-
1
-
-
4243098381
-
Dietary fat, insulin sensitivity and the metabolic syndrome
-
G Riccardi R Giacco AA Rivellese 2004 Dietary fat, insulin sensitivity and the metabolic syndrome Clin Nutr 23 447 456
-
(2004)
Clin Nutr
, vol.23
, pp. 447-456
-
-
Riccardi, G.1
Giacco, R.2
Rivellese, A.A.3
-
2
-
-
0345374579
-
Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
-
RH Unger 2003 Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome Endocrinology 144 5159 5165
-
(2003)
Endocrinology
, vol.144
, pp. 5159-5165
-
-
Unger, R.H.1
-
3
-
-
33744781581
-
Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis
-
J Mao FJ DeMayo H Li L Abu-Elheiga Z Gu TE Shaikenov P Kordari SS Chirala WC Heird SJ Wakil 2006 Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis Proc Natl Acad Sci U S A 103 8552 8557
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8552-8557
-
-
Mao, J.1
Demayo, F.J.2
Li, H.3
Abu-Elheiga, L.4
Gu, Z.5
Shaikenov, T.E.6
Kordari, P.7
Chirala, S.S.8
Heird, W.C.9
Wakil, S.J.10
-
4
-
-
22544480378
-
"new" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis
-
MV Chakravarthy Z Pan Y Zhu K Tordjman JG Schneider T Coleman J Turk CF Semenkovich 2005 "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis Cell Metab 1 309 322
-
(2005)
Cell Metab
, vol.1
, pp. 309-322
-
-
Chakravarthy, M.V.1
Pan, Z.2
Zhu, Y.3
Tordjman, K.4
Schneider, J.G.5
Coleman, T.6
Turk, J.7
Semenkovich, C.F.8
-
5
-
-
0037143752
-
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
-
JM Ntambi M Miyazaki JP Stoehr H Lan CM Kendziorski BS Yandell Y Song P Cohen JM Friedman AD Attie 2002 Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity Proc Natl Acad Sci U S A 99 11482 11486
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 11482-11486
-
-
Ntambi, J.M.1
Miyazaki, M.2
Stoehr, J.P.3
Lan, H.4
Kendziorski, C.M.5
Yandell, B.S.6
Song, Y.7
Cohen, P.8
Friedman, J.M.9
Attie, A.D.10
-
6
-
-
36448991861
-
Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
-
M Miyazaki MT Flowers H Sampath K Chu C Otzelberger X Liu JM Ntambi 2007 Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis Cell Metab 6 484 496
-
(2007)
Cell Metab
, vol.6
, pp. 484-496
-
-
Miyazaki, M.1
Flowers, M.T.2
Sampath, H.3
Chu, K.4
Otzelberger, C.5
Liu, X.6
Ntambi, J.M.7
-
7
-
-
34948904815
-
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
-
T Matsuzaka H Shimano N Yahagi T Kato A Atsumi T Yamamoto N Inoue M Ishikawa S Okada N Ishigaki H Iwasaki Y Iwasaki T Karasawa S Kumadaki T Matsui M Sekiya K Ohashi AH Hasty Y Nakagawa A Takahashi H Suzuki S Yatoh H Sone H Toyoshima J Osuga N Yamada 2007 Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance Nat Med 13 1193 1202
-
(2007)
Nat Med
, vol.13
, pp. 1193-1202
-
-
Matsuzaka, T.1
Shimano, H.2
Yahagi, N.3
Kato, T.4
Atsumi, A.5
Yamamoto, T.6
Inoue, N.7
Ishikawa, M.8
Okada, S.9
Ishigaki, N.10
Iwasaki, H.11
Iwasaki, Y.12
Karasawa, T.13
Kumadaki, S.14
Matsui, T.15
Sekiya, M.16
Ohashi, K.17
Hasty, A.H.18
Nakagawa, Y.19
Takahashi, A.20
Suzuki, H.21
Yatoh, S.22
Sone, H.23
Toyoshima, H.24
Osuga, J.25
Yamada, N.26
more..
-
9
-
-
33646018341
-
Fatty acid elongases in mammals: Their regulation and roles in metabolism
-
A Jakobsson R Westerberg A Jacobsson 2006 Fatty acid elongases in mammals: Their regulation and roles in metabolism Prog Lipid Res 45 237 249
-
(2006)
Prog Lipid Res
, vol.45
, pp. 237-249
-
-
Jakobsson, A.1
Westerberg, R.2
Jacobsson, A.3
-
10
-
-
0035977004
-
Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins
-
YA Moon NA Shah S Mohapatra JA Warrington JD Horton 2001 Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins J Biol Chem 276 45358 45366
-
(2001)
J Biol Chem
, vol.276
, pp. 45358-45366
-
-
Moon, Y.A.1
Shah, N.A.2
Mohapatra, S.3
Warrington, J.A.4
Horton, J.D.5
-
11
-
-
0035988360
-
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
-
T Matsuzaka H Shimano N Yahagi T Yoshikawa M Amemiya-Kudo AH Hasty H Okazaki Y Tamura Y Iizuka K Ohashi J Osuga A Takahashi S Yato H Sone S Ishibashi N Yamada 2002 Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs J Lipid Res 43 911 920
-
(2002)
J Lipid Res
, vol.43
, pp. 911-920
-
-
Matsuzaka, T.1
Shimano, H.2
Yahagi, N.3
Yoshikawa, T.4
Amemiya-Kudo, M.5
Hasty, A.H.6
Okazaki, H.7
Tamura, Y.8
Iizuka, Y.9
Ohashi, K.10
Osuga, J.11
Takahashi, A.12
Yato, S.13
Sone, H.14
Ishibashi, S.15
Yamada, N.16
-
12
-
-
39549097750
-
Mouse Elovl-6 promoter is an SREBP target
-
S Kumadaki T Matsuzaka T Kato N Yahagi T Yamamoto S Okada K Kobayashi A Takahashi S Yatoh H Suzuki N Yamada H Shimano 2008 Mouse Elovl-6 promoter is an SREBP target Biochem Biophys Res Commun 368 261 266
-
(2008)
Biochem Biophys Res Commun
, vol.368
, pp. 261-266
-
-
Kumadaki, S.1
Matsuzaka, T.2
Kato, T.3
Yahagi, N.4
Yamamoto, T.5
Okada, S.6
Kobayashi, K.7
Takahashi, A.8
Yatoh, S.9
Suzuki, H.10
Yamada, N.11
Shimano, H.12
-
13
-
-
3543029821
-
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
-
VT Samuel ZX Liu X Qu BD Elder S Bilz D Befroy AJ Romanelli GI Shulman 2004 Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J Biol Chem 279 32345 32353
-
(2004)
J Biol Chem
, vol.279
, pp. 32345-32353
-
-
Samuel, V.T.1
Liu, Z.X.2
Qu, X.3
Elder, B.D.4
Bilz, S.5
Befroy, D.6
Romanelli, A.J.7
Shulman, G.I.8
-
14
-
-
33847404482
-
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease
-
VT Samuel ZX Liu A Wang SA Beddow JG Geisler M Kahn XM Zhang BP Monia S Bhanot GI Shulman 2007 Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease J Clin Invest 117 739 745
-
(2007)
J Clin Invest
, vol.117
, pp. 739-745
-
-
Samuel, V.T.1
Liu, Z.X.2
Wang, A.3
Beddow, S.A.4
Geisler, J.G.5
Kahn, M.6
Zhang, X.M.7
Monia, B.P.8
Bhanot, S.9
Shulman, G.I.10
-
15
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
WL Holland JT Brozinick LP Wang ED Hawkins KM Sargent Y Liu K Narra KL Hoehn TA Knotts A Siesky DH Nelson SK Karathanasis GK Fontenot MJ Birnbaum SA Summers 2007 Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance Cell Metab 5 167 179
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
Hawkins, E.D.4
Sargent, K.M.5
Liu, Y.6
Narra, K.7
Hoehn, K.L.8
Knotts, T.A.9
Siesky, A.10
Nelson, D.H.11
Karathanasis, S.K.12
Fontenot, G.K.13
Birnbaum, M.J.14
Summers, S.A.15
-
16
-
-
2342483040
-
SREBPs suppress IRS-2-mediated insulin signalling in the liver
-
T Ide H Shimano N Yahagi T Matsuzaka M Nakakuki T Yamamoto Y Nakagawa A Takahashi H Suzuki H Sone H Toyoshima A Fukamizu N Yamada 2004 SREBPs suppress IRS-2-mediated insulin signalling in the liver Nat Cell Biol 6 351 357
-
(2004)
Nat Cell Biol
, vol.6
, pp. 351-357
-
-
Ide, T.1
Shimano, H.2
Yahagi, N.3
Matsuzaka, T.4
Nakakuki, M.5
Yamamoto, T.6
Nakagawa, Y.7
Takahashi, A.8
Suzuki, H.9
Sone, H.10
Toyoshima, H.11
Fukamizu, A.12
Yamada, N.13
-
17
-
-
21744446895
-
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases
-
Y Wang D Botolin B Christian J Busik J Xu D Jump 2005 Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases J Lipid Res. 46 706 715
-
(2005)
J Lipid Res.
, vol.46
, pp. 706-715
-
-
Wang, Y.1
Botolin, D.2
Christian, B.3
Busik, J.4
Xu, J.5
Jump, D.6
-
18
-
-
33748744535
-
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity
-
Y Wang D Botolin J Xu B Christian E Mitchell B Jayaprakasam MG Nair JM Peters JV Busik LK Olson DB Jump 2006 Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity J Lipid Res 47 2028 2041
-
(2006)
J Lipid Res
, vol.47
, pp. 2028-2041
-
-
Wang, Y.1
Botolin, D.2
Xu, J.3
Christian, B.4
Mitchell, E.5
Jayaprakasam, B.6
Nair, M.G.7
Peters, J.M.8
Busik, J.V.9
Olson, L.K.10
Jump, D.B.11
-
19
-
-
0034193457
-
Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids
-
P Tvrdik R Westerberg S Silve A Asadi A Jakobsson B Cannon G Loison A Jacobsson 2000 Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids J Cell Biol. 149 707 717
-
(2000)
J Cell Biol.
, vol.149
, pp. 707-717
-
-
Tvrdik, P.1
Westerberg, R.2
Silve, S.3
Asadi, A.4
Jakobsson, A.5
Cannon, B.6
Loison, G.7
Jacobsson, A.8
-
20
-
-
0031438705
-
Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue
-
P Tvrdik A Asadi LP Kozak J Nedergaard B Cannon A Jacobsson 1997 Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue J Biol Chem. 272 31738 31746
-
(1997)
J Biol Chem.
, vol.272
, pp. 31738-31746
-
-
Tvrdik, P.1
Asadi, A.2
Kozak, L.P.3
Nedergaard, J.4
Cannon, B.5
Jacobsson, A.6
-
21
-
-
0035168415
-
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
-
K Zhang M Kniazeva M Han W Li Z Yu Z Yang Y Li ML Metzker R Allikmets DJ Zack LE Kakuk PS Lagali PW Wong IM MacDonald PA Sieving DJ Figueroa CP Austin RJ Gould R Ayyagari K Petrukhin 2001 A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy Nat Genet 27 89 93
-
(2001)
Nat Genet
, vol.27
, pp. 89-93
-
-
Zhang, K.1
Kniazeva, M.2
Han, M.3
Li, W.4
Yu, Z.5
Yang, Z.6
Li, Y.7
Metzker, M.L.8
Allikmets, R.9
Zack, D.J.10
Kakuk, L.E.11
Lagali, P.S.12
Wong, P.W.13
Sieving, P.A.14
Figueroa, D.J.15
Austin, C.P.16
Gould, R.J.17
Ayyagari, R.18
Petrukhin, K.19
-
22
-
-
0034664989
-
Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
-
AE Leonard EG Bobik J Dorado PE Kroeger LT Chuang JM Thurmond JM Parker-Barnes T Das YS Huang P Mukerji 2000 Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids Biochem J. 350 765 770
-
(2000)
Biochem J.
, vol.350
, pp. 765-770
-
-
Leonard, A.E.1
Bobik, E.G.2
Dorado, J.3
Kroeger, P.E.4
Chuang, L.T.5
Thurmond, J.M.6
Parker-Barnes, J.M.7
Das, T.8
Huang, Y.S.9
Mukerji, P.10
-
23
-
-
10744233172
-
Role for ELOVL3 and fatty acid chain length in development of hair and skin function
-
R Westerberg P Tvrdik A UndŽn J MŒnsson L NorlŽn A Jakobsson W Holleran P Elias A Asadi P Flodby R ToftgŒrd M Capecchi A Jacobsson 2004 Role for ELOVL3 and fatty acid chain length in development of hair and skin function J Biol Chem 279 5621 5629
-
(2004)
J Biol Chem
, vol.279
, pp. 5621-5629
-
-
Westerberg, R.1
Tvrdik, P.2
Undžn, A.3
MŒnsson, J.4
Norlžn, L.5
Jakobsson, A.6
Holleran, W.7
Elias, P.8
Asadi, A.9
Flodby, P.10
ToftgŒrd, R.11
Capecchi, M.12
Jacobsson, A.13
-
24
-
-
33846924619
-
Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
-
DJ Cameron Z Tong Z Yang J Kaminoh S Kamiyah H Chen J Zeng Y Chen L Luo K Zhang 2007 Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival Int J Biol Sci 3 111 119
-
(2007)
Int J Biol Sci
, vol.3
, pp. 111-119
-
-
Cameron, D.J.1
Tong, Z.2
Yang, Z.3
Kaminoh, J.4
Kamiyah, S.5
Chen, H.6
Zeng, J.7
Chen, Y.8
Luo, L.9
Zhang, K.10
-
25
-
-
33846903325
-
Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice
-
W Li R Sandhoff M Kono P Zerfas V Hoffmann BC Ding RL Proia CX Deng 2007 Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice Int J Biol Sci 3 120 128
-
(2007)
Int J Biol Sci
, vol.3
, pp. 120-128
-
-
Li, W.1
Sandhoff, R.2
Kono, M.3
Zerfas, P.4
Hoffmann, V.5
Ding, B.C.6
Proia, R.L.7
Deng, C.X.8
-
26
-
-
64149083800
-
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
-
YA Moon RE Hammer JD Horton 2009 Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice J Lipid Res 50 412 423
-
(2009)
J Lipid Res
, vol.50
, pp. 412-423
-
-
Moon, Y.A.1
Hammer, R.E.2
Horton, J.D.3
-
27
-
-
50949112066
-
Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition
-
Y Wang M Torres-Gonzalez S Tripathy D Botolin B Christian DB Jump 2008 Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition J Lipid Res 49 1538 1552
-
(2008)
J Lipid Res
, vol.49
, pp. 1538-1552
-
-
Wang, Y.1
Torres-Gonzalez, M.2
Tripathy, S.3
Botolin, D.4
Christian, B.5
Jump, D.B.6
-
28
-
-
51549107903
-
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
-
H Cao K Gerhold JR Mayers MM Wiest SM Watkins GS Hotamisligil 2008 Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism Cell 134 933 944
-
(2008)
Cell
, vol.134
, pp. 933-944
-
-
Cao, H.1
Gerhold, K.2
Mayers, J.R.3
Wiest, M.M.4
Watkins, S.M.5
Hotamisligil, G.S.6
-
29
-
-
18244363982
-
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
-
K Maeda H Cao K Kono CZ Gorgun M Furuhashi KT Uysal Q Cao G Atsumi H Malone B Krishnan Y Minokoshi BB Kahn RA Parker GS Hotamisligil 2005 Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes Cell Metab 1 107 119
-
(2005)
Cell Metab
, vol.1
, pp. 107-119
-
-
Maeda, K.1
Cao, H.2
Kono, K.3
Gorgun, C.Z.4
Furuhashi, M.5
Uysal, K.T.6
Cao, Q.7
Atsumi, G.8
Malone, H.9
Krishnan, B.10
Minokoshi, Y.11
Kahn, B.B.12
Parker, R.A.13
Hotamisligil, G.S.14
-
32
-
-
0035970805
-
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
-
L Abu-Elheiga MM Matzuk KA Abo-Hashema SJ Wakil 2001 Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 Science 291 2613 2616
-
(2001)
Science
, vol.291
, pp. 2613-2616
-
-
Abu-Elheiga, L.1
Matzuk, M.M.2
Abo-Hashema, K.A.3
Wakil, S.J.4
|