The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

PLoS Biology

Volumn 1, Issue 1, 2003, Pages

  Bozdech, Zbynek ^a   Llinás, Manuel ^a   Pulliam, Brian Lee ^a   Wong, Edith D ^a   Zhu, Jingchun ^b   DeRisi, Joseph L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APICAL MEMBRANE ANTIGEN 1; ERYTHROCYTE BINDING ANTIGEN 175; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; MEROZOITE SURFACE PROTEIN 1; MEROZOITE SURFACE PROTEIN 3; MEROZOITE SURFACE PROTEIN 5; PARASITE ANTIGEN; RAP1 PROTEIN; RING INFECTED SURFACE ANTIGEN 1; UNCLASSIFIED DRUG; VACCINE; ANTIMALARIAL AGENT; MESSENGER RNA; OLIGONUCLEOTIDE; PROTOZOAL PROTEIN;

ARTICLE; CELL INVASION; CHROMOSOME; DEVELOPMENTAL STAGE; DNA HYBRIDIZATION; ERYTHROCYTE; EUKARYOTE; GENE EXPRESSION; GENE SEQUENCE; GENETIC REGULATION; GENETIC VARIABILITY; GENOME; MALARIA; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM; PROTEIN FUNCTION; PROTEIN SYNTHESIS; ANIMAL; CHEMISTRY; CHROMOSOME MAP; DNA MICROARRAY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; METABOLISM; NUCLEIC ACID HYBRIDIZATION; OPEN READING FRAME; PARASITOLOGY; PLASTID; TIME; ULTRASTRUCTURE;

EUKARYOTA; INVERTEBRATA; PLASMODIUM FALCIPARUM; PROTOZOA;

ANIMALS; ANTIMALARIALS; CHROMOSOME MAPPING; CHROMOSOMES; ERYTHROCYTES; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, PROTOZOAN; GENOME; GENOME, PROTOZOAN; HUMANS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES; OPEN READING FRAMES; PLASMODIUM FALCIPARUM; PLASTIDS; PROTOZOAN PROTEINS; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 4243071596     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0000005     Document Type: Article

References (67)

1. Afonso Nogueira P, Wunderlich G, Shugiro Tada M, d'Arc Neves Costa J, Jose Menezeset M, et al. (2002) Plasmodium falciparum: Analysis of transcribed var gene sequences in natural isolates from the Brazilian Amazon region. Exp Parasitol 101: 111-120. Find this article online
2. Arbeitman MN, Furlong EE, Imam F, Johnson E, Null BH, et al. (2002) Gene expression during the life cycle of Drosophila melanogaster. Science 297: 2270-2275. Find this article online
3. Bahl A, Brunk B, Crabtree J, Fraunholz MJ, Gajria B, et al. (2003) PlasmoDB: The Plasmodium genome resource: A database integrating experimental and computational data. Nucleic Acids Res 31: 212-215. Find this article online
4. Ben Mamoun C, Gluzman IY, Hott C, MacMillan SK, Amarakone AS, et al. (2001) Co-ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis. Mol Microbiol 39: 26-36. Find this article online
5. Blackman MJ (2000) Proteases involved in erythrocyte invasion by the malaria parasite: Function and potential as chemotherapeutic targets. Curr Drug Targets 1: 59-83. Find this article online
6. Bozdech Z, Zhu J, Joachimiak MP, Cohen FE, Pulliam B, et al. (2003) Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol 4: R9. Find this article online
7. Cheng Q, Cloonan N, Fischer K, Thompson J, Waine G, et al. (1998) stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol Biochem Parasitol 97: 161-176. Find this article online
8. Coombs GH, Goldberg DE, Klemba M, Berry C, Kay J, et al. (2001) Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. Trends Parasitol 17: 532-537. Find this article online
9. Cowman AF, Baldi DL, Healer J, Mills KE, O'Donnell RA, et al. (2000) Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells. FEBS Lett 476: 84-88. Find this article online
10. Deitsch KW, Calderwood MS, Wellems TE (2001) Malaria: Cooperative silencing elements in var genes. Nature 412: 875-876. Find this article online
11. Dluzewski AR, Garcia CR (1996) Inhibition of invasion and intraerythrocytic development of Plasmodium falciparum by kinase inhibitors. Experientia 52: 621-623. Find this article online
12. Eisen MB, Brown PO (1999) DNA arrays for analysis of gene expression. Methods Enzymol 303: 179-205. Find this article online
13. Feagin JE, Gardner MJ, Williamson DH, Wilson RJ (1991) The putative mitochondrial genome of Plasmodium falciparum. J Protozool 38: 243-245. Find this article online
14. Fichera ME, Roos DS (1997) A plastid organelle as a drug target in apicomplexan parasites. Nature 390: 407-409. Find this article online
15. Florens L, Washburn MP, Raine JD, Anthony RM, Grainger M, et al. (2002) A proteomic view of the Plasmodium falciparum life cycle. Nature 419: 520-526. Find this article online
16. Foley M, Tilley L, Sawyer WH, Anders RF (1991) The ring-infected erythrocyte surface antigen of Plasmodium falciparum associates with spectrin in the erythrocyte membrane. Mol Biochem Parasitol 46: 137-147. Find this article online
17. Foth BJ, Ralph SA, Tonkin CJ, Struck NS, Fraunholz M, et al. (2003) Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science 299: 705-708. Find this article online
18. Fox BA, Li WB, Tanaka M, Inselburg J, Bzik DJ (1993) Molecular characterization of the largest subunit of Plasmodium falciparum RNA polymerase I. Mol Biochem Parasitol 61: 37-48. Find this article online
19. Francis SE, Sullivan DJ Jr, Goldberg DE (1997) Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu Rev Microbiol 51: 97-123. Find this article online
20. Gardner MJ, Hall N, Fung E, White O, Berriman M, et al. (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419: 498-511. Find this article online
21. Gero AM, O'Sullivan WJ (1990) Purines and pyrimidines in malarial parasites. Blood Cells 16: 467-484. Find this article online
22. Good MF (2001) Towards a blood-stage vaccine for malaria: Are we following all the leads? Nat Rev Immunol 1: 117-125. Find this article online
23. Good MF, Doolan DL (1999) Immune effector mechanisms in malaria. Curr Opin Immunol 11: 412-419. Find this article online
24. Good MF, Kaslow DC, Miller LH (1998) Pathways and strategies for developing a malaria blood-stage vaccine. Annu Rev Immunol 16: 57-87. Find this article online
25. Gray JW, Collins C (2000) Genome changes and gene expression in human solid tumors. Carcinogenesis 21: 443-452. Find this article online
26. Greenbaum DC, Baruch A, Grainger M, Bozdech Z, Medzihradszky KF, et al. (2002) A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science 298: 2002-2006. Find this article online
27. Gruner AC, Brahimi K, Eling W, Konings R, Meis J, et al. (2001) The Plasmodium falciparum knob-associated PfEMP3 antigen is also expressed at preerythrocytic stages and induces antibodies which inhibit sporozoite invasion. Mol Biochem Parasitol 112: 253-261. Find this article online
28. Hayward RE, DeRisi JL, Alfadhli S, Kaslow DC, Brown PO, et al. (2000) Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria. Mol Microbiol 35: 6-14. Find this article online
29. Horrocks P, Dechering K, Lanzer M (1998) Control of gene expression in Plasmodium falciparum. Mol Biochem Parasitol 95: 171-181. Find this article online
30. Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, et al. (1999) Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285: 1573-1576. Find this article online
31. Kaneko O, Tsuboi T, Ling IT, Howell S, Shirano M, et al. (2001) The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii. Mol Biochem Parasitol 118: 223-231. Find this article online
32. Kissinger JC, Brunk BP, Crabtree J, Fraunholz MJ, Gajria B, et al. (2002) The Plasmodium genome database. Nature 419: 490-492. Find this article online
33. Kumar S, Epstein JE, Richie TL, Nkrumah FK, Soisson L, et al. (2002) A multilateral effort to develop DNA vaccines against falciparum malaria. Trends Parasitol 18: 129-135. Find this article online
34. Lang-Unnasch N (1992) Purification and properties of Plasmodium falciparum malate dehydrogenase. Mol Biochem Parasitol 50: 17-25. Find this article online
35. Lasonder E, Ishihama Y, Andersen JS, Vermunt AM, Pain A, et al. (2002) Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry. Nature 419: 537-542. Find this article online
36. Le Roch KG, Zhou Y, Batalov S, Winzeler EA (2002) Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. Am J Trop Med Hyg 67: 233-243. Find this article online
37. Li WB, Bzik DJ, Gu HM, Tanaka M, Fox BA, et al. (1989) An enlarged largest subunit of Plasmodium falciparum RNA polymerase II defines conserved and variable RNA polymerase domains. Nucleic Acids Res 17: 9621-9636. Find this article online
38. Li WB, Bzik DJ, Tanaka M, Gu HM, Fox BA, et al. (1991) Characterization of the gene encoding the largest subunit of Plasmodium falciparum RNA polymerase III. Mol Biochem Parasitol 46: 229-239. Find this article online
39. McFadden GI, Roos DS (1999) Apicomplexan plastids as drug targets. Trends Microbiol 7: 328-333. Find this article online
40. Miller SK, Good RT, Drew DR, Delorenzi M, Sanders PR, et al. (2002) A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J Biol Chem 277: 47524-47532. Find this article online
41. Myler PJ, Beverley SM, Cruz AK, Dobson DE, Ivens AC, et al. (2001) The Leishmania genome project: New insights into gene organization and function. Med Microbiol Immunol (Berl) 190: 9-12. Find this article online
42. Opitz C, Soldati D (2002) "The glideosome": A dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii. Mol Microbiol 45: 597-604. Find this article online
43. Patankar S, Munasinghe A, Shoaibi A, Cummings LM, Wirth DF (2001) Serial analysis of gene expression in Plasmodium falciparum reveals the global expression profile of erythrocytic stages and the presence of anti-sense transcripts in the malarial parasite. Mol Biol Cell 12: 3114-3125. Find this article online
44. Pinder J, Fowler R, Bannister L, Dluzewski A, Mitchell GH (2000) Motile systems in malaria merozoites: How is the red blood cell invaded? Parasitol Today 16: 240-245. Find this article online
45. Pollack JR, Perou CM, Alizadeh AA, Eisen MB, Pergamenschikov A, et al. (1999) Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet 23: 41-46. Find this article online
46. Pollack JR, Sorlie T, Perou CM, Rees CA, Jeffrey SS, et al. (2002) Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci U S A 99: 12963-12968. Find this article online
47. Preiser P, Kaviratne M, Khan S, Bannister L, Jarra W (2000) The apical organelles of malaria merozoites: Host cell selection, invasion, host immunity and immune evasion. Microbes Infect 2: 1461-1477. Find this article online
48. Ramasamy R, Ramasamy M, Yasawardena S (2001) Antibodies and Plasmodium falciparum merozoites. Trends Parasitol 17: 194-197. Find this article online
49. Reyes P, Rathod PK, Sanchez DJ, Mrema JE, Rieckmann KH, et al. (1982) Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum. Mol Biochem Parasitol 5: 275-290. Find this article online
50. Ridley RG (2002) Medical need, scientific opportunity and the drive for antimalarial drugs. Nature 415: 686-693. Find this article online
51. Rosenthal PJ (2002) Hydrolysis of erythrocyte proteins by proteases of malaria parasites. Curr Opin Hematol 9: 140-145. Find this article online
52. Roy A, Cox RA, Williamson DH, Wilson RJ (1999) Protein synthesis in the plastid of Plasmodium falciparum. Protist 150: 183-188. Find this article online
53. Sachs J, Malaney P (2002) The economic and social burden of malaria. Nature 415: 680-685. Find this article online
54. Sherman I (1998) Malaria: Parasite biology, pathogenesis, and protection. Washington, DC: American Society for Microbiology.
55. Spellman PT, Sherlock G, Zhang MQ, Iyer VR, Anders K, et al. (1998) Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell 9: 3273-3297. Find this article online
56. Troye-Blomberg M, Riley EM, Perlmann H, Andersson G, Larsson A, et al. (1989) T and B cell responses of Plasmodium falciparum malaria-immune individuals to synthetic peptides corresponding to sequences in different regions of the P. falciparum antigen Pf155/RESA. J Immunol 143: 3043-3048. Find this article online
57. Waller RF, Keeling PJ, Donald RG, Striepen B, Handman E, et al. (1998) Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci U S A 95: 12352-12357. Find this article online
58. Waller RF, Reed MB, Cowman AF, McFadden GI (2000) Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway. EMBO J 19: 1794-1802. Find this article online
59. Walliker D, Quakyi IA, Wellems TE, McCutchan TF, Szarfman A, et al. (1987) Genetic analysis of the human malaria parasite Plasmodium falciparum. Science 236: 1661-1666. Find this article online
60. Wang P, Wang Q, Sims PF, Hyde JE (2002) Rapid positive selection of stable integrants following transfection of Plasmodium falciparum. Mol Biochem Parasitol 123: 1-10. Find this article online
61. Wellems TE, Panton LJ, Gluzman IY, do Rosario VE, Gwadz RW, et al. (1990) Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature 345: 253-255. Find this article online
62. Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, et al. (2002) Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell 13: 1977-2000. Find this article online
63. Williamson DH, Preiser PR, Moore PW, McCready S, Strath M, et al. (2002) The plastid DNA of the malaria parasite Plasmodium falciparum is replicated by two mechanisms. Mol Microbiol 45: 533-542. Find this article online
64. Wilson RJ (2002) Progress with parasite plastids. J Mol Biol 319: 257-274. Find this article online
65. Wilson RJ, Denny PW, Preiser PR, Rangachari K, Roberts K, et al. (1996) Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum. J Mol Biol 261: 155-172. Find this article online
66. Wu Y, Wang X, Liu X, Wang Y (2003) Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite. Genome Res 13: 601-616. Find this article online
67. Zuegge J, Ralph S, Schmuker M, McFadden GI, Schneider G (2001) Deciphering apicoplast targeting signals-feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins. Gene 280: 19-26. Find this article online