespa GN, Cunha FQ, Silva JS. Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect Immun 1994; 62:5177-82.
33. Holscher C, Kohler G, Muller U, Mossmann H, Schaub GA, Brombacher F. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun 1998; 66:1208-15.
34. Saeftel M, Fleischer B, Hoerauf A. Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infection. Infect Immun 2001; 69:2252-9.
35. Tarleton RL, Grusby MJ, Zhang L. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol 2000; 165:1520-5.
36. Talvani A, Ribeiro CS, Aliberti JC et al. Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi. Microbes Infect 2000; 2:851-66.