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Volumn 47, Issue 7, 1998, Pages 1086-1094

Long-term exposure of β-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; ENZYME ACTIVITY; ESTERIFICATION; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; GLYCOLYSIS; LIPID METABOLISM; LIPOGENESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SENSITIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0031750277     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.7.1086     Document Type: Article
Times cited : (137)

References (71)
  • 1
    • 0026451942 scopus 로고
    • Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function
    • Eizirik DL, Korbutt OS, Hellerstrom C: Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest 90:1263-1268, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1263-1268
    • Eizirik, D.L.1    Korbutt, O.S.2    Hellerstrom, C.3
  • 3
    • 0026511753 scopus 로고
    • Beta-cell dysfunction induced by chronic hyperglycemia: Current ideas on mechanism of impaired glucose-induced insulin secretion
    • Leahy JL, Bonner-Weir S, Weir GC: Beta-cell dysfunction induced by chronic hyperglycemia: current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care 15:442-455, 1992
    • (1992) Diabetes Care , vol.15 , pp. 442-455
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 4
    • 0026625602 scopus 로고
    • Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture
    • Liang Y, Najafi H, Smith RM, Zimmerman EC, Magnuson MA, Tal M, Matschinsky FM: Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41:792-806, 1992
    • (1992) Diabetes , vol.41 , pp. 792-806
    • Liang, Y.1    Najafi, H.2    Smith, R.M.3    Zimmerman, E.C.4    Magnuson, M.A.5    Tal, M.6    Matschinsky, F.M.7
  • 5
    • 0029932643 scopus 로고    scopus 로고
    • New insights into pancreatic beta-cell metabolic signaling in insulin secretion
    • Prentki M: New insights into pancreatic beta-cell metabolic signaling in insulin secretion. Eur J Endocrinol 134:272-286, 1996
    • (1996) Eur J Endocrinol , vol.134 , pp. 272-286
    • Prentki, M.1
  • 6
    • 0029071517 scopus 로고
    • Metabolic coupling factors in pancreatic beta-cell signal transduction
    • Newgard CB, McGarry JD: Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu Rev Biochem 64:689-719, 1995
    • (1995) Annu Rev Biochem , vol.64 , pp. 689-719
    • Newgard, C.B.1    McGarry, J.D.2
  • 7
    • 0027993030 scopus 로고
    • Characterization of the murine high Km glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin secreting cell line
    • Waeber G, Thomson N, Haefliger J-A, Nicod P: Characterization of the murine high Km glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin secreting cell line. J Biol Chem 269:26912-26919, 1994
    • (1994) J Biol Chem , vol.269 , pp. 26912-26919
    • Waeber, G.1    Thomson, N.2    Haefliger, J.-A.3    Nicod, P.4
  • 9
    • 0030956626 scopus 로고    scopus 로고
    • Modulation of glucose responsiveness of insulinoma β-cells by graded overexpression of glucokinase
    • Wang H, Iyneadjian PB: Modulation of glucose responsiveness of insulinoma β-cells by graded overexpression of glucokinase. Proc Natl Acad Sci USA 94:4372-4377, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4372-4377
    • Wang, H.1    Iyneadjian, P.B.2
  • 10
    • 0030067317 scopus 로고    scopus 로고
    • Differential effects of overexpressed glucokinase and hexokinase I in isolated islets: Evidence for functional segregation of the high and low Km enzymes
    • Becker TC, Noel RJ, Johnson JH, Lynch RM, Hirose H, Tokuyama Y, Bell GI, Newgard CB: Differential effects of overexpressed glucokinase and hexokinase I in isolated islets: evidence for functional segregation of the high and low Km enzymes. J Biol Chem 271:390-394, 1996
    • (1996) J Biol Chem , vol.271 , pp. 390-394
    • Becker, T.C.1    Noel, R.J.2    Johnson, J.H.3    Lynch, R.M.4    Hirose, H.5    Tokuyama, Y.6    Bell, G.I.7    Newgard, C.B.8
  • 12
    • 0027436399 scopus 로고
    • The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type
    • Marie S, Diaz-Guerra MJ, Miquerol L, Kahn A, Iynedjian PB: The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type. J Biol Chem 268:23881-23890, 1993
    • (1993) J Biol Chem , vol.268 , pp. 23881-23890
    • Marie, S.1    Diaz-Guerra, M.J.2    Miquerol, L.3    Kahn, A.4    Iynedjian, P.B.5
  • 13
    • 0026468362 scopus 로고
    • What if Minkowski had been ageusic? An alternative angle on diabetes
    • McGarry JD: What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258:766-770, 1992
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 14
    • 0030029605 scopus 로고
    • Are the beta-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
    • Prentki M, Corkey BE: Are the beta-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1990
    • (1990) Diabetes , vol.45 , pp. 273-283
    • Prentki, M.1    Corkey, B.E.2
  • 15
    • 0028817443 scopus 로고
    • A malonyl-CoA fuel-sensing mechanism in muscle: Effects of insulin, glucose, and denervation
    • Sana AK, Kurowski TG, Ruderman NB: A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation. Am J Physiol 269:E283-E289, 1995
    • (1995) Am J Physiol , vol.269
    • Sana, A.K.1    Kurowski, T.G.2    Ruderman, N.B.3
  • 16
    • 0028522881 scopus 로고
    • Acetyl-CoA carboxylase: An important regulator of fatty acid oxidation in the heart
    • Lopaschuk GD, Gamble J: Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart. Can J Physiol Pharmacol 72:1101-1109, 1994
    • (1994) Can J Physiol Pharmacol , vol.72 , pp. 1101-1109
    • Lopaschuk, G.D.1    Gamble, J.2
  • 17
    • 0026649107 scopus 로고
    • Two sites for adenine-nucleotide regulation of ATP-sensitive potassium channels in mouse pancreatic β-colls and HIT colls
    • Hopkins WF, Fatherazi S, Peter-Riesch B, Corkey BE, Cook DL: Two sites for adenine-nucleotide regulation of ATP-sensitive potassium channels in mouse pancreatic β-colls and HIT colls. J Membr Biol 129:287-295, 1992
    • (1992) J Membr Biol , vol.129 , pp. 287-295
    • Hopkins, W.F.1    Fatherazi, S.2    Peter-Riesch, B.3    Corkey, B.E.4    Cook, D.L.5
  • 19
    • 0029097424 scopus 로고
    • Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets: Further implication of cytosolic NADPH in insulin secretion
    • MacDonald MJ: Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets: further implication of cytosolic NADPH in insulin secretion. J Biol Chem 270:20051-20058, 1995
    • (1995) J Biol Chem , vol.270 , pp. 20051-20058
    • MacDonald, M.J.1
  • 20
    • 0021961644 scopus 로고
    • Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implication for the management of diabetes
    • Unger RH, Grundy S: Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implication for the management of diabetes. Diabetologia 28:118-121, 1985
    • (1985) Diabetologia , vol.28 , pp. 118-121
    • Unger, R.H.1    Grundy, S.2
  • 22
    • 0030810982 scopus 로고    scopus 로고
    • Metabolic fate of glucose in purified islet cells: Glucose-regulated anaplerosis in β-cells
    • Schuit F, De Vos A, Farfari S, Moens K, Pipeleers D, Brun T, Prentki M: Metabolic fate of glucose in purified islet cells: glucose-regulated anaplerosis in β-cells. J Biol Chem 272:18572-18579, 1997
    • (1997) J Biol Chem , vol.272 , pp. 18572-18579
    • Schuit, F.1    De Vos, A.2    Farfari, S.3    Moens, K.4    Pipeleers, D.5    Brun, T.6    Prentki, M.7
  • 23
    • 0030926003 scopus 로고    scopus 로고
    • Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells
    • Maechler P, Kennedy ED, Pozzan T, Wollheim CB: Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells, EMBO J 16:3833-3841, 1997
    • (1997) EMBO J , vol.16 , pp. 3833-3841
    • Maechler, P.1    Kennedy, E.D.2    Pozzan, T.3    Wollheim, C.B.4
  • 24
    • 0030871847 scopus 로고    scopus 로고
    • β-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy
    • Koyama K, Chen G, Wang MY, Shimabukuro M, Newgard CB, Unger RH: β-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 46:1276-1280, 1997
    • (1997) Diabetes , vol.46 , pp. 1276-1280
    • Koyama, K.1    Chen, G.2    Wang, M.Y.3    Shimabukuro, M.4    Newgard, C.B.5    Unger, R.H.6
  • 27
    • 0031048115 scopus 로고    scopus 로고
    • Increased lipogenic capacity of the islets of obese rats: A role in the pathogenesis of NIDDM
    • Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH: Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Diabetes 46:408-413, 1997
    • (1997) Diabetes , vol.46 , pp. 408-413
    • Lee, Y.1    Hirose, H.2    Zhou, Y.T.3    Esser, V.4    McGarry, J.D.5    Unger, R.H.6
  • 28
    • 0028221978 scopus 로고
    • Mechanisms of the stimulation of insulin release by saturated fatty acids: A study of palmitate effects in mouse beta-cells
    • Warnotte C, Gilon P, Nenquin M, Henquin JC: Mechanisms of the stimulation of insulin release by saturated fatty acids: a study of palmitate effects in mouse beta-cells. Diabetes 43:703-711, 1994
    • (1994) Diabetes , vol.43 , pp. 703-711
    • Warnotte, C.1    Gilon, P.2    Nenquin, M.3    Henquin, J.C.4
  • 30
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB: Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines, Endocrinology 130:167-178, 1992
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 31
    • 0023277545 scopus 로고
    • Single step method of RNA isolation by acid guanidium thiocyanate phenol-chloroform extraction
    • Chomczinsky P, Sacchi N: Single step method of RNA isolation by acid guanidium thiocyanate phenol-chloroform extraction. Anal Biochem 162:156-160, 1987
    • (1987) Anal Biochem , vol.162 , pp. 156-160
    • Chomczinsky, P.1    Sacchi, N.2
  • 32
    • 0024560677 scopus 로고
    • Transblot identification of biotin-containing proteins in rat liver
    • Haneji T, Koide SS: Transblot identification of biotin-containing proteins in rat liver. Anal Biochem 177:57-61, 1989
    • (1989) Anal Biochem , vol.177 , pp. 57-61
    • Haneji, T.1    Koide, S.S.2
  • 33
    • 0014217485 scopus 로고
    • Pigeon liver malic enzyme. V. Kinetic studies
    • Hsu RY, Lardy HA, Cleland WW: Pigeon liver malic enzyme. V. Kinetic studies. J Biol Chem 242:5315-5322, 1967
    • (1967) J Biol Chem , vol.242 , pp. 5315-5322
    • Hsu, R.Y.1    Lardy, H.A.2    Cleland, W.W.3
  • 34
    • 0029166701 scopus 로고
    • Effect of oxaloacetate and phosphorylation on ATP-citrate lyase activity
    • Pentyala SN, Benjamin WB: Effect of oxaloacetate and phosphorylation on ATP-citrate lyase activity. Biochemistry 34:10961-10969, 1995
    • (1995) Biochemistry , vol.34 , pp. 10961-10969
    • Pentyala, S.N.1    Benjamin, W.B.2
  • 36
    • 0031019883 scopus 로고    scopus 로고
    • Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic β-cell line INS-1
    • Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M: Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic β-cell line INS-1. J Biol Chem 272:1659-1664, 1997
    • (1997) J Biol Chem , vol.272 , pp. 1659-1664
    • Assimacopoulos-Jeannet, F.1    Thumelin, S.2    Roche, E.3    Esser, V.4    McGarry, J.D.5    Prentki, M.6
  • 38
    • 77957001185 scopus 로고
    • Assay of citric acid cycle intermediates and related compounds
    • Williamson JR, Corkey BE: Assay of citric acid cycle intermediates and related compounds. Methods Enzymol 13:434-513, 1969
    • (1969) Methods Enzymol , vol.13 , pp. 434-513
    • Williamson, J.R.1    Corkey, B.E.2
  • 39
    • 0017071784 scopus 로고
    • An improved and simplified radioisotopic assay for the determination of free and esterified carnitine
    • McGarry JD, Foster DW: An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J Lipid Res 17:277-281, 1976
    • (1976) J Lipid Res , vol.17 , pp. 277-281
    • McGarry, J.D.1    Foster, D.W.2
  • 41
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, Sloane-Stanley GHA: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509, 1957
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Gha, S.-S.3
  • 42
    • 0018764767 scopus 로고
    • Actin microfilaments, cell shape, and secretory processes in isolated rat hepatocytes: Effect of phalloidin and cytochalasin D
    • Prentki M, Chaponnier C, Jeanrenuud B, Gabbiani G: Actin microfilaments, cell shape, and secretory processes in isolated rat hepatocytes: effect of phalloidin and cytochalasin D. J Cell Biol 81:592-607, 1979
    • (1979) J Cell Biol , vol.81 , pp. 592-607
    • Prentki, M.1    Chaponnier, C.2    Jeanrenuud, B.3    Gabbiani, G.4
  • 43
    • 0027199057 scopus 로고
    • Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1)
    • Brun T, Roche E, Kim KH, Prentki M: Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1). J Biol Chem 268:18905-18911, 1993
    • (1993) J Biol Chem , vol.268 , pp. 18905-18911
    • Brun, T.1    Roche, E.2    Kim, K.H.3    Prentki, M.4
  • 44
    • 0026783692 scopus 로고
    • Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue: A role for glucose 6-phosphate
    • Foufelle F, Gouhot B, Pegorier JP, Perdereau D, Girard J, Ferre P: Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue: a role for glucose 6-phosphate. J Biol Chem 267:20543-20546, 1992
    • (1992) J Biol Chem , vol.267 , pp. 20543-20546
    • Foufelle, F.1    Gouhot, B.2    Pegorier, J.P.3    Perdereau, D.4    Girard, J.5    Ferre, P.6
  • 45
    • 0026808466 scopus 로고
    • Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells
    • Louis NA, Witters LA: Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells. J Biol Chem 267:2287-2293, 1992
    • (1992) J Biol Chem , vol.267 , pp. 2287-2293
    • Louis, N.A.1    Witters, L.A.2
  • 46
    • 0026504568 scopus 로고
    • Identification of glucose response proteins in two biological models of beta-cell adaptation to chronic high glucose exposure
    • Collins H, Najafi H, Buettger C, Rombeau J, Settle RG, Matschinsky FM: Identification of glucose response proteins in two biological models of beta-cell adaptation to chronic high glucose exposure. J Biol Chem 267:1357-1366, 1992
    • (1992) J Biol Chem , vol.267 , pp. 1357-1366
    • Collins, H.1    Najafi, H.2    Buettger, C.3    Rombeau, J.4    Settle, R.G.5    Matschinsky, F.M.6
  • 47
    • 0027418977 scopus 로고
    • The biosynthesis of the subtillsin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
    • Alarcon C, Lincoln B, Rhodes CJ: The biosynthesis of the subtillsin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem 268:4276-4280, 1993
    • (1993) J Biol Chem , vol.268 , pp. 4276-4280
    • Alarcon, C.1    Lincoln, B.2    Rhodes, C.J.3
  • 48
    • 0027453493 scopus 로고
    • Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart
    • Saddik M, Gamble J, Witters LA Lopaschuk GD: Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem 268:25836-25845, 1993
    • (1993) J Biol Chem , vol.268 , pp. 25836-25845
    • Saddik, M.1    Gamble, J.2    Witters, L.A.3    Lopaschuk, G.D.4
  • 49
    • 0024503204 scopus 로고
    • Regulation of ketogenosis and the renaissance of carnitine palmitoyltransferase
    • McGarry JD, Woeltje KF, Kuwajima M, Foster DW: Regulation of ketogenosis and the renaissance of carnitine palmitoyltransferase. Diabetes Metab Rev 5:271-284, 1989
    • (1989) Diabetes Metab Rev , vol.5 , pp. 271-284
    • McGarry, J.D.1    Woeltje, K.F.2    Kuwajima, M.3    Foster, D.W.4
  • 50
    • 0029081369 scopus 로고
    • Glucose activation of acetyl-CoA carboxylase in association with insulin secretion in a pancreatic beta-cell line
    • Zhang S, Kim KH: Glucose activation of acetyl-CoA carboxylase in association with insulin secretion in a pancreatic beta-cell line. J Endocrinol 147:33-41, 1995
    • (1995) J Endocrinol , vol.147 , pp. 33-41
    • Zhang, S.1    Kim, K.H.2
  • 51
    • 0026581414 scopus 로고
    • Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay
    • Janjic D, Wollheim CB: Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 35:482-485, 1992
    • (1992) Diabetologia , vol.35 , pp. 482-485
    • Janjic, D.1    Wollheim, C.B.2
  • 53
    • 0014827428 scopus 로고
    • Enzymes of glucose metabolism in normal mouse pancreatic islets
    • Ashcroft SJH, Randle PJ: Enzymes of glucose metabolism in normal mouse pancreatic islets. Biochem J 119:5-15, 1970
    • (1970) Biochem J , vol.119 , pp. 5-15
    • Ashcroft, S.J.H.1    Randle, P.J.2
  • 54
    • 0025721159 scopus 로고
    • Pyruvate dehydrogenase and pyruvate carboxylase: Sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets
    • MacDonald MJ, Kaysen JH, Moran SM, Pomije CE: Pyruvate dehydrogenase and pyruvate carboxylase: sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets. J Biol Chem 266:22392-22397, 1991
    • (1991) J Biol Chem , vol.266 , pp. 22392-22397
    • MacDonald, M.J.1    Kaysen, J.H.2    Moran, S.M.3    Pomije, C.E.4
  • 55
    • 0023525741 scopus 로고
    • 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
    • 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67:1186-1248, 1987
    • (1987) Physiol Rev , vol.67 , pp. 1186-1248
    • Prentki, M.1    Matschinsky, F.M.2
  • 56
    • 0028236988 scopus 로고
    • More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling
    • Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD: More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling. Diabetes 43:878-883, 1994
    • (1994) Diabetes , vol.43 , pp. 878-883
    • Chen, S.1    Ogawa, A.2    Ohneda, M.3    Unger, R.H.4    Foster, D.W.5    McGarry, J.D.6
  • 58
    • 0027385108 scopus 로고
    • β-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats
    • Leahy JL, Bumbalo LM, Chen C: β-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats. Diabetologia 36:1238-1244, 1993
    • (1993) Diabetologia , vol.36 , pp. 1238-1244
    • Leahy, J.L.1    Bumbalo, L.M.2    Chen, C.3
  • 60
    • 0024791536 scopus 로고
    • A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells
    • Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M: A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. J Biol Chem 264:21608-21612, 1989
    • (1989) J Biol Chem , vol.264 , pp. 21608-21612
    • Corkey, B.E.1    Glennon, M.C.2    Chen, K.S.3    Deeney, J.T.4    Matschinsky, F.M.5    Prentki, M.6
  • 62
    • 0026733643 scopus 로고
    • Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
    • Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE: Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 267:5802-5810, 1992
    • (1992) J Biol Chem , vol.267 , pp. 5802-5810
    • Prentki, M.1    Vischer, S.2    Glennon, M.C.3    Regazzi, R.4    Deeney, J.T.5    Corkey, B.E.6
  • 63
    • 0030067124 scopus 로고    scopus 로고
    • A lesson in metabolic regulation inspired by the gluco-kinase glucose sensor paradigm
    • Matschinsky FM: A lesson in metabolic regulation inspired by the gluco-kinase glucose sensor paradigm. Diabetes 45:223-241, 1996
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 64
    • 84875738637 scopus 로고
    • Control of mitochondrial substrate oxidation
    • Hansford RG: Control of mitochondrial substrate oxidation Curr Top Bioenerg 10:217-278, 1980
    • (1980) Curr Top Bioenerg , vol.10 , pp. 217-278
    • Hansford, R.G.1
  • 65
    • 0029014451 scopus 로고
    • Influence of glucose on pyruvate carboxylase expression in pancreatic islets
    • Mac Donald MJ: Influence of glucose on pyruvate carboxylase expression in pancreatic islets. Arch Biochem Biophys 319:128-132, 1995
    • (1995) Arch Biochem Biophys , vol.319 , pp. 128-132
    • Mac Donald, M.J.1
  • 66
    • 0025886869 scopus 로고
    • Hexose metabolism in pancreatic islets: Pyruvate carboxylase activity
    • Curi R, Carpinelli AR, Malaisse WJ: Hexose metabolism in pancreatic islets: pyruvate carboxylase activity. Biochimie 73:583-586, 1991
    • (1991) Biochimie , vol.73 , pp. 583-586
    • Curi, R.1    Carpinelli, A.R.2    Malaisse, W.J.3
  • 67
    • 0026065018 scopus 로고
    • Content of CoA-esters in perifused rat islets stimulated by glucose and other fuels
    • Liang Y, Matschinsky FM: Content of CoA-esters in perifused rat islets stimulated by glucose and other fuels. Diabetes 40:327-333, 1991
    • (1991) Diabetes , vol.40 , pp. 327-333
    • Liang, Y.1    Matschinsky, F.M.2
  • 68
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Lee Y, Hirose H, Makoto O, Johnson JH, McGarry JD, Unger RH: Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA 91:10878-10882, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Makoto, O.3    Johnson, J.H.4    McGarry, J.D.5    Unger, R.H.6
  • 69
    • 0025255460 scopus 로고
    • Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets
    • McCormack JG, Longo EA, Corkey BE: Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets. Biochem J 267:527-530, 1990
    • (1990) Biochem J , vol.267 , pp. 527-530
    • McCormack, J.G.1    Longo, E.A.2    Corkey, B.E.3
  • 70
    • 0027391166 scopus 로고
    • Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic beta-cells
    • Purrello F, Buscema M, Rabuazzo AM, Caltabiano V, Forte F, Vinci C, Vetri M, Vigneri R: Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic beta-cells. Diabetes 42:199-205, 1993
    • (1993) Diabetes , vol.42 , pp. 199-205
    • Purrello, F.1    Buscema, M.2    Rabuazzo, A.M.3    Caltabiano, V.4    Forte, F.5    Vinci, C.6    Vetri, M.7    Vigneri, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.