The conformation of hepatitis C virus NS3 proteinase with and without NS4A: A structural basis for the activation of the enzyme by its cofactor

Clinical and Diagnostic Virology

Volumn 10, Issue 2-3, 1998, Pages 151-156

  Love, Robert A ^a   Parge, Hans E ^a   Wickersham, John A ^a   Hostomsky, Zdenek ^a   Habuka, Noriyuki ^b   Moomaw, Ellen W ^a   Adachi, Tsuyoshi ^b   Margosiak, Steve ^a   Dagostino, Eleanor ^a   Hostomska, Zuzana ^a  

^a AGOURON PHARMACEUTICALS INC   (United States)

^b JAPAN TOBACCO INC   (Japan)

Author keywords

Crystal structure; Hepatitis C; NS3 proteinase; NS4A cofactor

Indexed keywords

PROTEINASE;

CONFERENCE PAPER; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HEPACIVIRUS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RNA HELICASES; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0032527418     PISSN: 09280197     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0197(98)00036-1     Document Type: Conference Paper

References (10)

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