메뉴 건너뛰기




Volumn 12, Issue 9, 2007, Pages 483-495

Antiviral drugs in the treatment of AIDS: What is in the pipeline?

Author keywords

[No Author keywords available]

Indexed keywords

3' FLUOROTHYMIDINE; AMD 070; AMD 11070; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; APRICITABINE; AVX 754; BCH 10618; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; EFAVIRENZ; ELVITEGRAVIR; ELVUCITABINE; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; GS 9137; GW 695634; INTEGRASE INHIBITOR; IPILIMUMAB; ISENTRESS; JTK 303; KP 1461; MARAVIROC; MK 0518; PPL 100; PROTEINASE INHIBITOR; RALTEGRAVIR; RILPIVIRINE; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SIFUVIRTIDE; SN 1461; SPD 754; TNX 355; UK 453061; UNCLASSIFIED DRUG; UNINDEXED DRUG; VICRIVIROC; ZIDOVUDINE;

EID: 35548957272     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (19)

References (107)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
    • Mar 26;
    • Palella FJJr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998 Mar 26;338(13):853-60.
    • (1998) N Engl J Med , vol.338 , Issue.13 , pp. 853-860
    • FJJr, P.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5    Satten, G.A.6    Aschman, D.J.7    Holmberg, S.D.8
  • 4
    • 33745869106 scopus 로고    scopus 로고
    • Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive,. HIV-infected patients
    • Jun 12;
    • Cahn P, Cassetti I, Wood R, Phanuphak P, Shiveley L, Bethell RC, Sawyer J. Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive,. HIV-infected patients. Aids 2006 Jun 12;20(9):1261-8.
    • (2006) Aids , vol.20 , Issue.9 , pp. 1261-1268
    • Cahn, P.1    Cassetti, I.2    Wood, R.3    Phanuphak, P.4    Shiveley, L.5    Bethell, R.C.6    Sawyer, J.7
  • 5
    • 52149107312 scopus 로고    scopus 로고
    • Superior activity of apricitabine compared to 3TC over 21 days in treatment experienced HIV-1 infected patients failing therapy with M184V and NRTI resistance
    • Sydney, Australia abstract WESS203
    • Cahn P, Altclas J, Martins M, Losso M, Cassetti I, Cooper D. Superior activity of apricitabine compared to 3TC over 21 days in treatment experienced HIV-1 infected patients failing therapy with M184V and NRTI resistance. 4th IAS Conference Sydney, Australia abstract WESS203. 2007.
    • (2007) 4th IAS Conference
    • Cahn, P.1    Altclas, J.2    Martins, M.3    Losso, M.4    Cassetti, I.5    Cooper, D.6
  • 6
    • 35548984611 scopus 로고    scopus 로고
    • Efficacy and novel pharmacology of elvucitabine in a 7 day placebo controlled monotherapy study
    • San Francisco abstract H-1670d
    • Colucci P, Cottage J, Robison H, et al. Efficacy and novel pharmacology of elvucitabine in a 7 day placebo controlled monotherapy study. 46th ICAAC San Francisco abstract H-1670d. 2006.
    • (2006) 46th ICAAC
    • Colucci, P.1    Cottage, J.2    Robison, H.3
  • 7
    • 35548934433 scopus 로고    scopus 로고
    • Racivir Demonstrates Safety and Efficacy in Patients Harboring HIV with the M184V Mutation and <3 TAM
    • Los Angeles abstract 488
    • Cahn P, Sosa N, Wiznia A, Patel M, Ward D, Palella F, et al. Racivir Demonstrates Safety and Efficacy in Patients Harboring HIV with the M184V Mutation and <3 TAM. 14th Conf Retro Opportun Infect Los Angeles abstract 488. 2007.
    • (2007) 14th Conf Retro Opportun Infect
    • Cahn, P.1    Sosa, N.2    Wiznia, A.3    Patel, M.4    Ward, D.5    Palella, F.6
  • 9
    • 35548934003 scopus 로고    scopus 로고
    • Neuropsychiatric events with TMC278, an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Sydney, Australia abstract WEPEA105
    • Pozniak A, Steyn D, Grinsztejn B, Vinogradova E, Lupo S, Techasathit W, et al. Neuropsychiatric events with TMC278, an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI). 4th IAS Conference Sydney, Australia abstract WEPEA105. 2007.
    • (2007) 4th IAS Conference
    • Pozniak, A.1    Steyn, D.2    Grinsztejn, B.3    Vinogradova, E.4    Lupo, S.5    Techasathit, W.6
  • 10
    • 40749137751 scopus 로고    scopus 로고
    • The metabolic profile of TMC278, an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Sydney, Australia abstract TUAB105
    • Ruxrungtham K, Bellos N, Morales-Ramirez J, Timerman A, Madruga J, Katabira E, et al. The metabolic profile of TMC278, an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI). 4th IAS Conference Sydney, Australia abstract TUAB105. 2007.
    • (2007) 4th IAS Conference
    • Ruxrungtham, K.1    Bellos, N.2    Morales-Ramirez, J.3    Timerman, A.4    Madruga, J.5    Katabira, E.6
  • 13
    • 35549007403 scopus 로고    scopus 로고
    • PL-100, a Next Generation Protease Inhibitor against Drug-Resistant HIV: In Vitro and In Vivo Metabolism
    • San Francisco abstract H-253
    • Wu JJ, Stranix BR, Milot G, Ge M, Dandache S, Forté A, et al. PL-100, a Next Generation Protease Inhibitor against Drug-Resistant HIV: In Vitro and In Vivo Metabolism. 46th ICAAC San Francisco abstract H-253. 2006.
    • (2006) 46th ICAAC
    • Wu, J.J.1    Stranix, B.R.2    Milot, G.3    Ge, M.4    Dandache, S.5    Forté, A.6
  • 15
    • 35349021681 scopus 로고    scopus 로고
    • Rapid onset and durable antiretroviral effect of raltegravir (MK-0518), a novel HIV-1 integrase inhibitor, as part of combination ART in treatment HIV-1 infected patients: 48-week data
    • Sydney, Australia abstract TUAB104
    • Markowitz M, Nguyen B-Y, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, et al. Rapid onset and durable antiretroviral effect of raltegravir (MK-0518), a novel HIV-1 integrase inhibitor, as part of combination ART in treatment HIV-1 infected patients: 48-week data. 4th IAS Conference Sydney, Australia abstract TUAB104. 2007.
    • (2007) 4th IAS Conference
    • Markowitz, M.1    Nguyen, B.-Y.2    Gotuzzo, E.3    Mendo, F.4    Ratanasuwan, W.5    Kovacs, C.6
  • 18
    • 34248199833 scopus 로고    scopus 로고
    • The HIV Integrase Inhibitor GS-9137 Has Potent Antiretroviral Activity in Treatment-Experienced Patients
    • Los Angeles abstract 143LB
    • Zolopa AR, Mullen M, Berger D, Ruane P, Hawkins T, Zhong L, et al. The HIV Integrase Inhibitor GS-9137 Has Potent Antiretroviral Activity in Treatment-Experienced Patients. 14th Conf Retro Opportun Infect Los Angeles abstract 143LB. 2007.
    • (2007) 14th Conf Retro Opportun Infect
    • Zolopa, A.R.1    Mullen, M.2    Berger, D.3    Ruane, P.4    Hawkins, T.5    Zhong, L.6
  • 20
    • 35548971388 scopus 로고    scopus 로고
    • Norris D, Morales J, Godofsky E, Garcia F, Hardwicke R, Lewis S. TNX-355, in combination with optimized background regimen (OBR), achieves statistically significant viral load reduction and CD4 cell count increase when compared with OBR alone in phase 2 study at week 48. Int Conf Aids Toronto, Canada August 13-18 abstract ThLB0218. 2006.
    • Norris D, Morales J, Godofsky E, Garcia F, Hardwicke R, Lewis S. TNX-355, in combination with optimized background regimen (OBR), achieves statistically significant viral load reduction and CD4 cell count increase when compared with OBR alone in phase 2 study at week 48. Int Conf Aids Toronto, Canada August 13-18 abstract ThLB0218. 2006.
  • 24
    • 34948903088 scopus 로고    scopus 로고
    • Safety and Pharmacokinetics of Bevirimat (PA-457), a Novel Inhibitor of Human Immunodeficiency Virus Maturation, in Healthy Volunteers
    • Sep;
    • Martin DE, Blum R, Wilton J, Doto J, Galbraith H, Burgess GL, Smith PC, Ballow C. Safety and Pharmacokinetics of Bevirimat (PA-457), a Novel Inhibitor of Human Immunodeficiency Virus Maturation, in Healthy Volunteers. Antimicrob Agents Chemother 2007 Sep; 51(9): 3063-6.
    • (2007) Antimicrob Agents Chemother , vol.51 , Issue.9 , pp. 3063-3066
    • Martin, D.E.1    Blum, R.2    Wilton, J.3    Doto, J.4    Galbraith, H.5    Burgess, G.L.6    Smith, P.C.7    Ballow, C.8
  • 25
    • 33747604774 scopus 로고    scopus 로고
    • Pharmacokinetics/Pharmacodynamics of PA-457 in a 10-day Multiple Dose Monotherapy Trial in HIV-infected Patients
    • abstract 52
    • Smith P, Forrest A, Beatty J, Jacobson J, Lalezari J, Eron J, et al. Pharmacokinetics/Pharmacodynamics of PA-457 in a 10-day Multiple Dose Monotherapy Trial in HIV-infected Patients. 13th Conf Retrovir Opportun Infect abstract 52. 2006.
    • (2006) 13th Conf Retrovir Opportun Infect
    • Smith, P.1    Forrest, A.2    Beatty, J.3    Jacobson, J.4    Lalezari, J.5    Eron, J.6
  • 28
    • 0031282842 scopus 로고    scopus 로고
    • Phase I/II trial with fozivudine tidoxil (BM 21.1290): A 7 day randomized, placebo-controlled dose-escalating trial
    • Dec;
    • Bogner JR, Roecken M, Herrmann DB, Boerner D, Kaufmann B, Gurtler L, Plewig G, Goebel FD. Phase I/II trial with fozivudine tidoxil (BM 21.1290): a 7 day randomized, placebo-controlled dose-escalating trial. Antivir Ther 1997 Dec;2(4):257-64.
    • (1997) Antivir Ther , vol.2 , Issue.4 , pp. 257-264
    • Bogner, J.R.1    Roecken, M.2    Herrmann, D.B.3    Boerner, D.4    Kaufmann, B.5    Gurtler, L.6    Plewig, G.7    Goebel, F.D.8
  • 31
    • 35548986036 scopus 로고    scopus 로고
    • Heidelberg Pharma, Clinical effectiveness and tolerability of Fosalvudine (HIV) confirmed,21-5-2007, http://www.heidelberg-pharma.com/
    • Heidelberg Pharma, Clinical effectiveness and tolerability of Fosalvudine (HIV) confirmed,21-5-2007, http://www.heidelberg-pharma.com/
  • 32
    • 20444414897 scopus 로고    scopus 로고
    • KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
    • Jul;
    • Harris KS, Brabant W, Styrchak S, Gall A, Daifuku R. KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral Res 2005 Jul;67(1):1-9.
    • (2005) Antiviral Res , vol.67 , Issue.1 , pp. 1-9
    • Harris, K.S.1    Brabant, W.2    Styrchak, S.3    Gall, A.4    Daifuku, R.5
  • 33
    • 33847719131 scopus 로고    scopus 로고
    • Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study
    • Uckun FM, DuMez D, Qazi S, Tibbles H, Venkatachalam TK. Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study. Arzneimittelforschung 2007;57(2):112-21.
    • (2007) Arzneimittelforschung , vol.57 , Issue.2 , pp. 112-121
    • Uckun, F.M.1    DuMez, D.2    Qazi, S.3    Tibbles, H.4    Venkatachalam, T.K.5
  • 34
    • 33645099392 scopus 로고    scopus 로고
    • Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses
    • Feb;
    • Uckun FM, Venkatachalam TK, Qazi S. Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses. Arzneimittelforschung 2006 Feb;56(2A):193-203.
    • (2006) Arzneimittelforschung , vol.56 , Issue.2 A , pp. 193-203
    • Uckun, F.M.1    Venkatachalam, T.K.2    Qazi, S.3
  • 35
    • 33645114688 scopus 로고    scopus 로고
    • Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity
    • Feb;
    • Uckun FM. Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity. Arzneimittelforschung 2006 Feb;56(2A):121-35.
    • (2006) Arzneimittelforschung , vol.56 , Issue.2 A , pp. 121-135
    • Uckun, F.M.1
  • 36
    • 17644412826 scopus 로고    scopus 로고
    • In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs
    • Uckun FM, Qazi S, Venkatachalam TK. In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs. Arzneimittelforschung 2005;55(4):223-31.
    • (2005) Arzneimittelforschung , vol.55 , Issue.4 , pp. 223-231
    • Uckun, F.M.1    Qazi, S.2    Venkatachalam, T.K.3
  • 39
    • 33847027993 scopus 로고    scopus 로고
    • Highly selective action of triphosphate metabolite of 4′-ethynyl D4T: A novel anti-HIV compound against HIV-1 RT
    • Mar;
    • Yang G, Dutschman GE, Wang CJ, Tanaka H, Baba M, Anderson KS, Cheng YC. Highly selective action of triphosphate metabolite of 4′-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT. Antiviral Res 2007 Mar;73(3):185-91.
    • (2007) Antiviral Res , vol.73 , Issue.3 , pp. 185-191
    • Yang, G.1    Dutschman, G.E.2    Wang, C.J.3    Tanaka, H.4    Baba, M.5    Anderson, K.S.6    Cheng, Y.C.7
  • 40
    • 23744503171 scopus 로고    scopus 로고
    • Tanaka H, Haraguchi K, Kumamoto H, Baba M, Cheng YC. 4′-Ethynylstavudine (4′-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants. Antivir Chem Chemother 2005;16(4):217-21.
    • Tanaka H, Haraguchi K, Kumamoto H, Baba M, Cheng YC. 4′-Ethynylstavudine (4′-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants. Antivir Chem Chemother 2005;16(4):217-21.
  • 41
    • 23044505480 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus type 1 activity and resistance profile of 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine in vitro
    • Aug;
    • Nitanda T, Wang X, Kurnamoto H, Haraguchi K, Tanaka H, Cheng YC, Baba M. Anti-human immunodeficiency virus type 1 activity and resistance profile of 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine in vitro. Antimicrob Agents Chemother 2005 Aug;49(8):3355-60.
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.8 , pp. 3355-3360
    • Nitanda, T.1    Wang, X.2    Kurnamoto, H.3    Haraguchi, K.4    Tanaka, H.5    Cheng, Y.C.6    Baba, M.7
  • 42
    • 35548985150 scopus 로고    scopus 로고
    • Intracellular Metabolism of 2-Deoxy-4′-C-Ethynyl-2-Fluoroadenosine, a Novel 4′-C-Ethynyl Nucleoside Analog Potent against Multidrug-resistant HIV-1 Variants
    • abstract 499
    • Nakata H, Koh Y, Kodama E, Yang G, Kohgo S, Hayakawa H, et al. Intracellular Metabolism of 2-Deoxy-4′-C-Ethynyl-2-Fluoroadenosine, a Novel 4′-C-Ethynyl Nucleoside Analog Potent against Multidrug-resistant HIV-1 Variants. 13th Conf Retrovir Opportun Infect abstract 499. 2006.
    • (2006) 13th Conf Retrovir Opportun Infect
    • Nakata, H.1    Koh, Y.2    Kodama, E.3    Yang, G.4    Kohgo, S.5    Hayakawa, H.6
  • 43
    • 35549008298 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of a foscarnet analogue, synergy with zidovudine and analysis of resistance variants selected in vitro
    • Rio de Janeiro abstract TuPe6.1B16
    • Waninger S, Ramos S, Robbins J. Anti-HIV-1 activity of a foscarnet analogue, synergy with zidovudine and analysis of resistance variants selected in vitro. 3rd IAS Conference Rio de Janeiro abstract TuPe6.1B16. 2005.
    • (2005) 3rd IAS Conference
    • Waninger, S.1    Ramos, S.2    Robbins, J.3
  • 44
    • 33846697977 scopus 로고    scopus 로고
    • GS9148: A Novel Nucleotide Active Against HIV-1 Variants with Drug Resistance Mutations in Reverse Transcriptase
    • abstract 45
    • Cihlar T, Ray A, Boojamra D, Zhang L, Hui H, Grant D, et al. GS9148: A Novel Nucleotide Active Against HIV-1 Variants with Drug Resistance Mutations in Reverse Transcriptase. 13th Conf Retrovir Opportun Infect abstract 45. 2006.
    • (2006) 13th Conf Retrovir Opportun Infect
    • Cihlar, T.1    Ray, A.2    Boojamra, D.3    Zhang, L.4    Hui, H.5    Grant, D.6
  • 45
    • 43049114748 scopus 로고    scopus 로고
    • DUET-2: 24 week results of a phase III randomised double-blind trial to evaluate the efficacy and safety of TMC125 versus placebo in 591 treatment-experienced HIV-1 infected patients
    • Sydney, Australia abstract WESS204-2
    • Katlama C, Campbell T, Clotet B, Johnson M, Lazzarin A, Arasteh K, et al. DUET-2: 24 week results of a phase III randomised double-blind trial to evaluate the efficacy and safety of TMC125 versus placebo in 591 treatment-experienced HIV-1 infected patients. 4th IAS Conference Sydney, Australia abstract WESS204-2. 2007.
    • (2007) 4th IAS Conference
    • Katlama, C.1    Campbell, T.2    Clotet, B.3    Johnson, M.4    Lazzarin, A.5    Arasteh, K.6
  • 46
    • 35548950096 scopus 로고    scopus 로고
    • DUET-1: 24 week results of a phase III randomised double-blind trial to evaluate the efficacy and safety of TMC125 versus placebo in 612 treatment-experienced HIV-1 infected patients
    • Sydney, Australia abstract WESS204-1
    • Mills A, Cahn P, Grinsztejn B, Haubrich R, Lalezari J, Madruga JV, et al. DUET-1: 24 week results of a phase III randomised double-blind trial to evaluate the efficacy and safety of TMC125 versus placebo in 612 treatment-experienced HIV-1 infected patients. 4th IAS Conference Sydney, Australia abstract WESS204-1. 2007.
    • (2007) 4th IAS Conference
    • Mills, A.1    Cahn, P.2    Grinsztejn, B.3    Haubrich, R.4    Lalezari, J.5    Madruga, J.V.6
  • 47
    • 35548937142 scopus 로고    scopus 로고
    • Short-term monotherapy with UK-453,061, a novel NNRTT, reduces viral load in HIV infected patients
    • Sydney, Australia abstract WESS202
    • Fätkenheuer G, Staszewski S, Plettenberg A, Hackman F, Layton G, McFadyen L, et al. Short-term monotherapy with UK-453,061, a novel NNRTT, reduces viral load in HIV infected patients. 4th IAS Conference Sydney, Australia abstract WESS202. 2007.
    • (2007) 4th IAS Conference
    • Fätkenheuer, G.1    Staszewski, S.2    Plettenberg, A.3    Hackman, F.4    Layton, G.5    McFadyen, L.6
  • 48
    • 32544451872 scopus 로고    scopus 로고
    • Antiviral activity and safety of GW695634, a novel next generation NNRTI in NNRTI-resistant HIV-1 infected patients
    • Rio de Janeiro abstract WcPeb. 2003
    • Becker S. Antiviral activity and safety of GW695634, a novel next generation NNRTI in NNRTI-resistant HIV-1 infected patients. Third International AIDS Society Conference on HIV Pathogenesis and Treatment, Rio de Janeiro abstract WcPeb. 2003. 2005.
    • (2005) Third International AIDS Society Conference on HIV Pathogenesis and Treatment
    • Becker, S.1
  • 49
    • 0036867571 scopus 로고    scopus 로고
    • Safety and pharmacokinetic profile of multiple escalating doses of (+)-calanolide A, a naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy HIV-negative volunteers
    • Nov;
    • Eiznhamet DA, Creagh T, Ruckle JL, Tolbert DT, Giltnet J, Dutta B, Flavin MT, Jenta T, Xu ZQ. Safety and pharmacokinetic profile of multiple escalating doses of (+)-calanolide A, a naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy HIV-negative volunteers. HIV Clin Trials 2002 Nov;3(6):435-50.
    • (2002) HIV Clin Trials , vol.3 , Issue.6 , pp. 435-450
    • Eiznhamet, D.A.1    Creagh, T.2    Ruckle, J.L.3    Tolbert, D.T.4    Giltnet, J.5    Dutta, B.6    Flavin, M.T.7    Jenta, T.8    Xu, Z.Q.9
  • 50
    • 0035037065 scopus 로고    scopus 로고
    • Safety and pharmaco-kinetics of single doses of (+)-calanolide a, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects
    • May;
    • Creagh T, Ruckle JL, Tolbert DT, Giltner J, Eiznhamer DA, Dutta B, Flavin MT, Xu ZQ. Safety and pharmaco-kinetics of single doses of (+)-calanolide a, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects. Antimicrob Agents Chemother 2001 May;45(5):1379-86.
    • (2001) Antimicrob Agents Chemother , vol.45 , Issue.5 , pp. 1379-1386
    • Creagh, T.1    Ruckle, J.L.2    Tolbert, D.T.3    Giltner, J.4    Eiznhamer, D.A.5    Dutta, B.6    Flavin, M.T.7    Xu, Z.Q.8
  • 51
    • 32544437940 scopus 로고    scopus 로고
    • Crystallographic study with BILR 355 BS, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) with a broad anti HIV-1 profile
    • Rio de Janeiro abstract WePp0105
    • Coulombe R, Fink D, Landry S, Lessard IAD, McCollum R, Naud J, et al. Crystallographic study with BILR 355 BS, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) with a broad anti HIV-1 profile. 3rd IAS Conference Rio de Janeiro abstract WePp0105. 2005.
    • (2005) 3rd IAS Conference
    • Coulombe, R.1    Fink, D.2    Landry, S.3    Lessard, I.A.D.4    McCollum, R.5    Naud, J.6
  • 52
    • 70349302624 scopus 로고    scopus 로고
    • Antiviral Briefs
    • Antiviral Briefs. Aids Patient Care And Stds 20[12], 887-889. 2006.
    • (2006) Aids Patient Care And Stds , vol.20 , Issue.12 , pp. 887-889
  • 53
  • 56
    • 35548933510 scopus 로고    scopus 로고
    • ImQuest Pharmaceuticals, Inc, ImQuest Pharmaceuticals licenses Entire Series of Anti-HIV Therapeutic Compounds from Samjin Pharmaceutical Co.,28-2-2006, http://www.imquest.com/content_pages/File/ feb-28-samjin.pdf
    • ImQuest Pharmaceuticals, Inc, ImQuest Pharmaceuticals licenses Entire Series of Anti-HIV Therapeutic Compounds from Samjin Pharmaceutical Co.,28-2-2006, http://www.imquest.com/content_pages/File/ feb-28-samjin.pdf
  • 57
    • 35548934864 scopus 로고    scopus 로고
    • R1206, a representative of a new class of potent diphenyl ether non-nucleoside reverse transcriptase inhibitors broadly active against NNRTI-resistant HIV-1 variants and achieving high systemic exposures and benign safety profiles in animal species
    • abstract 28
    • Klumpp K, Dunn J, Heilek G, Zhou A, Stefanidis D, Chen CW, et al. R1206, a representative of a new class of potent diphenyl ether non-nucleoside reverse transcriptase inhibitors broadly active against NNRTI-resistant HIV-1 variants and achieving high systemic exposures and benign safety profiles in animal species. Antiviral Therapy 12[S30], abstract 28. 2007.
    • (2007) Antiviral Therapy , vol.12
    • Klumpp, K.1    Dunn, J.2    Heilek, G.3    Zhou, A.4    Stefanidis, D.5    Chen, C.W.6
  • 59
    • 35548930054 scopus 로고    scopus 로고
    • IDX12899 anti-HIV-1 activity and resistance profile is superior to efavirenz
    • abstract 30
    • Jakubik J, Seifer M, Gray L, Chapron C, Patty A, Dousson C, et al. IDX12899 anti-HIV-1 activity and resistance profile is superior to efavirenz. Antiviral Therapy 12[S32], abstract 30. 2007.
    • (2007) Antiviral Therapy , vol.12
    • Jakubik, J.1    Seifer, M.2    Gray, L.3    Chapron, C.4    Patty, A.5    Dousson, C.6
  • 63
    • 35548981134 scopus 로고    scopus 로고
    • Determination of Resistance Profile of GRL-02031, a Novel Nonpeptidic Protease Inhibitor Containing a Cyclopentanyltetrahydrofuran Moiety
    • abstract 503
    • Koh Y, Nakata H, Ogata-Aoki H, Nakayama M, Leschenko S, Ghosh A, et al. Determination of Resistance Profile of GRL-02031, a Novel Nonpeptidic Protease Inhibitor Containing a Cyclopentanyltetrahydrofuran Moiety. 13th Conf Retrovir Opportun Infect abstract 503. 2006.
    • (2006) 13th Conf Retrovir Opportun Infect
    • Koh, Y.1    Nakata, H.2    Ogata-Aoki, H.3    Nakayama, M.4    Leschenko, S.5    Ghosh, A.6
  • 64
    • 35548977358 scopus 로고    scopus 로고
    • UIC-02031: A Novel Nonpeptidic Protease Inhibbitor Containing a Stereochemically Defined Fused Cyclopentanyltetrahydroffuran Potent against Multi-PT-Resistant HIV-1 in vitro
    • abstract 562
    • Koh Y, Nakata H, Ogata-Aoki H, Leschenko S, Ghosh A, Mitsuya H. UIC-02031: A Novel Nonpeptidic Protease Inhibbitor Containing a Stereochemically Defined Fused Cyclopentanyltetrahydroffuran Potent against Multi-PT-Resistant HIV-1 in vitro. 12th Conf Retrovir Opportun Infect abstract 562. 2005.
    • (2005) 12th Conf Retrovir Opportun Infect
    • Koh, Y.1    Nakata, H.2    Ogata-Aoki, H.3    Leschenko, S.4    Ghosh, A.5    Mitsuya, H.6
  • 65
    • 35548958964 scopus 로고    scopus 로고
    • Bristol-Myers Squibb, Trial Details for Trial AI441-008,24-8-2007, http://ctr.bms.com/ctd/InitTrialDetailAction.do?pnum=AI441-008
    • Bristol-Myers Squibb, Trial Details for Trial AI441-008,24-8-2007, http://ctr.bms.com/ctd/InitTrialDetailAction.do?pnum=AI441-008
  • 66
    • 34248213533 scopus 로고    scopus 로고
    • A Double-Blind, Parallel, Randomized, Placebo-Controlled, Single and Repeat Dose Escalation Study to Investigate the Safety, Tolerability, and Pharmacokinetics of the HIV Integrase Inhibitor GSK364735 in Healthy Subjects (GRZ105655)
    • Los Angeles abstract 562
    • Reddy S, Min S, Borland J, Song I, Lin J, Mehta A, et al. A Double-Blind, Parallel, Randomized, Placebo-Controlled, Single and Repeat Dose Escalation Study to Investigate the Safety, Tolerability, and Pharmacokinetics of the HIV Integrase Inhibitor GSK364735 in Healthy Subjects (GRZ105655). 14th Conf Retro Opportun Infect Los Angeles abstract 562. 2007.
    • (2007) 14th Conf Retro Opportun Infect
    • Reddy, S.1    Min, S.2    Borland, J.3    Song, I.4    Lin, J.5    Mehta, A.6
  • 67
    • 35548981608 scopus 로고    scopus 로고
    • China Daily, Human trials begin for anti-HIV drug,23-2-2006, http//www.chinadaily.com.cn/english/doc/2006-02/23/content_523134.htm
    • China Daily, Human trials begin for anti-HIV drug,23-2-2006, http//www.chinadaily.com.cn/english/doc/2006-02/23/content_523134.htm
  • 69
    • 85036902393 scopus 로고    scopus 로고
    • Multiple dosing of the novel HIV-1 maturation inhibitor bevirimat (BVM): Aggregate adverse event (AE) and laboratory data from four short-term studies
    • Sydney, Australia abstract WEPEA110
    • McCallister S, Doto J, Allaway G, Martin DE. Multiple dosing of the novel HIV-1 maturation inhibitor bevirimat (BVM): aggregate adverse event (AE) and laboratory data from four short-term studies. 4th IAS Conference Sydney, Australia abstract WEPEA110. 2007.
    • (2007) 4th IAS Conference
    • McCallister, S.1    Doto, J.2    Allaway, G.3    Martin, D.E.4
  • 70
    • 35548950106 scopus 로고    scopus 로고
    • Characterization of PA1050040, a second generation HIV-1 maturation inhibitor
    • Sydney, Australia abstract MOPDX05
    • Kilgore N, Reddick M, Zuiderhof M, Stanley D, Nitz T, Bullock P, et al. Characterization of PA1050040, a second generation HIV-1 maturation inhibitor. 4th IAS Conference Sydney, Australia abstract MOPDX05. 2007.
    • (2007) 4th IAS Conference
    • Kilgore, N.1    Reddick, M.2    Zuiderhof, M.3    Stanley, D.4    Nitz, T.5    Bullock, P.6
  • 71
    • 35548942937 scopus 로고    scopus 로고
    • Blair W, Cao J, Jackson L, Peng Q, Isaacon J, Butler S, et al. Execution of a High Throughput HIV-1 Replication Screen and the Identification of a Novel Small Molecule Inhibitor that Targets HIV-1 Envelope Maturation. 13th Conf Retrovir Opportun Infect, abstract 50 LB. 2006.
    • Blair W, Cao J, Jackson L, Peng Q, Isaacon J, Butler S, et al. Execution of a High Throughput HIV-1 Replication Screen and the Identification of a Novel Small Molecule Inhibitor that Targets HIV-1 Envelope Maturation. 13th Conf Retrovir Opportun Infect, abstract 50 LB. 2006.
  • 74
    • 35549007841 scopus 로고    scopus 로고
    • H-Phar, An open, single-dose, two ways cross-over, food interaction study to assess the safety, bioavailability and pharmacokinetics of HPH116,2007, http://www.h-phar.com/News.php
    • H-Phar, An open, single-dose, two ways cross-over, food interaction study to assess the safety, bioavailability and pharmacokinetics of HPH116,2007, http://www.h-phar.com/News.php
  • 75
    • 35549009991 scopus 로고    scopus 로고
    • Medivir AB Sweden, press release,20-12-2006, http://www.medivir.se/v3/se/ ir_media/press_releases.aspx?id=137
    • Medivir AB Sweden, press release,20-12-2006, http://www.medivir.se/v3/se/ ir_media/press_releases.aspx?id=137
  • 77
    • 33744492607 scopus 로고    scopus 로고
    • Synergistic in vitro antiretroviral activity of a humanized monoclonal anti-CD4 antibody (TNX-355) and enfuvirtide (T-20)
    • Jun;
    • Zhang XQ, Sorensen M, Fung M, Schooley RT. Synergistic in vitro antiretroviral activity of a humanized monoclonal anti-CD4 antibody (TNX-355) and enfuvirtide (T-20). Antimicrob Agents Chemother 2006 Jun;50(6):2231-3.
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.6 , pp. 2231-2233
    • Zhang, X.Q.1    Sorensen, M.2    Fung, M.3    Schooley, R.T.4
  • 78
    • 35548934863 scopus 로고    scopus 로고
    • Development of Novel Orally Bioavailable CXCR4 Antagonists, KRH-3955 and KRH-3140: Binding Specificity, Pharmacokinetics and Anti-HIV-1 Activity in vivo and in vitro
    • abstract 49LB
    • Tanaka Y, Okuma K, Tanaka R, Kumakura S, Shimoyamada A, Hirose K, et al. Development of Novel Orally Bioavailable CXCR4 Antagonists, KRH-3955 and KRH-3140: Binding Specificity, Pharmacokinetics and Anti-HIV-1 Activity in vivo and in vitro. 13th Conf Retrovir Opportun Infect abstract 49LB. 2006.
    • (2006) 13th Conf Retrovir Opportun Infect
    • Tanaka, Y.1    Okuma, K.2    Tanaka, R.3    Kumakura, S.4    Shimoyamada, A.5    Hirose, K.6
  • 80
    • 35548993029 scopus 로고    scopus 로고
    • ACTG 5211: Phase II study of the safety and efficacy of vicriviroc (VCV) in HIV-infected treatment-experienced subjects: 48 week results
    • Sydney, Australia abstract TUAB102
    • Gulick R, Su Z, Flexner C, Hughes M, Skolnik P, Godfrey C, et al. ACTG 5211: phase II study of the safety and efficacy of vicriviroc (VCV) in HIV-infected treatment-experienced subjects: 48 week results. 4th IAS Conference Sydney, Australia abstract TUAB102. 2007.
    • (2007) 4th IAS Conference
    • Gulick, R.1    Su, Z.2    Flexner, C.3    Hughes, M.4    Skolnik, P.5    Godfrey, C.6
  • 81
    • 59749092344 scopus 로고    scopus 로고
    • Potent antiretroviral activity of the once-daily CCR5 antagonist INCB009471 over 14 days of monotherapy
    • Sydney, Australia abstract TUAB106
    • Cohen C, DeJesus E, Mills A, Pierone Jr. G, Kumar P, Ruane P, et al. Potent antiretroviral activity of the once-daily CCR5 antagonist INCB009471 over 14 days of monotherapy. 4th IAS Conference Sydney, Australia abstract TUAB106. 2007.
    • (2007) 4th IAS Conference
    • Cohen, C.1    DeJesus, E.2    Mills, A.3    Pierone Jr., G.4    Kumar, P.5    Ruane, P.6
  • 82
    • 52149087869 scopus 로고    scopus 로고
    • Antiviral effects and tolerability of the CCR5 monoclonal antibody PRO 140: A proof of concept study in HIV-infected individuals
    • Sydney, Australia abstract WESS201
    • Saag MS, Jacobson JM, Thompson M, Fischl M, Liporace R, Reichman RC, et al. Antiviral effects and tolerability of the CCR5 monoclonal antibody PRO 140: a proof of concept study in HIV-infected individuals. 4th IAS Conference Sydney, Australia abstract WESS201. 2007.
    • (2007) 4th IAS Conference
    • Saag, M.S.1    Jacobson, J.M.2    Thompson, M.3    Fischl, M.4    Liporace, R.5    Reichman, R.C.6
  • 83
    • 35548958963 scopus 로고    scopus 로고
    • The anti-CCR5 mAb004 inhibits hiv-1 replication synergistically in combination with other antiretroviral agents but does not select for resistance during in vitro passage
    • abstract 505
    • Giguel F, Beebe L, Migone TS, Kuritzkes D. The anti-CCR5 mAb004 inhibits hiv-1 replication synergistically in combination with other antiretroviral agents but does not select for resistance during in vitro passage. 13th Conf Retrovir Opportun Infect abstract 505. 2006.
    • (2006) 13th Conf Retrovir Opportun Infect
    • Giguel, F.1    Beebe, L.2    Migone, T.S.3    Kuritzkes, D.4
  • 84
    • 35548950520 scopus 로고    scopus 로고
    • CCR5 binding properties of a CCR5 small-molecule-inhibitor with high antiviral potency against a maraviroc-resistant HIV-1 strain
    • abstract 11
    • Jekle A, Kondru R, Ki C, Chuang KT, Swinney DC, Rotstein D, et al. CCR5 binding properties of a CCR5 small-molecule-inhibitor with high antiviral potency against a maraviroc-resistant HIV-1 strain. Antiviral Therapy 12[S13], abstract 11. 2007.
    • (2007) Antiviral Therapy , vol.12
    • Jekle, A.1    Kondru, R.2    Ki, C.3    Chuang, K.T.4    Swinney, D.C.5    Rotstein, D.6
  • 86
    • 27644506926 scopus 로고    scopus 로고
    • TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans
    • Nov;
    • Baba M, Takashima K, Miyake H, Kanzaki N, Teshima K, Wang X, Shiraishi M, Iizawa Y. TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans. Antimicrob Agents Chemother 2005 Nov;49(11):4584-91.
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.11 , pp. 4584-4591
    • Baba, M.1    Takashima, K.2    Miyake, H.3    Kanzaki, N.4    Teshima, K.5    Wang, X.6    Shiraishi, M.7    Iizawa, Y.8
  • 88
    • 35548949608 scopus 로고    scopus 로고
    • Proof of Concept of Antiretroviral Activity of AMD11070 (an Orally Administered CXCR4 Entry Inhibitor): Results of the First Dosing Cohort A Studied in ACTG Protocol A5210
    • Los Angeles abstract 512
    • Saag M, Rosenkranz S, Becker S, Klingman K, Kallungal B, Zadzilka A, et al. Proof of Concept of Antiretroviral Activity of AMD11070 (an Orally Administered CXCR4 Entry Inhibitor): Results of the First Dosing Cohort A Studied in ACTG Protocol A5210. 14th Conf Retro Opportun Infect Los Angeles abstract 512. 2007.
    • (2007) 14th Conf Retro Opportun Infect
    • Saag, M.1    Rosenkranz, S.2    Becker, S.3    Klingman, K.4    Kallungal, B.5    Zadzilka, A.6
  • 90
    • 18644369147 scopus 로고    scopus 로고
    • The Appealing Story of HIV Entry Inhibitors: From Discovery of Biological Mechanisms to Drug Development
    • Castagna A, Biswas F, Beretta A, Lazzarin A. The Appealing Story of HIV Entry Inhibitors: From Discovery of Biological Mechanisms to Drug Development. Drugs 65[7], 879-904. 2005.
    • (2005) Drugs , vol.65 , Issue.7 , pp. 879-904
    • Castagna, A.1    Biswas, F.2    Beretta, A.3    Lazzarin, A.4
  • 91
    • 35548942938 scopus 로고    scopus 로고
    • Zhang U. A bis-azo-dye (FP-21399) inhibits HIV-1 replication in the post-absorption stage. 4Th Conf Retro And Opportun Infect 1997 Jul;104(abstract no. 217):no-26.
    • Zhang U. A bis-azo-dye (FP-21399) inhibits HIV-1 replication in the post-absorption stage. 4Th Conf Retro And Opportun Infect 1997 Jul;104(abstract no. 217):no-26.
  • 93
    • 33746967066 scopus 로고    scopus 로고
    • FP-21399 (Lexigen Pharmaceuticals)
    • Nov;
    • Poli G, Vicenzi E. FP-21399 (Lexigen Pharmaceuticals). IDrugs 2001 Nov;4(11):1293-5.
    • (2001) IDrugs , vol.4 , Issue.11 , pp. 1293-1295
    • Poli, G.1    Vicenzi, E.2
  • 95
    • 35548989945 scopus 로고    scopus 로고
    • FusoGen, Sifuvirtide,2007, http://www.fusogen.com/en/lm3-1.asp
    • (2007)
  • 96
    • 35549010441 scopus 로고    scopus 로고
    • Trimeris, Pipeline. Next-Generation Fusion Inhibitors, 2007, http://www.trimeris.com/330NextGeneration.aspx
    • Trimeris, Pipeline. Next-Generation Fusion Inhibitors, 2007, http://www.trimeris.com/330NextGeneration.aspx
  • 97
    • 35549010879 scopus 로고    scopus 로고
    • Ambrilia Biopharma, HIV/AIDS - SPC3,2007, http://www.ambrilia.com/en/ products/hiv-aids-spc3.php
    • Ambrilia Biopharma, HIV/AIDS - SPC3,2007, http://www.ambrilia.com/en/ products/hiv-aids-spc3.php
  • 98
    • 35548935872 scopus 로고    scopus 로고
    • Samaritan Pharmaceuticals, Samaritan Partnered Its Phase II SP-01A HIV Drug to Pharmaplaz, Ireland,28-8-2007, http://www.samaritanpharma.com/ aids_hiv_program_sp-01a.asp
    • Samaritan Pharmaceuticals, Samaritan Partnered Its Phase II SP-01A HIV Drug to Pharmaplaz, Ireland,28-8-2007, http://www.samaritanpharma.com/ aids_hiv_program_sp-01a.asp
  • 99
    • 33846822055 scopus 로고    scopus 로고
    • Neurokinin-1 Receptor Antagonist (Aprepitant) Inhibits Drug-Resistant HIV-1 Infection of Macrophages in vitro
    • Jan 12;
    • Wang X, Douglas SD, Lai J-P, Tuluc F, Tebas P, Ho W. Neurokinin-1 Receptor Antagonist (Aprepitant) Inhibits Drug-Resistant HIV-1 Infection of Macrophages in vitro. Journal of NeuroImmune Pharmacology 2007 Jan 12;2(1):1557-904.
    • (2007) Journal of NeuroImmune Pharmacology , vol.2 , Issue.1 , pp. 1557-1904
    • Wang, X.1    Douglas, S.D.2    Lai, J.-P.3    Tuluc, F.4    Tebas, P.5    Ho, W.6
  • 101
    • 34548191221 scopus 로고    scopus 로고
    • Update on anti-CTLA-4 antibodies in clinical trials
    • Aug;
    • Langer LF, Clay TM, Morse MA. Update on anti-CTLA-4 antibodies in clinical trials. Expert Opin Biol Ther 2007 Aug;7(8):1245-56.
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.8 , pp. 1245-1256
    • Langer, L.F.1    Clay, T.M.2    Morse, M.A.3
  • 102
    • 35548954898 scopus 로고    scopus 로고
    • Medarex, Medarex Initiates Phase I Clinical Trial of MDX-010 in HIV,11-6-2007, http://www.medarex.com/cgi-local/item.pl/20030611-555575
    • Medarex, Medarex Initiates Phase I Clinical Trial of MDX-010 in HIV,11-6-2007, http://www.medarex.com/cgi-local/item.pl/20030611-555575
  • 104
    • 35549007402 scopus 로고    scopus 로고
    • Oxadiazols: A new class of rationally designed anti-HIV compounds targeting nuclear localization signal of the viral matrix protein
    • Rio de Janeiro abstract TuPe6.1B01
    • Haffar O, Dubrovsky L, Bukrinsky M. Oxadiazols: a new class of rationally designed anti-HIV compounds targeting nuclear localization signal of the viral matrix protein. 3rd IAS Conference Rio de Janeiro abstract TuPe6.1B01. 2005.
    • (2005) 3rd IAS Conference
    • Haffar, O.1    Dubrovsky, L.2    Bukrinsky, M.3
  • 106
    • 35548989530 scopus 로고    scopus 로고
    • Polyclonal Caprine IgG PEHRG214 (HRG); Anti-HIV Activity and Mapping of Novel Antibody Specificities
    • Rio de Janeiro abstract WePe 6.2C02
    • Sanford J, Dezube B, Perera T, Crumpacker C, Gelder F. Polyclonal Caprine IgG PEHRG214 (HRG); Anti-HIV Activity and Mapping of Novel Antibody Specificities. 3rd IAS Conference Rio de Janeiro abstract WePe 6.2C02. 2005.
    • (2005) 3rd IAS Conference
    • Sanford, J.1    Dezube, B.2    Perera, T.3    Crumpacker, C.4    Gelder, F.5
  • 107
    • 35548934000 scopus 로고    scopus 로고
    • Resistance Profile of a Novel Broadly Neutralizing Anti-HIV Monoclonal Antibody, KD-247, that Has Favorable Synergism with Anti-CCR5 Inhibitors in vitro
    • Yoshimura K, Shibata J, Honda A, Murakami T, Mitsuya H, Koito A, et al. Resistance Profile of a Novel Broadly Neutralizing Anti-HIV Monoclonal Antibody, KD-247, that Has Favorable Synergism with Anti-CCR5 Inhibitors in vitro. 13th Conf Retrovir Opportun Infect #506. 2006.
    • (2006) 13th Conf Retrovir Opportun Infect , Issue.506
    • Yoshimura, K.1    Shibata, J.2    Honda, A.3    Murakami, T.4    Mitsuya, H.5    Koito, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.