-
1
-
-
0024342876
-
Antiviral therapy in human immunodeficiency virus infection
-
Sandström, E. Antiviral therapy in human immunodeficiency virus infection. Drugs 1989, 38: 417-50.
-
(1989)
Drugs
, vol.38
, pp. 417-450
-
-
Sandström, E.1
-
2
-
-
0029775166
-
What can be expected from non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the treatment of human immunodeficiency virus type 1 (HIV-1) infections?
-
De Clercq, E. What can be expected from non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the treatment of human immunodeficiency virus type 1 (HIV-1) infections? Rev Med Virol 1996, 6: 97-117.
-
(1996)
Rev Med Virol
, vol.6
, pp. 97-117
-
-
De Clercq, E.1
-
3
-
-
3342877839
-
Collective motions in HIV-1 reverse transcriptase: Examination of flexibility and enzyme function
-
Bahar, I., Erman, B., Jernigan, R.L., Atilgan, A.R., Covell, D.G. Collective motions in HIV-1 reverse transcriptase: Examination of flexibility and enzyme function. J Mol Biol 1999, 285: 1023-37.
-
(1999)
J Mol Biol
, vol.285
, pp. 1023-1037
-
-
Bahar, I.1
Erman, B.2
Jernigan, R.L.3
Atilgan, A.R.4
Covell, D.G.5
-
4
-
-
0033047282
-
Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys
-
Balani, S.K., Kauffman, L.R., deLuna, F.A., Lin, J.H. Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys. Drug Metab Dispos 1999, 27: 41-5.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 41-45
-
-
Balani, S.K.1
Kauffman, L.R.2
DeLuna, F.A.3
Lin, J.H.4
-
5
-
-
0032537520
-
5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series
-
Vig, R., Mao, C., Venkatachalam, T.K., Tuel-Ahlgren, L., Sudbeck, E.A., Uckun, F.M. 5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series. Bioorg Med Chem Lett 1998, 8: 1461-6.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 1461-1466
-
-
Vig, R.1
Mao, C.2
Venkatachalam, T.K.3
Tuel-Ahlgren, L.4
Sudbeck, E.A.5
Uckun, F.M.6
-
6
-
-
0032544145
-
Structure-based design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase
-
Mao, C., Vig, R., Venkatachalam, T.K., Sudbeck, E.A., Uckun, F.M. Structure-based design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 1998, 8: 2213-8.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2213-2218
-
-
Mao, C.1
Vig, R.2
Venkatachalam, T.K.3
Sudbeck, E.A.4
Uckun, F.M.5
-
7
-
-
13144282707
-
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: Inhibitor flexibility is a useful design feature for reducing drug resistance
-
Hsiou, Y., Das, K., Ding, J. et al. Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: Inhibitor flexibility is a useful design feature for reducing drug resistance. J Mol Biol 1998, 284: 313-23.
-
(1998)
J Mol Biol
, vol.284
, pp. 313-323
-
-
Hsiou, Y.1
Das, K.2
Ding, J.3
-
8
-
-
0029951587
-
Non-nucleoside anti-HIV-1 reverse transcriptase inhibitors (NNRTIs): A chemical survey from lead compounds to selected drugs for clinical trials
-
Artico, M. Non-nucleoside anti-HIV-1 reverse transcriptase inhibitors (NNRTIs): A chemical survey from lead compounds to selected drugs for clinical trials. Il Farmaco 1996, 51: 305-31.
-
(1996)
Il Farmaco
, vol.51
, pp. 305-331
-
-
Artico, M.1
-
9
-
-
0028325491
-
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
-
De Clercq, E. Non-nucleoside reverse transcriptase inhibitors (NNRTIs). Exp Opin Invest Drugs 1994, 3: 253-71.
-
(1994)
Exp Opin Invest Drugs
, vol.3
, pp. 253-271
-
-
De Clercq, E.1
-
10
-
-
0024408374
-
A novel lead for specific anti-HIV-1 agents: 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine
-
Miyasaka, T., Tanaka, H., Baba, M. et al. A novel lead for specific anti-HIV-1 agents: 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine. J Med Chem 1989, 32: 2507-9.
-
(1989)
J Med Chem
, vol.32
, pp. 2507-2509
-
-
Miyasaka, T.1
Tanaka, H.2
Baba, M.3
-
11
-
-
0026071537
-
A new class of HIV-1-specific 6-substituted acyclouridine derivatives: Synthesis and anti-HIV-1 activity of 5-or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)
-
Tanaka, H., Baba, M., Hayakawa, H. et al. A new class of HIV-1-specific 6-substituted acyclouridine derivatives: Synthesis and anti-HIV-1 activity of 5-or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). J Med Chem 1991, 34: 349-57.
-
(1991)
J Med Chem
, vol.34
, pp. 349-357
-
-
Tanaka, H.1
Baba, M.2
Hayakawa, H.3
-
12
-
-
0025770237
-
Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: Synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine
-
Tanaka, H., Baba, M., Saito, S. et al. Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: Synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. J Med Chem 1991, 34: 1508-11.
-
(1991)
J Med Chem
, vol.34
, pp. 1508-1511
-
-
Tanaka, H.1
Baba, M.2
Saito, S.3
-
13
-
-
0025734369
-
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-1(2-hydroxyethoxy)methyl-6-(phenylthio)thymine (HEPT)
-
Tanaka, H., Baba, M., Ubasawa, M. et al. Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-1(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). J Med Chem 1991, 34: 1394-9.
-
(1991)
J Med Chem
, vol.34
, pp. 1394-1399
-
-
Tanaka, H.1
Baba, M.2
Ubasawa, M.3
-
14
-
-
0026543676
-
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: Effect of substitutions at the C-6 phenyl ring and at the C-5 position of anti-HIV-1 activity
-
Tanaka, H., Takashima, H., Ubasawa, M. et al. Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: Effect of substitutions at the C-6 phenyl ring and at the C-5 position of anti-HIV-1 activity. J Med Chem 1992, 35: 337-45.
-
(1992)
J Med Chem
, vol.35
, pp. 337-345
-
-
Tanaka, H.1
Takashima, H.2
Ubasawa, M.3
-
15
-
-
0027094782
-
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents
-
Tanaka, H., Takashima, H., Ubasawa, M. et al. Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. J Med Chem 1992, 35: 4713-9.
-
(1992)
J Med Chem
, vol.35
, pp. 4713-4719
-
-
Tanaka, H.1
Takashima, H.2
Ubasawa, M.3
-
16
-
-
0026694001
-
[2′,5′-Bis-O-(tert-butyldimethylsilyl)]-3′-spiro- 5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide) (TSAO) derivatives of purine and pyrimidine nucleosides as potent and selective inhibitors of human immunodeficiency virus type 1
-
Balzarini, J., Pérez-Pérez, M-J., San-Félix, A., Vélazquez, S., Camarasa, M-J., De Clerq, E. [2′,5′-Bis-O-(tert-butyldimethylsilyl)]-3′-spiro-5″- (4″-amino-1″,2″-oxathiole-2″,2″-dioxide) (TSAO) derivatives of purine and pyrimidine nucleosides as potent and selective inhibitors of human immunodeficiency virus type 1. Antimicrob Agents Chemother 1992, 36: 1073-80.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 1073-1080
-
-
Balzarini, J.1
Pérez-Pérez, M.-J.2
San-Félix, A.3
Vélazquez, S.4
Camarasa, M.-J.5
De Clerq, E.6
-
17
-
-
0028522917
-
Characterization of the anti-HIV-1 activity of 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), new non-nucleoside reverse transcriptase inhibitors
-
Tramontane, E., Marongiu, M.E., De Montis, A. et al. Characterization of the anti-HIV-1 activity of 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), new non-nucleoside reverse transcriptase inhibitors. Microbiologica 1994, 17: 269-79.
-
(1994)
Microbiologica
, vol.17
, pp. 269-279
-
-
Tramontane, E.1
Marongiu, M.E.2
De Montis, A.3
-
18
-
-
0029095334
-
Preparation and anti-HIV-1 activity of 6-benzyl-2-alkylthio-3,4-dihydro-(5-alkyl)-4-oxopyrimidines and related compounds
-
Mai, A., Artico, M., Sbardella, G. et al. Preparation and anti-HIV-1 activity of 6-benzyl-2-alkylthio-3,4-dihydro-(5-alkyl)-4-oxopyrimidines and related compounds. J Med Chem 1995, 38: 3258-63.
-
(1995)
J Med Chem
, vol.38
, pp. 3258-3263
-
-
Mai, A.1
Artico, M.2
Sbardella, G.3
-
19
-
-
0029877789
-
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: Strategies to overcome drug resistance development
-
De Clercq, E. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: Strategies to overcome drug resistance development. Med Res Rev 1996, 16: 125-57.
-
(1996)
Med Res Rev
, vol.16
, pp. 125-157
-
-
De Clercq, E.1
-
20
-
-
0028877325
-
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors
-
Dollé, V., Fan, E., Nguyen, C.H. et al. A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors. J Med Chem 1995, 38: 4679-86.
-
(1995)
J Med Chem
, vol.38
, pp. 4679-4686
-
-
Dollé, V.1
Fan, E.2
Nguyen, C.H.3
-
21
-
-
0021123061
-
General route to 5- and 6-substituted 4-amino-2-oxo-1,2-dihydropyridines
-
Nguyen, C.H., Bisagni, E.A. General route to 5- and 6-substituted 4-amino-2-oxo-1,2-dihydropyridines. Synthesis 1984, 765-6.
-
(1984)
Synthesis
, pp. 765-766
-
-
Nguyen, C.H.1
Bisagni, E.A.2
-
23
-
-
0027930721
-
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
-
Tucker, T.J., Lyle, T.A., Wiscount, C.M. et al. Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. J Med Chem 1994, 37: 2437-44.
-
(1994)
J Med Chem
, vol.37
, pp. 2437-2444
-
-
Tucker, T.J.1
Lyle, T.A.2
Wiscount, C.M.3
-
24
-
-
0028043362
-
Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors
-
Buckheit, R.W. Jr., Fliakas-Boltz, V., Decker, W.D. et al. Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors. Antiviral Res 1994, 25: 43-56.
-
(1994)
Antiviral Res
, vol.25
, pp. 43-56
-
-
Buckheit R.W., Jr.1
Fliakas-Boltz, V.2
Decker, W.D.3
-
25
-
-
0025812546
-
Anti-HIV agents II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles
-
Chimirri, A., Grasso, S., Monforte, A.M., Monforte, P., Zappala, M. Anti-HIV agents II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles. Farmaco 1991, 46: 925-33.
-
(1991)
Farmaco
, vol.46
, pp. 925-933
-
-
Chimirri, A.1
Grasso, S.2
Monforte, A.M.3
Monforte, P.4
Zappala, M.5
-
26
-
-
0027981826
-
Structure-activity relationships of antitumor thiazolo[3,4-a]benzimidazole derivatives
-
Chimirri, A., Grasso, S., Monforte, A.M., Monforte, P., Zappala, M., Carotti, A. Structure-activity relationships of antitumor thiazolo[3,4-a]benzimidazole derivatives. Farmaco 1994, 49: 337-44.
-
(1994)
Farmaco
, vol.49
, pp. 337-344
-
-
Chimirri, A.1
Grasso, S.2
Monforte, A.M.3
Monforte, P.4
Zappala, M.5
Carotti, A.6
-
27
-
-
0029942348
-
5H-Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A novel class of non-nucleoside reverse transcriptase inhibitors
-
Artico, M., Silverstri, R., Pagnozzi, E. et al. 5H-Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A novel class of non-nucleoside reverse transcriptase inhibitors. Bioorg Med Chem 1996, 4: 837-50.
-
(1996)
Bioorg Med Chem
, vol.4
, pp. 837-850
-
-
Artico, M.1
Silverstri, R.2
Pagnozzi, E.3
-
28
-
-
0028145135
-
Anti-HIV agents III. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines
-
Chimirri, A., Grasso, S., Monforte, A.M., Monforte, P., Zappala, M. Anti-HIV agents III. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines. Farmaco 1994, 49: 345-8.
-
(1994)
Farmaco
, vol.49
, pp. 345-348
-
-
Chimirri, A.1
Grasso, S.2
Monforte, A.M.3
Monforte, P.4
Zappala, M.5
-
29
-
-
0027257652
-
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity
-
Mertens, A., Zilch, H., König, B. et al. Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity. J Med Chem 1993, 36: 2526-35.
-
(1993)
J Med Chem
, vol.36
, pp. 2526-2535
-
-
Mertens, A.1
Zilch, H.2
König, B.3
-
30
-
-
0031463691
-
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles
-
Roth, T., Morningstar, M.L., Boyer, P.L., Hughes, S.H., Buckheit, R.W., Michejda, C.J. Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. J Med Chem 1997, 40: 4199-207.
-
(1997)
J Med Chem
, vol.40
, pp. 4199-4207
-
-
Roth, T.1
Morningstar, M.L.2
Boyer, P.L.3
Hughes, S.H.4
Buckheit, R.W.5
Michejda, C.J.6
-
31
-
-
0029877695
-
Clinical experience with non-nucleoside reverse transcriptase inhibitors. Advances in experimental
-
Kilby, J., Saag, M.M. Clinical experience with non-nucleoside reverse transcriptase inhibitors. Advances in experimental. Med Biol 1996, 394: 291-8.
-
(1996)
Med Biol
, vol.394
, pp. 291-298
-
-
Kilby, J.1
Saag, M.M.2
-
32
-
-
0343135973
-
Discovery and development of a non-nucleoside reverse transcripase inhibitor
-
Adams, J., Hargrave, K.D. Discovery and development of a non-nucleoside reverse transcripase inhibitor. Special Publication. Royal Soc Chem 1993, 119: 282-96.
-
(1993)
Special Publication. Royal Soc Chem
, vol.119
, pp. 282-296
-
-
Adams, J.1
Hargrave, K.D.2
-
33
-
-
0025740266
-
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones
-
Hargrave, K.D., Proudfoot, K.D. Jr., Grozinger, K.G. et al. Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones. J Med Chem 1991, 34: 2231-41.
-
(1991)
J Med Chem
, vol.34
, pp. 2231-2241
-
-
Hargrave, K.D.1
Proudfoot K.D., Jr.2
Grozinger, K.G.3
-
34
-
-
0026715578
-
Imidazo[2′,3′:6,5]-1,4-diazepines non-nucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine
-
Terrett, N.K., Bojanic, D., Merson, J.F., Stephenson, P.T. Imidazo[2′,3′:6,5]-1,4-diazepines non-nucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine. Bioorg Med Chem Lett 1992, 2: 1745-50.
-
(1992)
Bioorg Med Chem Lett
, vol.2
, pp. 1745-1750
-
-
Terrett, N.K.1
Bojanic, D.2
Merson, J.F.3
Stephenson, P.T.4
-
35
-
-
0030814171
-
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones
-
Kelly, T.A., McNeil, D.W., Rose, J.M., David, E., Shih, C-K., Grob, P.M. Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones. J Med Chem 1997, 40: 2430-3.
-
(1997)
J Med Chem
, vol.40
, pp. 2430-2433
-
-
Kelly, T.A.1
McNeil, D.W.2
Rose, J.M.3
David, E.4
Shih, C.-K.5
Grob, P.M.6
-
36
-
-
14444278761
-
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes
-
Klunder, J.M., Hoermann, M.A., Cywin, C.L. et al. Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes. J Med Chem 1998, 41: 2960-71.
-
(1998)
J Med Chem
, vol.41
, pp. 2960-2971
-
-
Klunder, J.M.1
Hoermann, M.A.2
Cywin, C.L.3
-
37
-
-
0025014499
-
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
-
Pauwels, R., Andries, K., Desmyter, J. et al. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature 1990, 343: 470-4.
-
(1990)
Nature
, vol.343
, pp. 470-474
-
-
Pauwels, R.1
Andries, K.2
Desmyter, J.3
-
38
-
-
0025973691
-
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives
-
Kukla, M.J., Breslin, H.J., Pauwels, R. et al. Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. J Med Chem 1991, 34: 746-51.
-
(1991)
J Med Chem
, vol.34
, pp. 746-751
-
-
Kukla, M.J.1
Breslin, H.J.2
Pauwels, R.3
-
39
-
-
0026347180
-
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2
-
Kukla, M.J., Breslin, H.J., Diamond, C.G. et al. Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2. J Med Chem 1991, 34: 3187-97.
-
(1991)
J Med Chem
, vol.34
, pp. 3187-3197
-
-
Kukla, M.J.1
Breslin, H.J.2
Diamond, C.G.3
-
40
-
-
0028968716
-
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3
-
Breslin, H.J., Kukla, M.J., Ludovici, D.W. et al. Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3. J Med Chem 1995, 38: 771-93.
-
(1995)
J Med Chem
, vol.38
, pp. 771-793
-
-
Breslin, H.J.1
Kukla, M.J.2
Ludovici, D.W.3
-
41
-
-
0028968716
-
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 4
-
Ho, W., Kukla, M.J., Breslin, H.J. et al. Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 4. J Med Chem 1995, 38: 794-802.
-
(1995)
J Med Chem
, vol.38
, pp. 794-802
-
-
Ho, W.1
Kukla, M.J.2
Breslin, H.J.3
-
42
-
-
0030011406
-
Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: Novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity
-
Campiani, G., Nacci, V., Fiorini, I. et al. Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: Novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity. J Med Chem 1996, 39: 2672-80.
-
(1996)
J Med Chem
, vol.39
, pp. 2672-2680
-
-
Campiani, G.1
Nacci, V.2
Fiorini, I.3
-
43
-
-
0028273009
-
Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors
-
Romero, D.L., Morge, R.A., Biles, C. et al. Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors. J Med Chem 1994, 37: 999-1014.
-
(1994)
J Med Chem
, vol.37
, pp. 999-1014
-
-
Romero, D.L.1
Morge, R.A.2
Biles, C.3
-
44
-
-
0027278282
-
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3-[1-methylethylamino]- pyridinyl]piperazine monomethanesulfonate (U-80152S), a second-generation clinical candidate
-
Romero, D.L., Morge, R.A., Genin, M.J. et al. Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3-[(1-methylethyl(amino]- pyridinyl]piperazine monomethanesulfonate (U-80152S), a second-generation clinical candidate. J Med Chem 1993, 36: 1505-8.
-
(1993)
J Med Chem
, vol.36
, pp. 1505-1508
-
-
Romero, D.L.1
Morge, R.A.2
Genin, M.J.3
-
45
-
-
0027407551
-
Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of a-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase
-
Pauwels, R., Andries, K., Debyser, Z. et al. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of a-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase. Proc Natl Acad Sci USA 1993, 90: 1711-5.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1711-1715
-
-
Pauwels, R.1
Andries, K.2
Debyser, Z.3
-
46
-
-
0028850110
-
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs
-
Bell, F.W., Cantrell, A.S., Hogberg, M. et al. Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs. J Med Chem 1995, 38: 4929-36.
-
(1995)
J Med Chem
, vol.38
, pp. 4929-4936
-
-
Bell, F.W.1
Cantrell, A.S.2
Hogberg, M.3
-
47
-
-
0028998825
-
The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase
-
Ahgren, C., Backro, K., Bell, F.W. et al. The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 1995, 39: 1329-35.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 1329-1335
-
-
Ahgren, C.1
Backro, K.2
Bell, F.W.3
-
48
-
-
0342266541
-
Thiocarboxamide derivatives: Highly potent and selective HIV inhibitors with a broad activity spectrum against mutant HIV-1 strains resistant to other non-nucleoside reverse transcriptase inhibitors
-
July 7-12, Vancouver Abst Mo.A.1051
-
Balzarini, J. et al. Thiocarboxamide derivatives: Highly potent and selective HIV inhibitors with a broad activity spectrum against mutant HIV-1 strains resistant to other non-nucleoside reverse transcriptase inhibitors. 11th Int Conf AIDS (July 7-12, Vancouver) 1996, Abst Mo.A.1051.
-
(1996)
11th Int Conf AIDS
-
-
Balzarini, J.1
-
49
-
-
0027182798
-
Design and synthesis of cosalane, a novel anti-HIV agent
-
Golebiewski, W.M. et al. Design and synthesis of cosalane, a novel anti-HIV agent. Bioorg Med Chem Lett 1993, 3: 1739.
-
(1993)
Bioorg Med Chem Lett
, vol.3
, pp. 1739
-
-
Golebiewski, W.M.1
-
50
-
-
0029783936
-
Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors
-
Cushman, M., Golebiewski, W.M., Graham, L. et al. Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors. J Med Chem 1996, 39: 3217-27.
-
(1996)
J Med Chem
, vol.39
, pp. 3217-3227
-
-
Cushman, M.1
Golebiewski, W.M.2
Graham, L.3
-
51
-
-
0027996494
-
Design, synthesis, and biological evaluation of cosalane, a novel anti-hiv agent which inhibits multiple features of virus reproduction
-
Cushman, M., Golebiewski, W.M., McMahon, J.B. et al. Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. J Med Chem 1994, 37: 3040-50.
-
(1994)
J Med Chem
, vol.37
, pp. 3040-3050
-
-
Cushman, M.1
Golebiewski, W.M.2
McMahon, J.B.3
-
52
-
-
0032482316
-
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors
-
Cushman, M., Casimiro-Garcia, A., Hejchman, E. et al. New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors. J Med Chem 1998, 41: 2076-89.
-
(1998)
J Med Chem
, vol.41
, pp. 2076-2089
-
-
Cushman, M.1
Casimiro-Garcia, A.2
Hejchman, E.3
-
53
-
-
0032560237
-
(-)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyridinamine PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor
-
Wishka, D.G., Graber, D.R., Kopta, L.A. et al. (-)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyridinamine PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor. J Med Chem 1998, 41: 1357-60.
-
(1998)
J Med Chem
, vol.41
, pp. 1357-1360
-
-
Wishka, D.G.1
Graber, D.R.2
Kopta, L.A.3
-
54
-
-
0027447592
-
Diarylsulfones, a new class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase
-
McMahon, J.B., Gulakowski, R.J., Weislow, O.S. et al. Diarylsulfones, a new class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 1993, 37: 754.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 754
-
-
McMahon, J.B.1
Gulakowski, R.J.2
Weislow, O.S.3
-
55
-
-
0027195714
-
5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide: A novel non-nucleoside inhibitor of HIV-1 reverse transcriptase
-
Williams, T.M., Ciccarone, T.M., Mactough, S.C. et al. 5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide: A novel non-nucleoside inhibitor of HIV-1 reverse transcriptase. J Med Chem 1993, 36: 1291-4.
-
(1993)
J Med Chem
, vol.36
, pp. 1291-1294
-
-
Williams, T.M.1
Ciccarone, T.M.2
Mactough, S.C.3
-
56
-
-
0028924117
-
2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase
-
Young, S.D., Amblard, M.C., Britcher, S.F. et al. 2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 1995, 5: 491-6.
-
(1995)
Bioorg Med Chem Lett
, vol.5
, pp. 491-496
-
-
Young, S.D.1
Amblard, M.C.2
Britcher, S.F.3
-
57
-
-
0028922354
-
Synthesis of pyrrolylaryl sulfones targeted at the HIV-1 reverse transcriptase
-
Artico, M., Silvestri, R., Stefancich, G. et al. Synthesis of pyrrolylaryl sulfones targeted at the HIV-1 reverse transcriptase. Arch Pharm (Weinheim) 1995, 328: 223-9.
-
(1995)
Arch Pharm (Weinheim)
, vol.328
, pp. 223-229
-
-
Artico, M.1
Silvestri, R.2
Stefancich, G.3
-
58
-
-
0030568131
-
Synthesis of novel ellipticine analogues and their inhibition of Moloney leukemia reverse transcriptase
-
Timári, G., Soós, T., Hajós, Gy., Messmer, A., Nacsa, J., Molnár, J. Synthesis of novel ellipticine analogues and their inhibition of Moloney leukemia reverse transcriptase. Bioorg Med Chem Lett 1996, 6: 2831-6.
-
(1996)
Bioorg Med Chem Lett
, vol.6
, pp. 2831-2836
-
-
Timári, G.1
Soós, T.2
Hajós, Gy.3
Messmer, A.4
Nacsa, J.5
Molnár, J.6
-
59
-
-
0027273015
-
Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication
-
Kleim, J-P., Bender, R., Billhardt, U-M. Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication. Antimicrob Agents Chemother 1993, 37: 1659-64.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 1659-1664
-
-
Kleim, J.-P.1
Bender, R.2
Billhardt, U.-M.3
-
60
-
-
0029147651
-
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication
-
Kleim, J-P., Bender, R., Kirsch, R. Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother 1995, 39: 2253-7.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 2253-2257
-
-
Kleim, J.-P.1
Bender, R.2
Kirsch, R.3
-
61
-
-
0028932873
-
Characterization of the antiviral activity of highly substituted pyrroles: A novel class of non-nucleoside HIV-1 reverse transcriptase inhbitor
-
Antonucci, T., Warmus, J.S., Hodges, U.C., Nickell, D.G. Characterization of the antiviral activity of highly substituted pyrroles: A novel class of non-nucleoside HIV-1 reverse transcriptase inhbitor. Antiviral Chem Chemother 1995, 6: 98.
-
(1995)
Antiviral Chem Chemother
, vol.6
, pp. 98
-
-
Antonucci, T.1
Warmus, J.S.2
Hodges, U.C.3
Nickell, D.G.4
-
62
-
-
0027137488
-
Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines
-
Livermore, D.G.H., Bethell, R.C., Cammack, N. et al. Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines. J Med Chem 1993, 36: 3784.
-
(1993)
J Med Chem
, vol.36
, pp. 3784
-
-
Livermore, D.G.H.1
Bethell, R.C.2
Cammack, N.3
-
63
-
-
0025363921
-
Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases
-
Nakane, H., Ono, K. Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases. Biochemistry 1990, 29: 2841-5.
-
(1990)
Biochemistry
, vol.29
, pp. 2841-2845
-
-
Nakane, H.1
Ono, K.2
-
64
-
-
0025873994
-
Inhibition of HIV-reverse transcriptase activity by some phloroglucinol derivatives
-
Nakane, H., Arisawa, M., Fujita, A., Koshimura, S., Ono, K. Inhibition of HIV-reverse transcriptase activity by some phloroglucinol derivatives. FEBS Lett 1991, 286: 83-5.
-
(1991)
FEBS Lett
, vol.286
, pp. 83-85
-
-
Nakane, H.1
Arisawa, M.2
Fujita, A.3
Koshimura, S.4
Ono, K.5
-
65
-
-
0026340744
-
Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase
-
Tan, G.T., Kinghorn, A.D., Hughes, S.H., Pezzuto, J.M. Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase. J Biol Chem 1991, 226: 23529-36.
-
(1991)
J Biol Chem
, vol.226
, pp. 23529-23536
-
-
Tan, G.T.1
Kinghorn, A.D.2
Hughes, S.H.3
Pezzuto, J.M.4
-
66
-
-
0014964695
-
RNA-dependent DNA polymerase in virions of Rous sarcoma virus
-
Temin, H.M., Mizutani, S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 1970, 226: 1211-3.
-
(1970)
Nature
, vol.226
, pp. 1211-1213
-
-
Temin, H.M.1
Mizutani, S.2
-
67
-
-
0030037398
-
HIV receptors and the pathogenesis of AIDS
-
Weiss, R.A. HIV receptors and the pathogenesis of AIDS. Science 1996, 212: 1885-6.
-
(1996)
Science
, vol.212
, pp. 1885-1886
-
-
Weiss, R.A.1
-
68
-
-
0020596551
-
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome
-
Barré-Sinoussi, F., Chermann, J.C., Rey, F. et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome. Science 1983, 220: 868-71.
-
(1983)
Science
, vol.220
, pp. 868-871
-
-
Barré-Sinoussi, F.1
Chermann, J.C.2
Rey, F.3
-
69
-
-
0023052240
-
Isolation of a new human retrovirus from a west Africa patient with AIDS
-
Clavel, F., Guetard, D., Brun-Vezinet, F. et al. Isolation of a new human retrovirus from a West Africa patient with AIDS. Science 1986, 233: 343-6.
-
(1986)
Science
, vol.233
, pp. 343-346
-
-
Clavel, F.1
Guetard, D.2
Brun-Vezinet, F.3
-
70
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
-
Esnouf, R., Ren, J., Ross, C., Jones, Y., Stammers, D., Stuart, D. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nat Struct Biol 1995, 2: 303-8.
-
(1995)
Nat Struct Biol
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, C.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
71
-
-
0030753123
-
Inhibition of HIV infection of H9 cells by chlorpromazine derivatives
-
Hewlett, I., Lee, S., Molnár, J. et al. Inhibition of HIV infection of H9 cells by chlorpromazine derivatives. J Acquir Immune Defic Syndr Hum Retrovir 1997, 15: 16-20.
-
(1997)
J Acquir Immune Defic Syndr Hum Retrovir
, vol.15
, pp. 16-20
-
-
Hewlett, I.1
Lee, S.2
Molnár, J.3
-
72
-
-
0030865659
-
Inhibition of GP 120 and antibodies binding to CD4 by metal complexes
-
Kidd, S.E., Nelson, M.J., Epstein, M., Aszalós, A., Pine, S., Molnár, J. Inhibition of GP 120 and antibodies binding to CD4 by metal complexes. Anti-infect Drugs Chemother 1997, 15: 71-7.
-
(1997)
Anti-infect Drugs Chemother
, vol.15
, pp. 71-77
-
-
Kidd, S.E.1
Nelson, M.J.2
Epstein, M.3
Aszalós, A.4
Pine, S.5
Molnár, J.6
|