Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding

Current HIV Research

Volumn 2, Issue 4, 2004, Pages 323-332

  Sluis Cremer, Nicolas ^a   Temiz, N Alpay ^a   Bahar, Ivet ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

DNA polymerase; HIV 1 reverse transcriptase; Nonnucleoside reverse transcriptase inhibitor; Ribonuclease H

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; 3 ETHYL [2',5' BIS O (TERT BUTYLDIMETHYLSILYL) BETA DEXTRO RIBOFURANOSYL] 3' SPIRO 5 (4 AMINO 1,2 OXATHIOLE 2,2 DIOXIDE)THYMIDINE; 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; ABACAVIR; BENZAMIDE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CAPRAVIRINE; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; HYDRAZONE DERIVATIVE; LAMIVUDINE; LOVIRIDE; N (TERT BUTYLBENZOYL) 2 HYDROXYNAPHTHALDEHYDE HYDRAZONE; NEVIRAPINE; NUCLEOTIDE DERIVATIVE; PHENYLALANINE; PROTEIN P66; PROTEIN SUBUNIT; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TALVIRALINE; TENOFOVIR; THYMIDINE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZALCITABINE; ZIDOVUDINE;

BINDING SITE; CONFORMATIONAL TRANSITION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; MOLECULAR SIZE; REVERSE TRANSCRIPTION; REVIEW;

ANTI-HIV AGENTS; BINDING SITES; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 4544265135     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570162043351093     Document Type: Review

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