Efavirenz is a potent nonnucleoside reverse transcriptase inhibitor of HIV type 1 replication in microglia in vitro

AIDS Research and Human Retroviruses

Volumn 16, Issue 15, 2000, Pages 1527-1537

  Albright, A V ^a   Erickson Viitanen, S ^b   O'Connor, M ^c   Frank, I ^d   Rayner, M M ^b   Gonzalez Scarano, F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DUPONT COMPANY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFAVIRENZ; GAG PROTEIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CEREBROSPINAL FLUID LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; MICROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS ISOLATION; VIRUS REPLICATION;

ADULT; ANTI-HIV AGENTS; CELLS, CULTURED; COCULTURE TECHNIQUES; HIV-1; HUMANS; MICROGLIA; NEUROGLIA; NUCLEOSIDES; OXAZINES; REVERSE TRANSCRIPTASE INHIBITORS; STAVUDINE; VIRUS REPLICATION; ZALCITABINE; ZIDOVUDINE;

EID: 0034633611     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922200750006056     Document Type: Article

References (34)

1. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
2. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
3. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy: Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy
4. Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy
5. +T cells
6. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
7. Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: Evidence of differential tropism
8. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy
9. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: Identification by the combination of in situ polymerase chain reaction and immunohisto-chemistry
10. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy
11. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients
12. Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune encephalomyelitis: An investigation using rat radiation bone marrow chimeras
13. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia
14. HIV infection in macrophage: Role of long-lived cells and related therapeutical strategies
15. Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy
16. Clinical implications of HIV dynamics and drug resistance in macrophages
17. HIV-1 entry and reverse transcription in macrophages
18. In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents
19. The entry of antiviral and antiretroviral drugs into the CNS
20. Failure to detect nelfinavir in the CSF of HIV-1 infected patients with and without AIDS dementia complex
21. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
22. Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells
23. Comparison of metabolism and in vitro antiviral activity of stavudine versus other 2',3'-dideoxynucleoside analogues
24. Culture of glial cells from human brain biopsies
25. HIV-1 infection of cultured human adult oligodendrocytes
26. Function of microglia in organotypic slice cultures
27. Macrophages tropism of HIV-1
28. Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses
29. L-743, 726 (DMP-266): A novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase
30. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy
31. Levels of HIV-1 RNA in CSF correlate with AIDS dementia stage
32. CSF, plasma viral load and HIV associated dementia