Leveraging cell cycle analysis in anticancer drug discovery to identify novel plasmodial drug targets

Infectious Disorders - Drug Targets

Volumn 10, Issue 3, 2010, Pages 165-190

  Kozlov, Sergei ^a   Waters, Norman C ^b   Chavchich, Marina ^b  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

Author keywords

Apoptosis; Artemisinin; Cancer; Cell cycle; Checkpoint; Kinases; Malaria; Plasmodium falciparum; Signal transduction

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 1 CYCLOPROPYL 3 [3 (5 MORPHOLINOMETHYL 1H BENZIMIDAZOL 2 YL) 1H PYRAZOL 4 YL]UREA; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 (2 METHYL 2 PYRROLIDINYL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; 2 [[3 [4 [5 [2 (3 FLUOROANILINO) 2 OXOETHYL] 1H PYRAZOL 3 YLAMINO] 7 QUINAZOLINYLOXY]PROPYL](ETHYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; 3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; 4 (8 CYCLOPENTYL 7 ETHYL 5,6,7,8 TETRAHYDRO 5 METHYL 6 OXO 2 PTERIDINYLAMINO) 3 METHOXY N (1 METHYL 4 PIPERIDINYL)BENZAMIDE; 4 [1 (3 FLUOROBENZYL) 5 INDAZOLYLAMINO] 5 METHYLPYRROLO[2,1 F][1,2,4]TRIAZINE 6 CARBAMIC ACID 3 MORPHOLINOMETHYL ESTER; 4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; 4 [4 [2 (4 CHLOROPHENYL) 5,5 DIMETHYL 1 CYCLOHEXEN 1 YLMETHYL] 1 PIPERAZINYL] N [4 [3 MORPHOLINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 (TRIFLUOROMETHYLSULFONYL)BENZENESULFONYL]BENZAMIDE; 4 [[9 CHLORO 7 (2,6 DIFLUOROPHENYL) 5H PYRIMIDO[5,4 D][2]BENZAZEPIN 2 YL]AMINO]BENZOIC ACID; 5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; 6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; 7 HYDROXYSTAUROSPORINE; 8 FLUORO 3,4 DIHYDRO 2 [4 (METHYLAMINOMETHYL)PHENYL]PYRROLO[3,4,5 E,F][2]BENZAZEPIN 6(5H) ONE; AG 024322; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ARQ 197; ARRY 162; ARRY 334543; ARRY 520; ARRY 797; AS 703569; AT 7519; AUROTHIOMALATE; AZD 5438; AZD 7762; BGT 226; BMS 690514; BMS 863233; BOSUTINIB; BRYOSTATIN 1; BSI 201; CHIR 124; CHIR 265; CP 466722; CYC 116; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; DANUSERTIB; DASATINIB; DEFOROLIMUS; EM 1421; ENMD 2076; ENZASTAURIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; GPI 21016; GSK 1070916; GSK 461364; HMN 214; IC 86621; IMATINIB; INDISULAM; INO 1001; ISPINESIB; JNJ 388; K 858; KX 010107; LAPATINIB; LONAFARNIB; MGCD 265; MIDOSTAURIN; MK 5108; MLN 8237; MSX 122; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; N [4 (3 CHLORO 4 FLUOROANILINO) 7 (TETRAHYDRO 3 FURYLOXY) 6 QUINAZOLINYL] 4 DIMETHYLAMINO 2 BUTENAMIDE; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL]ISONIPECOTAMIDE; NORDIHYDROGUAIARETIC ACID; NU 7026; OBATOCLAX; OLAPARIB; ON 01910; OSI 906; P1446A 05; P276 00; PF 00477736; PF 03814735; PF 299804; PHA 767491; PLX 4032; R 763; RAPAMYCIN; RDEA 119; RO 4584820; ROSCOVITINE; SB 743921; SCH 727965; SNS 314; SORAFENIB; TEMSIROLIMUS; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VX 689; XL 147; XL 228; XL 281; XL 413; XL 518; XL 647; XL 765; XL 844; XL 880; XL 999; YM 115; ZK 304709;

ANTIMALARIAL ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; DNA REPAIR; DNA REPLICATION; DRUG TARGETING; MITOSIS SPINDLE; NONHUMAN; PLASMODIUM; PLASMODIUM FALCIPARUM; SIGNAL TRANSDUCTION; TUMOR CELL;

EID: 77953751339     PISSN: 18715265     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152610791163354     Document Type: Article

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