메뉴 건너뛰기




Volumn 13, Issue 1, 2007, Pages 38-48

Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: A new tool in Alzheimer's disease research

Author keywords

1H magnetic resonance spectroscopy; Alzheimer's disease; Alzheimer's disease therapy; Magnetic resonance microimaging; Transgenic Alzheimer's mice

Indexed keywords

ALZHEIMER DISEASE; BRAIN REGION; DISEASE COURSE; IMMUNOTHERAPY; MAGNETIC FIELD; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

EID: 33845995054     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858406295610     Document Type: Review
Times cited : (69)

References (66)
  • 1
    • 0345415139 scopus 로고    scopus 로고
    • 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): Novel diagnostic and therapeutic tools in Alzheimer's disease
    • Agdeppa ED, Kepe V, Liu J, Small GW, Huang SC, Petric A, and others. 2003. 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease. Mol Imaging Biol 5: 404 - 417.
    • (2003) Mol Imaging Biol , vol.5 , pp. 404-417
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Small, G.W.4    Huang, S.C.5    Petric, A.6
  • 2
    • 0142123057 scopus 로고    scopus 로고
    • Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice
    • Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, and others. 2003. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proc Natl Acad Sci USA 100: 12462 - 12467.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12462-12467
    • Bacskai, B.J.1    Hickey, G.A.2    Skoch, J.3    Kajdasz, S.T.4    Wang, Y.5    Huang, G.F.6
  • 3
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-Mediated mechanisms are involved in clearance of amyloid-β in vivo by immunotherapy
    • Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, and others. 2002. Non-Fc-Mediated mechanisms are involved in clearance of amyloid-β in vivo by immunotherapy. J Neurosci 22: 7873 - 7878.
    • (2002) J Neurosci , vol.22 , pp. 7873-7878
    • Bacskai, B.J.1    Kajdasz, S.T.2    McLellan, M.E.3    Games, D.4    Seubert, P.5    Schenk, D.6
  • 4
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, and others. 2000. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6: 916 - 919.
    • (2000) Nat Med , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6
  • 5
    • 0033598746 scopus 로고    scopus 로고
    • Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy
    • Beneviste H, Einstein G, Kim KR, Hulette C, Johnson GA. 1999. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc Natl Acad Sci USA 96: 14079 - 14084.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14079-14084
    • Beneviste, H.1    Einstein, G.2    Kim, K.R.3    Hulette, C.4    Johnson, G.A.5
  • 6
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimerrelated changes
    • Braak H, Braak E. 1991. Neuropathological staging of Alzheimerrelated changes. Acta Neuropathol 82: 239 - 259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 7
    • 2442582930 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile
    • Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG. 2004. Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res 1012: 60 - 65.
    • (2004) Brain Res , vol.1012 , pp. 60-65
    • Dedeoglu, A.1    Choi, J.K.2    Cormier, K.3    Kowall, N.W.4    Jenkins, B.G.5
  • 8
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma Aβ clearance and decreases brain a beta burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. 2001. Peripheral anti-A beta antibody alters CNS and plasma Aβ clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98: 8850 - 8855.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 9
    • 0036091386 scopus 로고    scopus 로고
    • Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images
    • Dhenain M, Privat N, Duyckaerts C, Jacobs RE. 2002. Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images. NMR Biomed 15: 197 - 203.
    • (2002) NMR Biomed , vol.15 , pp. 197-203
    • Dhenain, M.1    Privat, N.2    Duyckaerts, C.3    Jacobs, R.E.4
  • 10
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain A-beta burden in Alzheimer's disease model
    • Dodard J-C, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, and others. 2002. Immunization reverses memory deficits without reducing brain A-beta burden in Alzheimer's disease model. Nat Neurosci 5: 452 - 457.
    • (2002) Nat Neurosci , vol.5 , pp. 452-457
    • Dodard, J.-C.1    Bales, K.R.2    Gannon, K.S.3    Greene, S.J.4    Demattos, R.B.5    Mathis, C.6
  • 11
    • 0024317904 scopus 로고
    • Prevalence of Alzheimer's disease in a community population of older persons
    • Evans DA, Funkenstein HH, Albert MS. 1989. Prevalence of Alzheimer's disease in a community population of older persons. JAMA 262: 2551 - 2556.
    • (1989) JAMA , vol.262 , pp. 2551-2556
    • Evans, D.A.1    Funkenstein, H.H.2    Albert, M.S.3
  • 12
    • 33644832047 scopus 로고    scopus 로고
    • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid A-β42 in humans
    • Fagan AM, Minun MA, Mach RH, Lee SY, Dence CS, Shah AR, and others. 2006. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid A-β42 in humans. Ann Neurol 59: 512 - 519.
    • (2006) Ann Neurol , vol.59 , pp. 512-519
    • Fagan, A.M.1    Ma, M.2    MacH, R.H.3    Lee, S.Y.4    Dence, C.S.5    Shah, A.R.6
  • 13
    • 17644397044 scopus 로고    scopus 로고
    • Histological co-localization of iron in A-β plaques of PS/APP transgenic mice
    • Falangola MF, Lee SP, Nixon RA, Duff KE, Helpern JA. 2005. Histological co-localization of iron in A-β plaques of PS/APP transgenic mice. Neurochem Res 30: 201 - 205.
    • (2005) Neurochem Res , vol.30 , pp. 201-205
    • Falangola, M.F.1    Lee, S.P.2    Nixon, R.A.3    Duff, K.E.4    Helpern, J.A.5
  • 14
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloidbeta immunization in Alzheimer's disease
    • Ferrer I, Boada RM, Sanchez GML, Rey MJ, Costa-Jussa F. 2004. Neuropathology and pathogenesis of encephalitis following amyloidbeta immunization in Alzheimer's disease. Brain Pathol 14: 11 - 20.
    • (2004) Brain Pathol , vol.14 , pp. 11-20
    • Ferrer, I.1    Boada, R.M.2    Gml, S.3    Rey, M.J.4    Costa-Jussa, F.5
  • 16
    • 0035742326 scopus 로고    scopus 로고
    • The return of the frequency sweep: Designing adiabatic pulses for contemporary NMR
    • Garwood M, DelaBarre L. 2001. The return of the frequency sweep: designing adiabatic pulses for contemporary NMR. J Magn Reson 153: 155 - 177.
    • (2001) J Magn Reson , vol.153 , pp. 155-177
    • Garwood, M.1    Delabarre, L.2
  • 17
    • 44949273876 scopus 로고
    • Symmetric pulses to induce arbitrary flip angles with compensation for RF inhomogeneity and resonance offsets
    • Garwood M, Ke Y. 1991. Symmetric pulses to induce arbitrary flip angles with compensation for RF inhomogeneity and resonance offsets. J Magn Reson 94: 511 - 525.
    • (1991) J Magn Reson , vol.94 , pp. 511-525
    • Garwood, M.1    Ke, Y.2
  • 18
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. 2002. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353 - 356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 19
    • 21544468846 scopus 로고    scopus 로고
    • Treatment with an amyloid-β antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
    • Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, Holtzman DM. 2005. Treatment with an amyloid-β antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. Neurobiol Aging 25: 6213 - 6220.
    • (2005) Neurobiol Aging , vol.25 , pp. 6213-6220
    • Hartman, R.E.1    Izumi, Y.2    Bales, K.R.3    Paul, S.M.4    Wozniak, D.F.5    Holtzman, D.M.6
  • 22
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon M, McGowan E, Yu X, Benkovic S, Jantzen P, and others. 1998. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4: 97 - 100.
    • (1998) Nat Med , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6
  • 23
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, A-beta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin D, and others. 1996. Correlative memory deficits, A-beta elevation, and amyloid plaques in transgenic mice. Science 274: 99 - 102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, D.6
  • 24
    • 10044278300 scopus 로고    scopus 로고
    • In vivo visualization of Alzheimer's amyloid plaques by MRI in transgenic mice without a contrast agent
    • Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curan GL, Lin J, and others. 2004. In vivo visualization of Alzheimer's amyloid plaques by MRI in transgenic mice without a contrast agent. Magn Reson Med 52: 1263 - 1271.
    • (2004) Magn Reson Med , vol.52 , pp. 1263-1271
    • Jack Jr., C.R.1    Garwood, M.2    Wengenack, T.M.3    Borowski, B.4    Curan, G.L.5    Lin, J.6
  • 25
    • 27344439224 scopus 로고    scopus 로고
    • In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice
    • Jack CR Jr, Wengenack TM, Reyes DA, Garwood M, Curran GL, Borowski BJ, and others. 2005. In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice. J Neurosci 25: 10041 - 10048.
    • (2005) J Neurosci , vol.25 , pp. 10041-10048
    • Jack Jr., C.R.1    Wengenack, T.M.2    Reyes, D.A.3    Garwood, M.4    Curran, G.L.5    Borowski, B.J.6
  • 26
    • 0034700471 scopus 로고    scopus 로고
    • A-beta peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease
    • Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, and others. 2000. A-beta peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease. Nature 408: 979 - 982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3    Mathews, P.M.4    Jiang, Y.5    Schmidt, S.D.6
  • 27
    • 0038517131 scopus 로고    scopus 로고
    • Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: Comparison of 1.5T and 3T
    • Kantarci K, Reynolds G, Petersen R, Boeve BF, Knopman DS, Edland SD, and others. 2003. Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5T and 3T. AJNR Am J Neuroradiol 24: 843 - 849.
    • (2003) AJNR Am J Neuroradiol , vol.24 , pp. 843-849
    • Kantarci, K.1    Reynolds, G.2    Petersen, R.3    Boeve, B.F.4    Knopman, D.S.5    Edland, S.D.6
  • 28
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B
    • Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, and others. 2004. Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B. Ann Neurol 55: 306 - 319.
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3    Wang, Y.4    Blomqvist, G.5    Holt, D.P.6
  • 29
    • 27944471285 scopus 로고    scopus 로고
    • Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse brain
    • Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamson EE, and others. 2005. Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse brain. J Neurosci 25: 10598 - 10606.
    • (2005) J Neurosci , vol.25 , pp. 10598-10606
    • Klunk, W.E.1    Lopresti, B.J.2    Ikonomovic, M.D.3    Lefterov, I.M.4    Koldamova, R.P.5    Abrahamson, E.E.6
  • 30
    • 0037444535 scopus 로고    scopus 로고
    • The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    • Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, and others. 2003. The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci 23: 2086 - 2092.
    • (2003) J Neurosci , vol.23 , pp. 2086-2092
    • Klunk, W.E.1    Wang, Y.2    Huang, G.F.3    Debnath, M.L.4    Holt, D.P.5    Shao, L.6
  • 32
    • 5444264488 scopus 로고    scopus 로고
    • Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease
    • Kung M-P, Hou C, Zhuang A-P, Skovronsky DM, Kung HF. 2004. Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease. Brain Res 1025: 98 - 105.
    • (2004) Brain Res , vol.1025 , pp. 98-105
    • Kung, M.-P.1    Hou, C.2    Zhuang, A.-P.3    Skovronsky, D.M.4    Kung, H.F.5
  • 33
    • 0642341172 scopus 로고    scopus 로고
    • Characterization of radioiodinated ligand binding to amyloid beta plaques
    • Kung M-P, Zhuang Z-P, Hou C, Jin L-W, Kung HF. 2003. Characterization of radioiodinated ligand binding to amyloid beta plaques. J Mol Neurosci 20: 249 - 251.
    • (2003) J Mol Neurosci , vol.20 , pp. 249-251
    • Kung, M.-P.1    Zhuang, Z.-P.2    Hou, C.3    Jin, L.-W.4    Kung, H.F.5
  • 34
    • 4243157452 scopus 로고    scopus 로고
    • Visualization of amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents
    • Lee S-P, Falangola MF, Nixon RA, Duff K, Helpern JA. 2004. Visualization of amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med 52: 538 - 544.
    • (2004) Magn Reson Med , vol.52 , pp. 538-544
    • Lee, S.-P.1    Falangola, M.F.2    Nixon, R.A.3    Duff, K.4    Helpern, J.A.5
  • 35
    • 31044433933 scopus 로고    scopus 로고
    • Anti-Abeta42-and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model
    • Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, and others. 2006. Anti-Abeta42-and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest 116: 193 - 201.
    • (2006) J Clin Invest , vol.116 , pp. 193-201
    • Levites, Y.1    Das, P.2    Price, R.W.3    Rochette, M.J.4    Kostura, L.A.5    McGowan, E.M.6
  • 36
    • 31844439888 scopus 로고    scopus 로고
    • Antibodies against β-amyloid reduce Aβ oligomers, glycogen synthase kinase-3β activation and tau phosphorylation in vivo and in vitro
    • Ma Q-L, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, and others. 2006. Antibodies against β-amyloid reduce Aβ oligomers, glycogen synthase kinase-3β activation and tau phosphorylation in vivo and in vitro. J Neurosci Res 83: 374 - 384.
    • (2006) J Neurosci Res , vol.83 , pp. 374-384
    • Ma, Q.-L.1    Lim, G.P.2    Harris-White, M.E.3    Yang, F.4    Ambegaokar, S.S.5    Ubeda, O.J.6
  • 37
    • 23844505632 scopus 로고    scopus 로고
    • Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy
    • Marjanska M, Curran GL, Wengenach TM, Henry P-G, Bliss RL, Poduslo JF, and others. 2005. Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc Natl Acad Sci USA 102: 11906 - 11910.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11906-11910
    • Marjanska, M.1    Curran, G.L.2    Wengenach, T.M.3    Henry, P.-G.4    Bliss, R.L.5    Poduslo, J.F.6
  • 38
    • 0027322890 scopus 로고
    • Alzheimer disease: Depiction of increased cerebral myo-inositol with proton MR spectroscopy
    • Miller BL, Moats RA, Shonk T, Ernst T, Woolley S, Ross BD. 1993. Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy. Radiology 187: 433 - 437.
    • (1993) Radiology , vol.187 , pp. 433-437
    • Miller, B.L.1    Moats, R.A.2    Shonk, T.3    Ernst, T.4    Woolley, S.5    Ross, B.D.6
  • 39
    • 0028244281 scopus 로고
    • Abnormal cerebral metabolite concentrations in patients with probable Alzheimer disease
    • Moats RA, Ernst T, Shonk TK, Ross BD. 1994. Abnormal cerebral metabolite concentrations in patients with probable Alzheimer disease. Magn Reson Med 32: 110 - 115.
    • (1994) Magn Reson Med , vol.32 , pp. 110-115
    • Moats, R.A.1    Ernst, T.2    Shonk, T.K.3    Ross, B.D.4
  • 40
    • 84984755327 scopus 로고    scopus 로고
    • A-beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, and others. 2000. A-beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408: 982 - 985.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3    Ugen, K.E.4    Dickey, C.5    Hardy, J.6
  • 41
    • 0142075238 scopus 로고    scopus 로고
    • 11C-labeled stilbene derivative as A-beta aggregate-specific PET imaging agents for Alzheimer's disease
    • Ono M, Wilson AA, Nobrega J, Westaway D, Verhoeff P, Zhuang Z-P, and others. 2003. 11C-labeled stilbene derivative as A-beta aggregate-specific PET imaging agents for Alzheimer's disease. Nucl Med Biol 30: 565 - 571.
    • (2003) Nucl Med Biol , vol.30 , pp. 565-571
    • Ono, M.1    Wilson, A.A.2    Nobrega, J.3    Westaway, D.4    Verhoeff, P.5    Zhuang, Z.-P.6
  • 44
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, and others. 1999. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400: 173 - 177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6
  • 45
    • 0031454126 scopus 로고    scopus 로고
    • Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease: A proton MR spectroscopic imaging and MRI study
    • Schuff N, Amend DL, Ezekiel F, Steinman SK, Tanabe J, Norman D, and others. 1997. Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease: a proton MR spectroscopic imaging and MRI study. Neurology 49: 1513 - 1521.
    • (1997) Neurology , vol.49 , pp. 1513-1521
    • Schuff, N.1    Amend, D.L.2    Ezekiel, F.3    Steinman, S.K.4    Tanabe, J.5    Norman, D.6
  • 46
    • 0037177094 scopus 로고    scopus 로고
    • Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD
    • Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, and others. 2002. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology 58: 928 - 935.
    • (2002) Neurology , vol.58 , pp. 928-935
    • Schuff, N.1    Capizzano, A.A.2    Du, A.T.3    Amend, D.L.4    O'Neill, J.5    Norman, D.6
  • 47
    • 0004918058 scopus 로고
    • Deciphering Alzheimer's disease: Molecular genetics and cell biology yield major clues
    • Selkoe DJ. 1995. Deciphering Alzheimer's disease: molecular genetics and cell biology yield major clues. J NIH Res 7: 57 - 64.
    • (1995) J NIH Res , vol.7 , pp. 57-64
    • Selkoe, D.J.1
  • 49
    • 18844426044 scopus 로고    scopus 로고
    • Imaging beta-amyloid fibrils in Alzheimer's disease: A critical analysis through simulation of amyloid fibril polymerization
    • Shoghi-Jadid K, Barrio JR, Kepe V, Wu HM, Phelps ME, Huang SC. 2005. Imaging beta-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerization. Nucl Med Biol 32: 337 - 351.
    • (2005) Nucl Med Biol , vol.32 , pp. 337-351
    • Shoghi-Jadid, K.1    Barrio, J.R.2    Kepe, V.3    Wu, H.M.4    Phelps, M.E.5    Huang, S.C.6
  • 50
    • 84903202261 scopus 로고    scopus 로고
    • Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
    • Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, and others. 2002. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Psychiatry 10: 24 - 35.
    • (2002) Am J Psychiatry , vol.10 , pp. 24-35
    • Shoghi-Jadid, K.1    Small, G.W.2    Agdeppa, E.D.3    Kepe, V.4    Ercoli, L.M.5    Siddarth, P.6
  • 51
    • 0029015918 scopus 로고
    • Role of increased cerebral myo-inositol in the dementia of Down syndrome
    • Shonk T, Ross BD. 1995. Role of increased cerebral myo-inositol in the dementia of Down syndrome. Magn Reson Med 33: 858 - 861.
    • (1995) Magn Reson Med , vol.33 , pp. 858-861
    • Shonk, T.1    Ross, B.D.2
  • 53
    • 48549111126 scopus 로고
    • Highly selective TT/2 and TT pulse generation
    • Silver MS, Jospeh RI, Hoult DI. 1984. Highly selective TT/2 and TT pulse generation. J Magn Reson 59: 347 - 351.
    • (1984) J Magn Reson , vol.59 , pp. 347-351
    • Silver, M.S.1    Jospeh, R.I.2    Hoult, D.I.3
  • 55
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, and others. 1991. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572 - 580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6
  • 56
    • 14744298662 scopus 로고    scopus 로고
    • Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease
    • Vanhoutte G, Dewachter I, Borghgraef P, Van Leuven F, Van der Linden A. 2005. Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magn Reson Med 53: 607 - 613.
    • (2005) Magn Reson Med , vol.53 , pp. 607-613
    • Vanhoutte, G.1    Dewachter, I.2    Borghgraef, P.3    Van Leuven, F.4    Van Der Linden, A.5
  • 58
    • 11844258289 scopus 로고    scopus 로고
    • Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span
    • von Kienlin M, Kunnecke B, Metzger F, Steiner G, Richards JG, Ozmen L, and others. 2005. Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span. Neurobiol Dis 18: 32 - 39.
    • (2005) Neurobiol Dis , vol.18 , pp. 32-39
    • Von Kienlin, M.1    Kunnecke, B.2    Metzger, F.3    Steiner, G.4    Richards, J.G.5    Ozmen, L.6
  • 61
    • 0034736182 scopus 로고    scopus 로고
    • Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain
    • Wengenack TM, Whelan S, Curran GL, Duff KE, Poduslo JF. 2000b. Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience 101: 939 - 944.
    • (2000) Neuroscience , vol.101 , pp. 939-944
    • Wengenack, T.M.1    Whelan, S.2    Curran, G.L.3    Duff, K.E.4    Poduslo, J.F.5
  • 62
    • 33745001453 scopus 로고    scopus 로고
    • Deglycosylated anti-amyloid-β antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
    • Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, and others. 2006. Deglycosylated anti-amyloid-β antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J Neurosci 26: 5340 - 5346.
    • (2006) J Neurosci , vol.26 , pp. 5340-5346
    • Wilcock, D.M.1    Alamed, J.2    Gottschall, P.E.3    Grimm, J.4    Rosenthal, A.5    Pons, J.6
  • 63
    • 1642497601 scopus 로고    scopus 로고
    • Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration
    • Wilcock DM, Munireddy SK, Rosenthal A, Ugen K, Gordon MN, Morgan D. 2004a. Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration. Neurobiol Dis 15: 11 - 20.
    • (2004) Neurobiol Dis , vol.15 , pp. 11-20
    • Wilcock, D.M.1    Munireddy, S.K.2    Rosenthal, A.3    Ugen, K.4    Gordon, M.N.5    Morgan, D.6
  • 64
    • 3042839092 scopus 로고    scopus 로고
    • Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
    • Wilcock DM, Rojiani A, Rosenthal A, Levkowitz G, Subbarao S, Alamed J, and others. 2004b. Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. J Neurosci 24: 6144 - 6151.
    • (2004) J Neurosci , vol.24 , pp. 6144-6151
    • Wilcock, D.M.1    Rojiani, A.2    Rosenthal, A.3    Levkowitz, G.4    Subbarao, S.5    Alamed, J.6
  • 65
    • 14244255355 scopus 로고    scopus 로고
    • Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
    • Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, Gordon MN, and others. 2004c. Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J Neuroinflammation 1: 24-24.
    • (2004) J Neuroinflammation , vol.1 , pp. 24-24
    • Wilcock, D.M.1    Rojiani, A.2    Rosenthal, A.3    Subbarao, S.4    Freeman, M.J.5    Gordon, M.N.6
  • 66
    • 1542346922 scopus 로고    scopus 로고
    • Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging
    • Zhang J, Yarowsky P, Gordon MN, DiCarlo G, Munireddy S, van Zijl PCM, and others. 2004. Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging. Mag Reson Med 51: 452 - 457.
    • (2004) Mag Reson Med , vol.51 , pp. 452-457
    • Zhang, J.1    Yarowsky, P.2    Gordon, M.N.3    Dicarlo, G.4    Munireddy, S.5    Zijl Pcm, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.