Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care

Seminars in Fetal and Neonatal Medicine

Volumn 15, Issue 4, 2010, Pages 196-202

  Park, Angela M ^a   Sanders, Timothy A ^a   Maltepe, Emin ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hypoxia; Hypoxia inducible factor; Necrotizing enterocolitis; Neonate, retinopathy of prematurity; Prolyl hydroxylase inhibitor; Respiratory distress syndrome

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MORPHOGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; UBIQUITIN PROTEIN LIGASE E3; VON HIPPEL LINDAU PROTEIN;

AEROBIC METABOLISM; ANGIOGENESIS; ARTICLE; DIABETES MELLITUS; ELECTRON TRANSPORT; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; HYDROXYLATION; HYPOXIA; INFLAMMATION; LUNG DEVELOPMENT; NECROTIZING ENTEROCOLITIS; NEWBORN CARE; OXYGEN TENSION; PRACTICE GUIDELINE; PREMATURITY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RESPIRATORY DISTRESS SYNDROME; RETROLENTAL FIBROPLASIA; TISSUE OXYGENATION; TRANSCRIPTION REGULATION; UBIQUITINATION;

ANIMALS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFANT, NEWBORN; INFANT, PREMATURE; ISOENZYMES; NEONATOLOGY; OXIDATIVE STRESS; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; REACTIVE OXYGEN SPECIES;

EID: 77955053835     PISSN: 1744165X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.siny.2010.05.006     Document Type: Article

References (75)

1. Maltepe E., Saugstad O.D. Oxygen in health and disease: regulation of oxygen homeostasis - clinical implications. Pediatr Res 2009, 65:261-268.
2. Klimova T., Chandel N.S. Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ 2008, 15:660-666.
3. Semenza G.L. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 2009, 24:97-106.
4. Dunwoodie S.L. The role of hypoxia in development of the mammalian embryo. Dev Cell 2009, 17:755-773.
5. 2 tension. Proc Natl Acad Sci USA 1995, 92:5510-5514.
6. Wang G.L., Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995, 270:1230-1237.
7. Semenza G.L., Nejfelt M.K., Chi S.M., Antonarakis S.E. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proc Natl Acad Sci USA 1991, 88:5680-5684.
8. Semenza G.L. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 2000, 59:47-53.
9. Wenger R.H., Stiehl D.P., Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005, 2005(306):re12.
10. Pugh C.W., Ebert B.L., Ebrahim O., Maxwell P.H., Ratcliffe P.J. Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines. Ann NY Acad Sci 1994, 718:31-39. discussion 9-40.
11. Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001, 294(5545):1337-1340.
12. 2-regulated prolyl hydroxylation. Science 2001, 292(5516):468-472.
13. Ivan M., Kondo K., Yang H., et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001, 292(5516):464-468.
14. Schofield C.J., Ratcliffe P.J. Signalling hypoxia by HIF hydroxylases. Biochem Biophys Res Commun 2005, 338:617-626.
15. Kim W., Kaelin W.G. The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Curr Opin Genet Dev 2003, 13:55-60.
16. Masson N., Willam C., Maxwell P.H., Pugh C.W., Ratcliffe P.J. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J 2001, 20:5197-5206.
17. Lando D., Peet D.J., Gorman J.J., et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002, 16:1466-1471.
18. Lando D., Peet D.J., Whelan D.A., Gorman J.J., Whitelaw M.L. Asparagine hydroxylation of the HIF transactivation domain - a hypoxic switch. Science 2002, 295(5556):858-861.
19. Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Molec Cell 2008, 30:393-402.
20. Kaelin W.G. Proline hydroxylation and gene expression. Annu Rev Biochem 2005, 74:115-128.
21. Lieb M.E., Menzies K., Moschella M.C., Ni R., Taubman M.B. Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. Biochem Cell Biol 2002, 80:421-426.
22. Takeda K., Ho V.C., Takeda H., et al. Placental but not heart defects are associated with elevated hypoxia-inducible factor α levels in mice lacking prolyl hydroxylase domain protein 2. Molec Cell Biol 2006, 26:8336-8346.
23. Minamishima Y.A., Moslehi J., Bardeesy N., et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 2008, 111:3236-3244.
24. Fong G.H., Takeda K. Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ 2008, 15:635-641.
25. Jain S., Maltepe E., Lu M.M., Simon C., Bradfield C.A. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech Dev 1998, 73:117-123.
26. Hu C.J., Wang L.Y., Chodosh L.A., Keith B., Simon M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Molec Cell Biol 2003, 23:9361-9374.
27. Skuli N., Liu L., Runge A., et al. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 2009, 114:469-477.
28. Covello K.L., Kehler J., Yu H., et al. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev 2006, 20:557-570.
29. Raval R.R., Lau K.W., Tran M.G., et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molec Cell Biol 2005, 25:5675-5686.
30. Gordan J.D., Bertout J.A., Hu C.J., Diehl J.A., Simon M.C. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007, 11:335-347.
31. Makino Y., Cao R., Svensson K., et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001, 414(6863):550-554.
32. Chandel N.S., Maltepe E., Goldwasser E., et al. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 1998, 95:11715-11720.
33. Chandel N.S., McClintock D.S., Feliciano C.E., et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 2000, 275:25130-25138.
34. Brunelle J.K., Bell E.L., Quesada N.M., et al. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 2005, 1:409-414.
35. Guzy R.D., Hoyos B., Robin E., et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 2005, 1:401-408.
36. Mansfield K.D., Guzy R.D., Pan Y., et al. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 2005, 1:393-399.
37. Gerald D., Berra E., Frapart Y.M., et al. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 2004, 118:781-794.
38. Liu L., Simon M.C. Regulation of transcription and translation by hypoxia. Cancer Biol Ther 2004, 3:492-497.
39. Salmeen A., Barford D. Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxid Redox Signal 2005, 7:560-577.
40. Emerling B.M., Platanias L.C., Black E., et al. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Molec Cell Biol 2005, 25:4853-4862.
41. Okazaki K., Maltepe E. Oxygen, epigenetics and stem cell fate. Regen Med 2006, 1:71-83.
42. Goldwasser E. From protein to gene to protein: the molecular biology of erythropoietin. Am J Kidney Dis 1991, 18(4 Suppl. 1):10-13.
43. Yoon D., Pastore Y.D., Divoky V., et al. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem 2006, 281:25703-25711.
44. Rolfs A., Kvietikova I., Gassmann M., Wenger R.H. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem 1997, 272:20055-20062.
45. Tacchini L., Bianchi L., Bernelli-Zazzera A., Cairo G. Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J Biol Chem 1999, 274:24142-24146.
46. Adelman D.M., Maltepe E., Simon M.C. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev 1999, 13:2478-2483.
47. Gruber M., Hu C.J., Johnson R.S., et al. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci USA 2007, 104:2301-2306.
48. Maltepe E., Schmidt J.V., Baunoch D., Bradfield C.A., Simon M.C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997, 386(6623):403-407.
49. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998, 12:149-162.
50. Kozak K.R., Abbott B., Hankinson O. ARNT-deficient mice and placental differentiation. Dev Biol 1997, 191:297-305.
51. Ryan H.E., Lo J., Johnson R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998, 17:3005-3015.
52. Ozaki H., Yu A.Y., Della N., et al. Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 1999, 40:182-189.
53. Gerber H.P., Condorelli F., Park J., Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 1997, 272:23659-23667.
54. Ding K., Scortegagna M., Seaman R., Birch D.G., Garcia J.A. Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. Invest Ophthalmol Vis Sci 2005, 46:1010-1016.
55. Morita M., Ohneda O., Yamashita T., et al. HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J 2003, 22:1134-1146.
56. Chen C., Pore N., Behrooz A., Ismail-Beigi F., Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 2001, 276:9519-9525.
57. Gunton J.E., Kulkarni R.N., Yim S., et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005, 122:337-349.
58. Wang X.L., Suzuki R., Lee K., et al. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab 2009, 9:428-439.
59. Hung M.S., Avner P., Rogner U.C. Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6. Hum Mol Genet 2006, 15:2732-2742.
60. Woon P.Y., Kaisaki P.J., Braganca J., et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci USA 2007, 104:14412-14417.
61. Das S.K., Sharma N.K., Chu W.S., Wang H., Elbein S.C. Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: mutation detection, case-control studies, and gene expression analysis. BMC Med Genet 2008, 9:16.
62. Eichenwald E.C., Stark A.R. Management and outcomes of very low birth weight. N Engl J Med 2008, 358:1700-1711.
63. Carpenter T., Schomberg S., Steudel W., et al. Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression. Circ Res 2003, 93:456-463.
64. Asikainen T.M., Ahmad A., Schneider B.K., White C.W. Effect of preterm birth on hypoxia-inducible factors and vascular endothelial growth factor in primate lungs. Pediatr Pulmonol 2005, 40:538-546.
65. Compernolle V., Brusselmans K., Acker T., et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 2002, 8:702-710.
66. Le Cras T.D., Markham N.E., Tuder R.M., Voelkel N.F., Abman S.H. Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. Am J Physiol Lung Cell Mol Physiol 2002, 283:L555-L562.
67. Henry M.C., Moss R.L. Necrotizing enterocolitis. Annu Rev Med 2009, 60:111-124.
68. Karhausen J., Furuta G.T., Tomaszewski J.E., et al. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest 2004, 114:1098-1106.
69. Louis N.A., Hamilton K.E., Canny G., et al. Selective induction of mucin-3 by hypoxia in intestinal epithelia. J Cell Biochem 2006, 99:1616-1627.
70. Hernandez C., Santamatilde E., McCreath K.J., et al. Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: implications for gastric mucosal healing. Br J Pharmacol 2009, 156:262-272.
71. Nizet V., Johnson R.S. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009, 9:609-617.
72. Rius J., Guma M., Schachtrup C., et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 2008, 453(7196):807-811.
73. Sears J.E., Hoppe G., Ebrahem Q., Anand-Apte B. Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc Natl Acad Sci USA 2008, 105:19898-19903.
74. Asikainen T.M., Chang L.Y., Coalson J.J., et al. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J 2006, 20:1698-1700.
75. Asikainen T.M., Waleh N.S., Schneider B.K., Clyman R.I., White C.W. Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo. Am J Physiol Lung Cell Mol Physiol 2006, 291:L588-L595.